AR033941A1 - Derivados de 3-amino-3-arilpropan-1-ol, procedimiento para su preparacion y su uso para la preparacion de medicamentos - Google Patents

Derivados de 3-amino-3-arilpropan-1-ol, procedimiento para su preparacion y su uso para la preparacion de medicamentos

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Publication number
AR033941A1
AR033941A1 ARP000101520A ARP000101520A AR033941A1 AR 033941 A1 AR033941 A1 AR 033941A1 AR P000101520 A ARP000101520 A AR P000101520A AR P000101520 A ARP000101520 A AR P000101520A AR 033941 A1 AR033941 A1 AR 033941A1
Authority
AR
Argentina
Prior art keywords
alkyl
phenyl
ring
treatment
benzyl
Prior art date
Application number
ARP000101520A
Other languages
English (en)
Inventor
Sundermann Bernd Dr
Hennies Hagen-Heinrich Dr
Babette-Ivonne Koegel
Helmut Heinrich Buschmann
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR033941A1 publication Critical patent/AR033941A1/es

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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C215/70—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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Abstract

Derivados de 3-amino-3-arilpropan-1-ol, de la fórmula general (1), en la cual: R1 y R2 representan, independientemente entre sí, alquilo C1-6, ó R1 y R2 forman conjuntamente un anillo (CH2)2-6, que también puede estar sustituido con fenilo; R3 representa alquilo C1-6, cicloalquilo C3-6, arilo con en caso dado heteroátomos en el sistema anular y los sustituyentes R6 a R8 en el anillo de arilo, o un alquil C1-3-fenilo sustituido de fórmula (2), donde n es 1, 2 ó 3; R4 y R5 representan, independientemente entre sí, alquilo C1-6, cicloalquilo C3-6, fenilo, bencilo, fenetilo, o R4 y R5 conjuntamente forman un anillo (CH2)3-6 o un anillo CH2CH2OCH2CH2; R6 a R8 representan, independientemente entre sí, H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, fenilo, SO2CH3, SO2CF3, alquilo C1-6, CN, COOR14, CONR15R16, ó R6 y R7 forman conjuntamente un anillo OCH2O, OCH2CH2O, CH=CHO, CH=C(CH3)O ó (CH2)4, en dondeR14 representa alquilo C1-6, fenilo, bencilo, fenetilo y R15 y R16 representan, independientemente entre sí, H, alquilo C1-6, fenilo, bencilo, fenetilo; y A representa un resto arilo, que en caso dado presenta heteroátomos en el sistema anular y/o puede estar sustituido; y sus diastereómeros o enantiómeros en la forma de sus bases o sales fisiológicamente tolerables, exceptuándose 1-bencil-2-(dimetilaminofenilmetil)ciclohexanol, sus diastereómeros y sus enantiómeros en la forma de sus bases y su producto de reacción con ioduro de metilo, procedimiento para su fabricación y su uso para la preparación de medicamentos para el tratamiento del dolor, de dolores neuropáticos, de dolores crónicos, con un efecto de anestésico local antiarrítmico, antiemético, nootrópico (neurotrópico), para el tratamiento de enfermedades cardiovasculares, incontinencia, diarrea, prurito, para el tratamiento de la dependencia del alcohol, para el tratamiento de la dependencia de medicamentos, para el tratamiento de inflamaciones, depresiones, para el aumento de la líbido, y del estado de vigilia.
ARP000101520A 1999-04-07 2000-04-03 Derivados de 3-amino-3-arilpropan-1-ol, procedimiento para su preparacion y su uso para la preparacion de medicamentos AR033941A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19915601A DE19915601A1 (de) 1999-04-07 1999-04-07 3-Amino-3-arylpropan-1-ol-Derivate, deren Herstellung und Verwendung

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AR033941A1 true AR033941A1 (es) 2004-01-21

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ARP000101520A AR033941A1 (es) 1999-04-07 2000-04-03 Derivados de 3-amino-3-arilpropan-1-ol, procedimiento para su preparacion y su uso para la preparacion de medicamentos

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US (1) US6410790B1 (es)
EP (1) EP1043307B1 (es)
JP (1) JP2000327642A (es)
KR (1) KR20000071575A (es)
CN (1) CN1183098C (es)
AR (1) AR033941A1 (es)
AT (1) ATE242197T1 (es)
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DE10049483A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
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DE10132747A1 (de) * 2001-07-05 2003-01-23 Gruenenthal Gmbh Substituierte 1-Aryl-but-3-enylamin- und 1-Aryl-but-2-enylaminverbindungen
DE10161809A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Arzneimittel enthaltend N,N'-disubstituierte Piperazin-Verbindungen
DE10161644A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh N,N'-disubstituierte Piperazin-Verbindungen
DE10161818A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
DE10164581A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte Aminoalkohole
DE10213051B4 (de) * 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
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JP2000327642A (ja) 2000-11-28
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CA2304127A1 (en) 2000-10-07
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PT1043307E (pt) 2003-10-31
BR0008682A (pt) 2002-02-26
EP1043307A3 (de) 2001-07-18
EP1043307A2 (de) 2000-10-11
IL135451A0 (en) 2001-05-20
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SI1043307T1 (en) 2003-12-31
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CZ299556B6 (cs) 2008-09-03
HK1031725A1 (en) 2001-06-22
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ATE242197T1 (de) 2003-06-15
PE20001648A1 (es) 2001-01-20
CN1270162A (zh) 2000-10-18
CN1183098C (zh) 2005-01-05
HUP0001396A2 (hu) 2002-04-29
EP1043307B1 (de) 2003-06-04
NO20001781L (no) 2000-10-09
DE19915601A1 (de) 2000-10-19
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PL200272B1 (pl) 2008-12-31
CZ20001250A3 (cs) 2000-11-15

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