NO329332B1 - Faste farmasoytiske preparater som innbefatter en S1P-reseptoragonist og en sukkeralkohol - Google Patents

Faste farmasoytiske preparater som innbefatter en S1P-reseptoragonist og en sukkeralkohol Download PDF

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Publication number
NO329332B1
NO329332B1 NO20055231A NO20055231A NO329332B1 NO 329332 B1 NO329332 B1 NO 329332B1 NO 20055231 A NO20055231 A NO 20055231A NO 20055231 A NO20055231 A NO 20055231A NO 329332 B1 NO329332 B1 NO 329332B1
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NO
Norway
Prior art keywords
preparation according
receptor agonist
sugar alcohol
sip receptor
weight
Prior art date
Application number
NO20055231A
Other languages
English (en)
Norwegian (no)
Other versions
NO20055231L (no
NO20055231D0 (no
Inventor
Alan Edward Royce
Tomoyuki Oomura
Madhusudhan Pudipeddi
Colleen Ruegger
Masaki Sasaki
Tokuhiro Tamura
Original Assignee
Mitsubishi Pharma Corp
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32326722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO329332(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mitsubishi Pharma Corp, Novartis Ag filed Critical Mitsubishi Pharma Corp
Publication of NO20055231D0 publication Critical patent/NO20055231D0/no
Publication of NO20055231L publication Critical patent/NO20055231L/no
Publication of NO329332B1 publication Critical patent/NO329332B1/no

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Surgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
NO20055231A 2003-04-08 2005-11-07 Faste farmasoytiske preparater som innbefatter en S1P-reseptoragonist og en sukkeralkohol NO329332B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46121503P 2003-04-08 2003-04-08
PCT/EP2004/003656 WO2004089341A1 (fr) 2003-04-08 2004-04-06 Compositions pharmaceutiques solides contenant un agoniste des recepteurs de la s1p et un alcool de sucre

Publications (3)

Publication Number Publication Date
NO20055231D0 NO20055231D0 (no) 2005-11-07
NO20055231L NO20055231L (no) 2006-01-09
NO329332B1 true NO329332B1 (no) 2010-09-27

Family

ID=32326722

Family Applications (4)

Application Number Title Priority Date Filing Date
NO20055231A NO329332B1 (no) 2003-04-08 2005-11-07 Faste farmasoytiske preparater som innbefatter en S1P-reseptoragonist og en sukkeralkohol
NO20100250A NO334116B1 (no) 2003-04-08 2010-02-18 Farmasøytisk preparat som innbefatter en S1P reseptoragonist og en sukkeralkohol, og framgangsmåte til fremstilling derav
NO2011016C NO2011016I2 (no) 2003-04-08 2011-09-08 Inn navn: Fingolimod=2-amino-2-[2-(4-oktylfenyl)etyl]propan-1,3-diol, hydroklorid
NO20131287A NO335120B1 (no) 2003-04-08 2013-09-26 Fremgangsmåte for fremstilling av en farmasøytisk preparat som innbefatter en S1P reseptoragonist og en sukkeralkohol.

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO20100250A NO334116B1 (no) 2003-04-08 2010-02-18 Farmasøytisk preparat som innbefatter en S1P reseptoragonist og en sukkeralkohol, og framgangsmåte til fremstilling derav
NO2011016C NO2011016I2 (no) 2003-04-08 2011-09-08 Inn navn: Fingolimod=2-amino-2-[2-(4-oktylfenyl)etyl]propan-1,3-diol, hydroklorid
NO20131287A NO335120B1 (no) 2003-04-08 2013-09-26 Fremgangsmåte for fremstilling av en farmasøytisk preparat som innbefatter en S1P reseptoragonist og en sukkeralkohol.

Country Status (42)

Country Link
US (11) US20060275357A1 (fr)
EP (5) EP2316431B1 (fr)
JP (3) JP5495467B2 (fr)
KR (3) KR20110005320A (fr)
CN (2) CN1767819B (fr)
AR (3) AR043987A1 (fr)
AT (3) AT501681B1 (fr)
AU (1) AU2004228929B2 (fr)
BE (2) BE1015972A5 (fr)
BR (1) BRPI0409250B8 (fr)
CA (2) CA2707750A1 (fr)
CL (2) CL2004000745A1 (fr)
CY (3) CY1110260T1 (fr)
DE (4) DE202004021680U1 (fr)
DK (2) DK1613288T3 (fr)
EC (1) ECSP056090A (fr)
ES (3) ES2228282B1 (fr)
FR (2) FR2854073B1 (fr)
GB (1) GB2400318B (fr)
GR (1) GR1005052B (fr)
HK (3) HK1071685A1 (fr)
HR (3) HRP20050886B1 (fr)
HU (2) HUE028247T2 (fr)
IL (3) IL170888A (fr)
IS (2) IS2682B (fr)
IT (1) ITMI20040682A1 (fr)
LU (1) LU91867I2 (fr)
MA (1) MA27729A1 (fr)
MX (1) MXPA05010860A (fr)
MY (1) MY141249A (fr)
NO (4) NO329332B1 (fr)
NZ (3) NZ542622A (fr)
PE (5) PE20090743A1 (fr)
PL (2) PL2316431T3 (fr)
PT (1) PT1613288E (fr)
RU (5) RU2358716C2 (fr)
SG (1) SG175449A1 (fr)
SI (2) SI1613288T1 (fr)
TN (1) TNSN05256A1 (fr)
TW (1) TWI332847B (fr)
WO (1) WO2004089341A1 (fr)
ZA (1) ZA200507394B (fr)

Families Citing this family (69)

