CA2747752A1 - Novel benzenesulfonamides as calcium channel blockers - Google Patents

Novel benzenesulfonamides as calcium channel blockers Download PDF

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Publication number
CA2747752A1
CA2747752A1 CA2747752A CA2747752A CA2747752A1 CA 2747752 A1 CA2747752 A1 CA 2747752A1 CA 2747752 A CA2747752 A CA 2747752A CA 2747752 A CA2747752 A CA 2747752A CA 2747752 A1 CA2747752 A1 CA 2747752A1
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CA
Canada
Prior art keywords
pyrazin
hexahydropyrrolo
ylcarbonyl
benzenesulfonamide
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2747752A
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English (en)
French (fr)
Inventor
Qingwei Zhang
Andrew O. Stewart
Zhiren Xia
Michael F. Jarvis
Victoria E. SCOTT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Bahamas Ltd
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41796157&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2747752(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2747752A1 publication Critical patent/CA2747752A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
CA2747752A 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers Pending CA2747752A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14489909P 2009-01-15 2009-01-15
US61/144,899 2009-01-15
PCT/US2010/020964 WO2010083264A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Publications (1)

Publication Number Publication Date
CA2747752A1 true CA2747752A1 (en) 2010-07-22

Family

ID=41796157

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2747752A Pending CA2747752A1 (en) 2009-01-15 2010-01-14 Novel benzenesulfonamides as calcium channel blockers

Country Status (22)

Country Link
US (3) US8101614B2 (enExample)
EP (1) EP2382191B1 (enExample)
JP (1) JP5619773B2 (enExample)
KR (1) KR20110110299A (enExample)
CN (1) CN102282131B (enExample)
AR (1) AR077440A1 (enExample)
AU (1) AU2010204753A1 (enExample)
BR (1) BRPI1005675A2 (enExample)
CA (1) CA2747752A1 (enExample)
CL (1) CL2011001714A1 (enExample)
CO (1) CO6400194A2 (enExample)
DO (1) DOP2011000217A (enExample)
ES (1) ES2527467T3 (enExample)
IL (1) IL213500A0 (enExample)
MX (1) MX337190B (enExample)
PE (1) PE20120126A1 (enExample)
RU (1) RU2011134052A (enExample)
SG (1) SG172308A1 (enExample)
TW (1) TW201028421A (enExample)
UY (1) UY32384A (enExample)
WO (1) WO2010083264A1 (enExample)
ZA (1) ZA201104715B (enExample)

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US8420823B2 (en) 2008-04-24 2013-04-16 Msd K.K. Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers
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WO2013103867A1 (en) 2012-01-05 2013-07-11 Abbvie Inc. Benzenesulfonamide derivative for use in the treatment of diabetic neuropathy
KR20150093237A (ko) 2012-12-12 2015-08-17 애브비 인코포레이티드 통증 치료시 칼슘 채널 차단제로서 유용한 디아제핀 유도체
KR102300576B1 (ko) * 2013-09-10 2021-09-08 보드 오브 리전츠 더 유니버시티 오브 텍사스 시스템 절단된 선종성 결장 폴립증 (ａｐｃ) 단백질을 타겟화하는 치료제
WO2015051336A1 (en) * 2013-10-03 2015-04-09 David Wise Compositions and methods for treating pelvic pain and other conditions
US10082496B2 (en) 2014-09-10 2018-09-25 Board Of Regents Of The University Of Texas System Targeting emopamil binding protein (EBP) with small molecules that induce an abnormal feedback response by lowering endogenous cholesterol biosynthesis
ES2936400T3 (es) 2015-10-22 2023-03-16 Cavion Inc Métodos para tratar el síndrome Angelman
WO2018152317A1 (en) 2017-02-15 2018-08-23 Cavion, Inc. Calcium channel inhibitors
KR102654466B1 (ko) 2017-04-26 2024-04-08 카비온, 인코포레이티드 기억 및 인지 개선 방법 및 기억 및 인지 장애 치료 방법
AU2019207491A1 (en) 2018-01-10 2020-07-30 Cura Therapeutics, Llc Pharmaceutical compositions comprising phenylsulfonamides, and their therapeutic applications
EP3841096A4 (en) 2018-08-24 2022-05-18 Sunshine Lake Pharma Co., Ltd. PYRIDINYLMETHYLENEPIPERIDEINDIVATES AND THEIR USES
TW202602439A (zh) 2018-10-03 2026-01-16 美商卡凡恩公司 以(r)-2-(4-異丙基苯基)-n-(1-(5-(2,2,2-三氟乙氧基)吡啶-2-基)乙基)乙醯胺治療自發性震顫
TW202031645A (zh) * 2018-10-30 2020-09-01 丹麥商Ｈ 朗德貝克公司 作為Kv3鉀通道激活劑之芳基磺醯基吡咯甲醯胺衍生物
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AU2020311404A1 (en) * 2019-07-11 2022-03-03 Cura Therapeutics, Llc Sulfone compounds and pharmaceutical compositions thereof, and their therapeutic applications for the treatment of neurodegenerative diseases
CN117229257B (zh) * 2022-06-06 2026-01-30 中国药科大学 间氨磺酰苯甲酰胺类化合物及制法、药物组合物和应用
WO2025255502A1 (en) 2024-06-07 2025-12-11 Cavion, Inc. PYRIDYL AMIDE Cav3 CHANNEL MODULATORS

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US8420823B2 (en) 2008-04-24 2013-04-16 Msd K.K. Long-chain fatty acyl elongase inhibitor comprising arylsulfonyl derivative as active ingredient
TW201028421A (en) * 2009-01-15 2010-08-01 Abbott Lab Novel benzenesulfonamides as calcium channel blockers

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CN102282131A (zh) 2011-12-14
US20130210827A1 (en) 2013-08-15
RU2011134052A (ru) 2013-02-20
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