AR037098A1 - Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso - Google Patents
Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho procesoInfo
- Publication number
- AR037098A1 AR037098A1 ARP020103762A ARP020103762A AR037098A1 AR 037098 A1 AR037098 A1 AR 037098A1 AR P020103762 A ARP020103762 A AR P020103762A AR P020103762 A ARP020103762 A AR P020103762A AR 037098 A1 AR037098 A1 AR 037098A1
- Authority
- AR
- Argentina
- Prior art keywords
- halo
- sulfona
- rental
- prepare
- compounds used
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 4
- MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960002258 fulvestrant Drugs 0.000 abstract 1
- -1 halo alkyl sulfone Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/30—Isothioureas
- C07C335/32—Isothioureas having sulfur atoms of isothiourea groups bound to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un proceso para preparar un compuesto intermediario, derivado de halo alquil sulfona de fórmula (1) donde n es un entero entre 3 y 14; R1 es haloC1-10alquilo, C1-10alquilo, C2-10alquenilo, C2-10cicloalquilo, carboxiC1-10alquilo, C1-10alcoxicarbonilC1-10alquilo, arilo (tal como fenilo), aril(C1-10)alquilo (tal como fenil(C1-10)alquilo) o di(C1-6alquil)amino; y R2 es un grupo halo; proceso que comprende la halogenación de un compuesto de fórmula(2) donde n y R1 son como se los definió previamente. También se describen y reivindican compuestos intermediarios de fórmula (3) donde n es un entero entre 3 y 14 y compuesto de fórmula (4) donde R6 es haloC1-10alquilo. Mediante este proceso se obtienen compuestos intermediarios que pueden ser usados en la síntesis de fulvestrant.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0123961.5A GB0123961D0 (en) | 2001-10-05 | 2001-10-05 | Process and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037098A1 true AR037098A1 (es) | 2004-10-20 |
Family
ID=9923306
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103762A AR037098A1 (es) | 2001-10-05 | 2002-10-04 | Proceso para preparar un compuesto intermediario derivado de halo alquil sulfona y compuestos intermediarios que se usan en dicho proceso |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7323602B2 (es) |
| EP (1) | EP1436256B1 (es) |
| JP (1) | JP4346440B2 (es) |
| KR (1) | KR100937916B1 (es) |
| CN (1) | CN100522938C (es) |
| AR (1) | AR037098A1 (es) |
| AT (1) | ATE519736T1 (es) |
| AU (1) | AU2002329452B2 (es) |
| BR (2) | BRPI0212982B1 (es) |
| CA (1) | CA2462237C (es) |
| ES (1) | ES2368903T3 (es) |
| GB (1) | GB0123961D0 (es) |
| HK (1) | HK1066786A1 (es) |
| IL (2) | IL161084A0 (es) |
| MX (1) | MXPA04003020A (es) |
| MY (1) | MY139404A (es) |
| NO (1) | NO331195B1 (es) |
| NZ (1) | NZ531943A (es) |
| SA (1) | SA02230410B1 (es) |
| WO (1) | WO2003031399A1 (es) |
| ZA (1) | ZA200402470B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0025221D0 (en) * | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
| WO2006015081A2 (en) * | 2004-07-27 | 2006-02-09 | Sicor, Inc. | A PROCESS FOR THE PREPARATION OF 7α-ALKYLATED 19-NORSTEROIDS |
| DK2180787T3 (da) | 2007-08-01 | 2014-02-03 | Univ Pittsburgh | Nitrooliesyremodulering af type ii-diabetes |
| CA2729053A1 (en) | 2008-05-01 | 2009-11-05 | Bruce A. Freeman | Vinyl substituted fatty acids |
| US20140024713A1 (en) | 2008-06-19 | 2014-01-23 | University Of Utah Research Foundation | Use of nitrated lipids for treatment of side effects of toxic medical therapies |
| CN102099024B (zh) | 2008-06-19 | 2015-11-25 | 犹他大学研究基金会 | 硝化脂质在毒性医疗疗法的副作用的治疗上的用途 |
| CN102227441A (zh) * | 2008-10-15 | 2011-10-26 | 斯索恩有限公司 | 制备氟维司群的方法和中间体 |
| EP3045167A1 (en) | 2009-07-31 | 2016-07-20 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Keto fatty acids as anti-inflammatory agents |
| WO2011041639A2 (en) | 2009-10-02 | 2011-04-07 | Miller Raymond A | Heteroatom containing substituted fatty acids |
| EP2744491B1 (en) | 2011-08-19 | 2020-07-29 | The University of Utah Research Foundation | Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system |
