NZ221224A - Cyrstalline (4r,5s,6s,8r,2's,4's)--4-mehept-2-en-7-one-2-carboxylic acid and pharmaceutical comp - Google Patents

Cyrstalline (4r,5s,6s,8r,2's,4's)--4-mehept-2-en-7-one-2-carboxylic acid and pharmaceutical comp

Info

Publication number
NZ221224A
NZ221224A NZ221224A NZ22122487A NZ221224A NZ 221224 A NZ221224 A NZ 221224A NZ 221224 A NZ221224 A NZ 221224A NZ 22122487 A NZ22122487 A NZ 22122487A NZ 221224 A NZ221224 A NZ 221224A
Authority
NZ
New Zealand
Prior art keywords
mehept
cyrstalline
carboxylic acid
pharmaceutical comp
comp
Prior art date
Application number
NZ221224A
Other languages
English (en)
Inventor
Sunagawa Makoto
Isobe Yutaka
Takeuchi Yutaka
Matsumura Haruki
Noguchi Tetsuo
Ozaki Yukio
Original Assignee
Sumitomo Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharma filed Critical Sumitomo Pharma
Publication of NZ221224A publication Critical patent/NZ221224A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ221224A 1986-07-30 1987-07-28 Cyrstalline (4r,5s,6s,8r,2's,4's)--4-mehept-2-en-7-one-2-carboxylic acid and pharmaceutical comp NZ221224A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP17932186 1986-07-30
JP15776987 1987-06-26

Publications (1)

Publication Number Publication Date
NZ221224A true NZ221224A (en) 1989-10-27

Family

ID=26485103

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ221224A NZ221224A (en) 1986-07-30 1987-07-28 Cyrstalline (4r,5s,6s,8r,2's,4's)--4-mehept-2-en-7-one-2-carboxylic acid and pharmaceutical comp

Country Status (20)

Country Link
US (1) US4888344A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0256377B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2665767B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR243189A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU596857B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1322371C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3781980T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK172666B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2052524T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI88037C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006254T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK169595A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU199473B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE60588B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL83372A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU88635I2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX173359B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO165543C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ221224A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH24710A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
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JP2696807B2 (ja) * 1992-08-06 1998-01-14 田辺製薬株式会社 カルバペネム誘導体の製法
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DE60009695T2 (de) 1999-06-03 2004-09-23 Eisai Co., Ltd. Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion
TWI250160B (en) 1999-07-06 2006-03-01 Sankyo Co Crystalline 1-methylcarbapenem compound
US7041660B2 (en) 1999-07-06 2006-05-09 Sankyo Company, Limited Crystalline 1-methylcarbapenem derivatives
PT1280531E (pt) * 2000-05-12 2007-02-28 Novalar Pharmaceuticals Inc Formulação consistindo de mesilato de fentolamina e sua utilização
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JP5079190B2 (ja) * 2001-04-27 2012-11-21 大日本住友製薬株式会社 アゼチジノン誘導体およびその製造方法
BR0209970A (pt) * 2001-05-21 2004-04-06 Kyoto Pharma Ind Composto de carbapenem
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
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NZ566460A (en) 2005-09-15 2010-04-30 Orchid Chemicals & Pharm Ltd An improved process for the preparation of beta-lactam antibiotic
CN100497338C (zh) * 2006-01-05 2009-06-10 上海医药工业研究院 4－甲基－7－氧－1－氮杂双环[3.2.0]庚－2－烯－2－羧酸类衍生物的制备方法
KR100781821B1 (ko) * 2006-02-16 2007-12-03 문순구 카르바페넴계 화합물의 제조방법
KR20090007375A (ko) * 2006-03-28 2009-01-16 카네카 코포레이션 카르바페넴 화합물의 개량된 제조 방법
JP5671204B2 (ja) * 2006-04-28 2015-02-18 株式会社カネカ カルバペネム抗生物質中間体の改良された晶析方法
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US20090216010A1 (en) * 2008-02-22 2009-08-27 Wei-Hong Tseng Crystalline carbapenem compound and produced method thereof
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US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
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US9233963B2 (en) 2009-03-13 2016-01-12 Daewoong Pharmaceutical Co., Ltd. Method for preparing meropenem using zinc powder
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CN101962383A (zh) * 2010-11-12 2011-02-02 上海巴迪生物医药科技有限公司 一种美罗培南的合成方法
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CN102532140B (zh) * 2010-12-21 2015-03-11 北大方正集团有限公司 一种美罗培南三水合物的制备方法
CN102250096B (zh) * 2011-09-05 2016-04-06 江西华邦药业有限公司 一种美罗培南的制备方法
CN103570720B (zh) * 2012-07-31 2016-02-10 新乡海滨药业有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570718B (zh) * 2012-07-31 2016-06-29 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
CN103570719B (zh) * 2012-07-31 2016-03-02 深圳市海滨制药有限公司 一种美罗培南原料药、其制备方法及包含其的药物组合物
KR101331762B1 (ko) 2012-12-28 2013-11-20 주식회사 대웅제약 메로페넴의 삼수화물의 제조방법
CN103044429B (zh) * 2013-01-28 2015-04-01 苏州二叶制药有限公司 一种美罗培南的制备方法
WO2014121027A1 (en) 2013-02-01 2014-08-07 Oculars Pharma, Llc Aqueous ophthalmic solutions of phentolamine and medical uses thereof
DK2950800T3 (da) 2013-02-01 2020-11-16 Ocuphire Pharma Inc Fremgangsmåder og sammensætninger til daglig ophthalmisk administration af phentolamin til forbedring af synsevnen
KR102144777B1 (ko) 2013-06-19 2020-08-18 제이더블유중외제약 주식회사 결정형 메로페넴 삼수화물의 제조방법
CN106459052B (zh) 2014-03-27 2021-07-30 庄信万丰股份有限公司 制备碳青霉烯抗生素的方法
AU2019360953A1 (en) 2018-10-15 2021-05-13 Ocuphire Pharma, Inc. Methods and compositions for treatment of glaucoma and related conditions
KR20210096096A (ko) 2018-10-26 2021-08-04 오큐파이어 파마, 인크. 노안, 산동, 및 기타 안구 장애의 치료를 위한 방법 및 조성물
CN115368310B (zh) 2021-05-18 2025-06-27 奥库菲尔医药公司 合成甲磺酸酚妥拉明的方法

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Also Published As

Publication number Publication date
CA1322371C (en) 1993-09-21
HK169595A (en) 1995-11-10
JP2665767B2 (ja) 1997-10-22
FI88037C (fi) 1993-03-25
GR3006254T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-21
MX173359B (es) 1994-02-23
FI873299A0 (fi) 1987-07-29
EP0256377A1 (en) 1988-02-24
DK399087A (da) 1988-01-31
HU199473B (en) 1990-02-28
FI873299L (fi) 1988-01-31
NO873205D0 (no) 1987-07-30
EP0256377B1 (en) 1992-09-30
JPS6434986A (en) 1989-02-06
HUT44553A (en) 1988-03-28
MX7534A (es) 1993-10-01
DE3781980T2 (de) 1993-02-18
AU7619687A (en) 1988-03-03
DK172666B1 (da) 1999-05-10
LU88635I2 (fr) 1995-12-01
US4888344A (en) 1989-12-19
FI88037B (fi) 1992-12-15
DE3781980D1 (de) 1992-11-05
IL83372A0 (en) 1987-12-31
IL83372A (en) 1992-05-25
AU596857B2 (en) 1990-05-17
NO165543B (no) 1990-11-19
NO165543C (no) 1991-02-27
IE60588B1 (en) 1994-07-27
IE871959L (en) 1988-01-30
DK399087D0 (da) 1987-07-30
PH24710A (en) 1990-10-01
ES2052524T3 (es) 1994-07-16
NO873205L (no) 1988-02-01
AR243189A1 (es) 1993-07-30
NO1997013I1 (no) 1997-10-17

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