NO313490B1 - Farmasöytisk preparat inneholdende en glukosidase- og/eller amylasehemmer og en lipasehemmer - Google Patents
Farmasöytisk preparat inneholdende en glukosidase- og/eller amylasehemmer og en lipasehemmer Download PDFInfo
- Publication number
- NO313490B1 NO313490B1 NO19942900A NO942900A NO313490B1 NO 313490 B1 NO313490 B1 NO 313490B1 NO 19942900 A NO19942900 A NO 19942900A NO 942900 A NO942900 A NO 942900A NO 313490 B1 NO313490 B1 NO 313490B1
- Authority
- NO
- Norway
- Prior art keywords
- inhibitor
- glucosidase
- lipase
- amylase
- acarbose
- Prior art date
Links
- 239000003392 amylase inhibitor Substances 0.000 title claims abstract description 17
- 102000004366 Glucosidases Human genes 0.000 title claims abstract description 16
- 108010056771 Glucosidases Proteins 0.000 title claims abstract description 16
- 229940122816 Amylase inhibitor Drugs 0.000 title claims abstract description 14
- 229940086609 Lipase inhibitor Drugs 0.000 title claims abstract description 13
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
- 239000003937 drug carrier Substances 0.000 claims abstract description 3
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical group CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 claims description 10
- 229960001243 orlistat Drugs 0.000 claims description 10
- 208000008589 Obesity Diseases 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical group O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims description 8
- 229960002632 acarbose Drugs 0.000 claims description 8
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims description 8
- 239000013543 active substance Substances 0.000 claims description 7
- AHLBNYSZXLDEJQ-UHFFFAOYSA-N N-formyl-L-leucylester Natural products CCCCCCCCCCCC(OC(=O)C(CC(C)C)NC=O)CC1OC(=O)C1CCCCCC AHLBNYSZXLDEJQ-UHFFFAOYSA-N 0.000 claims description 6
- 208000012696 congenital leptin deficiency Diseases 0.000 claims description 6
- 208000001022 morbid obesity Diseases 0.000 claims description 6
- FOZFSEMFCIPOSZ-SPCKQMHLSA-N (2r,3r,4r,5s)-2-(hydroxymethyl)-1-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxyoxan-2-yl]methyl]piperidine-3,4,5-triol;trihydrate Chemical compound O.O.O.O[C@H]1[C@H](O)[C@@H](O)[C@@H](OC)O[C@@H]1CN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1.O[C@H]1[C@H](O)[C@@H](O)[C@@H](OC)O[C@@H]1CN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1 FOZFSEMFCIPOSZ-SPCKQMHLSA-N 0.000 claims description 4
- -1 Bay-N-3176 Natural products 0.000 claims description 4
- IBAQFPQHRJAVAV-ULAWRXDQSA-N Miglitol Chemical compound OCCN1C[C@H](O)[C@@H](O)[C@H](O)[C@H]1CO IBAQFPQHRJAVAV-ULAWRXDQSA-N 0.000 claims description 4
- NWWORXYTJRPSMC-QKPAOTATSA-N ethyl 4-[2-[(2r,3r,4r,5s)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]ethoxy]benzoate Chemical compound C1=CC(C(=O)OCC)=CC=C1OCCN1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](O)C1 NWWORXYTJRPSMC-QKPAOTATSA-N 0.000 claims description 4
- SIKWOTFNWURSAY-UHFFFAOYSA-N Lipstatin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)C(=O)OC(CC(C)C)NC=O)OC1=O SIKWOTFNWURSAY-UHFFFAOYSA-N 0.000 claims description 3
