NO308533B1 - Heteroarylaminer, anvendelse derav og farmasøytisk preparat - Google Patents

Heteroarylaminer, anvendelse derav og farmasøytisk preparat

Info

Publication number
NO308533B1
NO308533B1 NO941179A NO941179A NO308533B1 NO 308533 B1 NO308533 B1 NO 308533B1 NO 941179 A NO941179 A NO 941179A NO 941179 A NO941179 A NO 941179A NO 308533 B1 NO308533 B1 NO 308533B1
Authority
NO
Norway
Prior art keywords
heteroarlamines
pharmaceutical composition
pharmaceutical
composition
Prior art date
Application number
NO941179A
Other languages
English (en)
Norwegian (no)
Other versions
NO941179D0 (no
NO941179L (no
Inventor
Yuhpyng Liang Chen
Arthur Adam Nagel
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO941179D0 publication Critical patent/NO941179D0/no
Publication of NO941179L publication Critical patent/NO941179L/no
Publication of NO308533B1 publication Critical patent/NO308533B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Control Of El Displays (AREA)
NO941179A 1991-10-03 1994-03-30 Heteroarylaminer, anvendelse derav og farmasøytisk preparat NO308533B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77128391A 1991-10-03 1991-10-03
PCT/US1992/007230 WO1993007140A1 (en) 1991-10-03 1992-08-31 Heteroaryl amines as novel acetyl cholinesterase inhibitors

Publications (3)

Publication Number Publication Date
NO941179D0 NO941179D0 (no) 1994-03-30
NO941179L NO941179L (no) 1994-03-30
NO308533B1 true NO308533B1 (no) 2000-09-25

Family

ID=25091318

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941179A NO308533B1 (no) 1991-10-03 1994-03-30 Heteroarylaminer, anvendelse derav og farmasøytisk preparat

Country Status (36)

Country Link
US (4) US5574046A (de)
EP (1) EP0606248B1 (de)
JP (1) JP2546785B2 (de)
KR (1) KR0170458B1 (de)
CN (1) CN1035615C (de)
AP (1) AP314A (de)
AT (1) ATE235490T1 (de)
AU (1) AU667053B2 (de)
BG (1) BG61727B1 (de)
BR (1) BR9206577A (de)
CA (1) CA2119647C (de)
CZ (1) CZ290807B6 (de)
DE (2) DE69232976T2 (de)
DK (1) DK0606248T3 (de)
EG (1) EG21481A (de)
ES (1) ES2193137T3 (de)
FI (1) FI116939B (de)
HU (1) HU225049B1 (de)
IL (1) IL103274A (de)
IS (1) IS1745B (de)
MA (1) MA22672A1 (de)
MX (1) MX9205678A (de)
NO (1) NO308533B1 (de)
NZ (1) NZ244601A (de)
OA (1) OA09895A (de)
PH (1) PH31290A (de)
PL (3) PL171693B1 (de)
PT (1) PT100917B (de)
RO (1) RO112868B1 (de)
RU (1) RU2100357C1 (de)
SG (1) SG52618A1 (de)
TW (1) TW263504B (de)
UA (1) UA41290C2 (de)
UY (1) UY23484A1 (de)
WO (1) WO1993007140A1 (de)
ZA (1) ZA927589B (de)

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US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
EP0976404A3 (de) * 1998-07-30 2001-06-27 Pfizer Products Inc. Pharmazeutische Zubereitung zur Vorbeugung und Behandlung von kognitiven Störungen bei Säugetieren
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
AU2001296193B2 (en) * 2000-10-20 2006-04-27 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl)indoles and their use in therapy
AU2003287160A1 (en) * 2002-10-15 2004-05-04 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
US20060014801A1 (en) * 2002-11-22 2006-01-19 The Johns Hopkins University Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
WO2005112946A1 (en) * 2004-05-14 2005-12-01 The Johns Hopkins University Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor
EP1600447A1 (de) * 2004-05-28 2005-11-30 Neuropharma S.A.U. Selektive Butyrylcholinesterase Inhibitoren
RU2006147278A (ru) 2004-06-09 2008-07-20 Глэксо Груп Лимитед (GB) Производные пирролопиридина
CN101087618A (zh) * 2004-12-23 2007-12-12 航行药物公司 醋酸亮丙瑞林和乙酰胆碱酯酶抑制剂或nmda受体抑制剂在阿尔茨海默氏病治疗中的应用
CN1808106B (zh) * 2005-01-21 2010-11-24 中国科学院上海药物研究所 一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
US8815508B2 (en) 2008-08-12 2014-08-26 Zinfandel Pharmaceuticals, Inc. Method of identifying disease risk factors
CN101503414B (zh) * 2009-03-04 2013-10-30 沈阳药科大学 噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
NO2482815T3 (de) * 2009-10-02 2018-09-29
WO2011100373A1 (en) 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
UA114704C2 (uk) 2011-01-10 2017-07-25 Зінфандел Фармасьютікалз, Інк. Способи та лікарські засоби для лікування хвороби альцгеймера
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN110128370A (zh) 2013-01-29 2019-08-16 埃维克辛公司 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
EP3827820A1 (de) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam zur verbesserung der kognitiven funktion
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ, インコーポレイテッド 認知機能を改善するための方法および組成物
CN103333163A (zh) * 2013-07-09 2013-10-02 广州中医药大学 一种苯并呋喃类衍生物及其制备方法和应用
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
CN107141266B (zh) * 2017-06-28 2019-04-09 佳木斯大学附属第一医院 一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN115466211B (zh) * 2022-06-09 2024-02-23 中国人民解放军空军军医大学 一种n-苯基喹啉-4-胺类化合物及其应用

