BRPI0410871A - 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n - Google Patents

3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n

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Publication number
BRPI0410871A
BRPI0410871A BRPI0410871-0A BRPI0410871A BRPI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A
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BR
Brazil
Prior art keywords
channel blockers
calcium channel
type calcium
aminomethyl
independently
Prior art date
Application number
BRPI0410871-0A
Other languages
English (en)
Inventor
Terrance P Snutch
Hassan Pajouhesh
Hossein Pajouhesh
Yanbing Ding
Original Assignee
Neuromed Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuromed Tech Inc filed Critical Neuromed Tech Inc
Publication of BRPI0410871A publication Critical patent/BRPI0410871A/pt

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"3-AMINOMETIL-PIRROLIDINAS COMO BLOQUEADORES DO CANAL DE CáLCIO DO TIPO N". A presente invenção refere-se a compostos, que são derivados de 3-aminometil-pirrolidona das fórmulas I e II em que: Y é (X¬ 2¬)~ <124>~A ou (X¬ 1¬)~ m~CR¬ 4¬A~ 2~; W é CR¬ 4¬ ou N; R¬ 1¬ - R¬ 4¬ são substituintes não-interferentes; n é O - 7; I e m são independentemente 0 ou 1; X¬ 1¬ - X¬ 2¬ são agentes de ligação; e cada A é independentemente um anel alifático ou aromático opcionalmente substituído de 5 a 7 elementos, contendo um ou mais heteroátomos selecionados de 0, N e S. Contêm, geralmente, pelo menos uma porção benzidrila e são úteis no tratamento de condições que se beneficiam do bloqueio de canais de íons de cálcio.
BRPI0410871-0A 2003-05-30 2004-05-28 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n BRPI0410871A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47486403P 2003-05-30 2003-05-30
PCT/CA2004/000797 WO2004105750A1 (en) 2003-05-30 2004-05-28 3-aminomethyl-pyrrolidines as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
BRPI0410871A true BRPI0410871A (pt) 2006-07-04

Family

ID=33490738

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410871-0A BRPI0410871A (pt) 2003-05-30 2004-05-28 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n

Country Status (9)

Country Link
US (1) US7244758B2 (pt)
EP (1) EP1633343A1 (pt)
JP (1) JP2006526000A (pt)
CN (1) CN1816332A (pt)
AU (1) AU2004243511A1 (pt)
BR (1) BRPI0410871A (pt)
CA (1) CA2527159A1 (pt)
MX (1) MXPA05012899A (pt)
WO (1) WO2004105750A1 (pt)

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TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
GB0428250D0 (en) * 2004-12-23 2005-01-26 Novartis Ag Organic compounds
WO2006105670A1 (en) * 2005-04-08 2006-10-12 Neuromed Pharmaceuticals Ltd. Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain
JP4573133B2 (ja) * 2005-05-19 2010-11-04 アステラス製薬株式会社 ピロリジン誘導体またはその塩
US7767710B2 (en) 2005-05-25 2010-08-03 Calosyn Pharma, Inc. Method for treating osteoarthritis
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US8299211B2 (en) * 2005-09-30 2012-10-30 The Board Of Trustees Of The University Of Illinois Peptides and regulation of calcium channels
WO2007041360A2 (en) * 2005-09-30 2007-04-12 The Board Of Trustees Of The University Of Illinois Peptides and calcium regulation in mammalian cells
US8247442B2 (en) 2006-03-29 2012-08-21 Purdue Pharma L.P. Benzenesulfonamide compounds and their use
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US8937181B2 (en) 2006-04-13 2015-01-20 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
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JP5323063B2 (ja) 2007-05-31 2013-10-23 塩野義製薬株式会社 オキシイミノ化合物およびその使用
US20090163440A1 (en) * 2007-09-26 2009-06-25 Waddell David D Ion-Channel Regulator Compositions and Methods of Using Same
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
US20090270394A1 (en) * 2008-04-28 2009-10-29 Galemmo Jr Robert Cyclylamine derivatives as calcium channel blockers
US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
EP2346820B1 (en) 2008-06-11 2013-02-13 Shionogi & Co., Ltd. Oxycarbamoyl compounds and the use thereof
WO2011112263A1 (en) 2010-03-11 2011-09-15 New York University AMIDO COMPOUNDS AS RORγt MODULATORS AND USES THEREOF
WO2012004604A1 (en) * 2010-07-09 2012-01-12 Convergence Pharmaceuticals Limited Tetrazole compounds as calcium channel blockers
WO2012122279A1 (en) 2011-03-08 2012-09-13 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
US9765063B2 (en) * 2011-09-09 2017-09-19 New York University Amido compounds as RORγt modulators and uses thereof
US20130178477A1 (en) * 2012-01-05 2013-07-11 Abbvie Inc. Methods of treating diabetic neuropathy using benzenesulfonamides
EA201590380A1 (ru) * 2012-08-16 2015-07-30 Янссен Фармацевтика Нв Замещенные пиразолы, используемые в качестве блокаторов кальциевых каналов n-типа
WO2014134306A1 (en) 2013-03-01 2014-09-04 Zalicus Pharmaceuticals, Ltd. Heterocyclic inhibitors of the sodium channel
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
KR102183666B1 (ko) * 2018-08-23 2020-11-26 한국과학기술연구원 Ｔ-형 칼슘 채널에 활성을 가지는 피롤리딘 또는 피페리딘 화합물
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Also Published As

Publication number Publication date
US20050014748A1 (en) 2005-01-20
AU2004243511A1 (en) 2004-12-09
EP1633343A1 (en) 2006-03-15
US7244758B2 (en) 2007-07-17
CA2527159A1 (en) 2004-12-09
JP2006526000A (ja) 2006-11-16
CN1816332A (zh) 2006-08-09
WO2004105750A1 (en) 2004-12-09
MXPA05012899A (es) 2006-06-23

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.