PE20021057A1 - Proceso para preparar oxazolidinonas - Google Patents

Proceso para preparar oxazolidinonas

Info

Publication number
PE20021057A1
PE20021057A1 PE2002000317A PE2002000317A PE20021057A1 PE 20021057 A1 PE20021057 A1 PE 20021057A1 PE 2002000317 A PE2002000317 A PE 2002000317A PE 2002000317 A PE2002000317 A PE 2002000317A PE 20021057 A1 PE20021057 A1 PE 20021057A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
formula
ch3co
benzyl
Prior art date
Application number
PE2002000317A
Other languages
English (en)
Inventor
Bruce A Pearlman
William R Perrault
Delara B Godrej
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26963272&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20021057(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20021057A1 publication Critical patent/PE20021057A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

SE REFIERE A UN PROCESO PARA PREPARAR 2-OXO-5-OXAZOLIDINILMETILACETAMIDAS DE FORMULA I EN UN SOLO PASO QUE COMPRENDE REACCIONAR N-ARIL-O-ALQUILCARBAMATO DE FORMULA II CON COMPUESTOS DE FORMULA III EN PRESENCIA DE CATION LITIO, UNA BASE CON UN pKDMSO MAYOR de 12 TAL COMO ALCOXIDO, CARBANION DE ALQUILO C1-C4, BASE CONJUGADA DE CARBAMATO, ENTRE OTROS, UN NUCLEOFILO TAL COMO METOXIDO, ETOXIDO, ISOPROPOXIDO, ISOBUTOXIDO, 2-ETOXIETILO, ENTRE OTROS; EN UN SISTEMA DE SOLVENTES TAL COMO THF Y ACETONITRILO; X E Y SON H, F; W1 ES Cl, Br, OSO2-R; W2 ES H, COR1; R ES ARILO, ALQUILO, I; R1 ES CH3; R2 ES CICLOALQUILO, FENILO, NR2aR2b, ENTRE OTROS; R2a, R2b SON H, ALQUILO C1-C4; Q ES i, ii, v; Q Y X JUNTOS FORMAN DIHIDROPIRROLIDINA OPCIONALMENTE SUSTITUIDA CON R5; Z1 ES CH2(CH2)p; CH(OH)(CH2)p, CO; Z2 ES S, SO, SO2, O, NR6; Z3 ES S, SO, SO2, O; R3 ES H, CH3; R4 ES H, OH, ALQUILO C1-C3; ALCOXI C1-C4; R7OCH2=CONH; R8OCONH, ALQUILO C1-C3-O-CO, ENTRE OTROS; R3 Y R4 JUNTOS FORMAN CO, C=NR9; R5 ES CH3CO, HCO, Cl2CHCO, HOCH2CO, CH3SO2, F2CHCO, ENTRE OTROS; R6 ES H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON OH, CN, HALO, (CH2)h-ARILO, COR11, COOR12, ENTRE OTROS; R7 ES H, CH3, BENCILO, CH3CO; R8 ES ALQUILO C1-C3, ARILO, BENCILO; R9 ES OH, CH3O; H2N; CH3OCOO, CH3COOCH2COO, ENTRE OTROS; R10 ES CH3, HOCH2, FENIL-NH, (CH3)2N-CH2; R11 ES H, ALQUILO C1-C6, (CH2)h-ARILO, (CH2)hOR13; R12 ES ALQUILO C1-C6, R13 ES H, ALQUILO C1-C6, (CH2)hARILO, CO-ALQUILO C1-C6; h ES 1-4; i Y m SON 0-1; n ES 1-3; p ES 0-2
PE2002000317A 2001-04-20 2002-04-16 Proceso para preparar oxazolidinonas PE20021057A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28558601P 2001-04-20 2001-04-20
US36558102P 2002-03-19 2002-03-19

Publications (1)

Publication Number Publication Date
PE20021057A1 true PE20021057A1 (es) 2002-11-27

Family

ID=26963272

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000317A PE20021057A1 (es) 2001-04-20 2002-04-16 Proceso para preparar oxazolidinonas

Country Status (18)

Country Link
US (2) US6887995B2 (es)
EP (1) EP1380121B1 (es)
JP (1) JP2005504007A (es)
AR (1) AR035830A1 (es)
AT (1) ATE374463T1 (es)
AU (1) AU2002255803B2 (es)
CA (1) CA2440600A1 (es)
CY (1) CY1107003T1 (es)
DE (1) DE60222645T2 (es)
DK (1) DK1380121T3 (es)
ES (1) ES2291465T3 (es)
MX (1) MXPA03009645A (es)
MY (1) MY129372A (es)
NZ (1) NZ528996A (es)
PE (1) PE20021057A1 (es)
PT (1) PT1380121E (es)
TW (1) TWI252229B (es)
WO (1) WO2002085849A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2535796A1 (en) * 2003-08-22 2005-03-03 Pharmacia & Upjohn Company Llc N-aryl-2-cyanooxazolidinones and their derivatives
ES2803516T3 (es) 2003-10-16 2021-01-27 Symed Labs Ltd Una forma cristalina de linezolid
US7186844B2 (en) * 2004-01-13 2007-03-06 Mitsubishi Gas Chemical Co., Inc. Method for producing cyclic carbamate ester
CN100369909C (zh) * 2004-03-23 2008-02-20 中国科学院上海药物研究所 N-[4（r）－（1，3－二噁烷基）甲基]苯胺、制备方法和用途
WO2005099353A2 (en) 2004-04-19 2005-10-27 Symed Labs Limited A novel process for the preparation of linezolid and related compounds
AU2006231919A1 (en) 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
EP2033960A3 (en) * 2007-09-04 2009-04-29 Dipharma Francis S.r.l. Linezolid crystalline hydrate form and linezolid salts
ITMI20072359A1 (it) * 2007-12-18 2009-06-19 Dipharma Francis Srl Procedimento per la preparazione di derivati ossazolidinonici
EP2163547A1 (en) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
CA2785620A1 (en) * 2009-12-26 2011-06-30 Alembic Pharmaceuticals Limited Process for the preparation of linezolid
CA2816515A1 (en) 2010-11-03 2012-05-10 Wockhardt Limited Process for the preparation of phosphoric acid mono-(1-{4-[(s)-5-(acetylaminomethyl)-2-oxo-oxazolidin-3-yl]-2,6-difluorophenyl}-4-methoxymethylpiperidin-4-yl) ester
CN102731336B (zh) 2011-04-12 2014-05-07 浙江医药股份有限公司新昌制药厂 利奈唑胺中间体及合成利奈唑胺的方法
CN102267955A (zh) * 2011-06-02 2011-12-07 山东鲁抗医药股份有限公司 一种利奈唑胺的制备方法
CN103130733B (zh) * 2011-12-02 2015-07-01 重庆圣华曦药业股份有限公司 制备利奈唑胺的方法
CN102516191B (zh) * 2011-12-21 2014-03-26 吉林省博大伟业制药有限公司 一种利奈唑胺的制备方法
CN102977056B (zh) * 2012-11-28 2014-11-26 深圳万乐药业有限公司 N-苄氧羰基-3-氟-4-吗啉基苯胺的合成方法
CN104140399A (zh) * 2013-05-08 2014-11-12 江苏豪森药业股份有限公司 利奈唑胺的制备方法
CN103483294B (zh) * 2013-08-12 2015-01-28 四川大学 3-氨基-2-丙醇乙酰胺类化合物的盐、其制备方法和用途
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
CN105111160B (zh) * 2015-09-11 2017-04-12 浙江新东港药业股份有限公司 一种利奈唑胺的制备方法
US20170217911A1 (en) * 2015-12-18 2017-08-03 Mankind Research Centre Process For Preparation Of Linezolid
CN111077248A (zh) * 2019-12-24 2020-04-28 江苏乾元生物科技有限公司 Uplc-ms/ms检测(s)-1-氨基-3-氯-2-丙醇盐酸盐的方法
CN115219632B (zh) * 2022-07-29 2024-04-05 山东达因海洋生物制药股份有限公司 一种(s)-1-氨基-3-氯-2-丙醇盐酸盐的hplc-elsd检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
JPH10508844A (ja) * 1994-11-15 1998-09-02 ファルマシア・アンド・アップジョン・カンパニー 二環式オキサジンおよびチアジンオキサゾリジノン抗菌剤
EP0856002B1 (en) * 1995-09-01 2001-10-24 PHARMACIA & UPJOHN COMPANY Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
MX9703040A (es) * 1995-09-12 1997-07-31 Upjohn Co Antimicrobianos de feniloxazolidinona.
EP1114819B1 (en) * 1996-04-11 2008-01-09 Pharmacia & Upjohn Company LLC Process to prepare oxazolidinones
CA2634657A1 (en) 1997-11-07 1999-05-20 Pharmacia & Upjohn Company Process to produce oxazolidinones
PE20020044A1 (es) 2000-06-16 2002-01-30 Upjohn Co Tiazina oxazolidinona

Also Published As

Publication number Publication date
DE60222645T2 (de) 2008-07-17
MY129372A (en) 2007-03-30
WO2002085849A2 (en) 2002-10-31
NZ528996A (en) 2006-01-27
AR035830A1 (es) 2004-07-14
EP1380121A2 (en) 2004-01-14
US7087784B2 (en) 2006-08-08
TWI252229B (en) 2006-04-01
US20020169312A1 (en) 2002-11-14
PT1380121E (pt) 2007-11-21
ATE374463T1 (de) 2007-10-15
ES2291465T3 (es) 2008-03-01
DK1380121T3 (da) 2007-12-27
MXPA03009645A (es) 2004-01-29
AU2002255803B2 (en) 2008-07-03
CY1107003T1 (el) 2012-09-26
US20040220407A1 (en) 2004-11-04
WO2002085849A3 (en) 2003-03-06
EP1380121B1 (en) 2007-09-26
DE60222645D1 (de) 2007-11-08
US6887995B2 (en) 2005-05-03
JP2005504007A (ja) 2005-02-10
CA2440600A1 (en) 2002-10-31

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed