HUP0000882A3 - Indole derivatives as nmda (n-methyl-d-aspartate) antagonists and pharmaceutical compositions containing them - Google Patents
Indole derivatives as nmda (n-methyl-d-aspartate) antagonists and pharmaceutical compositions containing themInfo
- Publication number
- HUP0000882A3 HUP0000882A3 HU0000882A HUP0000882A HUP0000882A3 HU P0000882 A3 HUP0000882 A3 HU P0000882A3 HU 0000882 A HU0000882 A HU 0000882A HU P0000882 A HUP0000882 A HU P0000882A HU P0000882 A3 HUP0000882 A3 HU P0000882A3
- Authority
- HU
- Hungary
- Prior art keywords
- nmda
- aspartate
- antagonists
- methyl
- pharmaceutical compositions
- Prior art date
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 2
- 239000005557 antagonist Substances 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72317596A | 1996-09-30 | 1996-09-30 | |
| PCT/US1997/014486 WO1998014427A1 (en) | 1996-09-30 | 1997-08-18 | Nmda (n-methyl-d-aspartate) antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0000882A2 HUP0000882A2 (hu) | 2000-09-28 |
| HUP0000882A3 true HUP0000882A3 (en) | 2001-04-28 |
Family
ID=24905175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0000882A HUP0000882A3 (en) | 1996-09-30 | 1997-08-18 | Indole derivatives as nmda (n-methyl-d-aspartate) antagonists and pharmaceutical compositions containing them |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0929521B1 (hu) |
| JP (1) | JP2001501221A (hu) |
| KR (1) | KR20000048715A (hu) |
| CN (1) | CN1139572C (hu) |
| AR (1) | AR009374A1 (hu) |
| AT (1) | ATE309215T1 (hu) |
| AU (1) | AU732997B2 (hu) |
| BR (1) | BR9712144A (hu) |
| CA (1) | CA2266556C (hu) |
| DE (1) | DE69734594T2 (hu) |
| DK (1) | DK0929521T3 (hu) |
| HU (1) | HUP0000882A3 (hu) |
| IL (1) | IL129187A0 (hu) |
| NO (1) | NO314080B1 (hu) |
| NZ (1) | NZ334343A (hu) |
| TW (1) | TW492958B (hu) |
| WO (1) | WO1998014427A1 (hu) |
| ZA (1) | ZA978602B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010053849A1 (en) * | 1999-06-16 | 2001-12-20 | Mary Jeanne Kreek | Plural biological sample arrays, and preparation and uses thereof |
| IL152473A0 (en) | 2000-04-28 | 2003-05-29 | Sloan Kettering Inst Cancer | Topical anesthetic/opioid formulations and uses thereof |
| HU227197B1 (en) | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
| US7820688B2 (en) | 2001-04-27 | 2010-10-26 | Memorial Sloan-Kettering Cancer Center | Topical anesthetic/opioid formulations and uses thereof |
| US20030162825A1 (en) * | 2001-11-09 | 2003-08-28 | Sepracor Inc. | D-amino acid oxidase inhibitors for learning and memory |
| DE10306202A1 (de) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen |
| US7884124B2 (en) | 2006-06-30 | 2011-02-08 | Sepracor Inc. | Fluoro-substituted inhibitors of D-amino acid oxidase |
| RU2453536C2 (ru) * | 2007-10-22 | 2012-06-20 | Оркид Рисерч Лабораториз Лимитед | Ингибиторы гистондезацетилазы |
| KR20120123089A (ko) | 2010-02-16 | 2012-11-07 | 화이자 인코포레이티드 | 5-ＨＴ₄ 수용체의 부분 효능제인 (Ｒ)-4-((4-((4-(테트라히드로푸란-3-일옥시)벤조［ｄ］이속사졸-3-일옥시)메틸)피페리딘-1-일)메틸)테트라히드로-2Ｈ-피란-4-올 |
