HUP0001396A2 - 3-Amino-3 aril-propán-1-ol-származékok, előállításuk és felhasználásuk - Google Patents
3-Amino-3 aril-propán-1-ol-származékok, előállításuk és felhasználásukInfo
- Publication number
- HUP0001396A2 HUP0001396A2 HU0001396A HUP0001396A HUP0001396A2 HU P0001396 A2 HUP0001396 A2 HU P0001396A2 HU 0001396 A HU0001396 A HU 0001396A HU P0001396 A HUP0001396 A HU P0001396A HU P0001396 A2 HUP0001396 A2 HU P0001396A2
- Authority
- HU
- Hungary
- Prior art keywords
- ring
- substituted
- group
- derivatives
- amino
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
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- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Psychiatry (AREA)
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- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Urology & Nephrology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Abstract
A tal lm ny (I) ltal nos képletű helyettesített 3amino-3-aril-prop n-1-ol-sz rmazékokra (mely képletben R1 és R2 jelentése egym stólfüggetlenül 1-6 szénatomos alkilcsoport, vagy R1 és R2 együtt adottesetben fenil-helyettesített -(CH2)2-6-gyűrűt képez; R3 jelentése 3-6szénatomos alkil-, 3-6 szénatomos cikloalkilcsoport, agyűrűrendszerben adott esetben heteroatomokat tartalmazó és azarilgyűrűn adott esetben R6-R8 helyettesítőket hordozó arilcsoport,vagy (XII) ltal nos képletű helyettesített 1-3 szénatomos alkil-fenil-csoport; n értéke 1, 2 vagy 3; R4 és R5 jelentése egym stólfüggetlenül 1-6 szénatomos alkil-, 3-6 szénatomos cikloalkil-, fenil-,benzil-, fenil-etilcsoport, vagy R4 és R5 együtt -(CH2)3-6 vagy -CH2CH2CH2CH2-gyűrűt képez; A jelentése a gyűrűrendszerben adottesetben heteroatomokat tartalmazó és/vagy adott esetben helyettesítettarilcsoport) e vegyületek elő llít s ra és gyógyszerként t"rténőfelhaszn l s ra vonatkozik. A vegyületek analgetikus és egyéb hatsúak. Ó
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19915601A DE19915601A1 (de) | 1999-04-07 | 1999-04-07 | 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
HU0001396D0 HU0001396D0 (en) | 2000-06-28 |
HUP0001396A2 true HUP0001396A2 (hu) | 2002-04-29 |
Family
ID=7903730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0001396A HUP0001396A2 (hu) | 1999-04-07 | 2000-04-05 | 3-Amino-3 aril-propán-1-ol-származékok, előállításuk és felhasználásuk |
Country Status (26)
Country | Link |
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US (1) | US6410790B1 (hu) |
EP (1) | EP1043307B1 (hu) |
JP (1) | JP2000327642A (hu) |
KR (1) | KR20000071575A (hu) |
CN (1) | CN1183098C (hu) |
AR (1) | AR033941A1 (hu) |
AT (1) | ATE242197T1 (hu) |
BR (1) | BR0008682A (hu) |
CA (1) | CA2304127A1 (hu) |
CO (1) | CO5160346A1 (hu) |
CZ (1) | CZ299556B6 (hu) |
DE (2) | DE19915601A1 (hu) |
DK (1) | DK1043307T3 (hu) |
ES (1) | ES2200740T3 (hu) |
HK (1) | HK1031725A1 (hu) |
HU (1) | HUP0001396A2 (hu) |
IL (1) | IL135451A0 (hu) |
MY (1) | MY133112A (hu) |
NO (1) | NO20001781L (hu) |
NZ (1) | NZ503396A (hu) |
PE (1) | PE20001648A1 (hu) |
PL (1) | PL200272B1 (hu) |
PT (1) | PT1043307E (hu) |
SI (1) | SI1043307T1 (hu) |
SK (1) | SK285259B6 (hu) |
ZA (1) | ZA200001746B (hu) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4426245A1 (de) | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
DE19915602A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
DE19963175A1 (de) | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Verwendung von substituierten 4-Amino-1-phenylbutan-2-ol-Verbindungen als Arzneimittel |
DE10025238A1 (de) * | 2000-05-22 | 2001-11-29 | Gruenenthal Gmbh | Verwendung substituierter 1-Amino-5-phenylpentan-3-ol- und/oder 1-Amino-6-phenylhexan-3-ol- Verbindungen als Arzneimittel |
DE10049483A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte 1-Aminobutan-3-ol-Derivate |
DE10049481A1 (de) * | 2000-09-29 | 2002-05-02 | Gruenenthal Gmbh | Substituierte C-Cyclohexylmethylamin-Derivate |
DE10108307A1 (de) * | 2001-02-21 | 2002-08-29 | Gruenenthal Gmbh | Substituierte Propan-1,3-diamin-Derivate |
DE10132747A1 (de) | 2001-07-05 | 2003-01-23 | Gruenenthal Gmbh | Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen |
DE10161818A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte 1,5-Diaminopentan-3-ol-Verbindungen |
DE10164581A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Substituierte Aminoalkohole |
DE10161809A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen |
DE10161644A1 (de) * | 2001-12-14 | 2003-06-26 | Gruenenthal Gmbh | N,N'-disubstituierte Piperazin-Verbindungen |
DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
DE102004034619A1 (de) * | 2004-07-16 | 2006-02-23 | Grünenthal GmbH | Substituierte Aminoverbindungen als 5-HT/NA Uptakehemmer |
DE102005061428A1 (de) * | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
JP5420534B2 (ja) * | 2007-05-31 | 2014-02-19 | サノビオン ファーマシューティカルズ インク | モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン |
AU2015202379B2 (en) * | 2007-05-31 | 2016-10-13 | Sunovion Pharmaceuticals Inc. | Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors |
CN118108610A (zh) * | 2024-04-30 | 2024-05-31 | 山东新华制药股份有限公司 | 盐酸去甲曲马多的制备方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB815217A (en) * | 1957-12-03 | 1959-06-17 | Bayer Ag | 1-o-chlorophenyl-1-phenyl-3-(dimethylamino)-propan-1-ol and its salts and therapeuticcompositions containing them |
AT28628B (de) * | 1905-11-04 | 1907-06-10 | Neue Photographische Ges Ag | Verwandlungsbilder, bei welchen die Umwandlung des Bildes durch Lichtwirkung hervorgerufen wird. |
GB657301A (en) * | 1948-02-25 | 1951-09-19 | Wellcome Found | Improvements in and relating to the preparation of substituted amino-alcohols and derivatives thereof |
GB811659A (en) * | 1955-07-05 | 1959-04-08 | Bayer Ag | Process for producing derivatives of 1-aryl-3-amino propanol-1 |
US4155935A (en) * | 1973-03-26 | 1979-05-22 | American Home Products Corporation | Benzylamine analgesics |
US4017637A (en) | 1973-03-26 | 1977-04-12 | American Home Products Corporation | Benzylamine analgesics |
US4366172A (en) * | 1977-09-29 | 1982-12-28 | The Upjohn Company | 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use |
AU566673B2 (en) * | 1983-09-15 | 1987-10-29 | F. Hoffmann-La Roche Ag | Phenethylamine derivatives |
JPS60246349A (ja) * | 1984-05-22 | 1985-12-06 | Tozaburo Kurihara | 2−置換−1−ジメチルアミノメチル−シクロヘキサン及びその製造法 |
JPH08198823A (ja) * | 1995-01-23 | 1996-08-06 | Nippon Soda Co Ltd | 3−アミノ−3−アリール−1−プロパノール誘導体の製造方法 |
DE19915602A1 (de) * | 1999-04-07 | 2000-10-19 | Gruenenthal Gmbh | 3-Amino-4-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung |
CZ20001251A3 (cs) * | 2000-04-06 | 2000-11-15 | Grünenthal GmbH | Deriváty 3-amino-3-aryIpropan-l-olu, způsob jejich výroby, léčiva tyto látky obsahující a jejich použití |
-
1999
- 1999-04-07 DE DE19915601A patent/DE19915601A1/de not_active Withdrawn
-
2000
- 2000-03-08 AT AT00104477T patent/ATE242197T1/de not_active IP Right Cessation
- 2000-03-08 DE DE50002417T patent/DE50002417D1/de not_active Expired - Lifetime
- 2000-03-08 EP EP00104477A patent/EP1043307B1/de not_active Expired - Lifetime
- 2000-03-08 ES ES00104477T patent/ES2200740T3/es not_active Expired - Lifetime
- 2000-03-08 SI SI200030171T patent/SI1043307T1/xx unknown
- 2000-03-08 PT PT00104477T patent/PT1043307E/pt unknown
- 2000-03-08 DK DK00104477T patent/DK1043307T3/da active
- 2000-03-14 NZ NZ503396A patent/NZ503396A/xx unknown
- 2000-03-31 MY MYPI20001313A patent/MY133112A/en unknown
- 2000-04-03 AR ARP000101520A patent/AR033941A1/es not_active Application Discontinuation
- 2000-04-04 PE PE2000000292A patent/PE20001648A1/es not_active Application Discontinuation
- 2000-04-04 IL IL13545100A patent/IL135451A0/xx unknown
- 2000-04-05 CA CA002304127A patent/CA2304127A1/en not_active Abandoned
- 2000-04-05 BR BR0008682-7A patent/BR0008682A/pt not_active IP Right Cessation
- 2000-04-05 HU HU0001396A patent/HUP0001396A2/hu unknown
- 2000-04-05 CO CO00024762A patent/CO5160346A1/es unknown
- 2000-04-06 KR KR1020000017910A patent/KR20000071575A/ko not_active Application Discontinuation
- 2000-04-06 SK SK496-2000A patent/SK285259B6/sk not_active IP Right Cessation
- 2000-04-06 NO NO20001781A patent/NO20001781L/no not_active Application Discontinuation
- 2000-04-06 ZA ZA200001746A patent/ZA200001746B/xx unknown
- 2000-04-06 CZ CZ20001250A patent/CZ299556B6/cs not_active IP Right Cessation
- 2000-04-06 JP JP2000105250A patent/JP2000327642A/ja not_active Withdrawn
- 2000-04-06 CN CNB001049798A patent/CN1183098C/zh not_active Expired - Fee Related
- 2000-04-06 PL PL339486A patent/PL200272B1/pl not_active IP Right Cessation
- 2000-04-07 US US09/545,371 patent/US6410790B1/en not_active Expired - Fee Related
-
2001
- 2001-03-31 HK HK01102345A patent/HK1031725A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2304127A1 (en) | 2000-10-07 |
US6410790B1 (en) | 2002-06-25 |
CN1183098C (zh) | 2005-01-05 |
ZA200001746B (en) | 2000-12-06 |
ATE242197T1 (de) | 2003-06-15 |
EP1043307A3 (de) | 2001-07-18 |
DE19915601A1 (de) | 2000-10-19 |
AR033941A1 (es) | 2004-01-21 |
SK4962000A3 (en) | 2000-10-09 |
PL200272B1 (pl) | 2008-12-31 |
CN1270162A (zh) | 2000-10-18 |
PT1043307E (pt) | 2003-10-31 |
MY133112A (en) | 2007-10-31 |
DK1043307T3 (da) | 2003-09-22 |
KR20000071575A (ko) | 2000-11-25 |
SI1043307T1 (en) | 2003-12-31 |
HU0001396D0 (en) | 2000-06-28 |
BR0008682A (pt) | 2002-02-26 |
JP2000327642A (ja) | 2000-11-28 |
CZ299556B6 (cs) | 2008-09-03 |
CZ20001250A3 (cs) | 2000-11-15 |
PE20001648A1 (es) | 2001-01-20 |
NO20001781L (no) | 2000-10-09 |
ES2200740T3 (es) | 2004-03-16 |
EP1043307A2 (de) | 2000-10-11 |
IL135451A0 (en) | 2001-05-20 |
NZ503396A (en) | 2000-11-24 |
DE50002417D1 (de) | 2003-07-10 |
PL339486A1 (en) | 2000-10-09 |
SK285259B6 (sk) | 2006-10-05 |
CO5160346A1 (es) | 2002-05-30 |
NO20001781D0 (no) | 2000-04-06 |
EP1043307B1 (de) | 2003-06-04 |
HK1031725A1 (en) | 2001-06-22 |
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