NO20063371L - Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser - Google Patents

Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser

Info

Publication number
NO20063371L
NO20063371L NO20063371A NO20063371A NO20063371L NO 20063371 L NO20063371 L NO 20063371L NO 20063371 A NO20063371 A NO 20063371A NO 20063371 A NO20063371 A NO 20063371A NO 20063371 L NO20063371 L NO 20063371L
Authority
NO
Norway
Prior art keywords
methods
amino
cycloheptene
analogues
substituted diaryl
Prior art date
Application number
NO20063371A
Other languages
English (en)
Norwegian (no)
Inventor
Fredrik Ek
Roger Olsson
Jorgen Ohlsson
Original Assignee
Acadia Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc filed Critical Acadia Pharm Inc
Publication of NO20063371L publication Critical patent/NO20063371L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/38—[b, e]- or [b, f]-condensed with six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO20063371A 2003-12-22 2006-07-20 Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser NO20063371L (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53192703P 2003-12-22 2003-12-22
US54809004P 2004-02-24 2004-02-24
US54860404P 2004-02-27 2004-02-27
PCT/US2004/043224 WO2005063254A2 (en) 2003-12-22 2004-12-21 Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders

Publications (1)

Publication Number Publication Date
NO20063371L true NO20063371L (no) 2006-09-22

Family

ID=34743692

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063371A NO20063371L (no) 2003-12-22 2006-07-20 Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser

Country Status (23)

Country Link
US (5) US7550454B2 (pt)
EP (2) EP1696931B1 (pt)
JP (1) JP2007534656A (pt)
KR (1) KR101157881B1 (pt)
CN (1) CN101962369A (pt)
AT (1) ATE426405T1 (pt)
AU (1) AU2004308955B2 (pt)
BR (1) BRPI0417749A (pt)
CA (1) CA2550735A1 (pt)
CY (1) CY1109171T1 (pt)
DE (1) DE602004020263D1 (pt)
DK (1) DK1696931T3 (pt)
ES (1) ES2324713T3 (pt)
HK (1) HK1095092A1 (pt)
IL (1) IL176447A0 (pt)
MX (1) MXPA06007244A (pt)
NO (1) NO20063371L (pt)
NZ (1) NZ547911A (pt)
PL (1) PL1696931T3 (pt)
PT (1) PT1696931E (pt)
SG (1) SG133606A1 (pt)
SI (1) SI1696931T1 (pt)
WO (1) WO2005063254A2 (pt)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2398765C1 (ru) 2000-03-06 2010-09-10 Акадиа Фармасьютикалз, Инк. Азациклические соединения для применения при лечении опосредованных серотонином заболеваний
NZ533567A (en) 2001-12-28 2007-06-29 Acadia Pharm Inc Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
US20030216376A1 (en) * 2002-03-20 2003-11-20 Revital Lifshitz-Liron Crystalline forms of quetiapine hemifumarate
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
WO2004000808A2 (en) 2002-06-24 2003-12-31 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
ES2314362T3 (es) 2003-01-16 2009-03-16 Acadia Pharmaceuticals Inc. Agonistas inversos selectivos de los receptores 2a o 2c de serotonina utilizados como agentes terapeuticos contra enfermedades neurodegenerativas.
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
JP2006515628A (ja) * 2003-01-23 2006-06-01 アカディア ファーマシューティカルズ，インコーポレーテッド ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
NZ527142A (en) 2003-07-23 2006-03-31 Douglas Pharmaceuticals Ltd A stable suspension formulation
WO2008021463A2 (en) * 2006-08-15 2008-02-21 Acadia Pharmaceuticals, Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
US20090239840A1 (en) * 2003-12-22 2009-09-24 Acadia Pharmaceuticals, Inc. AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS
SG133606A1 (en) 2003-12-22 2007-07-30 Acadia Pharm Inc Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
US20050171088A1 (en) * 2004-01-30 2005-08-04 Astrazeneca Ab Treatment of psychoses with dibenzothiazepine antipsychotic
CA2560671A1 (en) * 2004-04-01 2006-01-05 Acadia Pharmaceuticals Inc. Crystalline forms of n-desmethylclozapine
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
MX2007002033A (es) 2004-08-19 2007-04-26 Vertex Pharma Moduladores de receptores muscarinicos.
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
US20060081361A1 (en) * 2004-09-13 2006-04-20 Gabbey Lawrence W Oil cooler with integral filter
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
JP5154227B2 (ja) * 2004-09-27 2013-02-27 アカディア ファーマシューティカルズ インコーポレイテッド Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミドの塩及びその調製
RU2007124373A (ru) * 2004-11-29 2009-01-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецептеров
JP2008526839A (ja) * 2005-01-07 2008-07-24 アストラゼネカ・アクチエボラーグ １１−ピペラジン−１−イルジベンゾ［ｂ，ｆ］［１，４］チアゼピン又はその薬学的に許容される塩の新規な使用及び経口医薬組成物への新規な使用
AU2006231497A1 (en) * 2005-04-04 2006-10-12 Acadia Pharmaceuticals Inc. Use of N-desmethylclozapine and related compounds as dopamine stabilizing agents
EP1869007A1 (en) * 2005-04-14 2007-12-26 Teva Pharmaceutical Industries Ltd Process for preparing quetiapine fumarate
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
US20080090805A1 (en) * 2005-10-17 2008-04-17 Acadia Pharmaceuticals Inc. Cb-1 modulating compounds and their use
US20070105819A1 (en) * 2005-10-17 2007-05-10 Roger Olsson CB-1 modulating compounds and their use
WO2007047776A1 (en) * 2005-10-17 2007-04-26 Acadia Pharmaceuticals Inc. Iron catalyzed cross-coupling reactions of imidoyl derivatives
EP1940389A2 (en) 2005-10-21 2008-07-09 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070105836A1 (en) * 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070105835A1 (en) * 2005-11-07 2007-05-10 Kazantsev Aleksey G Compositions and methods for modulating poly(ADP-ribose) polymerase activity
WO2007062339A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Liquid formulations
JP2009516705A (ja) * 2005-11-18 2009-04-23 アストラゼネカ・アクチエボラーグ 塩の形態
RU2008137593A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US20070264330A1 (en) * 2006-05-15 2007-11-15 Bo Ragnar-Tolf Pharmaceutical formulations of pimavanserin
DE102006032426A1 (de) * 2006-07-13 2008-01-17 Neuraxpharm Arzneimittel Gmbh U. Co. Kg Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung
DE102006032427A1 (de) * 2006-07-13 2008-01-17 Neuraxpharm Arzneimittel Gmbh U. Co. Kg Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung
JP2010501561A (ja) * 2006-08-18 2010-01-21 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008118141A2 (en) * 2006-10-17 2008-10-02 Acadia Pharmaceuticals Inc. Use of cannabinoid modulating compounds in combination with other therapeutic compounds for adjunctive therapy
US20100056492A1 (en) * 2006-12-20 2010-03-04 Astrazeneca Ab Compounds and uses thereof - 152
CN101622002A (zh) * 2006-12-20 2010-01-06 阿斯利康(瑞典)有限公司 化合物及其用途
GB0701970D0 (en) * 2007-02-01 2007-03-14 Wilson Stuart Treatment of protein aggregation diseases
CA2678897C (en) * 2007-03-15 2015-10-20 Aryx Therapeutics, Inc. Dibenzo[b,f][1,4]oxazapine compounds
JP2010522198A (ja) 2007-03-19 2010-07-01 アカドイア プハルマセウチカルス インコーポレーテッド ５−ｈｔ２ａインバースアゴニスト及びアンタゴニストの抗精神病薬との併用
EP2207549A1 (en) * 2007-10-03 2010-07-21 Vertex Pharmceuticals Incorporated Modulators of muscarinic receptors
WO2009149347A1 (en) 2008-06-05 2009-12-10 President And Fellows Of Harvard College High-valent palladium fluoride complexes and uses thereof
CN102131791B (zh) * 2008-06-20 2014-12-24 阿斯利康(瑞典)有限公司 二苯并硫杂氮杂*衍生物及其用途
WO2010062565A1 (en) * 2008-10-27 2010-06-03 Acadia Pharmaceuticals Inc. Muscarinic agonists
KR20110095898A (ko) 2008-11-20 2011-08-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유기 화합물의 플루오르화
JP2012514655A (ja) * 2009-01-09 2012-06-28 プレジデント アンド フェローズ オブ ハーバード カレッジ フッ素含有化合物およびその使用法
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN101531570B (zh) * 2009-04-17 2012-10-10 中国科学院上海有机化学研究所 1，2-取代-5-乙炔基-(或10，11-二氢)-5H-二苯基[a，d]环庚烯(烷)-5-醇、合成方法及用途
HUE044653T2 (hu) 2009-07-22 2019-11-28 PureTech Health LLC Készítmények olyan rendellenességek kezelésére, amelyek muszkarin-receptor aktiválással enyhíthetõk
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
WO2011025748A1 (en) * 2009-08-26 2011-03-03 Acadia Pharmaceuticals, Inc. Amino substituted diaryl [a, d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2012142162A2 (en) 2011-04-12 2012-10-18 President And Fellows Of Harvard College Fluorination of organic compounds
US9273083B2 (en) 2012-09-26 2016-03-01 President And Fellows Of Harvard College Nickel fluorinating complexes and uses thereof
CA2923835C (en) 2013-09-11 2022-11-29 The Administrators Of The Tulane Educational Fund Novel anthranilic amides and the use thereof
US10759764B2 (en) 2013-10-18 2020-09-01 President And Fellows Of Harvard College Fluorination of organic compounds
CN104016937B (zh) * 2014-05-09 2016-12-07 中科院广州化学有限公司 一种n-芳基氧氮杂卓酮类化合物及其制备方法
AR105238A1 (es) * 2015-07-02 2017-09-20 Hoffmann La Roche Compuestos de benzoxacepina oxazolidinona y métodos de uso
SI3325444T1 (sl) 2015-07-20 2021-11-30 Acadia Pharmaceuticals Inc. Postopki za pripravo N-(4-fluorobenzil)-N-(1-metilpiperidin-4-il)-N'- (4-(2-metilpropiloksi)fenilmetil)karbamida in njegove tartratne soli in polimorfne oblike C
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
WO2018139471A1 (ja) * 2017-01-25 2018-08-02 大日本住友製薬株式会社 ジベンゾジアゼピン誘導体
WO2018148529A1 (en) * 2017-02-10 2018-08-16 Florida A&M University Identification of agents displaying functional activation of dopamine d2 and d4 receptors
WO2018200977A1 (en) 2017-04-28 2018-11-01 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
EP3675827A1 (en) 2017-08-30 2020-07-08 Acadia Pharmaceuticals Inc. Formulations of pimavanserin
WO2019068859A1 (en) 2017-10-06 2019-04-11 Leyden Technologies B.V. STABLE SOLUTIONS OF MULTICYCLIC ANTIDEPRESSANTS
CN107903244B (zh) * 2017-11-29 2019-06-14 武汉珈创生物技术股份有限公司 具有抗肿瘤活性的2-胺基取代苯并二氮卓化合物及其制备方法
AU2019214891A1 (en) 2018-01-30 2020-08-20 Apnimed, Inc. (Delaware) Methods and compositions for treating sleep apnea
JP2021104931A (ja) * 2018-02-22 2021-07-26 大日本住友製薬株式会社 含窒素複素環を有するジベンゾアゼピン誘導体
CN110627735A (zh) * 2018-06-25 2019-12-31 江阴安博生物医药有限公司 一种新的喹硫平类似物及其制备方法和应用
SG11202102349PA (en) 2018-09-28 2021-04-29 Karuna Therapeutics Inc Compositions and methods for treating disorders ameliorated by muscarnic receptor activation
KR20220084369A (ko) 2019-10-21 2022-06-21 알라이리온, 인크. 수면 장애의 치료를 위한 H1 및 5-HT2A-수용체 조정제로서의 3-(4-(11H-디벤조[b,e][1,4]아제핀-6-일)피페라진-1-일)- 및 3-(4-(디벤조[b,f][1,4]옥사제핀/티아제핀/디아제핀-11-일)피페라진-1-일)-프로판산 유도체
CN112358455B (zh) * 2020-11-16 2022-07-19 吉林奥来德光电材料股份有限公司 一种二苯并七元杂环类化合物及其制备方法与应用
TWI820605B (zh) * 2022-02-18 2023-11-01 國立臺灣大學 抗菌化合物、其製備方法及其用途

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR870763A (fr) 1939-12-19 1942-03-24 Zeiss Ikon Ag Procédé destiné à faire disparaître les bruits produits par les boucles du film dans les appareils de prise de vues et de reproduction, en particulier pour la priseet la reproduction de films sonores
CH240228A (de) 1944-07-28 1945-12-15 Ciba Geigy Schaumisoliermasse auf Kunstharzbasis.
FR939591A (fr) 1946-01-09 1948-11-18 Philips Nv Récepteur de télévision
FR939595A (fr) 1947-01-08 1948-11-18 Perfectionnements apportés aux tuiles à recouvrement en matériaux de toute nature
FR51M (pt) 1960-06-03 1960-11-28
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
FR1334944A (fr) * 1961-08-11 1963-08-16 Wander Ag Dr A Procédé de préparation d'amidines de la série des 5-dibenzo-[b,e] [1,4]-diazépines
DE1470416A1 (de) * 1962-05-25 1969-05-14 Wander Ag Dr A Verfahren zur Herstellung ll-basisch substituierter 5 H-Dibenzo[b,e],[1,4] diazepine
CH476743A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe
NL140242B (nl) * 1963-03-01 1973-11-15 Wander Ag Dr A Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen.
US3389139A (en) 1963-06-14 1968-06-18 Wander Ag Dr A 6-homopiperazino and piperazinomorphanthridines
GB1006156A (en) 1963-06-14 1965-09-29 Wander Ag Dr A 6-basic substituted morphanthridines
US3908010A (en) 1967-03-22 1975-09-23 Wander Ag Dr A Basically substituted heterocycles as anti-emetics
US3884920A (en) 1967-07-14 1975-05-20 Sandoz Ag 11-Basically substituted dibenz {8 b,f{9 {0 {8 1,4{9 {0 oxazepines
AT252925B (de) 1964-05-27 1967-03-10 Wander Ag Dr A Verfahren zur Herstellung neuer 11-basisch substituierter Dibenz[b,f][1,4]oxazepine
US3412193A (en) 1965-12-13 1968-11-19 American Cyanamid Co 11-(4-methyl-1-piperazinyl)dibenz[b, f][1, 4]oxazepines or thiazepines for controlling fertility
US3444169A (en) 1966-01-17 1969-05-13 American Cyanamid Co Process for 11 - aminodibenz(b,f)(1,4)oxazepines and analogous thiazepines
GB1184251A (en) 1966-04-15 1970-03-11 American Cyanamid Co Oxazepines and Thiazepines
GB1192812A (en) 1966-05-20 1970-05-20 American Cyanamid Co 2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts
NL6715650A (pt) 1966-12-16 1968-06-17
GB1177956A (en) 1966-12-23 1970-01-14 American Cyanamid Co Production of Oxazepines and Thiazepines
CA979441A (en) 1967-02-27 1975-12-09 American Cyanamid Company 11-(piperazinyl) dibenz (b,f) (1,4) oxazepines and analogous thiazepines
CH517759A (de) 1967-03-13 1972-01-15 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenz(b,f)-1,4-oxazepine und Dibenzo(b,e)-1,4-diazepine
US3852446A (en) 1967-03-13 1974-12-03 Sandoz Ag Organic compounds in treatment of psychotic disturbances
IL29571A (en) 1967-03-13 1972-04-27 Wander Ag Dr A 11-substituted dibenzo(b,f)-1,4-oxazepines,dibenzo(b,f)-1,4-thiazepines and dibenzo(b,e)-1,4-diazepines and their preparation
US3758479A (en) 1967-03-22 1973-09-11 Sandoz Ag Nitro and sulphamoyl substituted dibenzodiazepines
US3751415A (en) 1967-03-22 1973-08-07 Sandoz Ag 2-nitro-11-(1-piperazinyl)-dibenz(b,f)(1,4)oxazepines
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
CA918659A (en) 1969-07-31 1973-01-09 Yoshitomi Pharmaceutical Industries 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
NL7110453A (pt) 1970-08-06 1972-02-08 Wander Ag Dr A
US3660406A (en) 1970-10-26 1972-05-02 American Cyanamid Co 2-chloro-7-hydroxy-11-(1-piperazinyl)dibenz(b f)(1 4)oxazepines
CH555856A (de) 1971-05-04 1974-11-15 Hoffmann La Roche Verfahren zur herstellung von tricyclischen verbindungen.
US3962248A (en) 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
CH569731A5 (pt) 1972-04-04 1975-11-28 Wander Ag Dr A
CH585222A5 (en) 1973-02-14 1977-02-28 Wander Ag Dr A Prepn. of antipsychotic heterocyclic piperazine derivs. - by reaction of heterocyclic ketones with metal piperazine complexes
NL7403657A (pt) * 1973-03-23 1974-09-25
US3983234A (en) 1974-07-04 1976-09-28 Sandoz Ltd. Treatment of dyskinesias
DE2625258A1 (de) 1975-06-06 1976-12-09 Hoffmann La Roche Dibenzo eckige klammer auf b,f eckige klammer zu thiepinderivat
DE2641378A1 (de) 1975-09-24 1977-04-07 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
US4045445A (en) 1975-12-14 1977-08-30 American Cyanamid Company 11-(4-Piperidyl)dibenzo-diazepines
CS179793B1 (en) 1976-02-13 1977-11-30 Miroslav Protiva Biological derivative of 11-/4-methylpiperazino/-5h-dib)nzo/b,e/-1,4-diazepine
CH601288A5 (en) 1976-06-09 1978-07-14 Sandoz Ag 11-Piperazino-5H-di:benzodiazepine derivs.
US4406900A (en) 1976-11-10 1983-09-27 Sandoz Ltd. Neuroleptic use of morphanthridines
CH624682A5 (pt) 1976-11-10 1981-08-14 Sandoz Ag
US4191760A (en) 1977-02-23 1980-03-04 Abbott Laboratories Dibenzodiazepines
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines
US4096261A (en) 1977-02-23 1978-06-20 Abbott Laboratories Dibenzodiazepines
DD133235A1 (de) 1977-10-10 1978-12-20 Carla Rueger Verfahren zur herstellung von in 11-stellung basisch substituierten 5h-dibenzo eckige klammer auf b,e eckige klammer zu eckige klammer auf 1,4 eckige klammer zu diazepinen
CS196893B1 (en) 1977-12-22 1980-04-30 Miroslav Protiva 3-fluor-10-piperazino-8-substituted 10,11-dihydro-dibenzothiepines
US4263207A (en) 1978-08-01 1981-04-21 Merck & Co., Inc. 10,11-Dihydrodibenzo[b,f][1,4]thiazepine carboxylic acids esters and amides thereof
US4404137A (en) 1979-10-16 1983-09-13 Lilly Industries Limited Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4764616A (en) 1983-05-18 1988-08-16 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
US4663453A (en) 1983-05-18 1987-05-05 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepines having dopamine receptor activity
GB8607684D0 (en) * 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
JPH04211071A (ja) 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
BE1004596A4 (fr) 1990-09-26 1992-12-22 Therabel Res S A N V Derives de methylpiperazinoazepine, leur preparation et leur utilisation.
US5817655A (en) * 1991-04-23 1998-10-06 Eli Lilly And Company Methods of treatment using a thieno-benzodiazepine
US5300422A (en) 1991-12-04 1994-04-05 Case Western Reserve University Screening method for controlling agranulocytosis
US5393752A (en) 1992-05-26 1995-02-28 Therabel Research S.A./N.V. Methylpiperazinoazepine compounds, preparation and use thereof
WO1994026107A1 (en) 1993-05-13 1994-11-24 New York University Psychosis protecting nucleic acid, peptides, compositions and method of use
US5354747A (en) 1993-06-16 1994-10-11 G. D. Searle & Co. 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9- and/or 10-substituted dibenzoxazepine and dibenzthiazepine compounds, pharmaceutical compositions and methods of use
IL110298A (en) 1993-07-13 1999-04-11 Brann Mark Robert Identification of ligands by selective amplification of cells transfected with receptors
US5538965A (en) 1993-12-23 1996-07-23 Allelix Biopharmaceuticals Inc. Dopamine receptor ligands
US6566065B1 (en) 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
GB2292685A (en) 1994-07-27 1996-03-06 Sankyo Co Allosteric effectors at muscarinic receptors
US5602120A (en) 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. Benzyl-substituted compounds having dopamine receptor affinity
US5700445A (en) 1994-12-12 1997-12-23 Allelix Biopharmaceuticals, Inc. N-methyl piperazine compounds having dopamine receptor affinity
US5602124A (en) 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
US5602121A (en) 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. Alkyl-substituted compounds having dopamine receptor affinity
SE9500998D0 (sv) 1995-03-19 1995-03-19 Haakan Wilhelm Wikstroem New sulfone ester analogues of iso-clozapine and related structures: atypical neuroleptics
GB9617305D0 (en) 1996-08-17 1996-09-25 Glaxo Wellcome Spa Heterocyclic compounds
CN1249051C (zh) 2000-04-28 2006-04-05 阿卡蒂亚药品公司 毒蕈碱性激动剂
WO2002060870A2 (en) 2000-11-17 2002-08-08 Adolor Corporation Delta agonist analgesics
JP2005533009A (ja) * 2002-03-28 2005-11-04 イーライ・リリー・アンド・カンパニー ピペラジン置換されたアリールベンゾジアゼピン類およびそのドーパミン受容体アンタゴニストとしての精神病性障害の処置のための使用
MXPA05002884A (es) 2002-09-18 2005-06-22 Fmc Corp Derivados triciclicos insecticidas.
AU2003290079A1 (en) 2002-12-20 2004-07-14 Basf Aktiengesellschaft Pesticidal dibenzo(hetero)azepine derivatives
JP2006515628A (ja) 2003-01-23 2006-06-01 アカディア ファーマシューティカルズ，インコーポレーテッド ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
US20050085463A1 (en) 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050250767A1 (en) 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20070275957A1 (en) 2003-01-23 2007-11-29 Weiner David M Use of n-desmethylclozapine to treat human neuropsychiatric disease
WO2004073639A2 (en) 2003-02-19 2004-09-02 Merck & Co. Inc. Treatment of psychosis with a muscarinic m1 receptor ectopic activator
SG133606A1 (en) 2003-12-22 2007-07-30 Acadia Pharm Inc Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
EP2357474A1 (en) 2004-02-20 2011-08-17 Dainippon Sumitomo Pharma Co., Ltd. Lurasidone for use in the treatment of memory or learning dysfunction by schizophrenia
CA2560671A1 (en) 2004-04-01 2006-01-05 Acadia Pharmaceuticals Inc. Crystalline forms of n-desmethylclozapine
US20060063754A1 (en) 2004-09-21 2006-03-23 Edgar Dale M Methods of treating a sleep disorder
DK1804804T3 (da) 2004-09-21 2012-02-20 Hypnion Inc 3-[4-(dibenzo[b,f][1,4]oxazepin-11-yl)-piperazin-1-yl]-2,2-dimethylpropansyre til anvendelse ved behandlingen af søvnforstyrrelser
AU2006231497A1 (en) 2005-04-04 2006-10-12 Acadia Pharmaceuticals Inc. Use of N-desmethylclozapine and related compounds as dopamine stabilizing agents
US20070105836A1 (en) 2005-10-31 2007-05-10 Lars Pettersson Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders

Also Published As

Publication number Publication date
IL176447A0 (en) 2006-10-05
EP2088147A1 (en) 2009-08-12
US20050192268A1 (en) 2005-09-01
ATE426405T1 (de) 2009-04-15
ES2324713T3 (es) 2009-08-13
US20060199798A1 (en) 2006-09-07
SG133606A1 (en) 2007-07-30
JP2007534656A (ja) 2007-11-29
PL1696931T3 (pl) 2009-10-30
WO2005063254A2 (en) 2005-07-14
US7622461B2 (en) 2009-11-24
HK1095092A1 (en) 2007-04-27
EP1696931B1 (en) 2009-03-25
KR101157881B1 (ko) 2012-07-06
AU2004308955A1 (en) 2005-07-14
US20100129473A1 (en) 2010-05-27
US20070197502A1 (en) 2007-08-23
CY1109171T1 (el) 2014-07-02
EP1696931A2 (en) 2006-09-06
AU2004308955B2 (en) 2011-08-04
PT1696931E (pt) 2009-06-12
MXPA06007244A (es) 2006-08-18
BRPI0417749A (pt) 2007-04-10
CN101962369A (zh) 2011-02-02
NZ547911A (en) 2010-06-25
US7550454B2 (en) 2009-06-23
DK1696931T3 (da) 2009-06-29
CA2550735A1 (en) 2005-07-14
KR20060128943A (ko) 2006-12-14
DE602004020263D1 (de) 2009-05-07
WO2005063254A3 (en) 2005-09-15
SI1696931T1 (sl) 2009-08-31
US20060194784A1 (en) 2006-08-31
US7491715B2 (en) 2009-02-17
US7517871B2 (en) 2009-04-14

Similar Documents

Publication Publication Date Title
NO20063371L (no) Aminosubstituerte diaryl[a,d]cykloheptenanaloger som muscarinagonister og fremgangsmater for behandling av neuropsykiatriske lidelser
NO2020010I1 (no) fostamatinib eller et farmasøytisk akseptabelt salt av fostamatinib, eller et hydrat, solvat eller N-oksid av fostamatinib eller det farmasøytisk akseptable saltet av fostamatinib, spesielt fostamatinib dinatrium, eventuelt på form av et hydrat
WO2008021463A3 (en) Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
DK1525177T3 (da) Substituerede 1,3-diphenylprop-2-en-1-on-derivater, fremstilling og anvendelse deraf
WO2002074758A3 (en) Novel amines as histamine-3 receptor ligands and their therapeutic applications
DK1663206T3 (da) 1-(2,3-dimethyl-phenyl)-ethyl-1,3-dihydro-imizadol-2-thion som ikke-sedativ alpha 2A-agonist
IS7857A (is) Setnar pýrróló-pýrasól afleiður sem kínasa hindrar
SE0202241D0 (sv) Novel Compounds
AP2004003123A0 (en) Thiazole and oxazole derivatives that modulate PPAR activity
NO976074D0 (no) To- og treverdige småmolekylinhibitorer for selektin
NO20062599L (no) Fremgangsmate for syntese av perindopril og farmasoytisk akseptable salter derav
DK1246625T3 (da) Anvendelser og sammensætninger af nitratestere til tilvejebringelse af sedering
BR0211063A (pt) Sais de derivados anticonvulsivantes
HRP20050075A2 (en) Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure
DK0812831T3 (da) Benzimidazolderivater og deres anvendelse som antagonister for corticotropinfrigørende faktor
IT1318535B1 (it) Processo per la preparazione di sali farmaceuticamente accettabili di(ss,rs)-s-adenosil-l-metionina.
PT2112154E (pt) Ésteres na posição 20 de camptotecinas
WO2003057213A3 (en) Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor
ITMI20010077A1 (it) Procedimento per la produzione dell'imipenem
EA200300272A1 (ru) Новые производные хиназолина, способ их получения и фармацевтические композиции, содержащие их
DE602006003204D1 (de) Reinigungsverfahren von Moxonidine
MY139348A (en) Method for synthesis of perindopril and its pharmaceutically acceptable salts
ATE330956T1 (de) Bizyklisch substituierte 4- aminopyridopyrimidinderivate
DE60300683D1 (de) Prucaloprid-n-oxid
EE200400016A (et) Protsess 1,5-diarüül-3-trifluorometüül-delta²-pürasoliinide ratseemiliste ja enantiomeerselt puhaste derivaatide valmistamiseks

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application