ES8203364A1 - Un procedimiento para la preparacion de un derivado de ani- lina. - Google Patents
Un procedimiento para la preparacion de un derivado de ani- lina.Info
- Publication number
- ES8203364A1 ES8203364A1 ES498013A ES498013A ES8203364A1 ES 8203364 A1 ES8203364 A1 ES 8203364A1 ES 498013 A ES498013 A ES 498013A ES 498013 A ES498013 A ES 498013A ES 8203364 A1 ES8203364 A1 ES 8203364A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- halogen
- iii
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS E ANILINA. CONSISTE EN HACER REACCIONAR UN ACIDO DE FORMULA GENERAL (I) O UN DERIVADO REACTIVO DEL MISMO CON UN COMPUESTO (II). SE OBTIENE EL COMPUESTO (III), EN QUE R1 ES UN GRUPO ALCOXI O ALQUILTIO; R2 Y R3 SON HIDROGENO, HALOGENO, ACILO, ACILAMINO, AMINO, AMINOCARBONILO O AMINOSULFONILO; R4 ES ALQUILO O UN GRUPO -(CH2)SR6, EN QUE S ES 0 O 2; R6 ES UN GRUPO CICLOALQUILO; R7 ES FENILO; P, Q Y N SON INDEPENDIENTEMENTE 0 A 2.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7943985 | 1979-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES498013A0 ES498013A0 (es) | 1982-04-01 |
ES8203364A1 true ES8203364A1 (es) | 1982-04-01 |
Family
ID=10509974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES498013A Expired ES8203364A1 (es) | 1979-12-20 | 1980-12-19 | Un procedimiento para la preparacion de un derivado de ani- lina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4350691A (es) |
EP (1) | EP0031219B1 (es) |
JP (1) | JPS5692888A (es) |
AU (1) | AU6552880A (es) |
DE (1) | DE3066884D1 (es) |
DK (1) | DK541480A (es) |
ES (1) | ES8203364A1 (es) |
IL (1) | IL61642A0 (es) |
ZA (1) | ZA807691B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2440946A2 (fr) * | 1978-01-20 | 1980-06-06 | Ile De France | Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement |
NZ199080A (en) * | 1980-12-12 | 1984-07-31 | Beecham Group Ltd | 2-alkoxy-4-amino-5-alkylsulphonyl-n-(3beta-(8-hydrocarbyl-8-azabicyclo (3,2,1)octyl))benzamides |
EP0067615B1 (en) * | 1981-06-17 | 1986-01-08 | Beecham Group Plc | Alkylthio derivatives of azabicyclobenzamides, their preparation and pharmaceutical compositions |
EP0069481A1 (en) * | 1981-06-17 | 1983-01-12 | Beecham Group Plc | Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them |
EP0069482A1 (en) * | 1981-06-29 | 1983-01-12 | Beecham Group Plc | Azabicycloalkyl benzamides, process for their preparation and pharmaceutical compositions containing them |
EP0068700A1 (en) * | 1981-06-29 | 1983-01-05 | Beecham Group Plc | Azobicycloalkylbenzamides, process for their preparation and pharmaceutical compositions containing them |
GB2111479A (en) * | 1981-10-01 | 1983-07-06 | Beecham Group Plc | Benzamides |
DE3204157A1 (de) * | 1982-02-06 | 1983-08-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Substituierte dibenzodiazepinone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
NZ203861A (en) * | 1982-04-14 | 1986-07-11 | Beecham Group Plc | Bicyclic heterocyclic compounds and pharmaceutical compositions containing such |
EP0095262B1 (en) * | 1982-05-11 | 1986-12-03 | Beecham Group Plc | Azabicycloalkane derivatives, their preparation and medicaments containing them |
AU1508183A (en) * | 1982-06-04 | 1983-12-08 | Beecham Group Plc | Benzamide and anilide derivatives of 8-azabicyclo-(3.2.1)- -octane |
EP0101641A3 (en) * | 1982-07-22 | 1984-03-28 | Beecham Group Plc | Sulfonylamino-aza-bicyclo-alkyl derivatives |
EP0102195A3 (en) * | 1982-08-03 | 1984-04-11 | Beecham Group Plc | Substituted aza bicycloalkyl derivatives with dopamine antagonist activity |
GB8302483D0 (en) * | 1983-01-29 | 1983-03-02 | Beecham Group Plc | Compounds |
CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
US4621097A (en) * | 1985-08-16 | 1986-11-04 | Warner-Lambert Company | Saturated cycloalkyl[c] pyrrole-2(1H)-acetic acid amides and derivatives thereof |
US4920219A (en) * | 1988-11-29 | 1990-04-24 | Rorer Pharmaceutical Corp. | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents |
NZ241067A (en) * | 1990-12-27 | 1993-03-26 | Erba Carlo Spa | Dihydrobenzofuran carboxamide derivatives, preparation and pharmaceutical compositions thereof |
JP3235913B2 (ja) * | 1993-07-30 | 2001-12-04 | エーザイ株式会社 | アミノ安息香酸誘導体 |
GB9510459D0 (en) * | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
IL126882A0 (en) * | 1996-05-13 | 1999-09-22 | Zeneca Ltd | Bicyclic amines as insecticides |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
HUP0000582A3 (en) | 1996-11-26 | 2001-10-29 | Zeneca Ltd | Insecticidal, acaricidal and nematocidal 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, preparation and use thereof |
GB9624611D0 (en) * | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
UA58476C2 (uk) * | 1997-10-09 | 2003-08-15 | Санофі-Сентелябо | Похідні 8-азабіцикло[3.2.1]октан-3-метанаміну, фармацевтична композиція та лікарський засіб |
UA82517C2 (uk) * | 2003-06-24 | 2008-04-25 | Ньюросерч А/С | Нові похідні 8-аза-біцикло[3.2.1]октану та їх застосування як інгібіторів ресорбції моноамінових медіаторів |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1259992A (fr) * | 1958-03-19 | 1961-05-05 | Roques Ets | Procédé de préparation des amides substituées de l'ecgonidine |
GB1593146A (en) * | 1976-11-05 | 1981-07-15 | Beecham Group Ltd | Octahydro-quinolizinyl benzamide derivatives |
IL59004A0 (en) * | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
FR2476088A2 (fr) * | 1979-01-16 | 1981-08-21 | Delalande Sa | Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique |
-
1980
- 1980-12-05 IL IL61642A patent/IL61642A0/xx unknown
- 1980-12-05 US US06/213,237 patent/US4350691A/en not_active Expired - Lifetime
- 1980-12-09 ZA ZA00807691A patent/ZA807691B/xx unknown
- 1980-12-11 DE DE8080304467T patent/DE3066884D1/de not_active Expired
- 1980-12-11 EP EP80304467A patent/EP0031219B1/en not_active Expired
- 1980-12-18 AU AU65528/80A patent/AU6552880A/en not_active Abandoned
- 1980-12-18 DK DK541480A patent/DK541480A/da unknown
- 1980-12-19 JP JP18031980A patent/JPS5692888A/ja active Pending
- 1980-12-19 ES ES498013A patent/ES8203364A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
US4350691A (en) | 1982-09-21 |
DK541480A (da) | 1981-06-21 |
AU6552880A (en) | 1981-06-25 |
JPS5692888A (en) | 1981-07-27 |
EP0031219B1 (en) | 1984-03-07 |
ES498013A0 (es) | 1982-04-01 |
IL61642A0 (en) | 1981-01-30 |
ZA807691B (en) | 1981-11-25 |
DE3066884D1 (en) | 1984-04-12 |
EP0031219A1 (en) | 1981-07-01 |
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