NO324864B1 - Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse - Google Patents

Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse Download PDF

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Publication number
NO324864B1
NO324864B1 NO20032523A NO20032523A NO324864B1 NO 324864 B1 NO324864 B1 NO 324864B1 NO 20032523 A NO20032523 A NO 20032523A NO 20032523 A NO20032523 A NO 20032523A NO 324864 B1 NO324864 B1 NO 324864B1
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NO
Norway
Prior art keywords
lithium
complex
tetraazacyclododecane
ethanol
dihydroxypropyl
Prior art date
Application number
NO20032523A
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English (en)
Norwegian (no)
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NO20032523D0 (no
NO20032523L (no
Inventor
Johannes Platzek
Peter Blaszkiewicz
Orlin Petrov
Holger Hoffmann
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of NO20032523D0 publication Critical patent/NO20032523D0/no
Publication of NO20032523L publication Critical patent/NO20032523L/no
Publication of NO324864B1 publication Critical patent/NO324864B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/02—Lithium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20032523A 2000-12-15 2003-06-04 Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse NO324864B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064467A DE10064467C2 (de) 2000-12-15 2000-12-15 Lithium-Komplexe von N-(1-Hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren Herstellung und Verwendung
PCT/EP2001/014283 WO2002048119A2 (de) 2000-12-15 2001-12-05 Lithium-komplexe von n-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecan, deren herstellung und verwendung

Publications (3)

Publication Number Publication Date
NO20032523D0 NO20032523D0 (no) 2003-06-04
NO20032523L NO20032523L (no) 2003-06-04
NO324864B1 true NO324864B1 (no) 2007-12-17

Family

ID=7668584

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032523A NO324864B1 (no) 2000-12-15 2003-06-04 Litiumkomplekser av N-(1-hydroksymetyl-2,3-dihydroksypropyl)-1,4,7-triskarboksymetyl-1,4,7,10-tetraazasyklododekan, samt deres fremstilling og anvendelse

Country Status (34)

Country Link
US (1) US6894151B2 (cs)
EP (1) EP1343770B1 (cs)
JP (1) JP4399163B2 (cs)
KR (1) KR100869627B1 (cs)
CN (1) CN1229357C (cs)
AR (1) AR035609A1 (cs)
AT (1) ATE430737T1 (cs)
AU (2) AU3165902A (cs)
BG (1) BG66117B1 (cs)
BR (1) BR0116219A (cs)
CA (1) CA2431976C (cs)
CY (1) CY1109280T1 (cs)
CZ (1) CZ304573B6 (cs)
DE (2) DE10064467C2 (cs)
DK (1) DK1343770T3 (cs)
EC (1) ECSP034676A (cs)
EE (1) EE05245B1 (cs)
ES (1) ES2325982T3 (cs)
HR (1) HRP20030576B1 (cs)
HU (1) HU229657B1 (cs)
IL (1) IL156432A0 (cs)
ME (1) ME00157B (cs)
MX (1) MXPA03005240A (cs)
NO (1) NO324864B1 (cs)
NZ (1) NZ526478A (cs)
PL (1) PL204181B1 (cs)
PT (1) PT1343770E (cs)
RS (1) RS51862B (cs)
RU (1) RU2003120513A (cs)
SK (1) SK287424B6 (cs)
TW (1) TWI302531B (cs)
UY (1) UY27056A1 (cs)
WO (1) WO2002048119A2 (cs)
ZA (1) ZA200305421B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004112840A2 (en) * 2003-06-25 2004-12-29 Guerbet Peptide conjugate for magnetic resonance imaging
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
ATE429933T1 (de) * 2004-07-02 2009-05-15 Bracco Imaging Spa 1,4-bis(carboxymethyl)-6-
KR20080108989A (ko) 2006-03-14 2008-12-16 말린크로트, 인코포레이티드 테트라아자거대고리 유도체의 금속 착체
US7777029B2 (en) * 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
DE102009053252B3 (de) * 2009-11-09 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer Membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DE102010023105A1 (de) 2010-06-04 2011-12-08 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung im Eintopfverfahren mittels DMF-acetal und N-Methylimidazol
LT2896405T (lt) 2011-04-21 2020-03-25 Bayer Intellectual Property Gmbh Didelio grynumo gadobutrolio gamyba
CN106543094A (zh) * 2016-11-04 2017-03-29 嘉实（湖南）医药科技有限公司 高纯度钆布醇的制备方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
KR102033964B1 (ko) * 2018-01-19 2019-10-18 주식회사 엔지켐생명과학 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210112910A (ko) * 2020-03-06 2021-09-15 주식회사 엔지켐생명과학 가도부트롤 주사제 제조를 위한 부형제인 칼코부트롤의 제조 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE19724186C2 (de) * 1997-06-02 2002-07-18 Schering Ag Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe

Also Published As

Publication number Publication date
NO20032523D0 (no) 2003-06-04
UY27056A1 (es) 2002-07-31
HRP20030576A2 (en) 2005-06-30
US20020128472A1 (en) 2002-09-12
TWI302531B (en) 2008-11-01
CA2431976A1 (en) 2002-06-20
CZ304573B6 (cs) 2014-07-16
DE10064467A1 (de) 2002-07-11
BG66117B1 (bg) 2011-05-31
SK7292003A3 (en) 2003-11-04
ATE430737T1 (de) 2009-05-15
ES2325982T3 (es) 2009-09-28
DE10064467C2 (de) 2002-10-31
HUP0302563A3 (en) 2011-04-28
AU2002231659B2 (en) 2007-07-05
JP4399163B2 (ja) 2010-01-13
PL204181B1 (pl) 2009-12-31
MXPA03005240A (es) 2003-09-25
HRP20030576B1 (en) 2011-09-30
PT1343770E (pt) 2009-07-20
NO20032523L (no) 2003-06-04
WO2002048119A2 (de) 2002-06-20
ECSP034676A (es) 2003-08-29
PL366141A1 (en) 2005-01-24
CY1109280T1 (el) 2014-07-02
DE50114889D1 (de) 2009-06-18
CN1481371A (zh) 2004-03-10
NZ526478A (en) 2006-04-28
RS51862B (sr) 2012-02-29
BG107901A (bg) 2004-06-30
AU3165902A (en) 2002-06-24
YU48103A (sh) 2006-05-25
BR0116219A (pt) 2006-02-21
HK1064098A1 (en) 2005-01-21
KR100869627B1 (ko) 2008-11-21
HUP0302563A2 (hu) 2003-12-29
DK1343770T3 (da) 2009-08-10
IL156432A0 (en) 2004-01-04
EP1343770A2 (de) 2003-09-17
EP1343770B1 (de) 2009-05-06
CZ20031641A3 (cs) 2003-09-17
EE200300282A (et) 2003-10-15
KR20030077555A (ko) 2003-10-01
EE05245B1 (et) 2009-12-15
JP2004515545A (ja) 2004-05-27
AR035609A1 (es) 2004-06-16
RU2003120513A (ru) 2004-12-27
US6894151B2 (en) 2005-05-17
CN1229357C (zh) 2005-11-30
SK287424B6 (sk) 2010-09-07
ME00157B (me) 2010-10-10
HU229657B1 (en) 2014-03-28
ZA200305421B (en) 2004-08-27
WO2002048119A3 (de) 2002-11-07
CA2431976C (en) 2010-04-13
MEP15708A (en) 2010-06-10

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Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE

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