MX2009006818A - Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida. - Google Patents

Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida.

Info

Publication number
MX2009006818A
MX2009006818A MX2009006818A MX2009006818A MX2009006818A MX 2009006818 A MX2009006818 A MX 2009006818A MX 2009006818 A MX2009006818 A MX 2009006818A MX 2009006818 A MX2009006818 A MX 2009006818A MX 2009006818 A MX2009006818 A MX 2009006818A
Authority
MX
Mexico
Prior art keywords
processes
pyrrolidinedicarboxamide
difluoroethyl
pyridinyl
chlorophenyl
Prior art date
Application number
MX2009006818A
Other languages
English (en)
Inventor
Beat Wirz
Hans-Juergen Mair
Hans Iding
Jean-Michel Adam
Pascal Dott
Reinhard Reents
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006818A publication Critical patent/MX2009006818A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invención se refiere a los procesos para la manufactura de un derivado de pirrolidina-3,4-dicarboxamida de la fórmula (I), y los intermediarios útiles para esos procesos.
MX2009006818A 2006-12-22 2007-12-12 Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida. MX2009006818A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126969 2006-12-22
PCT/EP2007/063833 WO2008077797A1 (en) 2006-12-22 2007-12-12 Processes for the preparation of (3r, 4r) -n- (4 -chlorophenyl) -1- (2, 2-difluoroethyl) -n' - [2-fluoro-4- (2-oxo-1 (2h) -pyridinyl) phenyl] -3, 4-pyrrolidinedicarboxamide

Publications (1)

Publication Number Publication Date
MX2009006818A true MX2009006818A (es) 2009-07-02

Family

ID=39054096

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006818A MX2009006818A (es) 2006-12-22 2007-12-12 Procesos para la preparacion de (3r,4r)-n-(4-clorofenil)-1-(2,2-di fluoroetil)-n'-[2-fluoro-4-(2-oxo-1(2h)piridinil)fenil]-3,4-pirro dinadicarboxamida.

Country Status (10)

Country Link
US (1) US7872141B2 (es)
EP (1) EP2097401A1 (es)
JP (1) JP2010513381A (es)
KR (1) KR20090094386A (es)
CN (1) CN101611026A (es)
AU (1) AU2007338102A1 (es)
BR (1) BRPI0720849A2 (es)
CA (1) CA2672835A1 (es)
MX (1) MX2009006818A (es)
WO (1) WO2008077797A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009510478A (ja) * 2005-10-03 2009-03-12 バイオサイト インコーポレイテッド 全身性炎症反応症候群の診断および/または予後診断のための方法および組成物
JP2010526789A (ja) * 2007-05-10 2010-08-05 エフ.ホフマン−ラ ロシュ アーゲー Fxaインヒビターの新規固形形態
CN102241618B (zh) * 2010-05-14 2013-08-07 北京大学 1,3,4-三取代或3,4-二取代的吡咯环化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050013627A (ko) * 2002-06-25 2005-02-04 와이어쓰 Pr 조절제로서의 사이클로티오카바메이트 유도체 및피부 질환을 치료하기 위한 이의 용도
US7192956B2 (en) * 2002-06-25 2007-03-20 Wyeth Methods of treating hormone-related conditions using cyclothiocarbamate derivatives
JP2007502257A (ja) * 2003-08-14 2007-02-08 エフ.ホフマン−ラ ロシュ アーゲー γアミノ酪酸作動性モジュレーター
US7550487B2 (en) 2004-03-26 2009-06-23 Hoffmann-La Roche Inc. Pyrrolidine-3,4-dicarboxamide derivatives
JP2008540370A (ja) * 2005-05-04 2008-11-20 エフ.ホフマン−ラ ロシュ アーゲー ヘテロ環式抗ウイルス化合物

Also Published As

Publication number Publication date
JP2010513381A (ja) 2010-04-30
BRPI0720849A2 (pt) 2014-03-11
CN101611026A (zh) 2009-12-23
CA2672835A1 (en) 2008-07-03
KR20090094386A (ko) 2009-09-04
WO2008077797A1 (en) 2008-07-03
EP2097401A1 (en) 2009-09-09
AU2007338102A1 (en) 2008-07-03
US7872141B2 (en) 2011-01-18
US20080214826A1 (en) 2008-09-04

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