- OQMAKWGYQLJJIA-CUOOPAIESA-N lipstatin Chemical compound CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(C)C)NC=O)OC1=O OQMAKWGYQLJJIA-CUOOPAIESA-N 0.000 claims description 3
- VCIPQQCYKMORDY-KBYFLBCBSA-N (2r,3r,4s,5s,6r)-2-(hydroxymethyl)-6-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]piperidine-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)N[C@@H]1CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 VCIPQQCYKMORDY-KBYFLBCBSA-N 0.000 claims description 2
- QRGQONAZHIKMGC-UHFFFAOYSA-N (4-phenoxyphenyl) 4-methylpiperidine-1-carboxylate Chemical compound C1CC(C)CCN1C(=O)OC(C=C1)=CC=C1OC1=CC=CC=C1 QRGQONAZHIKMGC-UHFFFAOYSA-N 0.000 claims description 2
- QJLPWVUZFKETMK-LLVKDONJSA-N (5r)-1,5,7,9,11,14-hexahydroxy-3-methyl-8,13-dioxo-5,6-dihydrobenzo[a]tetracene-2-carboxylic acid Chemical compound O=C1C2=C(O)C=C(O)C=C2C(=O)C2=C1C(O)=C1C[C@@H](O)C(C=C(C(=C3O)C(O)=O)C)=C3C1=C2O QJLPWVUZFKETMK-LLVKDONJSA-N 0.000 claims description 2
- WOISDAHQBUYEAF-UHFFFAOYSA-N Ebelactone A Natural products CCC(C)C(O)C(C)C(=O)C(C)C=C(C)CC(C)C1OC(=O)C1C WOISDAHQBUYEAF-UHFFFAOYSA-N 0.000 claims description 2
- UNBMQQNYLCPCHS-UHFFFAOYSA-N Ebelactone B Natural products CCC(C)C(O)C(C)C(=O)C(C)C=C(C)CC(C)C1OC(=O)C1CC UNBMQQNYLCPCHS-UHFFFAOYSA-N 0.000 claims description 2
- VCIPQQCYKMORDY-UHFFFAOYSA-N MDL 25637 Natural products OC1C(O)C(O)C(CO)NC1COC1C(O)C(O)C(O)C(CO)O1 VCIPQQCYKMORDY-UHFFFAOYSA-N 0.000 claims description 2
- RXSVYGIGWRDVQC-UHFFFAOYSA-N N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester Chemical compound C1CCCCC1=NOC(=O)NCCCCCCNC(=O)ON=C1CCCCC1 RXSVYGIGWRDVQC-UHFFFAOYSA-N 0.000 claims description 2
- QJLPWVUZFKETMK-UHFFFAOYSA-N Pradimicin Q Natural products O=C1C2=C(O)C=C(O)C=C2C(=O)C2=C1C(O)=C1CC(O)C(C=C(C(=C3O)C(O)=O)C)=C3C1=C2O QJLPWVUZFKETMK-UHFFFAOYSA-N 0.000 claims description 2
- OCTNNXHKAOLDJL-BMGYQPLYSA-N Salbostatin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)OC[C@@H]1N[C@@H]1[C@H](O)[C@@H](O)[C@H](O)C(CO)=C1 OCTNNXHKAOLDJL-BMGYQPLYSA-N 0.000 claims description 2
- OCTNNXHKAOLDJL-UHFFFAOYSA-N Salbostatin Natural products OC1C(O)C(CO)OCC1NC1C(O)C(O)C(O)C(CO)=C1 OCTNNXHKAOLDJL-UHFFFAOYSA-N 0.000 claims description 2
- 229930186167 Trestatin Natural products 0.000 claims description 2
- WWGVIIVMPMBQFV-HAGHYFMRSA-N Valilactone Natural products CCCCCC[C@H]1[C@@H](C[C@H](CCCCC)OC(=O)[C@@H](NC=O)C(C)C)OC1=O WWGVIIVMPMBQFV-HAGHYFMRSA-N 0.000 claims description 2
- FZNCGRZWXLXZSZ-CIQUZCHMSA-N Voglibose Chemical compound OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O FZNCGRZWXLXZSZ-CIQUZCHMSA-N 0.000 claims description 2
- WWGVIIVMPMBQFV-MUGJNUQGSA-N [(2s)-1-[(2s,3s)-3-hexyl-4-oxooxetan-2-yl]heptan-2-yl] (2s)-2-formamido-3-methylbutanoate Chemical compound CCCCCC[C@H]1[C@H](C[C@H](CCCCC)OC(=O)[C@@H](NC=O)C(C)C)OC1=O WWGVIIVMPMBQFV-MUGJNUQGSA-N 0.000 claims description 2
- RLVLLBHWAQWLKL-UHFFFAOYSA-N [2-[4-(2-methylpropyl)cyclohexyl]-2-oxoethyl] benzenesulfonate Chemical compound C1CC(CC(C)C)CCC1C(=O)COS(=O)(=O)C1=CC=CC=C1 RLVLLBHWAQWLKL-UHFFFAOYSA-N 0.000 claims description 2
- 229950001261 camiglibose Drugs 0.000 claims description 2
- UNBMQQNYLCPCHS-VYNDPHDASA-N ebelactone b Chemical compound CC[C@@H](C)[C@@H](O)[C@H](C)C(=O)[C@H](C)\C=C(/C)C[C@H](C)[C@@H]1OC(=O)[C@H]1CC UNBMQQNYLCPCHS-VYNDPHDASA-N 0.000 claims description 2
- 229950000269 emiglitate Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960001110 miglitol Drugs 0.000 claims description 2
- 229950001790 tendamistat Drugs 0.000 claims description 2
- 108010037401 tendamistate Proteins 0.000 claims description 2
- 229960001729 voglibose Drugs 0.000 claims description 2
- 229940122069 Glycosidase inhibitor Drugs 0.000 claims 1
- 102000005744 Glycoside Hydrolases Human genes 0.000 claims 1
- 108010031186 Glycoside Hydrolases Proteins 0.000 claims 1
- 239000003316 glycosidase inhibitor Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940127470 Lipase Inhibitors Drugs 0.000 description 7
- 208000016261 weight loss Diseases 0.000 description 5
- 230000004580 weight loss Effects 0.000 description 5
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 239000002775 capsule Substances 0.000 description 3
- 235000020824 obesity Nutrition 0.000 description 3
- 238000011125 single therapy Methods 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 241000023308 Acca Species 0.000 description 1
- JKNGELGDDBUFHG-UHFFFAOYSA-N Esterastin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)OC(=O)C(CC(N)=O)NC(C)=O)OC1=O JKNGELGDDBUFHG-UHFFFAOYSA-N 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 208000031773 Insulin resistance syndrome Diseases 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- JKNGELGDDBUFHG-JJPNXARGSA-N [(2S,4Z,7Z)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]trideca-4,7-dien-2-yl] (2S)-2-acetamido-4-amino-4-oxobutanoate Chemical compound CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(N)=O)NC(C)=O)OC1=O JKNGELGDDBUFHG-JJPNXARGSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000019577 caloric intake Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000012262 fermentative production Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH233993 | 1993-08-05 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO942900D0 NO942900D0 (pt) | 1994-08-04 |
| NO942900L NO942900L (no) | 1995-02-06 |
| NO313490B1 true NO313490B1 (no) | 2002-10-14 |
Family
ID=4231504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19942900A NO313490B1 (no) | 1993-08-05 | 1994-08-04 | Farmasöytisk preparat inneholdende en glukosidase- og/eller amylasehemmer og en lipasehemmer |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5643874A (pt) |
| EP (1) | EP0638317B1 (pt) |
| JP (1) | JP2780932B2 (pt) |
| KR (1) | KR100342285B1 (pt) |
| CN (1) | CN1076196C (pt) |
| AT (1) | ATE190503T1 (pt) |
| AU (1) | AU684793B2 (pt) |
| BR (1) | BR9403170A (pt) |
| CA (1) | CA2128044C (pt) |
| CZ (1) | CZ286202B6 (pt) |
| DE (1) | DE59409200D1 (pt) |
| DK (1) | DK0638317T3 (pt) |
| ES (1) | ES2144019T3 (pt) |
| GR (1) | GR3033643T3 (pt) |
| HU (1) | HU222346B1 (pt) |
| IL (1) | IL110510A (pt) |
| NO (1) | NO313490B1 (pt) |
| NZ (1) | NZ264142A (pt) |
| PL (1) | PL175997B1 (pt) |
| PT (1) | PT638317E (pt) |
| RU (1) | RU2141844C1 (pt) |
| SA (1) | SA94150156B1 (pt) |
| TW (1) | TW381025B (pt) |
| ZA (1) | ZA945673B (pt) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998034630A1 (en) * | 1997-02-05 | 1998-08-13 | F.Hoffmann-La Roche Ag | Use of gastrointestinal lipase inhibitors |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| HU9701081D0 (en) * | 1997-06-23 | 1997-08-28 | Gene Research Lab Inc N | Pharmaceutical composition of antitumoral activity |
| GB9727131D0 (en) | 1997-12-24 | 1998-02-25 | Knoll Ag | Therapeutic agents |
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| DE19802700A1 (de) * | 1998-01-24 | 1999-07-29 | Bayer Ag | Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält |
| ATE293970T1 (de) * | 1998-08-14 | 2005-05-15 | Hoffmann La Roche | Lipasehemmer enthaltende pharmazeutische zusammensetzungen |
| WO2000013667A1 (en) * | 1998-09-08 | 2000-03-16 | Smithkline Beecham Corporation | Lipstatin derivative-soluble fiber tablets |
| DE60012301D1 (de) | 1999-01-22 | 2004-08-26 | Hunza Di Pistolesi Elvira & C | Lipoproteinkomplexe und zusammensetzungen, die diese enthalten |
| AR025587A1 (es) * | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| US6235305B1 (en) * | 1999-10-29 | 2001-05-22 | 2Pro Chemical | Essentially nonabsorbable lipase inhibitor derivatives, pharmaceutical compositions and methods of use therefor |
| WO2001032616A2 (en) * | 1999-10-29 | 2001-05-10 | John Jason Gentry Mullins | Oxetanone derivatives |
| US6348492B1 (en) * | 1999-10-29 | 2002-02-19 | 2Pro Chemical | Oxetanone derivatives |
| US6342519B2 (en) * | 1999-10-29 | 2002-01-29 | 2 Pro Chemical | Oxetanone derivatives |
| KR100349334B1 (ko) * | 1999-12-08 | 2002-08-21 | 박관화 | 아카비오신 글루코실 시몬진 및 그것의 제조방법. |
| US7713546B1 (en) | 2001-04-03 | 2010-05-11 | Soft Gel Technologies, Inc. | Corosolic acid formulation and its application for weight-loss management and blood sugar balance |
| CN1261094C (zh) * | 2000-07-28 | 2006-06-28 | 霍夫曼-拉罗奇有限公司 | 脂肪酶抑制剂的新用途 |
| RU2241462C2 (ru) * | 2000-07-28 | 2004-12-10 | Ф. Хоффманн-Ля Рош Аг | Новая фармацевтическая композиция |
| US6849609B2 (en) * | 2001-04-10 | 2005-02-01 | James U. Morrison | Method and composition for controlled release acarbose formulations |
| US6734314B2 (en) | 2001-12-04 | 2004-05-11 | Biogal Gyogyszergyar Rt. | Preparation of orlistat and orlistat crystalline forms |
| US7108869B2 (en) * | 2002-11-07 | 2006-09-19 | Access Business Group International Llc | Nutritional supplement containing alpha-glucosidase and alpha-amylase inhibitors |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| US20060185357A1 (en) * | 2004-05-07 | 2006-08-24 | Kovacevich Ian D | Independently drawing and tensioning lines with bi-directional rotary device having two spools |
| CA2564632C (en) | 2004-05-10 | 2019-06-18 | Den Kgl. Veterinaer - Og Landbohojskole | Flaxseeds for body weight management |