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CN1891212B (zh) * 2005-07-07 2010-10-13 马启明 一种口服制剂及其制备方法
NZ588372A (en) * 2005-09-09 2012-03-30 Novartis Ag Diphenyl ether or thioether derivatives for treatment of autoimmune diseases
JP5436860B2 (ja) 2005-11-09 2014-03-05 オニキス セラピューティクス, インク. 酵素阻害のための化合物
TWI389683B (zh) * 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
KR101441703B1 (ko) 2006-06-19 2014-09-17 오닉스 세라퓨틱스, 인크. 프로테아좀 저해를 위한 펩티드 에폭시케톤
GB0612721D0 (en) 2006-06-27 2006-08-09 Novartis Ag Organic compounds
EP1923054A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique à désintégration rapide comprenant un agoniste ou modulateur de S1P
CA2953372C (fr) * 2006-09-26 2020-06-23 Novartis Ag Compositon pharmaceutique renfermant un modulateur du recepteur s1p
EP1923055A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique lyophilisée comprenant un agoniste ou modulateur de S1P
EP1923058A1 (fr) * 2006-09-26 2008-05-21 Novartis AG Composition pharmaceutique enrobée comprenant un agoniste ou un modulateur de S1P
EP1905434A1 (fr) * 2006-09-26 2008-04-02 Novartis AG Compositions organiques comprenant d'un agoniste de S1P recepteur et leur utilisation therapeutique
AU2011235934A1 (en) * 2006-09-26 2011-11-03 Novartis Ag Pharmaceutical compositions comprising an S1P modulator
WO2008124210A1 (fr) * 2007-02-14 2008-10-16 Emory University Procédés et compositions destinés à traiter ou prévenir une infection en utilisant des agents de séquestration des leucocytes
HUE035990T2 (en) 2007-03-29 2018-05-28 Daiichi Sankyo Co Ltd Pharmaceutical preparation
US8367617B2 (en) 2007-10-04 2013-02-05 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
EP2465492B1 (fr) * 2007-10-12 2015-07-01 Novartis AG Compositions comprenant des modulateurs de récepteur de sphingosine I (sip) phosphate
AU2012216630B2 (en) * 2007-10-12 2015-01-22 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
JP5534645B2 (ja) * 2008-01-11 2014-07-02 日医工株式会社 無包装状態において安定性に優れた塩酸サルポグレラート含有経口投与製剤
JP5452237B2 (ja) 2008-02-07 2014-03-26 杏林製薬株式会社 アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤
DK2278960T4 (da) 2008-03-17 2020-01-27 Actelion Pharmaceuticals Ltd Dosisregimen til en selektiv sip1 receptoragonist
ES2676288T3 (es) * 2008-06-20 2018-07-18 Merck Patent Gmbh Matriz de comprimidos directamente compresible y rápidamente desintegrable
CN102076335A (zh) 2008-06-20 2011-05-25 诺瓦提斯公司 用于治疗多发性硬化的儿科组合物
BRPI0919183B8 (pt) * 2008-09-04 2021-05-25 Cargill Inc composição comprimível de eritritol, processo e uso do mesmo
AP2011005690A0 (en) 2008-10-21 2011-06-30 Onyx Therapeutics Inc Combination therapy with peptide epoxyketones.
CA2741974A1 (fr) 2008-11-11 2010-05-20 Novartis Ag Sels de fingolimod
AU2013100531B4 (en) * 2008-11-11 2013-11-28 Novartis Ag Crystalline forms of fingolimod HCL
KR101393994B1 (ko) 2008-11-11 2014-05-14 노파르티스 아게 핑골리모드 hcl의 결정질 형태
JP5305421B2 (ja) 2008-12-17 2013-10-02 第一三共株式会社 ジアミン誘導体の製造方法
WO2010082531A1 (fr) 2009-01-13 2010-07-22 第一三共株式会社 Inhibiteur d'un facteur actif de la coagulation sanguine
CN102348688B (zh) 2009-03-10 2014-07-09 第一三共株式会社 用于制备二胺衍生物的方法
WO2010104106A1 (fr) 2009-03-13 2010-09-16 第一三共株式会社 Procédé de production d'un dérivé diamine optiquement actif
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
JPWO2010147169A1 (ja) * 2009-06-18 2012-12-06 第一三共株式会社 溶出性の改善された医薬組成物
US9675566B2 (en) 2009-07-16 2017-06-13 Pathologica Llc Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
ES2560955T3 (es) 2010-03-19 2016-02-23 Daiichi Sankyo Company, Limited Cristal de derivado de diamina y procedimiento de producción del mismo
BR112012023654B1 (pt) 2010-03-19 2022-04-12 Daiichi Sankyo Company, Limited Método para produzir grânulos contendo agente anticoagulante e método para produzir uma composição farmacêutica contendo o dito agente
EP2560619A2 (fr) * 2010-04-22 2013-02-27 Ratiopharm GmbH Procédé de préparation d'une forme galénique orale comprenant du fingolimod
BR112013000085B1 (pt) 2010-07-02 2022-04-19 Daiichi Sankyo Company, Limited Processos para a preparação de sal de derivado de diamina opticamente ativo
EP2646409A4 (fr) 2010-11-25 2015-12-16 Shilpa Medicare Ltd Polymorphes du fingolimode et leurs procédés
WO2012100043A2 (fr) 2011-01-19 2012-07-26 Pathlogica LLC Formes posologiques pharmaceutiques orales à libération contrôlée comprenant de la mgbg
AR085749A1 (es) 2011-04-01 2013-10-23 Novartis Ag Formulaciones
US9186333B2 (en) * 2011-08-01 2015-11-17 Teva Pharmaceutical Industries Ltd. Process for preparing pharmaceutical compositions of fingolimod
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