NO306255B1 - [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer - Google Patents

[(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer

Info

Publication number
NO306255B1
NO306255B1 NO943186A NO943186A NO306255B1 NO 306255 B1 NO306255 B1 NO 306255B1 NO 943186 A NO943186 A NO 943186A NO 943186 A NO943186 A NO 943186A NO 306255 B1 NO306255 B1 NO 306255B1
Authority
NO
Norway
Prior art keywords
benzodioxane
benzopyran
benzofuran
alkylamino
alkyl substituted
Prior art date
Application number
NO943186A
Other languages
English (en)
Norwegian (no)
Other versions
NO943186L (no
NO943186D0 (no
Inventor
Guy Rosalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Walter Jacobus Joseph Janssens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO943186L publication Critical patent/NO943186L/no
Publication of NO943186D0 publication Critical patent/NO943186D0/no
Publication of NO306255B1 publication Critical patent/NO306255B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Phenolic Resins Or Amino Resins (AREA)
  • Pyrane Compounds (AREA)
NO943186A 1992-02-27 1994-08-29 [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer NO306255B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84256092A 1992-02-27 1992-02-27
PCT/EP1993/000435 WO1993017017A1 (en) 1992-02-27 1993-02-19 [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors

Publications (3)

Publication Number Publication Date
NO943186L NO943186L (no) 1994-08-29
NO943186D0 NO943186D0 (no) 1994-08-29
NO306255B1 true NO306255B1 (no) 1999-10-11

Family

ID=25287639

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943186A NO306255B1 (no) 1992-02-27 1994-08-29 [(Benzodioksan, benzofuran eller benzopyran)-alkylamino]-alkylsubstituert guanidiner som selektive vasokonstriktorer

Country Status (37)

Country Link
US (4) US5541180A (ja)
EP (1) EP0639192B1 (ja)
JP (1) JP2779268B2 (ja)
KR (1) KR100190300B1 (ja)
CN (1) CN1038032C (ja)
AP (1) AP416A (ja)
AT (1) ATE138064T1 (ja)
AU (1) AU664237B2 (ja)
BG (1) BG62052B1 (ja)
CA (1) CA2117483C (ja)
CZ (1) CZ282092B6 (ja)
DE (1) DE69302687T2 (ja)
DK (1) DK0639192T3 (ja)
EE (1) EE03029B1 (ja)
ES (1) ES2087721T3 (ja)
FI (1) FI109122B (ja)
GR (1) GR3019927T3 (ja)
HR (1) HRP930235B1 (ja)
HU (2) HU222495B1 (ja)
IL (1) IL104868A (ja)
LT (1) LT3049B (ja)
LV (1) LV10715B (ja)
MX (1) MX9301053A (ja)
MY (1) MY110627A (ja)
NO (1) NO306255B1 (ja)
NZ (1) NZ249124A (ja)
OA (1) OA10095A (ja)
PH (1) PH31295A (ja)
PL (1) PL174736B1 (ja)
RO (1) RO115630B1 (ja)
RU (1) RU2121999C1 (ja)
SG (1) SG47763A1 (ja)
SI (1) SI9300097B (ja)
SK (1) SK280166B6 (ja)
TW (1) TW225531B (ja)
WO (1) WO1993017017A1 (ja)
ZA (1) ZA931404B (ja)

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HU228673B1 (en) * 1993-08-19 2013-05-28 Janssen Pharmaceutica Nv Vasoconstrictive substituted dihydropyranopyridines, process for producing them and pharmaceutical compositions containing them
KR100330696B1 (ko) * 1993-08-19 2002-10-04 얀센 파마슈티카 엔.브이. 혈관수축성디하이드로벤조피란유도체
PH31437A (en) * 1993-08-27 1998-11-03 Janssen Pharmaceutica Nv Tontophoretic delivery of an antimigrane drug.
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
US6054462A (en) * 1994-04-13 2000-04-25 Janssen Pharmaceutica, N.V. Intranasal antimigraine compositions
HRP950149A2 (en) * 1994-04-13 1997-06-30 Janssen Pharmaceutica Nv Intranasal antimigrene composition
FR2724383B1 (fr) * 1994-09-13 1996-10-18 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique
ATE210657T1 (de) * 1994-10-14 2001-12-15 Merck Patent Gmbh Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman
US5853383A (en) * 1995-05-03 1998-12-29 Alza Corporation Preparation for formulations for electrotransport drug delivery
WO1996041632A1 (en) * 1995-06-08 1996-12-27 Janssen Pharmaceutica N.V. Starch microsphere anti migraine composition
FR2752735B1 (fr) * 1996-09-05 1998-10-02 Synthelabo Utilisation de derives de benzofurane pour obtenir un medicament destine au traitement de l'insuffisance veineuse et de l'ulcere veineux
TW504510B (en) 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
JP2003501427A (ja) 1999-06-02 2003-01-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アミノアルキル置換（ベンゾジオキサン、ベンゾフランもしくはベンゾピラン）誘導体
EA004648B1 (ru) 1999-06-02 2004-06-24 Янссен Фармацевтика Н.В. Пирролидинил-, пиперидинил- или гомопиперидинилзамещенные производные, способ их получения, их применение в медицине, содержащая их фармацевтическая композиция и способ ее получения
UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
JO2352B1 (en) * 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
JP2004517081A (ja) * 2000-11-29 2004-06-10 イーライ・リリー・アンド・カンパニー １−（２−ｍ−メタンスルホンアミドフェニルエチル）−４−（ｍ−トリフルオロメチルフェニル）ピペラジンならびにその医薬的に許容しうる塩および溶媒和物
IL157254A0 (en) * 2001-02-23 2004-02-19 Merck & Co Inc N-substituted nonaryl-heterocyclic nmda/mr2b antagonists
US7872030B2 (en) 2001-07-26 2011-01-18 Merck Patent Gmbh Use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
ES2262840T3 (es) * 2001-09-19 2006-12-01 Merck Patent Gmbh Nuevo uso de los aminometil cromanos substituidos.
AU2004208821B2 (en) * 2003-01-31 2009-01-15 Zimmer Orthobiologics Inc. Hydrogel compositions comprising nucleus pulposus tissue
ZA200507112B (en) * 2003-03-31 2007-03-28 Taisho Pharmaceutical Co Ltd Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof
EP1464335A3 (en) * 2003-03-31 2007-05-09 Taisho Pharmaceutical Co. Ltd. Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
PL1976509T3 (pl) * 2006-01-18 2015-07-31 Evolva Sa Modulatory PPAR
CN105061392B (zh) * 2015-07-20 2017-07-18 上海现代哈森（商丘）药业有限公司 一种硫酸胍生合成方法

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FR1366479A (fr) * 1962-08-20 1964-07-10 Res Lab Dr C Janssen Nv Procédé de production de nouveaux dérivés de la pipéridine et de leurs sels
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Also Published As

Publication number Publication date
AP9300493A0 (en) 1993-04-30
IL104868A0 (en) 1993-06-10
NO943186L (no) 1994-08-29
BG98870A (bg) 1995-03-31
HRP930235B1 (en) 1999-04-30
DK0639192T3 (da) 1996-08-19
EP0639192B1 (en) 1996-05-15
IL104868A (en) 1998-01-04
MX9301053A (es) 1994-03-31
AP416A (en) 1995-09-29
FI943928A0 (fi) 1994-08-26
FI943928A (fi) 1994-08-26
BG62052B1 (bg) 1999-01-29
KR100190300B1 (ko) 1999-06-01
CS202094A3 (en) 1995-01-18
TW225531B (ja) 1994-06-21
RU2121999C1 (ru) 1998-11-20
AU664237B2 (en) 1995-11-09
NZ249124A (en) 1995-08-28
WO1993017017A1 (en) 1993-09-02
PH31295A (en) 1998-07-06
CA2117483A1 (en) 1993-09-02
DE69302687D1 (de) 1996-06-20
HU9402464D0 (en) 1994-10-28
LV10715B (en) 1995-12-20
SI9300097A (en) 1993-09-30
CN1079470A (zh) 1993-12-15
ZA931404B (en) 1994-08-26
NO943186D0 (no) 1994-08-29
HU222495B1 (hu) 2003-07-28
SK102994A3 (en) 1995-07-11
EE03029B1 (et) 1997-08-15
CA2117483C (en) 2001-01-09
LTIP367A (lt) 1994-04-25
CZ282092B6 (cs) 1997-05-14
US5688952A (en) 1997-11-18
RU94041210A (ru) 1996-07-10
US5541180A (en) 1996-07-30
LV10715A (lv) 1995-06-20
US5624952A (en) 1997-04-29
HUT71129A (en) 1995-11-28
DE69302687T2 (de) 1996-11-14
LT3049B (en) 1994-10-25
CN1038032C (zh) 1998-04-15
JP2779268B2 (ja) 1998-07-23
JPH07504408A (ja) 1995-05-18
GR3019927T3 (en) 1996-08-31
EP0639192A1 (en) 1995-02-22
HU211742A9 (en) 1995-12-28
AU3499193A (en) 1993-09-13
MY110627A (en) 1998-09-30
HRP930235A2 (en) 1997-10-31
ATE138064T1 (de) 1996-06-15
OA10095A (en) 1996-12-18
RO115630B1 (ro) 2000-04-28
SG47763A1 (en) 1998-04-17
US5607949A (en) 1997-03-04
FI109122B (fi) 2002-05-31
SK280166B6 (sk) 1999-09-10
ES2087721T3 (es) 1996-07-16
SI9300097B (en) 2001-12-31
PL174736B1 (pl) 1998-09-30

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