NO316762B1 - Fremgangsmate for industriell fremstilling av et preparat som inneholder rekonstituerte lipoproteinpartikler med hoy tetthet (rHDL) fra apolipoprotein A-I og fosfatidylcholin - Google Patents
Fremgangsmate for industriell fremstilling av et preparat som inneholder rekonstituerte lipoproteinpartikler med hoy tetthet (rHDL) fra apolipoprotein A-I og fosfatidylcholin Download PDFInfo
- Publication number
- NO316762B1 NO316762B1 NO19945101A NO945101A NO316762B1 NO 316762 B1 NO316762 B1 NO 316762B1 NO 19945101 A NO19945101 A NO 19945101A NO 945101 A NO945101 A NO 945101A NO 316762 B1 NO316762 B1 NO 316762B1
- Authority
- NO
- Norway
- Prior art keywords
- apolipoprotein
- detergent
- phosphatidylcholine
- solution
- lipid
- Prior art date
Links
- 239000002245 particle Substances 0.000 title claims abstract description 24
- 108010059886 Apolipoprotein A-I Proteins 0.000 title claims description 63
- 102000005666 Apolipoprotein A-I Human genes 0.000 title claims description 63
- 238000000034 method Methods 0.000 title claims description 51
- 239000000203 mixture Substances 0.000 title claims description 35
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 title claims description 35
- 108010010234 HDL Lipoproteins Proteins 0.000 title claims description 19
- 102000015779 HDL Lipoproteins Human genes 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 12
- 230000008569 process Effects 0.000 title claims description 4
- 150000002632 lipids Chemical class 0.000 claims abstract description 51
- 102000004895 Lipoproteins Human genes 0.000 claims abstract description 47
- 108090001030 Lipoproteins Proteins 0.000 claims abstract description 47
- 102000007592 Apolipoproteins Human genes 0.000 claims abstract description 36
- 108010071619 Apolipoproteins Proteins 0.000 claims abstract description 36
- 239000003599 detergent Substances 0.000 claims abstract description 33
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 28
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000003463 adsorbent Substances 0.000 claims abstract description 6
- 230000007717 exclusion Effects 0.000 claims abstract description 4
- 239000003381 stabilizer Substances 0.000 claims abstract description 4
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 3
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 239000000243 solution Substances 0.000 claims description 43
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 28
- 239000000872 buffer Substances 0.000 claims description 16
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical group [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 claims description 15
- 229930006000 Sucrose Natural products 0.000 claims description 14
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 14
- 239000005720 sucrose Substances 0.000 claims description 14
- 235000012000 cholesterol Nutrition 0.000 claims description 13
- 238000011534 incubation Methods 0.000 claims description 12
- 238000011026 diafiltration Methods 0.000 claims description 9
- 239000003960 organic solvent Substances 0.000 claims description 9
- 150000003904 phospholipids Chemical class 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000003613 bile acid Substances 0.000 claims description 7
- 238000009776 industrial production Methods 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 235000010469 Glycine max Nutrition 0.000 claims description 5
- 241000700605 Viruses Species 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 230000009466 transformation Effects 0.000 claims description 4
- 150000003626 triacylglycerols Chemical class 0.000 claims description 4
- 244000068988 Glycine max Species 0.000 claims description 3
- 235000013601 eggs Nutrition 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 230000002209 hydrophobic effect Effects 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 235000014633 carbohydrates Nutrition 0.000 claims description 2
- 230000003196 chaotropic effect Effects 0.000 claims description 2
- 150000001840 cholesterol esters Chemical class 0.000 claims description 2