| US20060029567A1 (en) * | 2004-08-04 | 2006-02-09 | Bki Holding Corporation | Material for odor control |
| KR20070084455A (ko) * | 2004-11-23 | 2007-08-24 | 워너-램버트 캄파니 엘엘씨 | 지질혈증 치료용 ｈｍｇ ｃｏ-ａ 환원효소 억제제로서의7-(2ｈ-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체 |
| US8283312B2 (en) * | 2005-02-04 | 2012-10-09 | The Research Foundation Of State University Of New York | Compositions and methods for modulating body weight and treating obesity-related disorders |
| US20060229261A1 (en) * | 2005-04-12 | 2006-10-12 | John Devane | Acarbose methods and formulations for treating chronic constipation |
| US20070009615A1 (en) * | 2005-04-29 | 2007-01-11 | Litao Zhong | Compositions and methods for controlling glucose uptake |
| ES2434072T3 (es) * | 2005-06-09 | 2013-12-13 | Norgine Bv | Preparación sólida de 2-hexadeciloxi-6-metil-4H-3,1-benzoxacin-4-ona |
| CA2617654A1 (en) * | 2005-08-04 | 2007-02-08 | Pfizer Limited | Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| CN100349614C (zh) * | 2005-10-21 | 2007-11-21 | 南京工业大学 | 一种含α－淀粉酶抑制剂的固体混合物及其制备工艺和在制药中的应用 |
| US20070104805A1 (en) * | 2005-11-01 | 2007-05-10 | Udell Ronald G | Compositions of Hoodia Gordonii and Pinolenic Acid Derivatives |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| CA2642922C (en) * | 2006-02-23 | 2011-08-02 | Pfizer Limited | Melanocortin type 4 receptor agonist piperidinoylpyrrolidines |
| TW200831497A (en) * | 2006-10-12 | 2008-08-01 | Epix Delaware Inc | Carboxamide compounds and their use |
| CN101583593A (zh) | 2006-11-13 | 2009-11-18 | 辉瑞产品公司 | 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途 |
| EP2099755A2 (en) * | 2006-11-20 | 2009-09-16 | Glenmark Pharmaceuticals S.A. | Acetylene derivatives as stearoyl coa desaturase inhibitors |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| SI2002825T1 (sl) * | 2007-06-14 | 2013-10-30 | Krka | Farmacevtski sestavki, ki obsegajo orlistat |
| EP2190303A1 (en) * | 2007-09-12 | 2010-06-02 | Københavns Universitet | Compositions and methods for increasing the suppression of hunger and reducing the digestibility of non-fat energy satiety |
| WO2009037542A2 (en) | 2007-09-20 | 2009-03-26 | Glenmark Pharmaceuticals, S.A. | Spirocyclic compounds as stearoyl coa desaturase inhibitors |
| US20100317642A1 (en) * | 2007-10-15 | 2010-12-16 | Inventis Dds Pvt Limited | Pharmaceutical composition of orlistat |
| JP2011506466A (ja) | 2007-12-11 | 2011-03-03 | 株式会社サイトパスファインダー | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 |
| MX2011001405A (es) * | 2008-08-06 | 2011-03-21 | Pfizer Ltd | Compuestos de diazepina y diazocano como agonistas de mc4. |
| JP5752359B2 (ja) * | 2010-02-25 | 2015-07-22 | 富士フイルム株式会社 | 体重増加抑制組成物及びこれを含む食品 |
| WO2011145022A1 (en) | 2010-05-21 | 2011-11-24 | Pfizer Inc. | 2-phenyl benzoylamides |
| TR201100148A2 (tr) * | 2011-01-06 | 2012-07-23 | Bi̇lgi̇ç Mahmut | Stabil akarboz förmülasyonları. |
| US20130345392A1 (en) | 2011-03-04 | 2013-12-26 | Pfizer Inc | Edn3-like peptides and uses thereof |
| CN102805744A (zh) * | 2011-06-02 | 2012-12-05 | 鲁南制药集团股份有限公司 | 一种治疗或预防肥胖症以及代谢综合症的药物组合物 |
