NO323750B1 - Dipeptylpeptidase IV-inhibitorer og anvendelse derav, samt farmasoytisk preparat. - Google Patents
Dipeptylpeptidase IV-inhibitorer og anvendelse derav, samt farmasoytisk preparat. Download PDFInfo
- Publication number
- NO323750B1 NO323750B1 NO20025118A NO20025118A NO323750B1 NO 323750 B1 NO323750 B1 NO 323750B1 NO 20025118 A NO20025118 A NO 20025118A NO 20025118 A NO20025118 A NO 20025118A NO 323750 B1 NO323750 B1 NO 323750B1
- Authority
- NO
- Norway
- Prior art keywords
- thiazolidine
- carbonyl
- mmol
- pyrrolidine
- carbonitrile
- Prior art date
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- 239000003112 inhibitor Substances 0.000 title abstract description 21
- 102000035195 Peptidases Human genes 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 title 1
- 235000019833 protease Nutrition 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 46
- 150000003839 salts Chemical class 0.000 claims abstract description 9
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims abstract description 9
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 4
- OGYGFUAIIOPWQD-UHFFFAOYSA-N 1,3-thiazolidine Chemical compound C1CSCN1 OGYGFUAIIOPWQD-UHFFFAOYSA-N 0.000 claims description 46
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 46
- -1 hydroxy- Chemical class 0.000 claims description 44
- ALSCEGDXFJIYES-UHFFFAOYSA-N pyrrolidine-2-carbonitrile Chemical compound N#CC1CCCN1 ALSCEGDXFJIYES-UHFFFAOYSA-N 0.000 claims description 32
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0010188.1A GB0010188D0 (en) | 2000-04-26 | 2000-04-26 | Inhibitors of dipeptidyl peptidase IV |
PCT/GB2001/001875 WO2001081337A1 (en) | 2000-04-26 | 2001-04-26 | Inhibitors of dipeptidyl peptidase iv |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20025118L NO20025118L (no) | 2002-10-24 |
NO20025118D0 NO20025118D0 (no) | 2002-10-24 |
NO323750B1 true NO323750B1 (no) | 2007-07-02 |
Family
ID=9890560
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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NO20025118A NO323750B1 (no) | 2000-04-26 | 2002-10-24 | Dipeptylpeptidase IV-inhibitorer og anvendelse derav, samt farmasoytisk preparat. |
Country Status (30)
Country | Link |
---|---|
US (1) | US7125863B2 (pt) |
EP (1) | EP1280797B1 (pt) |
JP (1) | JP2003531204A (pt) |
KR (1) | KR20020093942A (pt) |
CN (1) | CN1249056C (pt) |
AT (1) | ATE279408T1 (pt) |
AU (1) | AU784007B2 (pt) |
BR (1) | BR0110021A (pt) |
CA (1) | CA2407662A1 (pt) |
CZ (1) | CZ20023512A3 (pt) |
DE (1) | DE60106422T2 (pt) |
DK (1) | DK1280797T3 (pt) |
EE (1) | EE200200603A (pt) |
ES (1) | ES2231474T3 (pt) |
GB (1) | GB0010188D0 (pt) |
HK (1) | HK1051043A1 (pt) |
HR (1) | HRP20020813B1 (pt) |
HU (1) | HUP0300563A3 (pt) |
IL (1) | IL151917A0 (pt) |
MX (1) | MXPA02010490A (pt) |
NO (1) | NO323750B1 (pt) |
NZ (1) | NZ522436A (pt) |
PL (1) | PL357724A1 (pt) |
PT (1) | PT1280797E (pt) |
RU (1) | RU2280035C2 (pt) |
SI (1) | SI1280797T1 (pt) |
SK (1) | SK15292002A3 (pt) |
UA (1) | UA73166C2 (pt) |
WO (1) | WO2001081337A1 (pt) |
ZA (1) | ZA200208523B (pt) |
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2000
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2001
- 2001-04-26 IL IL15191701A patent/IL151917A0/xx unknown
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- 2001-04-26 MX MXPA02010490A patent/MXPA02010490A/es active IP Right Grant
- 2001-04-26 KR KR1020027014230A patent/KR20020093942A/ko active IP Right Grant
- 2001-04-26 RU RU2002131639/04A patent/RU2280035C2/ru not_active IP Right Cessation
- 2001-04-26 DE DE60106422T patent/DE60106422T2/de not_active Expired - Fee Related
- 2001-04-26 HU HU0300563A patent/HUP0300563A3/hu unknown
- 2001-04-26 JP JP2001578427A patent/JP2003531204A/ja active Pending
- 2001-04-26 NZ NZ522436A patent/NZ522436A/en unknown
- 2001-04-26 US US10/258,804 patent/US7125863B2/en not_active Expired - Fee Related
- 2001-04-26 ES ES01923854T patent/ES2231474T3/es not_active Expired - Lifetime
- 2001-04-26 WO PCT/GB2001/001875 patent/WO2001081337A1/en active IP Right Grant
- 2001-04-26 SK SK1529-2002A patent/SK15292002A3/sk unknown
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- 2001-04-26 EE EEP200200603A patent/EE200200603A/xx unknown
- 2001-04-26 PT PT01923854T patent/PT1280797E/pt unknown
- 2001-04-26 DK DK01923854T patent/DK1280797T3/da active
- 2001-04-26 PL PL01357724A patent/PL357724A1/xx not_active Application Discontinuation
- 2001-04-26 CA CA002407662A patent/CA2407662A1/en not_active Abandoned
- 2001-04-26 BR BR0110021-1A patent/BR0110021A/pt not_active IP Right Cessation
- 2001-04-26 EP EP01923854A patent/EP1280797B1/en not_active Expired - Lifetime
- 2001-04-26 CN CNB018086748A patent/CN1249056C/zh not_active Expired - Fee Related
- 2001-04-26 CZ CZ20023512A patent/CZ20023512A3/cs unknown
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