WO2008021463A3 - Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders - Google Patents

Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders Download PDF

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Publication number
WO2008021463A3
WO2008021463A3 PCT/US2007/018201 US2007018201W WO2008021463A3 WO 2008021463 A3 WO2008021463 A3 WO 2008021463A3 US 2007018201 W US2007018201 W US 2007018201W WO 2008021463 A3 WO2008021463 A3 WO 2008021463A3
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WO
WIPO (PCT)
Prior art keywords
analogs
methods
cycloheptene
treatment
amino substituted
Prior art date
Application number
PCT/US2007/018201
Other languages
French (fr)
Other versions
WO2008021463A2 (en
Inventor
Fredrik Ek
Roger Olsson
Jorgen Ohlsson
Original Assignee
Acadia Pharm Inc
Fredrik Ek
Roger Olsson
Jorgen Ohlsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc, Fredrik Ek, Roger Olsson, Jorgen Ohlsson filed Critical Acadia Pharm Inc
Publication of WO2008021463A2 publication Critical patent/WO2008021463A2/en
Publication of WO2008021463A3 publication Critical patent/WO2008021463A3/en
Priority to US12/370,560 priority Critical patent/US20090239840A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.
PCT/US2007/018201 2003-12-22 2007-08-15 Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders WO2008021463A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/370,560 US20090239840A1 (en) 2003-12-22 2009-02-12 AMINO SUBSTITUTED DIARYL[a,d]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83805606P 2006-08-15 2006-08-15
US60/838,056 2006-08-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/019,555 Continuation US7550454B2 (en) 2003-12-22 2004-12-21 Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders

Publications (2)

Publication Number Publication Date
WO2008021463A2 WO2008021463A2 (en) 2008-02-21
WO2008021463A3 true WO2008021463A3 (en) 2008-12-24

Family

ID=38819733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/018201 WO2008021463A2 (en) 2003-12-22 2007-08-15 Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders

Country Status (1)

Country Link
WO (1) WO2008021463A2 (en)

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CA2746220A1 (en) 2008-12-08 2010-07-08 Vm Pharma Llc Compositions of protein receptor tyrosine kinase inhibitors
US8999992B2 (en) 2013-03-15 2015-04-07 Vm Pharma Llc Crystalline forms of tryosine kinase inhibitors and their salts
ES2754385T3 (en) 2013-04-23 2020-04-17 Esteve Pharmaceuticals Sa Pyrazine- [1,2-a] indole compounds, their preparation and use in medicinal products
RU2610169C2 (en) 2014-09-11 2017-02-08 Общество С Ограниченной Ответственностью "Валентек" Derivatives of 7-fluoro-8-chloro-5h-dibenzo [b, e] [1, 4] diazepine and their application
MX2017003439A (en) 2014-09-17 2017-12-04 Mundipharma International Corporation Ltd Crystalline forms of tyrosine kinase inhibitors and their salts.
TW201831462A (en) * 2017-01-25 2018-09-01 日商大日本住友製藥股份有限公司 Dibenzodiazepine derivative
CN107903244B (en) * 2017-11-29 2019-06-14 武汉珈创生物技术股份有限公司 2- amido with anti-tumor activity replaces Benzodiazepine compound and preparation method thereof
CN108586364B (en) * 2017-12-28 2021-11-09 新乡医学院 Dibenzoazepine compound and preparation method and application thereof
JP2021104931A (en) * 2018-02-22 2021-07-26 大日本住友製薬株式会社 Dibenzoazepine derivative having nitrogen-containing heterocycle
AU2020370063A1 (en) 2019-10-21 2022-06-02 Alairion, Inc. 3-(4-(llH-dibenzo[b,e][l,4]azepin-6- yl)piperazin-l-yl)- and 3- (4-(dibenzo[b,f][l,4]oxazepin/thiazepin/diazepin-11-yl)piperazin-1-yl)-propano ic acid derivatives as HI and 5- HT2A-receptor modulators for the treatment of sleep disorders

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH493538A (en) * 1966-12-16 1970-07-15 American Cyanamid Co 11-aminodibenz b f 1 4-oxa-thia-or dia-zepines
US3546226A (en) * 1963-03-01 1970-12-08 A Wander Sa Dr 11-basic-substituted dibenzoxazepines
FR2222102A1 (en) * 1973-03-23 1974-10-18 Wander Ag Dr A 11-Piperazino dibenzo diazepines neuroleptics - and anti-depressants, prepd. from a dibenzo diazepin-11-one and a piperazine
WO2005002586A1 (en) * 2003-07-02 2005-01-13 Astrazeneca Ab Metabolite of quetiapine
WO2005063254A2 (en) * 2003-12-22 2005-07-14 Acadia Pharmaceuticals Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2006107948A2 (en) * 2005-04-04 2006-10-12 Acadia Pharmaceuticals Inc. Use of n-desmethylclozapine and related compounds as dopamine stabilizing agents
WO2007062337A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Crystalline forms
WO2007062339A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Liquid formulations
WO2007062338A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Solid formulations
WO2007062336A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Salt forms
WO2008066620A2 (en) * 2006-10-20 2008-06-05 Concert Pharmaceuticals Inc. Dibenzothiazepine derivatives

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546226A (en) * 1963-03-01 1970-12-08 A Wander Sa Dr 11-basic-substituted dibenzoxazepines
CH493538A (en) * 1966-12-16 1970-07-15 American Cyanamid Co 11-aminodibenz b f 1 4-oxa-thia-or dia-zepines
FR2222102A1 (en) * 1973-03-23 1974-10-18 Wander Ag Dr A 11-Piperazino dibenzo diazepines neuroleptics - and anti-depressants, prepd. from a dibenzo diazepin-11-one and a piperazine
WO2005002586A1 (en) * 2003-07-02 2005-01-13 Astrazeneca Ab Metabolite of quetiapine
WO2005063254A2 (en) * 2003-12-22 2005-07-14 Acadia Pharmaceuticals Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2006107948A2 (en) * 2005-04-04 2006-10-12 Acadia Pharmaceuticals Inc. Use of n-desmethylclozapine and related compounds as dopamine stabilizing agents
WO2007062337A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Crystalline forms
WO2007062339A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Liquid formulations
WO2007062338A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Solid formulations
WO2007062336A2 (en) * 2005-11-18 2007-05-31 Astrazeneca Ab Salt forms
WO2008066620A2 (en) * 2006-10-20 2008-06-05 Concert Pharmaceuticals Inc. Dibenzothiazepine derivatives

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