AR009374A1 - Compuestos novedosos antagonistas de nmda (n-metil-d-aspartato), composicion farmaceutica y usos para fabricar medicamentos. - Google Patents
Compuestos novedosos antagonistas de nmda (n-metil-d-aspartato), composicion farmaceutica y usos para fabricar medicamentos.Info
- Publication number
- AR009374A1 AR009374A1 ARP970104462A ARP970104462A AR009374A1 AR 009374 A1 AR009374 A1 AR 009374A1 AR P970104462 A ARP970104462 A AR P970104462A AR P970104462 A ARP970104462 A AR P970104462A AR 009374 A1 AR009374 A1 AR 009374A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- hydrogen
- physiologically acceptable
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se describen compuestos de formula (1) donde: X se elige del grupo formado por hidroxi, un éster fisiologicamente aceptable y una amida fisiologicamenteaceptable; Y se elige del grupo formado por hidroxi, un éster fisiologicamente aceptable, y unaamida fisiologicamente aceptable; R es de 1 a 3 sustituyenteselegidos independientemente del grupo formado por hidrogeno, alquilo C1-C4, alcoxi C1-C4, halogeno, -CF3, y -OCF3; R1 se elige del grupo formado porhidrogeno y alquilo C1-C4; R2 es un radical elegido del grupo formado por la formula (2) donde: R3 se elige del grupo formado por hidrogeno y alquilo C1-C4;R4 es de 1 a 2 sustituyentes elegidos independientemente del grupo formado por hidrogeno, alquilo C1-C4, halogeno, y -CF3, R5 es alquilo C1-C4; R6 es alquiloC1-C4; R7 es de 1 a 2 sustituyentes elegidos independientemente del grupo formado por hidrogeno, alquilo C1-C4, alcoxi C1-C4, halogeno y -CF3; y lassales de adicion de ácido farmacéuticamente aceptables del mismo.También se describe una composicion farmacéutica que incluye dicho compuesto y los usos dedichos compuestos para la fabricacion de medicamentos para el tratamiento de enfermedades neurovegetativas, para prevenir el deterioro isquémico/hipoxico/hipoglicémico del tejido cerebral para el tratamiento de la ansiedad y los con efecto analgésico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72317596A | 1996-09-30 | 1996-09-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009374A1 true AR009374A1 (es) | 2000-04-12 |
Family
ID=24905175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104462A AR009374A1 (es) | 1996-09-30 | 1997-09-29 | Compuestos novedosos antagonistas de nmda (n-metil-d-aspartato), composicion farmaceutica y usos para fabricar medicamentos. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0929521B1 (es) |
| JP (1) | JP2001501221A (es) |
| KR (1) | KR20000048715A (es) |
| CN (1) | CN1139572C (es) |
| AR (1) | AR009374A1 (es) |
| AT (1) | ATE309215T1 (es) |
| AU (1) | AU732997B2 (es) |
| BR (1) | BR9712144A (es) |
| CA (1) | CA2266556C (es) |
| DE (1) | DE69734594T2 (es) |
| DK (1) | DK0929521T3 (es) |
| HU (1) | HUP0000882A3 (es) |
| IL (1) | IL129187A0 (es) |
| NO (1) | NO314080B1 (es) |
| NZ (1) | NZ334343A (es) |
| TW (1) | TW492958B (es) |
| WO (1) | WO1998014427A1 (es) |
| ZA (1) | ZA978602B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010053849A1 (en) * | 1999-06-16 | 2001-12-20 | Mary Jeanne Kreek | Plural biological sample arrays, and preparation and uses thereof |
| WO2001082914A2 (en) | 2000-04-28 | 2001-11-08 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| HU227197B1 (en) | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| US7820688B2 (en) | 2001-04-27 | 2010-10-26 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| WO2003039540A2 (en) * | 2001-11-09 | 2003-05-15 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
| DE10306202A1 (de) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| US8450525B2 (en) * | 2007-10-22 | 2013-05-28 | Orchid Chemicals & Pharmaceuticals Limited | Histone deacetylase inhibitors |
| CN102762554A (zh) | 2010-02-16 | 2012-10-31 | 辉瑞大药厂 | 5-ht4受体的部分激动剂(r)-4-((4-((4-(四氢呋喃-3-基氧基)苯并[d]异*唑-3-基氧基)甲基)哌啶-1-基)甲基)四氢-2h-吡喃-4-醇 |
| WO2021007366A1 (en) | 2019-07-08 | 2021-01-14 | St. Louis College Of Pharmacy | G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0178469B1 (ko) * | 1990-07-16 | 1999-03-20 | 메이나드 알. 존슨 | 흥분성 아미노산 길항제 |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| ATE151750T1 (de) * | 1993-05-27 | 1997-05-15 | Merrell Pharma Inc | 3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind |
| US5519048A (en) * | 1993-05-27 | 1996-05-21 | Merrell Pharmaceuticals Inc. | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof |
| GB9319243D0 (en) * | 1993-09-17 | 1993-11-03 | Glaxo Spa | Heterocyclic compounds |
-
1997
- 1997-08-18 WO PCT/US1997/014486 patent/WO1998014427A1/en active IP Right Grant
- 1997-08-18 EP EP97938377A patent/EP0929521B1/en not_active Expired - Lifetime
- 1997-08-18 KR KR1019990702680A patent/KR20000048715A/ko not_active Application Discontinuation
- 1997-08-18 CA CA002266556A patent/CA2266556C/en not_active Expired - Fee Related
- 1997-08-18 HU HU0000882A patent/HUP0000882A3/hu unknown
- 1997-08-18 IL IL12918797A patent/IL129187A0/xx not_active IP Right Cessation
- 1997-08-18 CN CNB97198400XA patent/CN1139572C/zh not_active Expired - Fee Related
- 1997-08-18 NZ NZ334343A patent/NZ334343A/xx unknown
- 1997-08-18 JP JP10516523A patent/JP2001501221A/ja not_active Ceased
- 1997-08-18 AU AU40718/97A patent/AU732997B2/en not_active Ceased
- 1997-08-18 AT AT97938377T patent/ATE309215T1/de not_active IP Right Cessation
- 1997-08-18 DE DE69734594T patent/DE69734594T2/de not_active Expired - Fee Related
- 1997-08-18 BR BR9712144-4A patent/BR9712144A/pt not_active IP Right Cessation
- 1997-08-18 DK DK97938377T patent/DK0929521T3/da active
- 1997-09-24 TW TW086113932A patent/TW492958B/zh not_active IP Right Cessation
- 1997-09-25 ZA ZA9708602A patent/ZA978602B/xx unknown
- 1997-09-29 AR ARP970104462A patent/AR009374A1/es unknown
-
1999
- 1999-03-29 NO NO19991533A patent/NO314080B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1139572C (zh) | 2004-02-25 |
| DE69734594T2 (de) | 2006-07-06 |
| HUP0000882A3 (en) | 2001-04-28 |
| ZA978602B (en) | 1998-03-30 |
| IL129187A0 (en) | 2000-02-17 |
| DE69734594D1 (en) | 2005-12-15 |
| NO991533L (no) | 1999-05-28 |
| TW492958B (en) | 2002-07-01 |
| AU4071897A (en) | 1998-04-24 |
| NZ334343A (en) | 2001-01-26 |
| KR20000048715A (ko) | 2000-07-25 |
| CA2266556C (en) | 2007-11-06 |
| CA2266556A1 (en) | 1998-04-09 |
| CN1232452A (zh) | 1999-10-20 |
| NO314080B1 (no) | 2003-01-27 |
| BR9712144A (pt) | 1999-08-31 |
| EP0929521A1 (en) | 1999-07-21 |
| EP0929521B1 (en) | 2005-11-09 |
| NO991533D0 (no) | 1999-03-29 |
| DK0929521T3 (da) | 2006-03-27 |
| WO1998014427A1 (en) | 1998-04-09 |
| HUP0000882A2 (hu) | 2000-09-28 |
| ATE309215T1 (de) | 2005-11-15 |
| JP2001501221A (ja) | 2001-01-30 |
| AU732997B2 (en) | 2001-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |