WO2003057213A3 - Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor - Google Patents

Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor Download PDF

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Publication number
WO2003057213A3
WO2003057213A3 PCT/US2002/041637 US0241637W WO03057213A3 WO 2003057213 A3 WO2003057213 A3 WO 2003057213A3 US 0241637 W US0241637 W US 0241637W WO 03057213 A3 WO03057213 A3 WO 03057213A3
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WO
WIPO (PCT)
Prior art keywords
cycloheptapyrazole
cyclohexano
ht2c receptor
derivative compounds
diseases associated
Prior art date
Application number
PCT/US2002/041637
Other languages
French (fr)
Other versions
WO2003057213A2 (en
Inventor
Gaetan H Ladouceur
Emil Velthuisen
Soongyou Choi
Yamin Wang
Jeremy L Baryza
Philip Coish
James H Ii Cook
Original Assignee
Bayer Pharmaceuticals Corp
Gaetan H Ladouceur
Emil Velthuisen
Soongyou Choi
Yamin Wang
Jeremy L Baryza
Philip Coish
James H Ii Cook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharmaceuticals Corp, Gaetan H Ladouceur, Emil Velthuisen, Soongyou Choi, Yamin Wang, Jeremy L Baryza, Philip Coish, James H Ii Cook filed Critical Bayer Pharmaceuticals Corp
Priority to AU2002360819A priority Critical patent/AU2002360819A1/en
Publication of WO2003057213A2 publication Critical patent/WO2003057213A2/en
Publication of WO2003057213A3 publication Critical patent/WO2003057213A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Disclosed are cyclohexano- and cycloheptapyrazole derivative compounds or purified stereoisomers or stereoisomer mixtures of said compounds and their salts or prodrug forms thereof which have structural formulas (I), (Ia), (II) or (IIa): wherein the variables R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful for the treatment or prevention of diseases and/or behaviors involving the 5-HT2C receptor.
PCT/US2002/041637 2001-12-28 2002-12-28 Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor WO2003057213A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002360819A AU2002360819A1 (en) 2001-12-28 2002-12-28 Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34415001P 2001-12-28 2001-12-28
US60/344,150 2001-12-28

Publications (2)

Publication Number Publication Date
WO2003057213A2 WO2003057213A2 (en) 2003-07-17
WO2003057213A3 true WO2003057213A3 (en) 2004-02-19

Family

ID=23349268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/041637 WO2003057213A2 (en) 2001-12-28 2002-12-28 Cyclohexano- and cycloheptapyrazole derivative compounds, for use in diseases associated with the 5-ht2c receptor

Country Status (2)

Country Link
AU (1) AU2002360819A1 (en)
WO (1) WO2003057213A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2004000826A1 (en) 2003-04-25 2005-03-04 Pfizer USE OF AN AGONIST FOR THE 5-HT2C RECEPTOR TO PREPARE A USEFUL MEDICINAL PRODUCT IN THE TREATMENT OF URINARY INCONTINENCE CAUSED BY STRESS, WITH THE CONDITION THAT THE AGONIST IS NOT 1- [6-CHLORINE-5- (TRIFLUOROMETIL) -2- PIRIDINIL] PIPERAZINA (ORG-129
US20080125403A1 (en) 2004-04-02 2008-05-29 Merck & Co., Inc. Method of Treating Men with Metabolic and Anthropometric Disorders
WO2006022420A1 (en) 2004-08-25 2006-03-02 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
US7622492B2 (en) * 2005-08-31 2009-11-24 Hoffmann-La Roche Inc. Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase
ES2329413T3 (en) 2005-11-30 2009-11-25 F. Hoffmann-La Roche Ag 3-AMINO-2-ARILPROPIL AZAINDOLES AND USES OF THE SAME.
KR20080072753A (en) 2005-11-30 2008-08-06 에프. 호프만-라 로슈 아게 3-amino-1-arylpropyl indoles and aza-substituted indoles
WO2007132841A1 (en) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
US7897595B2 (en) 2006-05-26 2011-03-01 Forest Laboratories Holdings Limited Pyridoazepine derivatives
CA2668491A1 (en) * 2006-11-03 2008-05-08 Glenmark Pharmaceuticals S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and processes for their preparation
WO2009063992A1 (en) 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited Condensed pyridine derivative and use thereof
JPWO2011071136A1 (en) 2009-12-11 2013-04-22 アステラス製薬株式会社 Fibromyalgia treatment
CA2788762C (en) * 2010-04-08 2018-04-10 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A. Tricyclic indazole compound, method of preparation and pharmaceutical composition containing it
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030548A1 (en) * 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. 5-HT2c RECEPTOR AGONISTS AND AMINOALKYLINDAZOLE DERIVATIVES
WO2000012481A2 (en) * 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity________________
EP0990650A1 (en) * 1997-06-13 2000-04-05 Yamanouchi Pharmaceutical Co. Ltd. Tricyclic pyrrole or pyrazole derivatives
WO2001070702A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2001083487A1 (en) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Froindazole derivative
WO2002098350A2 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998030548A1 (en) * 1997-01-13 1998-07-16 Yamanouchi Pharmaceutical Co., Ltd. 5-HT2c RECEPTOR AGONISTS AND AMINOALKYLINDAZOLE DERIVATIVES
EP0990650A1 (en) * 1997-06-13 2000-04-05 Yamanouchi Pharmaceutical Co. Ltd. Tricyclic pyrrole or pyrazole derivatives
WO2000012481A2 (en) * 1998-09-01 2000-03-09 Vernalis Research Limited Indazole derivatives with 5-ht2 receptor activity________________
WO2001070702A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. 6-hydroxy-indazole derivatives for treating glaucoma
WO2001083487A1 (en) * 2000-04-28 2001-11-08 Yamanouchi Pharmaceutical Co., Ltd. Froindazole derivative
WO2002098350A2 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
AINSWORTH ET AL.: "Substituted Aminoethylindazoles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 80, 1958, pages 965 - 967, XP002237633 *

Also Published As

Publication number Publication date
AU2002360819A8 (en) 2003-07-24
AU2002360819A1 (en) 2003-07-24
WO2003057213A2 (en) 2003-07-17

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