PE20081838A1 - Derivados de ester o amida de imidazolilo como moduladores del receptor glucocorticoide - Google Patents
Derivados de ester o amida de imidazolilo como moduladores del receptor glucocorticoideInfo
- Publication number
- PE20081838A1 PE20081838A1 PE2008000011A PE2008000011A PE20081838A1 PE 20081838 A1 PE20081838 A1 PE 20081838A1 PE 2008000011 A PE2008000011 A PE 2008000011A PE 2008000011 A PE2008000011 A PE 2008000011A PE 20081838 A1 PE20081838 A1 PE 20081838A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- modulators
- glucocorticoid receptor
- amide derivatives
- ester
- Prior art date
Links
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract 2
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract 2
- DEPDDPLQZYCHOH-UHFFFAOYSA-N 1h-imidazol-2-amine Chemical class NC1=NC=CN1 DEPDDPLQZYCHOH-UHFFFAOYSA-N 0.000 title 1
- -1 IMIDAZOLYL Chemical class 0.000 abstract 2
- TZGPACAKMCUCKX-UHFFFAOYSA-N 2-hydroxyacetamide Chemical compound NC(=O)CO TZGPACAKMCUCKX-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
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- Diabetes (AREA)
- Pulmonology (AREA)
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- Neurology (AREA)
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- Hematology (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Urology & Nephrology (AREA)
- Obesity (AREA)
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- Pain & Pain Management (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87118406P | 2006-12-21 | 2006-12-21 | |
| US94174507P | 2007-06-04 | 2007-06-04 | |
| US97852607P | 2007-10-09 | 2007-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081838A1 true PE20081838A1 (es) | 2009-03-14 |
Family
ID=39536557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000011A PE20081838A1 (es) | 2006-12-21 | 2008-01-02 | Derivados de ester o amida de imidazolilo como moduladores del receptor glucocorticoide |
Country Status (36)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH081035Y2 (ja) | 1993-06-30 | 1996-01-17 | 伸夫 高橋 | 家庭用雑排水の処理装置 |
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| JO2754B1 (en) | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| WO2009142588A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) a chemokine receptor 1 (ccr1) antagonist and (b) glucocorticoid receptor modulator |
| TW200951114A (en) * | 2008-05-20 | 2009-12-16 | Astrazeneca Ab | Phenyl or pyridinyl substituted indazoles derivatives |
| WO2009142568A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a b2-agonist |
| WO2009142589A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
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