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NL100127C (de) * 1954-04-28
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4122265A (en) * 1976-05-21 1978-10-24 Hoffmann-La Roche Inc. Derivatives of 3-phenylisoindole-1-carboxylic acid
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
GB8615562D0 (en) * 1986-06-25 1986-07-30 Maggioni Farma Aminoalcohols
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
US5064840A (en) * 1989-08-03 1991-11-12 Merrell Dow Pharmaceuticals Anti-psychotic piperidylbenzimidazole compounds
TW197442B (de) * 1990-02-08 1993-01-01 Pfizer
US5116846A (en) * 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
TW197435B (de) * 1990-11-22 1993-01-01 Takeda Pharm Industry Co Ltd
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
JP3357879B2 (ja) * 1992-02-13 2002-12-16 メレルダウファーマス−ティカルズ インコーポレイテッド ピペリジニルチア環状誘導体類
CA2092112A1 (en) * 1992-03-23 1993-09-24 Nobuyoshi Iwata Indole and indazole derivatives, for the treatment and prophylaxis of cerebral disorders, their preparation and their use

Also Published As

Publication number Publication date
PT100917A (pt) 1993-11-30
ZA927589B (en) 1994-04-05
JP2546785B2 (ja) 1996-10-23
HU225049B1 (en) 2006-05-29
IS1745B (is) 2000-05-18
US5574046A (en) 1996-11-12
EP0606248B1 (de) 2003-03-26
ES2193137T3 (es) 2003-11-01
BG61727B1 (bg) 1998-04-30
UA41290C2 (uk) 2001-09-17
SG52618A1 (en) 1998-09-28
OA09895A (en) 1995-09-15
DK0606248T3 (da) 2003-06-23
HUT70544A (en) 1995-10-30
EP0606248A1 (de) 1994-07-20
UY23484A1 (es) 1993-03-11
CN1035615C (zh) 1997-08-13
TW263504B (de) 1995-11-21
BR9206577A (pt) 1995-10-10
FI941518A0 (fi) 1994-03-31
KR0170458B1 (ko) 1999-02-18
DE69232976T2 (de) 2003-10-02
ATE235490T1 (de) 2003-04-15
RO112868B1 (ro) 1998-01-30
IS3919A (is) 1993-04-04
PL171669B1 (en) 1997-06-30
BG98689A (bg) 1995-03-31
PT100917B (pt) 1999-07-30
CN1071166A (zh) 1993-04-21
NO941179D0 (no) 1994-03-30
AU667053B2 (en) 1996-03-07
DE9290112U1 (de) 1994-06-01
US6124321A (en) 2000-09-26
FI116939B (fi) 2006-04-13
JPH06510788A (ja) 1994-12-01
CZ78594A3 (en) 1995-07-12
US6303633B1 (en) 2001-10-16
MA22672A1 (fr) 1993-07-01
CA2119647A1 (en) 1993-04-15
IL103274A0 (en) 1993-02-21
WO1993007140A1 (en) 1993-04-15
IL103274A (en) 1996-11-14
EG21481A (en) 2001-11-28
HU9400952D0 (en) 1994-06-28
AU2519692A (en) 1993-05-03
RU2100357C1 (ru) 1997-12-27
PH31290A (en) 1998-07-06
CZ290807B6 (cs) 2002-10-16
NO941179L (no) 1994-03-30
CA2119647C (en) 1998-08-04
NZ244601A (en) 1995-03-28
DE69232976D1 (de) 2003-04-30
PL171984B1 (pl) 1997-07-31
AP314A (en) 1994-02-04
US20020049210A1 (en) 2002-04-25
AP9200421A0 (en) 1992-10-31
PL171693B1 (pl) 1997-06-30
FI941518A (fi) 1994-03-31
MX9205678A (es) 1993-04-01

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