ATE269848T1 - Calciumkanalblocker als antikrebsmittel - Google Patents
Calciumkanalblocker als antikrebsmittelInfo
- Publication number
- ATE269848T1 ATE269848T1 AT00921867T AT00921867T ATE269848T1 AT E269848 T1 ATE269848 T1 AT E269848T1 AT 00921867 T AT00921867 T AT 00921867T AT 00921867 T AT00921867 T AT 00921867T AT E269848 T1 ATE269848 T1 AT E269848T1
- Authority
- AT
- Austria
- Prior art keywords
- anticancer
- calcium channel
- channel blockers
- compounds
- directed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12814399P | 1999-04-07 | 1999-04-07 | |
PCT/US2000/009310 WO2000059882A1 (en) | 1999-04-07 | 2000-04-07 | Anticancer calcium channel blockers |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE269848T1 true ATE269848T1 (de) | 2004-07-15 |
Family
ID=22433855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00921867T ATE269848T1 (de) | 1999-04-07 | 2000-04-07 | Calciumkanalblocker als antikrebsmittel |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1165508B1 (de) |
JP (1) | JP4932994B2 (de) |
AT (1) | ATE269848T1 (de) |
CA (1) | CA2369588C (de) |
DE (1) | DE60011755T2 (de) |
WO (1) | WO2000059882A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0410871A (pt) * | 2003-05-30 | 2006-07-04 | Neuromed Tech Inc | 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n |
WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
US7504431B2 (en) | 2004-04-16 | 2009-03-17 | Bristol-Myers Squibb Company | Sulfonyl amide inhibitors of calcium channel function |
US20080194669A1 (en) * | 2004-08-20 | 2008-08-14 | Gray Lloyd S | T Type Calcium Channel Blockers and the Treatment of Diseases |
EP2073799A4 (de) * | 2007-03-12 | 2009-08-19 | Vm Discovery Inc | Neuartige wirkstoffe aus kalziumionenkanalmodulatoren |
PT3092901T (pt) | 2007-10-05 | 2020-05-21 | Senhwa Biosciences Inc | Análogos de quinolona e respetivos métodos relacionados |
EP2252608A4 (de) | 2008-02-29 | 2012-10-03 | Vm Discovery Inc | Verfahren zur behandlung von schmerzsysyndrom und anderen leiden |
ES2530091T3 (es) | 2008-03-19 | 2015-02-26 | Soricimed Biopharma Inc. | Composiciones peptídicas para el tratamiento del cáncer por la inhibición de la actividad del canal de calcio TRPV6 |
EP2350002A1 (de) | 2008-10-02 | 2011-08-03 | Abbott Laboratories | Neue verbindungen als kalziumkanalblocker |
AR074226A1 (es) * | 2008-11-26 | 2010-12-29 | Abbott Lab | Octahidrociclopenta[c]pirrol-4-aminas sustituidas como bloqueantes de los canales de calcio, composiciones farmaceuticas que las comprenden y el uso de las mismas para el tratamiento del dolor. |
US8691865B2 (en) | 2008-11-26 | 2014-04-08 | Abbvie Inc. | Substituted octahydrocyclopenta[C]pyrrol-4-amines as calcium channel blockers |
TW201028421A (en) | 2009-01-15 | 2010-08-01 | Abbott Lab | Novel benzenesulfonamides as calcium channel blockers |
MX2012000086A (es) | 2009-06-26 | 2012-06-12 | Soricimed Biopharma Inc | Peptidos derivados de soricidi y metodos para la la deteccion de canceres trpv-6 y suministro de farmaco. |
MX360640B (es) | 2010-03-01 | 2018-11-09 | Tau Therapeutics Llc Star | Diagnosis e imagenologia de cancer. |
WO2011115813A1 (en) | 2010-03-18 | 2011-09-22 | Abbott Laboratories | Lactam acetamides as calcium channel blockers |
WO2011149993A2 (en) | 2010-05-25 | 2011-12-01 | Abbott Laboratories | SUBSTITUTED OCTAHYDROCYCLOPENTA[c]PYRROLES AS CALCIUM CHANNEL MODULATORS |
US8648074B2 (en) | 2011-09-29 | 2014-02-11 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazine sulfonamides as calcium channel blockers |
US8669255B2 (en) | 2011-09-29 | 2014-03-11 | Abbvie Inc. | Substituted octahydropyrrolo[1,2-a]pyrazines as calcium channel blockers |
MX2015007460A (es) | 2012-12-12 | 2015-09-04 | Abbvie Inc | Agentes para el tratamiento del dolor y usos de los mismos. |
WO2017087235A1 (en) | 2015-11-20 | 2017-05-26 | Senhwa Biosciences, Inc. | Combination therapy of tetracyclic quinolone analogs for treating cancer |
US9957282B2 (en) | 2015-12-14 | 2018-05-01 | Senhwa Biosciences, Inc. | Crystalline forms of quinolone analogs and their salts |
TW202000195A (zh) | 2018-02-15 | 2020-01-01 | 生華生物科技股份有限公司 | 喹啉酮類似物及其鹽、組合物及其使用方法 |
CN115215800B (zh) * | 2021-04-21 | 2023-07-18 | 赣江中药创新中心 | 一种二苯并环基-环胺基醚衍生物或盐及其制备方法和应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2454092A (en) * | 1947-06-02 | 1948-11-16 | Parke Davis & Co | Benzhydryl amino ethers |
US2708194A (en) * | 1952-12-10 | 1955-05-10 | Univ Michigan | 2-(1-methyl) polymethyleniminylmethyl benzhydryl ethers and preparation thereof |
GB833807A (en) * | 1957-07-10 | 1960-04-27 | Beecham Res Lab | Benzhydryl ethers |
US3732247A (en) * | 1970-08-14 | 1973-05-08 | Robins Co Inc A H | 3-di-substituted methylene pyrrolidines wherein the 1-or n-lower-alkyl substituent contains at least two carbon atoms |
GB1307255A (en) * | 1970-09-12 | 1973-02-14 | Pfizer Ltd | Substituted basic benzhydryl ethers |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
FR2636946B1 (fr) * | 1988-09-23 | 1990-11-02 | Lipha | ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant |
GB9000301D0 (en) * | 1990-01-06 | 1990-03-07 | Pfizer Ltd | Piperidine & pyrrolidine derivatives |
MX9100513A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
GB9020051D0 (en) * | 1990-09-13 | 1990-10-24 | Pfizer Ltd | Muscarinic receptor antagonists |
US5981539A (en) * | 1995-09-15 | 1999-11-09 | Neurosearch A/S | Piperidine compounds as calcium channel blockers |
CA2204082A1 (en) * | 1996-05-03 | 1997-11-03 | Michael William John Urquhart | Pharmaceutical compounds |
JPH1135483A (ja) * | 1997-05-20 | 1999-02-09 | Nippon Kayaku Co Ltd | 頻尿又は尿失禁の治療剤又は予防剤 |
-
2000
- 2000-04-07 EP EP00921867A patent/EP1165508B1/de not_active Expired - Lifetime
- 2000-04-07 CA CA2369588A patent/CA2369588C/en not_active Expired - Lifetime
- 2000-04-07 JP JP2000609394A patent/JP4932994B2/ja not_active Expired - Lifetime
- 2000-04-07 AT AT00921867T patent/ATE269848T1/de not_active IP Right Cessation
- 2000-04-07 DE DE60011755T patent/DE60011755T2/de not_active Expired - Lifetime
- 2000-04-07 WO PCT/US2000/009310 patent/WO2000059882A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP1165508B1 (de) | 2004-06-23 |
WO2000059882A9 (en) | 2001-11-29 |
JP4932994B2 (ja) | 2012-05-16 |
WO2000059882A1 (en) | 2000-10-12 |
JP2002541142A (ja) | 2002-12-03 |
DE60011755T2 (de) | 2005-06-30 |
CA2369588C (en) | 2011-02-08 |
CA2369588A1 (en) | 2000-10-12 |
EP1165508A1 (de) | 2002-01-02 |
DE60011755D1 (de) | 2004-07-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |