CO5680439A2 - Derivados de ciclotiocarbamato como moduladores de pr y su uso para el tratamiento de desordenes de la piel - Google Patents
Derivados de ciclotiocarbamato como moduladores de pr y su uso para el tratamiento de desordenes de la pielInfo
- Publication number
- CO5680439A2 CO5680439A2 CO05004456A CO05004456A CO5680439A2 CO 5680439 A2 CO5680439 A2 CO 5680439A2 CO 05004456 A CO05004456 A CO 05004456A CO 05004456 A CO05004456 A CO 05004456A CO 5680439 A2 CO5680439 A2 CO 5680439A2
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- alkyl
- group
- carbon
- ring
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Birds (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- Una composición para acondicionar la piel de un mamífero: (i) un componente acondicionador de la piel; y (ii) un compuesto de formula 1, o un tautómero de este, en donde la formula l es: en donde R1 y R2 son sustituyentes independientes seleccionados del grupo consistente de H, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C2 a C6, alquenilo C2 a C6 sustituido, alquinilo C2 a C6, alquinilo C2 a C6 sustituido, cicloalquilo C3 a C6, cicloalquilo C3 a C8 sustituido, arilo, arilo sustituido, anillo heterocíclico con base en Carbono que tiene un su estructura 1 a 3 heteroátomos, anillo heterocíclico sustituido con base en Carbono que tiene un su estructura 1 a 3 heteroátomos, CORA y NRBCORA;o R1 y R2 están fusionados para formar un anillo seleccionado del grupo consistente de a), b) y c), en donde dicho anillo está opcionalmente sustituido por 1 a 3 sustituyentes seleccionados del grupo consistente de H y alquilo C1 a C3; a) un anillo espirocíclico saturado basado en carbono, de 3 a 8 miembros; b) un anillo espirocíclico basado en carbono, de 3 a 8 miembros que tiene uno o más enlaces dobles carbono-carbono; c) un anillo espirocíclico de 3 a 8 miembros que tiene en su estructura uno a tres heteroátomos seleccionados del grupo consistente de O, S y N;RA es seleccionado del grupo consistente de H, alquilo C1 a C3, alquilo C1 a C3 sustituido, arilo, arilo sustituido, alcoxi C1 a C3, alcoxi C1 a C3 sustituido, amino, aminoalquilo C1 a C3 y aminoalquilo C1 a C3 sustituido;RB es seleccionado del grupo consistente de H, alquilo C1 a C3, alquilo C1 a C3 sustituido;R3 es seleccionado del grupo consistente de H, OH, NH2, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C3 a C6, alquenilo C3 a C6 sustituido, alquinilo, alquinilo sustituido y CORC; ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39188502P | 2002-06-25 | 2002-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5680439A2 true CO5680439A2 (es) | 2006-09-29 |
Family
ID=30000769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05004456A CO5680439A2 (es) | 2002-06-25 | 2005-01-20 | Derivados de ciclotiocarbamato como moduladores de pr y su uso para el tratamiento de desordenes de la piel |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7268149B2 (es) |
| EP (1) | EP1531824A4 (es) |
| JP (1) | JP2005535628A (es) |
| KR (1) | KR20050013627A (es) |
| CN (1) | CN1665510A (es) |
| AR (1) | AR040644A1 (es) |
| AU (1) | AU2003245657A1 (es) |
| BR (1) | BR0312039A (es) |
| CA (1) | CA2489815A1 (es) |
| CO (1) | CO5680439A2 (es) |
| CR (1) | CR7608A (es) |
| EC (1) | ECSP055572A (es) |
| IL (1) | IL165397A0 (es) |
| MX (1) | MXPA04012420A (es) |
| NO (1) | NO20045214L (es) |
| RU (1) | RU2005101625A (es) |
| TW (1) | TW200400950A (es) |
| WO (1) | WO2004000230A2 (es) |
| ZA (1) | ZA200410407B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6509334B1 (en) | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6391907B1 (en) * | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| MXPA04012419A (es) * | 2002-06-25 | 2005-04-19 | Wyeth Corp | Uso de derivados de tio-oxindol en el tratamiento de condiciones relacionadas con la hormona. |
| ATE413398T1 (de) * | 2004-04-08 | 2008-11-15 | Wyeth Corp | Thioamidderivate als progesteronrezeptormodulatoren |
| BRPI0509213A (pt) * | 2004-04-08 | 2007-08-28 | Wyeth Corp | método para previnir, reduzir ou minimizar a formação de impurezas de tioamida durante a tionação de um composto de carbonila, produto, e, uso de um agente extrator |
| US7582755B2 (en) * | 2004-04-27 | 2009-09-01 | Wyeth | Cyanopyrrole-containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| CN1953967B (zh) * | 2004-04-27 | 2013-03-13 | 惠氏公司 | 孕酮受体调节剂的纯化 |
| JP5288796B2 (ja) * | 2004-07-07 | 2013-09-11 | ワイス・エルエルシー | 周期的プロゲスチンレジメン及びキット |
| PT1778710E (pt) * | 2004-08-13 | 2012-04-12 | Wyeth Llc | Derivados de tanaproget, metabolitos e suas utilizações |
| BRPI0514528A (pt) * | 2004-08-20 | 2008-06-10 | Wyeth Corp | estrutura de receptores de progesterona |
| ES2340518T3 (es) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | Tanaproget micronizado y composiciones que lo contienen. |
| CN101166532B (zh) | 2005-04-28 | 2011-06-22 | 惠氏公司 | 微粒化的他那普戈特、组合物及其制备方法 |
| AU2006287925B2 (en) | 2005-04-28 | 2012-03-01 | Wyeth | Compositions containing micronized tanaproget |
| MX2007013469A (es) * | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
| CN101184738B (zh) * | 2005-04-28 | 2012-05-23 | 惠氏公司 | 纯化型的tanaproget |
| MX2007015571A (es) * | 2005-06-09 | 2008-03-06 | Wyeth Corp | Composiciones de tanaproget que contienen etinilestradiol. |
| MX2009006818A (es) * | 2006-12-22 | 2009-07-02 | Hoffmann La Roche | Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida. |
| CA2710293A1 (en) * | 2007-12-20 | 2009-07-02 | Teva Women's Health, Inc. | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2664325A1 (en) * | 2012-05-16 | 2013-11-20 | PregLem S.A. | Methods for preventing or treating androgen mediated diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985000519A1 (en) * | 1983-07-29 | 1985-02-14 | Duke University | Method of treating androgen-related disorders |
| GB2310660A (en) * | 1996-03-01 | 1997-09-03 | Merck & Co Inc | Benzoxazinone oxytocin receptor antagonists |
| WO2000024366A1 (de) * | 1998-10-23 | 2000-05-04 | Aventis Pharma Deutschland Gmbh | Zubereitungen zur topischen applikation von antiandrogen wirksamen substanzen |
| US6355648B1 (en) | 1999-05-04 | 2002-03-12 | American Home Products Corporation | Thio-oxindole derivatives |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| EP1206761B1 (en) | 1999-08-26 | 2007-10-03 | Automotive Systems Laboratory Inc. | Magnetic sensor |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| CZ2002711A3 (cs) * | 1999-08-27 | 2003-11-12 | Ligand Pharmaceuticals Incorporated | Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití |
| DE60112064T2 (de) | 2000-04-10 | 2006-06-01 | Pfizer Products Inc., Groton | Benzoamid-piperidin verbindungen als substanz p-antagonisten |
| US7119207B2 (en) * | 2000-04-10 | 2006-10-10 | Pfizer Inc | Benzoamide piperidine containing compounds and related compounds |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
-
2003
- 2003-06-23 KR KR10-2004-7021150A patent/KR20050013627A/ko not_active Application Discontinuation
- 2003-06-23 AR AR20030102239A patent/AR040644A1/es not_active Application Discontinuation
- 2003-06-23 US US10/601,968 patent/US7268149B2/en not_active Expired - Fee Related
- 2003-06-23 MX MXPA04012420A patent/MXPA04012420A/es unknown
- 2003-06-23 IL IL16539703A patent/IL165397A0/xx unknown
- 2003-06-23 CA CA002489815A patent/CA2489815A1/en not_active Abandoned
- 2003-06-23 TW TW092116986A patent/TW200400950A/zh unknown
- 2003-06-23 EP EP03739286A patent/EP1531824A4/en not_active Withdrawn
- 2003-06-23 CN CN038151944A patent/CN1665510A/zh active Pending
- 2003-06-23 RU RU2005101625/04A patent/RU2005101625A/ru not_active Application Discontinuation
- 2003-06-23 WO PCT/US2003/019860 patent/WO2004000230A2/en not_active Application Discontinuation
- 2003-06-23 JP JP2004516187A patent/JP2005535628A/ja active Pending
- 2003-06-23 BR BR0312039-2A patent/BR0312039A/pt not_active IP Right Cessation
- 2003-06-23 AU AU2003245657A patent/AU2003245657A1/en not_active Abandoned
-
2004
- 2004-11-29 NO NO20045214A patent/NO20045214L/no not_active Application Discontinuation
- 2004-12-08 CR CR7608A patent/CR7608A/es not_active Application Discontinuation
- 2004-12-23 ZA ZA200410407A patent/ZA200410407B/en unknown
-
2005
- 2005-01-20 CO CO05004456A patent/CO5680439A2/es not_active Application Discontinuation
- 2005-01-25 EC EC2005005572A patent/ECSP055572A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004000230A3 (en) | 2004-04-29 |
| CR7608A (es) | 2006-07-14 |
| EP1531824A2 (en) | 2005-05-25 |
| US7268149B2 (en) | 2007-09-11 |
| AR040644A1 (es) | 2005-04-13 |
| KR20050013627A (ko) | 2005-02-04 |
| JP2005535628A (ja) | 2005-11-24 |
| CN1665510A (zh) | 2005-09-07 |
| BR0312039A (pt) | 2005-06-28 |
| CA2489815A1 (en) | 2003-12-31 |
| EP1531824A4 (en) | 2005-09-21 |
| ECSP055572A (es) | 2005-04-18 |
| TW200400950A (en) | 2004-01-16 |
| ZA200410407B (en) | 2007-07-25 |
| MXPA04012420A (es) | 2005-04-19 |
| WO2004000230A2 (en) | 2003-12-31 |
| RU2005101625A (ru) | 2005-06-27 |
| IL165397A0 (en) | 2006-01-15 |
| AU2003245657A1 (en) | 2004-01-06 |
| US20040014798A1 (en) | 2004-01-22 |
| NO20045214L (no) | 2005-03-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |