BRPI0410871A - 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n - Google Patents

3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n

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Publication number
BRPI0410871A
BRPI0410871A BRPI0410871-0A BRPI0410871A BRPI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A BR PI0410871 A BRPI0410871 A BR PI0410871A
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Brazil
Prior art keywords
channel blockers
calcium channel
type calcium
aminomethyl
independently
Prior art date
Application number
BRPI0410871-0A
Other languages
English (en)
Inventor
Terrance P Snutch
Hassan Pajouhesh
Hossein Pajouhesh
Yanbing Ding
Original Assignee
Neuromed Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neuromed Tech Inc filed Critical Neuromed Tech Inc
Publication of BRPI0410871A publication Critical patent/BRPI0410871A/pt

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
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  • Immunology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"3-AMINOMETIL-PIRROLIDINAS COMO BLOQUEADORES DO CANAL DE CáLCIO DO TIPO N". A presente invenção refere-se a compostos, que são derivados de 3-aminometil-pirrolidona das fórmulas I e II em que: Y é (X¬ 2¬)~ <124>~A ou (X¬ 1¬)~ m~CR¬ 4¬A~ 2~; W é CR¬ 4¬ ou N; R¬ 1¬ - R¬ 4¬ são substituintes não-interferentes; n é O - 7; I e m são independentemente 0 ou 1; X¬ 1¬ - X¬ 2¬ são agentes de ligação; e cada A é independentemente um anel alifático ou aromático opcionalmente substituído de 5 a 7 elementos, contendo um ou mais heteroátomos selecionados de 0, N e S. Contêm, geralmente, pelo menos uma porção benzidrila e são úteis no tratamento de condições que se beneficiam do bloqueio de canais de íons de cálcio.
BRPI0410871-0A 2003-05-30 2004-05-28 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n BRPI0410871A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47486403P 2003-05-30 2003-05-30
PCT/CA2004/000797 WO2004105750A1 (en) 2003-05-30 2004-05-28 3-aminomethyl-pyrrolidines as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
BRPI0410871A true BRPI0410871A (pt) 2006-07-04

Family

ID=33490738

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410871-0A BRPI0410871A (pt) 2003-05-30 2004-05-28 3-aminometil-pirrolidinas como bloqueadores do canal de cálcio do tipo n

Country Status (9)

Country Link
US (1) US7244758B2 (pt)
EP (1) EP1633343A1 (pt)
JP (1) JP2006526000A (pt)
CN (1) CN1816332A (pt)
AU (1) AU2004243511A1 (pt)
BR (1) BRPI0410871A (pt)
CA (1) CA2527159A1 (pt)
MX (1) MXPA05012899A (pt)
WO (1) WO2004105750A1 (pt)

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CA2603926A1 (en) * 2005-04-08 2006-10-12 Neuromed Pharmaceuticals Ltd. Combination therapy comprising an n-type calcium channel blocker for the alleviation of pain
CA2608957C (en) * 2005-05-19 2013-12-10 Astellas Pharma Inc. Pyrrolidine derivative or salt thereof
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US8299211B2 (en) * 2005-09-30 2012-10-30 The Board Of Trustees Of The University Of Illinois Peptides and regulation of calcium channels
WO2007041360A2 (en) * 2005-09-30 2007-04-12 The Board Of Trustees Of The University Of Illinois Peptides and calcium regulation in mammalian cells
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WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
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US8377968B2 (en) * 2008-06-02 2013-02-19 Zalicus Pharmaceuticals, Ltd. N-piperidinyl acetamide derivatives as calcium channel blockers
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US9492439B2 (en) 2010-03-11 2016-11-15 New York University Amido compounds as RORγt modulators and uses thereof
US9115132B2 (en) 2010-07-09 2015-08-25 Convergence Pharmaceuticals Limited Tetrazole compounds as calcium channel blockers
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
MX2013010306A (es) 2011-03-08 2013-12-09 Zalicus Pharmaceuticals Ltd Formulaciones de dispersion solida y metodos de uso de las mismas.
US9765063B2 (en) * 2011-09-09 2017-09-19 New York University Amido compounds as RORγt modulators and uses thereof
WO2013103867A1 (en) * 2012-01-05 2013-07-11 Abbvie Inc. Benzenesulfonamide derivative for use in the treatment of diabetic neuropathy
CN107857757A (zh) * 2012-08-16 2018-03-30 詹森药业有限公司 作为n型钙通道阻滞剂的取代的吡唑
US10208023B2 (en) 2013-03-01 2019-02-19 Mark G. DeGiacomo Heterocyclic inhibitors of the sodium channel
US9453002B2 (en) 2013-08-16 2016-09-27 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers
KR102183666B1 (ko) * 2018-08-23 2020-11-26 한국과학기술연구원 Ｔ-형 칼슘 채널에 활성을 가지는 피롤리딘 또는 피페리딘 화합물
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Also Published As

Publication number Publication date
MXPA05012899A (es) 2006-06-23
CN1816332A (zh) 2006-08-09
US20050014748A1 (en) 2005-01-20
US7244758B2 (en) 2007-07-17
CA2527159A1 (en) 2004-12-09
JP2006526000A (ja) 2006-11-16
EP1633343A1 (en) 2006-03-15
WO2004105750A1 (en) 2004-12-09
AU2004243511A1 (en) 2004-12-09

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