| CN102872062A (zh) * | 2011-07-13 | 2013-01-16 | 鲁南制药集团股份有限公司 | 一种治疗或预防肥胖症以及代谢综合症的药物组合物 |
| US8252312B1 (en) * | 2011-12-27 | 2012-08-28 | David Wong | Oral solid composition comprising a lipid absorption inhibitor |
| WO2013133685A1 (en) | 2012-03-09 | 2013-09-12 | Biotropics Malaysia Berhad | Extract formulations of rhodamnia cinerea and uses thereof |
| AU2013257716A1 (en) * | 2012-05-08 | 2014-11-27 | Cellixbio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| JP2016516804A (ja) | 2013-04-17 | 2016-06-09 | ファイザー・インク | 心血管疾患を治療するためのｎ−ピペリジン−３−イルベンズアミド誘導体 |
| FR3017536B1 (fr) | 2014-02-18 | 2017-05-26 | Univ La Rochelle | Compositions pour la prevention et/ou le traitement de pathologies liees a l'alpha-glucosidase |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| EP3233066B1 (en) | 2014-12-17 | 2021-11-10 | Empros Pharma AB | A modified release composition of orlistat and acarbose for the treatment of obesity and related metabolic disorders |
| KR101903150B1 (ko) | 2016-09-12 | 2018-10-01 | 가톨릭대학교산학협력단 | 퀴니자린을 유효성분으로 포함하는 비만 예방 또는 치료용 조성물 |
| CN107308154A (zh) * | 2017-07-19 | 2017-11-03 | 重庆植恩药业有限公司 | 治疗或预防肥胖症以及代谢综合征的药物组合物及其应用 |
| JOP20210193A1 (ar) | 2019-01-18 | 2023-01-30 | Astrazeneca Ab | مثبطات pcsk9 وطرق استخدامها |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS608117B2 (ja) * | 1977-02-08 | 1985-02-28 | 財団法人微生物化学研究会 | 新生理活性物質エステラスチンおよびその製造法 |
| JPS5953920B2 (ja) * | 1977-12-28 | 1984-12-27 | 東洋醸造株式会社 | 新規なアミノ糖化合物およびその製法 |
| CA1121290A (en) * | 1978-02-14 | 1982-04-06 | Yasuji Suhara | Amino sugar derivatives |
| JPS56128774A (en) * | 1980-03-14 | 1981-10-08 | Microbial Chem Res Found | New physiologically active substance ebelactone and its preparation |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| FI844289L (fi) * | 1984-01-21 | 1985-07-22 | Hoechst Ag | Nya polypeptider med -amylashaemmande verkan, foerfarande foer deras framstaellning, deras anvaendning och farmaceutiska preparat. |
| US4952567A (en) * | 1988-05-09 | 1990-08-28 | City Of Hope | Inhibition of lipogenesis |
| ATE86853T1 (de) * | 1988-08-22 | 1993-04-15 | Takeda Chemical Industries Ltd | Alpha-glucosidaseinhibitor zur foerderung der calciumabsorption. |
| DK244090D0 (da) * | 1990-10-09 | 1990-10-09 | Novo Nordisk As | Kemiske forbindelser |
| US5240962A (en) * | 1991-04-15 | 1993-08-31 | Takasago Institute For Interdisciplinary Science, Inc. | Antiobesity and fat-reducing agents |
| GB9122051D0 (en) * | 1991-10-17 | 1991-11-27 | Univ Nottingham | Medicines |
-
1994
- 1994-07-14 CA CA002128044A patent/CA2128044C/en not_active Expired - Lifetime
- 1994-07-14 TW TW083106429A patent/TW381025B/zh not_active IP Right Cessation
- 1994-07-22 US US08/279,127 patent/US5643874A/en not_active Expired - Lifetime
- 1994-07-22 PT PT94111436T patent/PT638317E/pt unknown
- 1994-07-22 DE DE59409200T patent/DE59409200D1/de not_active Expired - Lifetime
- 1994-07-22 AT AT94111436T patent/ATE190503T1/de active
- 1994-07-22 EP EP94111436A patent/EP0638317B1/de not_active Expired - Lifetime
- 1994-07-22 DK DK94111436T patent/DK0638317T3/da active
- 1994-07-22 ES ES94111436T patent/ES2144019T3/es not_active Expired - Lifetime
- 1994-07-29 IL IL11051094A patent/IL110510A/en not_active IP Right Cessation
- 1994-07-29 ZA ZA945673A patent/ZA945673B/xx unknown
- 1994-07-29 CZ CZ19941825A patent/CZ286202B6/cs not_active IP Right Cessation
- 1994-08-01 HU HU9402249A patent/HU222346B1/hu active IP Right Grant
- 1994-08-01 AU AU68839/94A patent/AU684793B2/en not_active Expired
- 1994-08-01 NZ NZ264142A patent/NZ264142A/en not_active IP Right Cessation
- 1994-08-02 JP JP6181109A patent/JP2780932B2/ja not_active Expired - Lifetime
- 1994-08-04 CN CN94109091A patent/CN1076196C/zh not_active Expired - Lifetime
- 1994-08-04 KR KR1019940019227A patent/KR100342285B1/ko not_active IP Right Cessation
- 1994-08-04 BR BR9403170A patent/BR9403170A/pt not_active Application Discontinuation
- 1994-08-04 PL PL94304557A patent/PL175997B1/pl unknown
- 1994-08-04 NO NO19942900A patent/NO313490B1/no not_active IP Right Cessation
- 1994-08-05 RU RU94028653A patent/RU2141844C1/ru active
- 1994-08-29 SA SA94150156A patent/SA94150156B1/ar unknown
-
2000
- 2000-06-12 GR GR20000401330T patent/GR3033643T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO313490B1 (no) | Farmasöytisk preparat inneholdende en glukosidase- og/eller amylasehemmer og en lipasehemmer | |
| Silverstone | Appetite suppressants: a review | |
| Moshal et al. | A clinical trial of trimebutine (Mebutin) in spastic colon | |
| Levine et al. | Inositol treatment of autism | |
| US5055460A (en) | Method for weight loss | |
| Bruera et al. | Psychostimulants as adjuvant analgesics | |
| Stewart et al. | High-fiber diet and serum tricyclic antidepressant levels | |
| Bray et al. | Diet, weight loss, and cardiovascular disease prevention | |
| US6673792B1 (en) | Broad-spectrum anti-emetic compositions and associated methods | |
| Manasrah et al. | Phentermine-associated atrial fibrillation: a case report and literature review | |
| Linn et al. | Patient symptoms and physician prescribing patterns in the elderly | |
| US3150043A (en) | Anorectic composition | |
| Wolf et al. | Straight to the Point: Obesity | |
| Spector et al. | Theophylline Dose-dumping | |
| Morrice | Variability in response to drugs. | |
| Prendergast | Anonymous Appointments | |
| Mullard | Medical management of heartburn. | |
| Small et al. | Quinidine-digoxin interaction: A discussion of a case report and review of the literature | |
| SU1261663A1 (ru) | Способ определени терапевтической чувствительности больных депрессией к трициклическим антидепрессантам | |
| Balakumaran et al. | ST 567 (alinidine) in stable angina: a comparison with metoprolol | |
| House et al. | ABC OF SEXUALLY TRANSMITTED DISEASES | |
| Lessing et al. | Severe cerebral confusion produced by prajmalium bitartrate. | |
| González | Advantages and Benefits of Once-Daily Nadolol Treatment in Hypertension | |
| Dobson | Past, Present and Future of Cardiovascular Disease in Australia | |
| Koller et al. | Four Misdiagnoses of Acute Abdominal Pain in a Young Woman |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |