NZ503396A - o(phenyl or benzyl)methyl]-1-(substituted phenyl, thiophene, furan or piperidinyl)-cyclohexanol derivatives and medicaments - Google Patents

o(phenyl or benzyl)methyl]-1-(substituted phenyl, thiophene, furan or piperidinyl)-cyclohexanol derivatives and medicaments

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Publication number
NZ503396A
NZ503396A NZ503396A NZ50339600A NZ503396A NZ 503396 A NZ503396 A NZ 503396A NZ 503396 A NZ503396 A NZ 503396A NZ 50339600 A NZ50339600 A NZ 50339600A NZ 503396 A NZ503396 A NZ 503396A
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NZ
New Zealand
Prior art keywords
phenyl
benzyl
optionally substituted
ring
cyclohexanol
Prior art date
Application number
NZ503396A
Inventor
Bernd Sundermann
Hagen-Heinrich Hennies
Babette-Yvonne Kogel
Helmut Buschmann
Original Assignee
Gruenenthal Chemie
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Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of NZ503396A publication Critical patent/NZ503396A/en

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
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Abstract

The substituted cyclohexanol derivatives or their diastereomers or enantiomers in the form of their bases or salts of physiological compatible acids have the formula I HO-C(R2)(R3)-C(H)(R1)-C(H)(A)-N(R4)R5 wherein: R1 and R2 are independently alkyl or together form a (CH2)2-6 ring optionally substituted by phenyl; R3 is alkyl, cycloalkyl or optionally substituted alkylphenyl, aryl or heteroaryl; R4 and R5 are independently alkyl, cycloalkyl, phenyl, benzyl, phenethyl or together form a (CH2)3-6 ring or -CH2CH2O-CH2CH2 ring; A is an optionally substituted aryl radical or heteroaryl radical; wherein 1-benzyl-2-(dimethylaminophenylmethyl)-cyclohexanol or its diastereomers or enantiomers in the form of their bases and its reaction product with methyliodide is excluded. A pharmaceutical composition thereof is useful for relieving pain or for use as a local anesthetic agent or for treating cardiovascular conditions, urinary incontinence, diarrhea, pruritis, alcohol and drug dependence, inflammation and depression.
NZ503396A 1999-04-07 2000-03-14 o(phenyl or benzyl)methyl]-1-(substituted phenyl, thiophene, furan or piperidinyl)-cyclohexanol derivatives and medicaments NZ503396A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19915601A DE19915601A1 (en) 1999-04-07 1999-04-07 3-Amino-3-arylpropan-1-ol derivatives, their preparation and use

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NZ503396A true NZ503396A (en) 2000-11-24

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US (1) US6410790B1 (en)
EP (1) EP1043307B1 (en)
JP (1) JP2000327642A (en)
KR (1) KR20000071575A (en)
CN (1) CN1183098C (en)
AR (1) AR033941A1 (en)
AT (1) ATE242197T1 (en)
BR (1) BR0008682A (en)
CA (1) CA2304127A1 (en)
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DE4426245A1 (en) 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-phenyl-3-dimethylamino-propane compounds with pharmacological activity
DE19915602A1 (en) * 1999-04-07 2000-10-19 Gruenenthal Gmbh 3-Amino-4-arylpropan-1-ol derivatives, their preparation and use
DE19963175A1 (en) 1999-12-27 2001-07-12 Gruenenthal Gmbh Use of substituted 4-amino-1-phenylbutan-2-ol compounds as medicaments
DE10025238A1 (en) * 2000-05-22 2001-11-29 Gruenenthal Gmbh Use of substituted 1-amino-5-phenylpentan-3-ol and / or 1-amino-6-phenylhexan-3-ol compounds as medicaments
DE10049483A1 (en) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituted 1-aminobutan-3-ol derivatives
DE10049481A1 (en) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituted C-cyclohexylmethylamine derivatives
DE10108307A1 (en) 2001-02-21 2002-08-29 Gruenenthal Gmbh Substituted propane-1,3-diamine derivatives
DE10132747A1 (en) * 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituted 1-aryl-but-3-enylamine and 1-aryl-but-2-enylamine compounds
DE10164581A1 (en) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Medicaments that inhibit noradrenaline reuptake, useful e.g. for treating emesis, diarrhea, inflammation, depression or especially pain, comprise new or known cyclic aminomethyl-substituted alcohols
DE10161644A1 (en) * 2001-12-14 2003-06-26 Gruenenthal Gmbh New N,N'-disubstituted piperazine derivatives are noradrenaline reuptake inhibitors, useful e.g. for the treatment of arrhythmia, emesis, diarrhea, inflammation or especially depression or pain
DE10161818A1 (en) * 2001-12-14 2003-06-26 Gruenenthal Gmbh New 1,5-diamino-pentan-3-ol derivatives, useful e.g. for the treatment of arrhythmia, emesis, migraine, narcolepsy, obesity, diarrhea, inflammation, asthma, glaucoma, depression or especially pain
DE10161809A1 (en) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Pharmaceutical compositions, useful e.g. for the treatment of neurodegenerative diseases, psychiatric or neuropathological diseases or especially pain and epilepsy, comprise N,N'-disubstituted piperazine derivatives
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