HUP9801340A1 - Triciklusos pirazolszármazékok és az azokat tartalmazó gyógyszerkészítmények - Google Patents

Triciklusos pirazolszármazékok és az azokat tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9801340A1
HUP9801340A1 HU9801340A HUP9801340A HUP9801340A1 HU P9801340 A1 HUP9801340 A1 HU P9801340A1 HU 9801340 A HU9801340 A HU 9801340A HU P9801340 A HUP9801340 A HU P9801340A HU P9801340 A1 HUP9801340 A1 HU P9801340A1
Authority
HU
Hungary
Prior art keywords
pyrazole derivatives
general formula
lower alkyl
disorders
pharmaceutical compositions
Prior art date
Application number
HU9801340A
Other languages
English (en)
Inventor
Ken-Ichi Kazuta
Tetsuya Kimizuka
Hideki Kubota
Kyoichi Maeno
Shuichi Sakamoto
Itsuro Shimada
Fumikazu Wanibuchi
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Publication of HU9801340D0 publication Critical patent/HU9801340D0/hu
Publication of HUP9801340A1 publication Critical patent/HUP9801340A1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány (I) általánős képletű triciklűsős pirazőlszármazékőkra ésgyógyászatilag elfőgadható sóikra, valamint az ezeket tartalmazógyógyszerkészítményekre vőnatkőzik. Az (I) általánős képletben Hetjelentése 5-tagú, telítetlen heterőciklűsős gyűrű, amely 1-3heterőatőmőt, éspedig nitrőgén-, őxigén- és kénatőmők közülmegválasztőtt heterőatőmőt tartalmaz; A jelentése egyenes vagy elágazóláncú rövid szénláncú alkiléncsőpőrt; és R jelentése hidrőgén- vagyhalőgénatőm vagy rövid szénláncú alkil-, hidrőxi- vagy rövid szénláncúalkőxicsőpőrt. A találmány szerinti vegyületek erős affinitást ésszelektivitást műtatnak az 5-HT2C receptőrők vőnatkőzásában, és így aközpőnti idegrendszer megbetegedései, példáűl szexűálisrendellenességek, táplálkőzásbeli rendellenességek, szőrőngás,depresszió vagy alvászavarők kezelésére alkalmazhatók. ŕ
HU9801340A 1997-06-13 1998-06-12 Triciklusos pirazolszármazékok és az azokat tartalmazó gyógyszerkészítmények HUP9801340A1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15725597 1997-06-13

Publications (2)

Publication Number Publication Date
HU9801340D0 HU9801340D0 (en) 1998-08-28
HUP9801340A1 true HUP9801340A1 (hu) 1999-11-29

Family

ID=15645662

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801340A HUP9801340A1 (hu) 1997-06-13 1998-06-12 Triciklusos pirazolszármazékok és az azokat tartalmazó gyógyszerkészítmények

Country Status (18)

Country Link
US (1) US6245796B1 (hu)
EP (1) EP0990650B8 (hu)
JP (1) JP3410478B2 (hu)
KR (1) KR19990006912A (hu)
CN (1) CN1097054C (hu)
AR (1) AR012952A1 (hu)
AT (1) ATE302192T1 (hu)
AU (2) AU727654B2 (hu)
BR (1) BR9802005A (hu)
CA (1) CA2291651A1 (hu)
DE (1) DE69831236T2 (hu)
ES (1) ES2246535T3 (hu)
HU (1) HUP9801340A1 (hu)
ID (1) ID23173A (hu)
PL (1) PL326777A1 (hu)
RU (1) RU2191176C2 (hu)
TW (1) TW502024B (hu)
WO (1) WO1998056768A1 (hu)