| CA3146163A1 (en) | 2019-07-08 | 2021-01-14 | University Of Health Sciences & Pharmacy In St. Louis | G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992001670A1 (en) * | 1990-07-16 | 1992-02-06 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| GB9208492D0 (en) * | 1992-04-16 | 1992-06-03 | Glaxo Spa | Heterocyclic compounds |
| US5519048A (en) * | 1993-05-27 | 1996-05-21 | Merrell Pharmaceuticals Inc. | 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof |
| DK0701551T3 (da) * | 1993-05-27 | 1997-10-20 | Merrell Pharma Inc | 3-(Indol-3-yl)propensyrederivater som NMDA-antagonister |
| GB9319243D0 (en) * | 1993-09-17 | 1993-11-03 | Glaxo Spa | Heterocyclic compounds |
-
1997
- 1997-08-18 CN CNB97198400XA patent/CN1139572C/zh not_active Expired - Fee Related
- 1997-08-18 DK DK97938377T patent/DK0929521T3/da active
- 1997-08-18 EP EP97938377A patent/EP0929521B1/en not_active Expired - Lifetime
- 1997-08-18 AT AT97938377T patent/ATE309215T1/de not_active IP Right Cessation
- 1997-08-18 BR BR9712144-4A patent/BR9712144A/pt not_active IP Right Cessation
- 1997-08-18 WO PCT/US1997/014486 patent/WO1998014427A1/en active IP Right Grant
- 1997-08-18 HU HU0000882A patent/HUP0000882A3/hu unknown
- 1997-08-18 AU AU40718/97A patent/AU732997B2/en not_active Ceased
- 1997-08-18 IL IL12918797A patent/IL129187A0/xx not_active IP Right Cessation
- 1997-08-18 JP JP10516523A patent/JP2001501221A/ja not_active Ceased
- 1997-08-18 NZ NZ334343A patent/NZ334343A/xx unknown
- 1997-08-18 KR KR1019990702680A patent/KR20000048715A/ko not_active Application Discontinuation
- 1997-08-18 DE DE69734594T patent/DE69734594T2/de not_active Expired - Fee Related
- 1997-08-18 CA CA002266556A patent/CA2266556C/en not_active Expired - Fee Related
- 1997-09-24 TW TW086113932A patent/TW492958B/zh not_active IP Right Cessation
- 1997-09-25 ZA ZA9708602A patent/ZA978602B/xx unknown
- 1997-09-29 AR ARP970104462A patent/AR009374A1/es unknown
-
1999
- 1999-03-29 NO NO19991533A patent/NO314080B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0000882A2 (hu) | 2000-09-28 |
| ATE309215T1 (de) | 2005-11-15 |
| CA2266556C (en) | 2007-11-06 |
| EP0929521B1 (en) | 2005-11-09 |
| ZA978602B (en) | 1998-03-30 |
| AU4071897A (en) | 1998-04-24 |
| NO991533D0 (no) | 1999-03-29 |
| AU732997B2 (en) | 2001-05-03 |
| DE69734594D1 (en) | 2005-12-15 |
| BR9712144A (pt) | 1999-08-31 |
| IL129187A0 (en) | 2000-02-17 |
| EP0929521A1 (en) | 1999-07-21 |
| DK0929521T3 (da) | 2006-03-27 |
| CN1232452A (zh) | 1999-10-20 |
| TW492958B (en) | 2002-07-01 |
| NZ334343A (en) | 2001-01-26 |
| WO1998014427A1 (en) | 1998-04-09 |
| AR009374A1 (es) | 2000-04-12 |
| CA2266556A1 (en) | 1998-04-09 |
| KR20000048715A (ko) | 2000-07-25 |
| CN1139572C (zh) | 2004-02-25 |
| NO314080B1 (no) | 2003-01-27 |
| JP2001501221A (ja) | 2001-01-30 |
| DE69734594T2 (de) | 2006-07-06 |
| NO991533L (no) | 1999-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |