CO5680438A2 - Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas - Google Patents
Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonasInfo
- Publication number
- CO5680438A2 CO5680438A2 CO05004450A CO05004450A CO5680438A2 CO 5680438 A2 CO5680438 A2 CO 5680438A2 CO 05004450 A CO05004450 A CO 05004450A CO 05004450 A CO05004450 A CO 05004450A CO 5680438 A2 CO5680438 A2 CO 5680438A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- alkyl
- group
- aryl
- carbon
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- El uso del compuesto de la fórmula I o la fórmula II, o un tautómero del mismo, en la preparación de un medicamento para el uso en la inducción de la contracepción, dicho medicamento usado en combinación con al menos un modulador del receptor de estrógeno selectivo, caracterizado porque:la fórmula I tiene la estructura: en donde:R1 y R2 son sustituyentes independientes seleccionados del grupo que consiste de H, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C2 a C6, alquenilo C2 a C6 sustituido, alquinilo C2 a C6, alquinilo C2 a C6 sustituido, cicloalquilo C3 a C8, cicloalquilo C3 a C8 sustituido, arilo, arilo sustituido, anillo heterocíclico basado en carbono que tiene en su esqueleto 1 a 3 heteroátomos, anillo heterocíclico basado en carbono sustituido que tiene en su esqueleto 1 a 3 heteroátomos, CORA, y NRBCORA;ó R1 y R2 están fusionados para formar un anillo seleccionado del grupo que consiste de a), b) y c), en donde dicho anillo es opcionalmente sustituido por 1 a 3 sustituyentes seleccionados del grupo que consiste de H y alquilo C1 a C3;a) un anillo espirocíclico saturado de 3 a 8 miembros basado en carbono;b) un anillo espirocíclico de 3 a 8 miembros basado en carbono que tiene uno o más dobles enlaces carbono carbono; y c) un anillo espirocíclico de 3 a 8 miembros que tiene en su esqueleto uno a tres heteroátomos seleccionados del grupo que consiste de O, S y N;RA es seleccionado del grupo que consiste de H, alquilo C1 a C3, alquilo C1 a C3 sustituido, arilo, arilo sustituido, alcoxilo C1 a C3, alcoxilo C1 a C3 sustituido, amino, aminoalquilo C1 a C3, y aminoalquilo C1 a C3 sustituido;RB es seleccionado del grupo que consiste de H, alquilo C1 a C3, y alquilo C1 a C3 sustituido;R3 es seleccionado del grupo que consiste de H, OH, NH2, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C3 a C6, alquenilo C3 a C6 sustituido, alquinilo, alquinilo sustituido, y CORC;RC es seleccionado del grupo que consiste de H, alquilo C1 a C4, alquilo C1 a C4 sustituido, arilo, arilo sustituido, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39187102P | 2002-06-25 | 2002-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5680438A2 true CO5680438A2 (es) | 2006-09-29 |
Family
ID=30000766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05004450A CO5680438A2 (es) | 2002-06-25 | 2005-01-20 | Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7192956B2 (es) |
| EP (1) | EP1515725A4 (es) |
| JP (1) | JP2005535624A (es) |
| KR (1) | KR20050013247A (es) |
| CN (1) | CN1662241A (es) |
| AR (1) | AR040333A1 (es) |
| AU (1) | AU2003247608A1 (es) |
| BR (1) | BR0312024A (es) |
| CA (1) | CA2489847A1 (es) |
| CO (1) | CO5680438A2 (es) |
| CR (1) | CR7611A (es) |
| EC (1) | ECSP055576A (es) |
| IL (1) | IL165396A0 (es) |
| MX (1) | MXPA04012421A (es) |
| NO (1) | NO20045216L (es) |
| RU (1) | RU2005101638A (es) |
| TW (1) | TW200404548A (es) |
| WO (1) | WO2004000801A2 (es) |
| ZA (1) | ZA200410411B (es) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| US6355648B1 (en) * | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| TW200407124A (en) * | 2002-06-25 | 2004-05-16 | Wyeth Corp | Use of thio-oxindole derivatives in treatment of hormone-related conditions |
| US20040248989A1 (en) | 2003-06-05 | 2004-12-09 | Risto Santti | Method for the treatment or prevention of lower urinary tract symptoms |
| AU2005233648B2 (en) * | 2004-04-08 | 2011-06-23 | Wyeth | Methods for minimizing thioamide impurities |
| ES2317223T3 (es) * | 2004-04-08 | 2009-04-16 | Wyeth | Derivados de tioamida como moduladores del receptor de progesterona. |
| MXPA06012402A (es) * | 2004-04-27 | 2007-01-17 | Wyeth Corp | Carbamato y tiocarbamato biarilos ciclicos que contienen cianopirrol y metodos para preparar los mismos. |
| CA2575737C (en) * | 2004-08-13 | 2013-09-24 | Wyeth | Tanaproget derivatives, metabolites, and uses thereof |
| US7399766B2 (en) * | 2004-08-18 | 2008-07-15 | Parion Sciences, Inc. | Soluble amide & ester pyrazinoylguanidine sodium channel blockers |
| CN101027321A (zh) * | 2004-08-20 | 2007-08-29 | 惠氏公司 | 孕酮受体结构 |
| ATE460937T1 (de) * | 2005-04-28 | 2010-04-15 | Wyeth Corp | Mikronisierte tanaproget zusammensetzungen und verfahren zu ihrer herstellung |
| EP1877059B8 (en) | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Micronized tanaproget and compostions containing same |
| BRPI0610156A2 (pt) * | 2005-04-28 | 2016-08-16 | Wyeth Corp | forma micronizada de um composto, forma purificada i do composto, kit, padrão de referência, e, método de preparaçao de uma composição farmacêutica. |
| AU2011226814B2 (en) * | 2005-04-28 | 2013-06-13 | Wyeth Llc | Micronized tanaproget, compositions, and methods of preparing the same |
| AU2011203520B2 (en) * | 2005-04-28 | 2012-06-14 | Wyeth | Micronized tanaproget and compostions containing same |
| DE602006007453D1 (de) * | 2005-04-28 | 2009-08-06 | Wyeth Corp | Zusammensetzungen mit mikronisiertem tanaproget |
| CN101166736B (zh) * | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| CN101193639A (zh) * | 2005-06-09 | 2008-06-04 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
| CA2672835A1 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Processes for the preparation of (3r, 4r) -n- (4-chlorophenyl) -1- (2, 2-difluoroethyl) -n'- [2-fluoro-4- (2-oxo-1 (2h) -pyridinyl) phenyl] -3 , 4-pyrrolidinedicarboxamide |
| US20090170823A1 (en) * | 2007-12-20 | 2009-07-02 | Duramed Pharmaceuticals, Inc. | Dosage Regimens and Pharmaceutical Compositions and Packages for Emergency Contraception |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2475366A1 (en) * | 2009-09-11 | 2012-07-18 | Bayer Pharma Aktiengesellschaft | Substituted (heteroarylmethyl) thiohydantoins as anticancer drugs |
| ES2627692T3 (es) | 2010-06-10 | 2017-07-31 | Aragon Pharmaceuticals, Inc. | Moduladores de receptores de estrógenos y usos de los mismos |
| SG11201403002RA (en) | 2011-12-14 | 2014-07-30 | Seragon Pharmaceuticals Inc | Fluorinated estrogen receptor modulators and uses thereof |
| US20170014174A1 (en) * | 2015-07-17 | 2017-01-19 | Candela Corporation | Cryogenic Cylinder |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) * | 1841-03-12 | Tor and planter for plowing | ||
| US2003A (en) * | 1841-03-12 | Improvement in horizontal windivhlls | ||
| WO1985000519A1 (en) | 1983-07-29 | 1985-02-14 | Duke University | Method of treating androgen-related disorders |
| GB2310660A (en) | 1996-03-01 | 1997-09-03 | Merck & Co Inc | Benzoxazinone oxytocin receptor antagonists |
| US6653297B1 (en) * | 1997-07-03 | 2003-11-25 | Medical College Of Hampton Roads | Control of selective estrogen receptor modulators |
| US6326392B1 (en) * | 1997-11-06 | 2001-12-04 | American Home Products Corporation | Anti-estrogen plus progestin containing oral contraceptives |
| ES2258342T3 (es) | 1998-10-23 | 2006-08-16 | Aventis Pharma S.A. | Preparaciones para aplicacion topica de sustancias que tienen efecto antiandrogenico. |
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6258802B1 (en) * | 1999-10-06 | 2001-07-10 | Medical College Of Hampton Roads | Corticoid therapy |
| WO2001030356A1 (fr) * | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| US20010034340A1 (en) * | 2000-03-20 | 2001-10-25 | American Home Products Corporation | Hormone replacement therapy |
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| GB0010683D0 (en) * | 2000-05-03 | 2000-06-28 | Univ Bristol | Cancer therapy |
| FR2814074B1 (fr) * | 2000-09-15 | 2003-03-07 | Theramex | Nouvelles compositions estro-progestatives topiques a effet systemique |
-
2003
- 2003-06-23 AU AU2003247608A patent/AU2003247608A1/en not_active Abandoned
- 2003-06-23 JP JP2004516143A patent/JP2005535624A/ja active Pending
- 2003-06-23 KR KR10-2004-7021183A patent/KR20050013247A/ko not_active Application Discontinuation
- 2003-06-23 WO PCT/US2003/019751 patent/WO2004000801A2/en not_active Application Discontinuation
- 2003-06-23 TW TW092116989A patent/TW200404548A/zh unknown
- 2003-06-23 MX MXPA04012421A patent/MXPA04012421A/es not_active Application Discontinuation
- 2003-06-23 EP EP03761263A patent/EP1515725A4/en not_active Withdrawn
- 2003-06-23 RU RU2005101638/15A patent/RU2005101638A/ru not_active Application Discontinuation
- 2003-06-23 US US10/601,481 patent/US7192956B2/en not_active Expired - Fee Related
- 2003-06-23 BR BR0312024-4A patent/BR0312024A/pt not_active IP Right Cessation
- 2003-06-23 AR ARP030102237A patent/AR040333A1/es not_active Application Discontinuation
- 2003-06-23 CN CN038146819A patent/CN1662241A/zh active Pending
- 2003-06-23 CA CA002489847A patent/CA2489847A1/en not_active Abandoned
-
2004
- 2004-11-25 IL IL16539604A patent/IL165396A0/xx unknown
- 2004-11-29 NO NO20045216A patent/NO20045216L/no not_active Application Discontinuation
- 2004-12-08 CR CR7611A patent/CR7611A/es not_active Application Discontinuation
- 2004-12-23 ZA ZA200410411A patent/ZA200410411B/en unknown
-
2005
- 2005-01-20 CO CO05004450A patent/CO5680438A2/es not_active Application Discontinuation
- 2005-01-25 EC EC2005005576A patent/ECSP055576A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1515725A4 (en) | 2005-09-21 |
| ZA200410411B (en) | 2007-06-27 |
| TW200404548A (en) | 2004-04-01 |
| AR040333A1 (es) | 2005-03-30 |
| US7192956B2 (en) | 2007-03-20 |
| AU2003247608A1 (en) | 2004-01-06 |
| WO2004000801A2 (en) | 2003-12-31 |
| JP2005535624A (ja) | 2005-11-24 |
| CA2489847A1 (en) | 2003-12-31 |
| BR0312024A (pt) | 2005-03-22 |
| IL165396A0 (en) | 2006-01-15 |
| CN1662241A (zh) | 2005-08-31 |
| WO2004000801A3 (en) | 2004-03-25 |
| ECSP055576A (es) | 2005-04-18 |
| US20040006060A1 (en) | 2004-01-08 |
| CR7611A (es) | 2006-05-30 |
| MXPA04012421A (es) | 2005-04-19 |
| NO20045216L (no) | 2005-01-24 |
| KR20050013247A (ko) | 2005-02-03 |
| RU2005101638A (ru) | 2006-01-20 |
| EP1515725A2 (en) | 2005-03-23 |
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