CN102282131B - 作为钙离子通道阻断剂的新的苯磺酰胺 - Google Patents

作为钙离子通道阻断剂的新的苯磺酰胺 Download PDF

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Publication number
CN102282131B
CN102282131B CN201080004675.3A CN201080004675A CN102282131B CN 102282131 B CN102282131 B CN 102282131B CN 201080004675 A CN201080004675 A CN 201080004675A CN 102282131 B CN102282131 B CN 102282131B
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ylcarbonyl
benzenesulfonamide
pyrazin
hexahydropyrrolo
formula
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Expired - Fee Related
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Chinese (zh)
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CN102282131A (zh
Inventor
张庆伟
A.O.斯图尔特
夏之仁
M.F.贾维斯
V.E.斯科特
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Abbott Laboratories Ltd
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Abbott Laboratories
AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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CN201080004675.3A 2009-01-15 2010-01-14 作为钙离子通道阻断剂的新的苯磺酰胺 Expired - Fee Related CN102282131B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15
US61/144899 2009-01-15
PCT/US2010/020964 WO2010083264A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

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CN102282131A CN102282131A (zh) 2011-12-14
CN102282131B true CN102282131B (zh) 2015-08-26

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US (3) US8101614B2 (enExample)
EP (1) EP2382191B1 (enExample)
JP (1) JP5619773B2 (enExample)
KR (1) KR20110110299A (enExample)
CN (1) CN102282131B (enExample)
AR (1) AR077440A1 (enExample)
AU (1) AU2010204753A1 (enExample)
BR (1) BRPI1005675A2 (enExample)
CA (1) CA2747752A1 (enExample)
CL (1) CL2011001714A1 (enExample)
CO (1) CO6400194A2 (enExample)
DO (1) DOP2011000217A (enExample)
ES (1) ES2527467T3 (enExample)
IL (1) IL213500A0 (enExample)
MX (1) MX337190B (enExample)
PE (1) PE20120126A1 (enExample)
RU (1) RU2011134052A (enExample)
SG (1) SG172308A1 (enExample)
TW (1) TW201028421A (enExample)
UY (1) UY32384A (enExample)
WO (1) WO2010083264A1 (enExample)
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WO2015051336A1 (en) 2013-10-03 2015-04-09 David Wise Compositions and methods for treating pelvic pain and other conditions
US10082496B2 (en) 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
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CN110545806A (zh) 2017-02-15 2019-12-06 卡维昂公司 钙通道抑制剂
EP3615521A4 (en) 2017-04-26 2021-02-17 Cavion, Inc. METHODS FOR IMPROVING MEMORY AND COGNITION AND TREATING MEMORY AND COGNITIVE DISORDERS
AU2019207491A1 (en) 2018-01-10 2020-07-30 Cura Therapeutics, Llc Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
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JP7480131B2 (ja) 2018-10-03 2024-05-09 カビオン・インコーポレイテッド （ｒ）－２－（４－イソプロピルフェニル）－ｎ－（１－（５－（２，２，２－トリフルオロエトキシ）ピリジン－２－イル）エチル）アセトアミドを使用した本態性振戦の処置
US20200131156A1 (en) * 2018-10-30 2020-04-30 H. Lundbeck A/S ARYLSULFONYLPYROLECARBOXAMIDE DERIVATIVES AS Kv3 POTASSIUM CHANNEL ACTIVATORS
WO2021007478A1 (en) * 2019-07-11 2021-01-14 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
WO2021007487A1 (en) 2019-07-11 2021-01-14 Praxis Precision Medicines, Inc. Formulations of t-type calcium channel modulators and methods of use thereof
CN117229257B (zh) * 2022-06-06 2026-01-30 中国药科大学 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用
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