- 238000000502 dialysis Methods 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 claims description 2
- 238000000108 ultra-filtration Methods 0.000 claims description 2
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229940042880 natural phospholipid Drugs 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000008348 synthetic phosphatidyl choline Substances 0.000 claims 1
- 230000007704 transition Effects 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 32
- 239000011780 sodium chloride Substances 0.000 description 15
- 239000000047 product Substances 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 239000012467 final product Substances 0.000 description 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 8
- 229940099352 cholate Drugs 0.000 description 8
- 239000002158 endotoxin Substances 0.000 description 8
- 238000007792 addition Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 6
- 229920006008 lipopolysaccharide Polymers 0.000 description 6
- 230000027455 binding Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- 241000282412 Homo Species 0.000 description 4
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 4
- 238000010828 elution Methods 0.000 description 4
- 238000002523 gelfiltration Methods 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 238000001542 size-exclusion chromatography Methods 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- 108010007622 LDL Lipoproteins Proteins 0.000 description 3
- 102000007330 LDL Lipoproteins Human genes 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102000054727 Serum Amyloid A Human genes 0.000 description 2
- 108700028909 Serum Amyloid A Proteins 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
- 108010062497 VLDL Lipoproteins Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 230000005796 circulatory shock Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229960000789 guanidine hydrochloride Drugs 0.000 description 2
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical compound [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 210000001616 monocyte Anatomy 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- 239000003549 soybean oil Substances 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 102000003390 tumor necrosis factor Human genes 0.000 description 2
- 101150037123 APOE gene Proteins 0.000 description 1
- 102000011767 Acute-Phase Proteins Human genes 0.000 description 1
- 108010062271 Acute-Phase Proteins Proteins 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 108010004103 Chylomicrons Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 101100216294 Danio rerio apoeb gene Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 238000011993 High Performance Size Exclusion Chromatography Methods 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010080283 Pre-beta High-Density Lipoproteins Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012436 analytical size exclusion chromatography Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000003833 bile salt Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 229940009976 deoxycholate Drugs 0.000 description 1
- KXGVEGMKQFWNSR-LLQZFEROSA-N deoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 KXGVEGMKQFWNSR-LLQZFEROSA-N 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 102000034238 globular proteins Human genes 0.000 description 1
- 108091005896 globular proteins Proteins 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical class N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1275—Lipoproteins; Chylomicrons; Artificial HDL, LDL, VLDL, protein-free species thereof; Precursors thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Heating, Cooling, Or Curing Plastics Or The Like In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93810920 | 1993-12-31 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO945101D0 NO945101D0 (no) | 1994-12-30 |
NO945101L NO945101L (no) | 1995-07-03 |
NO316762B1 true NO316762B1 (no) | 2004-05-03 |
Family
ID=8215104
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO19945101A NO316762B1 (no) | 1993-12-31 | 1994-12-30 | Fremgangsmate for industriell fremstilling av et preparat som inneholder rekonstituerte lipoproteinpartikler med hoy tetthet (rHDL) fra apolipoprotein A-I og fosfatidylcholin |
Country Status (17)
Country | Link |
---|---|
US (1) | US5652339A (ko) |
EP (1) | EP0663407B1 (ko) |
JP (1) | JP3553669B2 (ko) |
KR (1) | KR0184027B1 (ko) |
CN (1) | CN1056154C (ko) |
AT (1) | ATE220072T1 (ko) |
CA (1) | CA2138925C (ko) |
CZ (1) | CZ283620B6 (ko) |
DE (1) | DE59410149D1 (ko) |
DK (1) | DK0663407T3 (ko) |
ES (1) | ES2179064T3 (ko) |
FI (1) | FI113052B (ko) |
HU (1) | HU227382B1 (ko) |
NO (1) | NO316762B1 (ko) |
PL (1) | PL185414B1 (ko) |
PT (1) | PT663407E (ko) |
TW (1) | TW434253B (ko) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5932536A (en) * | 1994-06-14 | 1999-08-03 | The Rockefeller University | Compositions for neutralization of lipopolysaccharides |
AUPN030794A0 (en) | 1994-12-22 | 1995-01-27 | Aruba International Pty Ltd | Discontinuous plasma or serum delipidation |
SE9702776D0 (sv) * | 1997-07-22 | 1997-07-22 | Pharmacia & Upjohn Ab | Method of preparing pharmaceutical compositions |
US6306433B1 (en) | 1997-08-12 | 2001-10-23 | Pharmacia Ab | Method of preparing pharmaceutical compositions |
US6287590B1 (en) * | 1997-10-02 | 2001-09-11 | Esperion Therapeutics, Inc. | Peptide/lipid complex formation by co-lyophilization |
ES2280214T3 (es) * | 1999-06-02 | 2007-09-16 | Kyowa Medex Co., Ltd. | Lipoproteina desnaturalizada estabilizada y metodo para la produccion de la misma. |
US6514523B1 (en) * | 2000-02-14 | 2003-02-04 | Ottawa Heart Institute Research Corporation | Carrier particles for drug delivery and process for preparation |
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SE456136B (sv) * | 1985-06-17 | 1988-09-12 | Oncholab Ab | Forfarande for framstellning av en med ett lipofilt biologiskt aktivt emne bemengd berare pa basis av rekonstituerat ldl (lagdensitetslipoprotein) |
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JPH07507554A (ja) * | 1992-06-12 | 1995-08-24 | エヌ・ブイ・イノゲネテイクス・エス・エイ | 新規ペプチドおよびタンパク質,それらの調製方法,ならびにコレステロール受容体としてのそれらの使用 |
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1994
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- 1994-12-22 TW TW083112032A patent/TW434253B/zh not_active IP Right Cessation
- 1994-12-23 CZ CZ943299A patent/CZ283620B6/cs not_active IP Right Cessation
- 1994-12-28 DK DK94810753T patent/DK0663407T3/da active
- 1994-12-28 ES ES94810753T patent/ES2179064T3/es not_active Expired - Lifetime
- 1994-12-28 DE DE59410149T patent/DE59410149D1/de not_active Expired - Lifetime
- 1994-12-28 KR KR1019940038151A patent/KR0184027B1/ko not_active IP Right Cessation
- 1994-12-28 AT AT94810753T patent/ATE220072T1/de active
- 1994-12-28 JP JP32873294A patent/JP3553669B2/ja not_active Expired - Fee Related
- 1994-12-28 EP EP94810753A patent/EP0663407B1/de not_active Expired - Lifetime
- 1994-12-28 PT PT94810753T patent/PT663407E/pt unknown
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KR0184027B1 (ko) | 1999-04-01 |
CZ329994A3 (en) | 1995-10-18 |
US5652339A (en) | 1997-07-29 |
HUT70448A (en) | 1995-10-30 |
KR950018039A (ko) | 1995-07-22 |
CA2138925C (en) | 2002-11-05 |
CN1108662A (zh) | 1995-09-20 |
DK0663407T3 (da) | 2002-10-28 |
EP0663407A1 (de) | 1995-07-19 |
JPH07242699A (ja) | 1995-09-19 |
CA2138925A1 (en) | 1995-07-01 |
FI946199A (fi) | 1995-07-01 |
FI113052B (fi) | 2004-02-27 |
ES2179064T3 (es) | 2003-01-16 |
FI946199A0 (fi) | 1994-12-30 |
CN1056154C (zh) | 2000-09-06 |
JP3553669B2 (ja) | 2004-08-11 |
TW434253B (en) | 2001-05-16 |
HU9403830D0 (en) | 1995-02-28 |
ATE220072T1 (de) | 2002-07-15 |
CZ283620B6 (cs) | 1998-05-13 |
NO945101L (no) | 1995-07-03 |
PT663407E (pt) | 2002-11-29 |
DE59410149D1 (de) | 2002-08-08 |
PL306575A1 (en) | 1995-07-10 |
PL185414B1 (pl) | 2003-05-30 |
NO945101D0 (no) | 1994-12-30 |
HU227382B1 (en) | 2011-05-30 |
EP0663407B1 (de) | 2002-07-03 |
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