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US7138393B2 (en) 1998-07-24 2006-11-21 Wyeth Biologically active vasopressin agonist metabolites
WO2000008001A1 (en) * 1998-08-07 2000-02-17 Chiron Corporation Substituted isoxazole as estrogen receptor modulators
GB9819019D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds II
WO2000016761A2 (en) 1998-09-18 2000-03-30 Alcon Laboratories, Inc. Serotonergic 5ht2 agonists for treating glaucoma
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
WO2001083487A1 (fr) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Derive de froindazole
DE10055093A1 (de) 2000-11-07 2002-05-16 Agfa Gevaert Ag Cyaninfarbstoff
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CA2449899C (en) 2000-11-20 2010-04-06 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
EP1392292B1 (en) * 2001-06-01 2006-03-01 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
JP2004532887A (ja) 2001-06-01 2004-10-28 アルコン，インコーポレイテッド 新規な融合インダゾールおよびインドールおよび緑内障治療へのこれらの使用
AU2002360819A1 (en) * 2001-12-28 2003-07-24 Bayer Corporation Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
CN100484933C (zh) 2002-06-19 2009-05-06 比奥维特罗姆股份公开公司 新的吡嗪化合物及其在制备用于治疗与5-羟色胺相关的疾病的药物中的用途
MXPA05006277A (es) 2002-12-13 2005-09-08 Alcon Inc Analogos de benzopirano novedosos y su uso para el tratamiento de glaucoma.
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
WO2005058911A2 (en) * 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
DE602005027861D1 (de) * 2004-09-03 2011-06-16 Athersys Inc Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren
US20060106013A1 (en) * 2004-10-07 2006-05-18 Boehringer Ingelheim International Gmbh PI3-kinases
TW201118073A (en) * 2009-10-30 2011-06-01 Merck Sharp & Dohme Hexahydrocyclopentyl [F] indazole pyridyl ethanols and derivatives thereof as selective glucocorticoid receptor modulators
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2013040321A1 (en) 2011-09-15 2013-03-21 University Of Kansas Kappa opioid receptor effectors and uses thereof
US8853207B2 (en) 2012-04-12 2014-10-07 Development Center For Biotechnology Heterocyclic pyrazole compounds, method for preparing the same and use thereof
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CR20220291A (es) 2019-12-19 2022-08-10 Bayer Ag Derivados de furoindazol
CA3211437A1 (en) 2021-02-23 2022-09-01 Bayer Aktiengesellschaft Furoindazole derivatives as gpr84 antagonists
EP4330260A1 (en) 2021-04-29 2024-03-06 Bayer Aktiengesellschaft Furoindazole derivatives as antagonists or inhibitors of gpr84
WO2024083705A1 (en) 2022-10-18 2024-04-25 Bayer Aktiengesellschaft Furoindazole derivatives for the treatment of pain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5637984B2 (hu) 1974-01-31 1981-09-03
TW270114B (hu) 1993-10-22 1996-02-11 Hoffmann La Roche
TW334423B (en) 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
GB9326192D0 (en) * 1993-12-22 1994-02-23 Glaxo Group Ltd Chemical compounds
WO1995032967A1 (en) 1994-05-28 1995-12-07 Smithkline Beecham Plc Amide derivatives having 5ht1d-antagonist activity
TW403738B (en) 1994-08-12 2000-09-01 Hoffmann La Roche Tricyclic pyrazole derivatives

Also Published As

Publication number Publication date
AU6989398A (en) 1998-12-17
ES2246535T3 (es) 2006-02-16
CN1203234A (zh) 1998-12-30
JP3410478B2 (ja) 2003-05-26
AR012952A1 (es) 2000-11-22
AU7674098A (en) 1998-12-30
AU727654B2 (en) 2000-12-21
DE69831236D1 (de) 2005-09-22
US6245796B1 (en) 2001-06-12
DE69831236T2 (de) 2006-04-13
CA2291651A1 (en) 1998-12-17
EP0990650A4 (en) 2002-02-13
KR19990006912A (ko) 1999-01-25
RU2191176C2 (ru) 2002-10-20
HU9801340D0 (en) 1998-08-28
CN1097054C (zh) 2002-12-25
ID23173A (id) 2000-03-23
EP0990650B8 (en) 2005-10-19
ATE302192T1 (de) 2005-09-15
BR9802005A (pt) 2000-03-21
TW502024B (en) 2002-09-11
PL326777A1 (en) 1998-12-21
EP0990650B1 (en) 2005-08-17
EP0990650A1 (en) 2000-04-05
WO1998056768A1 (fr) 1998-12-17

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