| AU2016289856B2 (en) | 2015-07-07 | 2020-11-26 | H. Lundbeck A/S | PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases |
| EP3355879A4 (en) | 2015-10-02 | 2019-05-22 | Complexa, Inc. | PREVENTION, TREATMENT AND INVERSION OF DISEASE USING THERAPEUTICALLY EFFECTIVE AMOUNTS OF ACTIVATED FATTY ACIDS |
| SI3801526T1 (sl) | 2018-05-25 | 2024-05-31 | Cardurion Pharmaceuticals, Inc. | Monohidratne in kristalinične oblike 6-((3s, 4s)-4-metil-1-(pirimidin-2-ilmetil)pirolidin-3-il)-3-tetrahidropiran-4- il-7h-imidazo (1.5 - a) pirazin-8-ona |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8327256D0 (en) | 1983-10-12 | 1983-11-16 | Ici Plc | Steroid derivatives |
| SE8705150D0 (sv) * | 1987-12-23 | 1987-12-23 | Haessle Ab | Novel antiarrhythmic agents |
| US5552391A (en) * | 1990-01-16 | 1996-09-03 | La Jolla Pharmaceutical Company | Chemically-defined non-polymeric valency platform molecules and conjugates thereof |
| DE4132182A1 (de) * | 1991-09-24 | 1993-03-25 | Schering Ag | 11(beta)-substituierte 14, 17-ethanoestratriene, verfahren zur herstellung dieser verbindungen, sowie ihre verwendung zur herstellung von arzneimitteln |
| CA2391081A1 (en) * | 1999-11-12 | 2001-05-25 | Basf Aktiengesellschaft | Herbicidal 2-aryloxy-6-fluoroalkylthioalk(en)yloxy-pyridine |
| GB0025221D0 (en) | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
-
2001
- 2001-10-05 GB GBGB0123961.5A patent/GB0123961D0/en not_active Ceased
-
2002
- 2002-10-03 JP JP2003534383A patent/JP4346440B2/ja not_active Expired - Lifetime
- 2002-10-03 AU AU2002329452A patent/AU2002329452B2/en not_active Expired
- 2002-10-03 AT AT02765080T patent/ATE519736T1/de not_active IP Right Cessation
- 2002-10-03 MX MXPA04003020A patent/MXPA04003020A/es active IP Right Grant
- 2002-10-03 IL IL16108402A patent/IL161084A0/xx unknown
- 2002-10-03 BR BRPI0212982-5A patent/BRPI0212982B1/pt unknown
- 2002-10-03 NZ NZ531943A patent/NZ531943A/en not_active IP Right Cessation
- 2002-10-03 KR KR1020047004815A patent/KR100937916B1/ko active IP Right Grant
- 2002-10-03 ES ES02765080T patent/ES2368903T3/es not_active Expired - Lifetime
- 2002-10-03 CN CNB028197658A patent/CN100522938C/zh not_active Expired - Lifetime
- 2002-10-03 WO PCT/GB2002/004478 patent/WO2003031399A1/en active Application Filing
- 2002-10-03 CA CA2462237A patent/CA2462237C/en not_active Expired - Lifetime
- 2002-10-03 MY MYPI20023693A patent/MY139404A/en unknown
- 2002-10-03 EP EP02765080A patent/EP1436256B1/en not_active Expired - Lifetime
- 2002-10-03 BR BR0212982-5A patent/BR0212982A/pt active IP Right Grant
- 2002-10-03 US US10/491,738 patent/US7323602B2/en not_active Expired - Lifetime
- 2002-10-04 AR ARP020103762A patent/AR037098A1/es active IP Right Grant
- 2002-10-30 SA SA02230410A patent/SA02230410B1/ar unknown
-
2004
- 2004-03-25 IL IL161084A patent/IL161084A/en active IP Right Grant
- 2004-03-29 ZA ZA2004/02470A patent/ZA200402470B/en unknown
- 2004-03-31 NO NO20041387A patent/NO331195B1/no not_active IP Right Cessation
- 2004-12-07 HK HK04109696.4A patent/HK1066786A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4346440B2 (ja) | 2009-10-21 |
| NO20041387L (no) | 2004-03-31 |
| KR100937916B1 (ko) | 2010-01-21 |
| MXPA04003020A (es) | 2004-07-05 |
| US7323602B2 (en) | 2008-01-29 |
| ATE519736T1 (de) | 2011-08-15 |
| US20050033085A1 (en) | 2005-02-10 |
| CA2462237C (en) | 2012-07-03 |
| AU2002329452B2 (en) | 2009-03-12 |
| HK1066786A1 (en) | 2005-04-01 |
| BRPI0212982B1 (pt) | 2017-09-12 |
| CN1564812A (zh) | 2005-01-12 |
| CA2462237A1 (en) | 2003-04-17 |
| IL161084A0 (en) | 2004-08-31 |
| BR0212982A (pt) | 2004-10-13 |
| IL161084A (en) | 2011-06-30 |
| SA02230410B1 (ar) | 2009-01-31 |
| CN100522938C (zh) | 2009-08-05 |
| ES2368903T3 (es) | 2011-11-23 |
| GB0123961D0 (en) | 2001-11-28 |
| WO2003031399A1 (en) | 2003-04-17 |
| JP2005504845A (ja) | 2005-02-17 |
| NO331195B1 (no) | 2011-10-31 |
| EP1436256A1 (en) | 2004-07-14 |
| MY139404A (en) | 2009-09-30 |
| KR20050033507A (ko) | 2005-04-12 |
| ZA200402470B (en) | 2005-02-23 |
| NZ531943A (en) | 2006-09-29 |
| EP1436256B1 (en) | 2011-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |