NO20033538D0 - Nytt suksinatsalt av O-desmetyl-venlafaxine - Google Patents
Nytt suksinatsalt av O-desmetyl-venlafaxineInfo
- Publication number
- NO20033538D0 NO20033538D0 NO20033538A NO20033538A NO20033538D0 NO 20033538 D0 NO20033538 D0 NO 20033538D0 NO 20033538 A NO20033538 A NO 20033538A NO 20033538 A NO20033538 A NO 20033538A NO 20033538 D0 NO20033538 D0 NO 20033538D0
- Authority
- NO
- Norway
- Prior art keywords
- desmethyl
- venlafaxine
- fresh
- succinate salt
- succinate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26821401P | 2001-02-12 | 2001-02-12 | |
US29796301P | 2001-06-13 | 2001-06-13 | |
PCT/US2002/004103 WO2002064543A2 (en) | 2001-02-12 | 2002-02-11 | Novel succinate salt of o-desmethyl-venlafaxine |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20033538L NO20033538L (no) | 2003-08-11 |
NO20033538D0 true NO20033538D0 (no) | 2003-08-11 |
NO328807B1 NO328807B1 (no) | 2010-05-18 |
Family
ID=26952945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20033538A NO328807B1 (no) | 2001-02-12 | 2003-08-11 | Nytt suksinatsalt av O-desmetyl-venlafaxine, fremgangsmate for fremstilling av disse, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikament for behandling av sykdom |
Country Status (31)
Country | Link |
---|---|
US (5) | US6673838B2 (no) |
EP (3) | EP2319826A1 (no) |
JP (1) | JP4220243B2 (no) |
KR (1) | KR100875610B1 (no) |
CN (2) | CN101671260A (no) |
AR (2) | AR032671A1 (no) |
AT (1) | ATE369330T1 (no) |
AU (1) | AU2002250058B2 (no) |
BR (1) | BR0207157A (no) |
CA (2) | CA2436668C (no) |
CY (1) | CY1106952T1 (no) |
DE (1) | DE60221642T3 (no) |
DK (1) | DK1360169T3 (no) |
EA (1) | EA011451B1 (no) |
ES (1) | ES2290281T5 (no) |
HK (1) | HK1057885A1 (no) |
HN (1) | HN2002000030A (no) |
HU (1) | HUP0303128A3 (no) |
IL (4) | IL157340A0 (no) |
MX (1) | MXPA03007043A (no) |
NO (1) | NO328807B1 (no) |
NZ (1) | NZ539791A (no) |
PA (1) | PA8539901A1 (no) |
PE (1) | PE20020877A1 (no) |
PL (2) | PL212943B1 (no) |
PT (1) | PT1360169E (no) |
SI (1) | SI1360169T1 (no) |
TW (1) | TWI318201B (no) |
UY (1) | UY27175A1 (no) |
WO (1) | WO2002064543A2 (no) |
ZA (1) | ZA200307116B (no) |
Families Citing this family (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1317012A (zh) | 1998-10-30 | 2001-10-10 | 味之素株式会社 | 稳定性优良的天冬甜素衍生物晶体的结晶方法 |
US6342533B1 (en) * | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
PL350924A1 (en) * | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
KR100875610B1 (ko) * | 2001-02-12 | 2008-12-26 | 와이어쓰 | O-데스메틸-벤라팍신의 신규한 석시네이트 염 |
US20050244498A1 (en) * | 2001-09-14 | 2005-11-03 | Biovail Laboratories, Inc. | Modified-release compositions of at least one form of venlafaxine |
UA80543C2 (en) * | 2001-12-04 | 2007-10-10 | Wyeth Corp | Method for the preparation of o-desmethylvenlafaxine |
AU2003219117A1 (en) * | 2002-03-28 | 2003-10-13 | Synthon B.V. | Extended release venlafaxine formulations |
RU2004139075A (ru) * | 2002-06-10 | 2005-06-27 | Уайт (Us) | Новые формиат 0-десметилвенлафаксина |
WO2004019948A1 (en) * | 2002-08-29 | 2004-03-11 | Arachnova Therapeutics Ltd. | New therapeutic uses of (4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl) thieno[2,3-d]pyrimidine |
US7345096B2 (en) * | 2002-10-15 | 2008-03-18 | Wyeth | Use of norepinephrine reuptake modulators for preventing and treating vasomotor symptoms |
PL1628685T3 (pl) | 2003-04-25 | 2011-05-31 | Gilead Sciences Inc | Przeciwwirusowe analogi fosfonianowe |
JP2004359665A (ja) * | 2003-05-30 | 2004-12-24 | Rohm & Haas Co | 生体利用性増強剤を含有する治療組成物 |
US7365076B2 (en) | 2003-10-14 | 2008-04-29 | Wyeth | Substituted aryl cycloalkanol derivatives and methods of their use |
US7524846B2 (en) | 2003-10-14 | 2009-04-28 | Wyeth | Arylalkyl- and cycloalkylalkyl-piperazine derivatives and methods of their use |
US7491723B2 (en) | 2003-10-14 | 2009-02-17 | Wyeth | Alkanol and cycloalkanol-amine derivatives and methods of their use |
US7402698B2 (en) | 2003-10-14 | 2008-07-22 | Wyeth | Secondary amino-and cycloamino-cycloalkanol derivatives and methods of their use |
US7531543B2 (en) | 2003-10-14 | 2009-05-12 | Wyeth | Phenylpiperazine cycloalkanol derivatives and methods of their use |
US7419980B2 (en) | 2003-10-14 | 2008-09-02 | Wyeth | Fused-aryl and heteroaryl derivatives and methods of their use |
US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
EP1711167A1 (en) * | 2004-02-06 | 2006-10-18 | Wyeth | Multiparticulate o-desmethylvenlafaxine salts and uses thereof |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7439280B2 (en) * | 2004-04-06 | 2008-10-21 | Basf Corporation | Lignocellulosic composite material and method for preparing the same |
CN101410106A (zh) * | 2004-07-22 | 2009-04-15 | 惠氏公司 | 治疗神经系统障碍和病症的方法 |
EP1773321A2 (en) * | 2004-07-22 | 2007-04-18 | Wyeth | Method for treating nervous system disorders and conditions |
MX2007000851A (es) * | 2004-07-22 | 2007-03-26 | Wyeth Corp | Procedimiento para el tratamiento de trastornos y dolencias del sistema nervioso. |
DK1778251T3 (da) | 2004-07-27 | 2011-07-18 | Gilead Sciences Inc | Nukleosidphosphatkonjugater som anti-HIV-midler |
US20060228413A1 (en) * | 2005-02-28 | 2006-10-12 | Penwest Pharmaceuticals Co. | Controlled release venlafaxine formulations |
CN101151026A (zh) * | 2005-03-31 | 2008-03-26 | 惠氏公司 | O-去甲文拉法辛和巴泽昔芬联合产品及其应用 |
CN1955159B (zh) | 2005-06-17 | 2010-11-24 | 山东绿叶制药有限公司 | 用于阻断5-羟色胺以及去甲基肾上腺素再摄取的化合物,其制备方法及其用途 |
JP2009500420A (ja) * | 2005-07-06 | 2009-01-08 | セプラコア インコーポレーテッド | エスゾピクロン及びo−デスメチルベンラファキシンの組み合わせ、並びに閉経期並びに気分、不安、及び認知障害の治療方法 |
US7595340B2 (en) | 2005-07-15 | 2009-09-29 | Wyeth | Serotonin and norepinephrine reuptake inhibitor and uses thereof |
CA2615362A1 (en) * | 2005-07-15 | 2007-01-25 | Wyeth | Highly selective serotonin and norepinephrine dual reuptake inhibitor and use thereof |
US7687520B2 (en) | 2005-07-15 | 2010-03-30 | Wyeth Llc | Serotonin and norepinephrine reuptake inhibitors and uses thereof |
WO2007013936A2 (en) * | 2005-07-21 | 2007-02-01 | Wyeth | Method for treating nervous system disorders and conditions |
GT200600397A (es) * | 2005-09-07 | 2007-08-28 | Formulas topicas conteniendo o-desmetil venlafaxina (odv) o sus sales | |
GT200600396A (es) * | 2005-09-07 | 2007-04-23 | Dispositivos para la aplicacion de medicamentos transdermicos conteniendo o-desmetil venlafaxina (odv) o sus sales | |
CN1332946C (zh) * | 2005-10-21 | 2007-08-22 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 作用于中枢神经系统的前药 |
EP1954669B1 (en) | 2005-12-01 | 2015-07-08 | Auspex Pharmaceuticals, Inc. | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity |
CN101321741A (zh) * | 2005-12-05 | 2008-12-10 | 惠氏公司 | 选择性合成经取代1-(2-氨基-1-苯基-乙基)-环己醇的对映异构体的方法 |
EP1973866A1 (en) | 2005-12-20 | 2008-10-01 | Synthon B.V. | Process for making desvenlafaxine |
MX2007016179A (es) * | 2006-04-17 | 2008-03-11 | Teva Pharma | Formas cristalinas de o-desmetilvenlafaxina. |
WO2007120923A1 (en) | 2006-04-17 | 2007-10-25 | Teva Pharmaceutical Industries Ltd. | Substantially pure o-desmethylvenlafaxine and processes for preparing it |
SI2020996T1 (sl) * | 2006-05-16 | 2012-03-30 | Gilead Sciences Inc | Postopek in sestavki za zdravljenje hematološkihmalignosti |
US20090137846A1 (en) * | 2006-07-26 | 2009-05-28 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-Desmethylvenlafaxine |
US20090069601A1 (en) * | 2006-07-26 | 2009-03-12 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
EP1934168A2 (en) * | 2006-07-26 | 2008-06-25 | Teva Pharmaceutical Industries Ltd | Tridesmethylvenlafaxine and processes for the synthesis of o-desmethylvenlafaxine |
JP4763788B2 (ja) * | 2006-07-26 | 2011-08-31 | テバ ファーマシューティカル インダストリーズ リミティド | O−デスメチルベンラファキシンの合成方法 |
US20080221356A1 (en) * | 2006-07-26 | 2008-09-11 | Valerie Niddam-Hildesheim | Processes for the synthesis of O-desmethylvenlafaxine |
EP2061750A2 (en) * | 2006-08-04 | 2009-05-27 | Medichem, S.A. | Improved process for synthesizing desvenlafaxine free base and salts or solvates thereof |
WO2008017886A1 (en) * | 2006-08-08 | 2008-02-14 | Generics [Uk] Limited | Novel hydrate form of o-desmethyl venlafaxine succinate |
EP2074082A1 (en) * | 2006-10-18 | 2009-07-01 | Generics (UK) Limited | Polymorphs of o-desmethyl venlafaxine succinate |
CN101528667A (zh) * | 2006-10-25 | 2009-09-09 | 惠氏公司 | 分离得到的o-脱甲基文拉法辛的羟基和n-氧化物代谢物和衍生物以及治疗方法 |
EP2125786B1 (en) * | 2006-12-21 | 2011-03-16 | Pfizer Products Inc. | Succinate salt of 2-((4-(1-methyl-4-(pyridin-4-yl)-1h-pyrazol-3-yl) phenoxy)methyl)quinoline |
AR064507A1 (es) * | 2006-12-22 | 2009-04-08 | Medichem Sa | Nuevas formas solidas cristalinas de forma base de o-desvenlafaxina |
US7820716B2 (en) * | 2007-01-08 | 2010-10-26 | Mai De Ltd | Crystalline polymorphs of desvenlafaxine succinate and their preparations |
AR064987A1 (es) * | 2007-01-22 | 2009-05-06 | Medichem Sa | Proceso mejorado para sintetizar desvenlafaxina como base libre y sales o solvatos de la misma |
CA2672808A1 (en) * | 2007-01-31 | 2008-08-07 | Generics [Uk] Limited | Process for the preparation of o-desmethyl venlafaxine |
NZ579137A (en) * | 2007-02-21 | 2012-05-25 | Sunovion Pharmaceuticals Inc | Solid forms comprising (-)-o-desmethylvenlafaxine and uses thereof |
WO2008110338A1 (en) * | 2007-03-09 | 2008-09-18 | Synthon B.V. | Polymorph of desvenlafaxine succinate |
US20080234516A1 (en) * | 2007-03-14 | 2008-09-25 | Valerie Niddam-Hildesheim | Processes for preparing solid states of O-desmethylvenlafaxine succinate |
ES2605371T3 (es) | 2007-03-15 | 2017-03-14 | Auspex Pharmaceuticals, Inc. | D9-Venlafaxina deuterada |
US20090012182A1 (en) * | 2007-06-15 | 2009-01-08 | Alexandr Jegorov | Crystal forms of O-desmethylvenlafaxine succinate |
CA2692738A1 (en) * | 2007-07-12 | 2009-01-15 | Dr. Reddy's Laboratories, Ltd. | O-desmethylvenlafaxine |
WO2009010990A2 (en) * | 2007-07-16 | 2009-01-22 | Matrix Laboratories Limited | Process for the preparation of o-desmethylvenlafaxine succinate polymorphic forms |
WO2009017813A1 (en) * | 2007-08-02 | 2009-02-05 | Teva Pharmaceutical Industries Ltd. | O-desmethyl venlafaxine saccharinate |
US20090076162A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched desvenlafaxine |
CN101938998A (zh) * | 2007-10-16 | 2011-01-05 | 阿尔法制药有限公司 | 控释药物制剂 |
WO2009053840A2 (en) * | 2007-10-22 | 2009-04-30 | Actavis Group Ptc Ehf | Solid forms of (±)-o-desmethylvenlafaxine salts |
US20110118357A1 (en) * | 2007-10-26 | 2011-05-19 | Generics Limited | Process for preparing o-desmethylvenlafaxine |
EP2217562A2 (en) * | 2007-11-26 | 2010-08-18 | Teva Pharmaceutical Industries Ltd. | Crystal forms of o-desmethylvenlafaxine fumarate |
EP2085377A1 (en) | 2008-01-29 | 2009-08-05 | LEK Pharmaceuticals D.D. | Novel salts of O-desmethyl-venlafaxine |
WO2009114685A2 (en) * | 2008-03-12 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | O-desmethylvenlafaxine salts |
WO2009118758A2 (en) * | 2008-03-24 | 2009-10-01 | Sun Pharmaceutical Industries Ltd. | Novel crystalline forms of desvenlafaxine succinate |
IN2008CH00818A (no) * | 2008-04-01 | 2009-10-09 | Actavis Group Ptc Ehf | |
KR100965527B1 (ko) * | 2008-05-08 | 2010-06-23 | 제일약품주식회사 | 신규(4-(2-(디메틸아미노)-1-(1-하이드록시사이클로헥실)에틸)페녹시)포스페이트 또는 이의 약학적으로 허용가능한 염,이의 제조방법 및 이를 유효성분으로 함유하는 중추신경계질환 예방 및 치료용 조성물 |
EP2119695A1 (en) | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
EP2119696A1 (en) * | 2008-05-16 | 2009-11-18 | Krka | Preparation of O-desmethylvenlafaxine salts |
EP2297087A2 (en) * | 2008-06-16 | 2011-03-23 | Teva Pharmaceutical Industries Ltd. | Solid states of o-desmethylvenlaf axine salts |
CN102089318B (zh) | 2008-07-08 | 2014-05-21 | 吉里德科学公司 | Hiv抑制剂化合物的盐 |
US20100016638A1 (en) * | 2008-07-21 | 2010-01-21 | Zdenko Hamersak | Method for preparation of o-desmethylvenlafaxine using polythiolates |
AU2009275667A1 (en) * | 2008-07-30 | 2010-02-04 | Generics [Uk] Limited | Process for the preparation of O-desmethylvenlafaxine |
KR101041960B1 (ko) * | 2008-08-14 | 2011-06-16 | 주식회사 루미맥스테크놀러지 | 파워 led를 구비하는 램프 장치 |
EP2191822A1 (en) * | 2008-11-26 | 2010-06-02 | LEK Pharmaceuticals d.d. | Controlled release pharmaceutical compositions comprising O-desmethyl-venlafaxine |
CZ2008756A3 (cs) * | 2008-11-27 | 2010-03-24 | Zentiva, A. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
ES2343050B1 (es) * | 2008-12-16 | 2011-06-14 | Chemo Iberica, S.A. | Procedimiento para la preparacion de desvenlafaxina y sus sales de adicion de acido farmaceuticamente aceptables. |
CZ200969A3 (cs) | 2009-02-06 | 2010-06-30 | Zentiva, K.S. | Nové soli desvenlafaxinu a zpusob jejich prípravy |
CZ2009454A3 (cs) | 2009-07-15 | 2010-11-10 | Zentiva, K. S. | Zpusob prípravy desvenlafaxinu a jeho solí |
US9012689B2 (en) | 2009-07-16 | 2015-04-21 | Cipla Limited | Process for the preparation of O-desmethyl venlafaxine and intermediate for use therein |
US20110098506A1 (en) * | 2009-10-26 | 2011-04-28 | Intas Pharmaceuticals Limited | Method of preparing o-desmethylvenlafaxine |
WO2011072703A1 (en) | 2009-12-16 | 2011-06-23 | Pharmathen S.A. | Process for the preparation of o-desmethyl-venlafaxine and salts thereof |
US20110184067A1 (en) * | 2010-01-25 | 2011-07-28 | Intas Pharmaceuticals Ltd. | O-desmethylvenlafaxine succinate polymorph & process for preparing thereof |
KR101409554B1 (ko) | 2010-03-29 | 2014-06-19 | 플리바 흐르바츠카 디.오.오. | O-데스메틸벤라팍신 푸마레이트의 결정형 |
MX2012010659A (es) | 2010-03-31 | 2013-03-05 | Wockhardt Ltd | Composicion farmaceutica de liberacion modificada que comprende desvenlafaxina o sus sales. |
CZ303249B6 (cs) * | 2010-04-06 | 2012-06-20 | Zentiva, K.S. | Zpusob výroby 4-(2-(substituovaných)-1-(1-hydroxycyklohexyl)ethyl)fenolu O-demethylací jejich methyletheru pomocí nepáchnoucích aromatických thiolu |
CN102212014B (zh) * | 2010-04-09 | 2013-12-25 | 江苏豪森医药集团有限公司 | O-去甲基-文拉法辛的谷氨酸盐的晶型、其制备方法及其在医药上的应用 |
WO2011141791A2 (en) | 2010-05-14 | 2011-11-17 | Alembic Limited | Extended release formulations of desvenlafaxine base |
CN102249936B (zh) * | 2010-05-19 | 2014-09-17 | 江苏豪森医药集团有限公司 | O-去甲基文拉法辛盐酸盐的水合物及其制备方法 |
PT2621891T (pt) | 2010-10-01 | 2020-02-04 | Shan Dong Luye Pharm Co Ltd | Polimorfos de cloridrato de 4-metilbenzoato de 4-[2- dimetilamino-1-(1-hidroxiciclohexil)etil]fenilo, métodos para a preparação dos mesmos e utilização dos mesmos |
US8933123B2 (en) * | 2010-10-08 | 2015-01-13 | Cadila Healthcare Limited | Polymorphic forms of O-desmethyl-venlafaxine succinate |
EP2685966A1 (en) | 2011-03-17 | 2014-01-22 | Lupin Limited | Controlled release pharmaceutical compositions of selective serotonin reuptake inhibitor |
BR112013025766A2 (pt) | 2011-04-12 | 2016-12-20 | Lupin Ltd | composições farmacêuticas de liberação modificada de desvenlafaxina |
US8481596B2 (en) | 2011-06-08 | 2013-07-09 | Lupin Limited | Polymomorph of desvenlafaxine benzoate |
UY35091A (es) * | 2012-10-24 | 2014-05-30 | Onyx Therapeutics Inc | Formulaciones de liberacion modificada para oprozomib |
CN104666291A (zh) * | 2013-11-26 | 2015-06-03 | 山东绿叶制药有限公司 | 去甲基文拉法辛苯甲酸酯类化合物在制备改善性功能障碍药物中的应用 |
CN104352469A (zh) * | 2014-11-20 | 2015-02-18 | 哈尔滨圣吉药业股份有限公司 | 一种琥珀酸去甲文拉法辛缓释片及其制备方法 |
CN106146323B (zh) * | 2015-04-03 | 2021-05-25 | 石药集团中奇制药技术(石家庄)有限公司 | 一种琥珀酸去甲文拉法辛一水合物新晶型及制备方法 |
MX367362B (es) | 2016-06-29 | 2019-08-16 | Alparis Sa De Cv | Nuevas formas solidas de desvenlafaxina. |
WO2018146529A1 (en) * | 2017-02-09 | 2018-08-16 | R L Finechem Private Limited | A process for preparation of1-[2-(dimethylamino)-1-(4-hydroxyphenyl) ethyl]-cyclohexanol and salts thereof |
CN107082745A (zh) * | 2017-04-21 | 2017-08-22 | 上海华源医药科技发展有限公司 | 一种改进的ⅰ型去甲文拉法辛琥珀酸盐的生产方法 |
JP7198264B2 (ja) * | 2017-07-11 | 2022-12-28 | ユニバーサル スタビリゼイション テクノロジーズ,インコーポレイテッド | バイオ医薬品を保存するための方法 |
PT3661937T (pt) | 2017-08-01 | 2021-09-24 | Gilead Sciences Inc | Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais |
EP3666254A4 (en) | 2017-08-11 | 2020-07-29 | Amorepacific Corporation | PHARMACEUTICAL COMPOSITION WITH (R) -N [1- (3,5-DIFLUOR-4-METHANESULFONYLAMINO-PHENYL) -ETHYL] -3- (2-PROPYL-6-TRIFLUORMETHYL-PYRIDIN-3-YL) -ACRYLAMIDE |
TR201820634A2 (tr) | 2018-12-27 | 2020-07-21 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Desvenlafaksi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
IE56324B1 (en) * | 1982-12-13 | 1991-06-19 | American Home Prod | Phenethylamine derivatives and intermediates therefor |
US4535186A (en) | 1983-04-19 | 1985-08-13 | American Home Products Corporation | 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives |
US4761501A (en) | 1983-10-26 | 1988-08-02 | American Home Products Corporation | Substituted phenylacetamides |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
GB8902209D0 (en) | 1989-02-01 | 1989-03-22 | Wyeth John And Brother Limited | Preparation of cyclohexanol derivatives and novel thioamide intermediates |
IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
CA2138998A1 (en) | 1992-06-23 | 1994-01-06 | James W. Young | Methods and compositions for treating depression and other disorders using optically pure(-) sibutramine |
AU4542993A (en) | 1992-06-23 | 1994-01-24 | Sepracor, Inc. | Methods and compositions for treating depression and other disorders using optically pure (+) sibutramine |
US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
DE69434872T2 (de) | 1993-06-28 | 2007-04-05 | Wyeth | Neue Behandlungsmethoden durch Verwendung von Phenethylderivaten |
TW344661B (en) * | 1993-11-24 | 1998-11-11 | Lilly Co Eli | Pharmaceutical composition for treatment of incontinence |
EP1245228A3 (en) † | 1994-02-14 | 2002-10-09 | Wyeth | Medicament for the inducement of cognition enhancement |
US5594586A (en) * | 1994-05-02 | 1997-01-14 | The United States Of America As Represented By The Secretary Of The Air Force | Photorefractive limiting quadratic processor |
IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
US5506270A (en) † | 1995-01-30 | 1996-04-09 | American Home Products Corporation | Venlafaxine in the treatment of hypothalamic amenorrhea in non-depressed women |
US5554383A (en) | 1995-04-06 | 1996-09-10 | Trustees Of Tufts College | Veterinary method for clinically modifying the behavior of dogs exhibiting canine affective aggression |
US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
WO1997044317A2 (en) † | 1996-05-21 | 1997-11-27 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Novel methods of o-demethylation and n-deprotection |
EP1029536B1 (en) † | 1997-10-01 | 2007-11-28 | Novadel Pharma Inc. | Buccal non-polar spray |
US6197828B1 (en) | 1998-12-01 | 2001-03-06 | Sepracor, Inc. | Derivatives of (+)-venlafaxine and methods of preparing and using the same |
US6342533B1 (en) | 1998-12-01 | 2002-01-29 | Sepracor, Inc. | Derivatives of (−)-venlafaxine and methods of preparing and using the same |
PL350924A1 (en) * | 1999-04-06 | 2003-02-10 | Sepracor Inc | Derivatives of venlafaxine and methods of preparing and using the same |
KR100752000B1 (ko) † | 1999-05-27 | 2007-08-28 | 아쿠스피어 인코포레이티드. | 다공성 약물 매트릭스의 제조방법 |
WO2000076955A1 (en) * | 1999-06-15 | 2000-12-21 | American Home Products Corporation | Enantiomers of o-desmethyl venlafaxine |
US20020022662A1 (en) | 1999-06-15 | 2002-02-21 | American Home Products Corporation | Enantiomers of O-desmethyl venlafaxine |
KR100875610B1 (ko) * | 2001-02-12 | 2008-12-26 | 와이어쓰 | O-데스메틸-벤라팍신의 신규한 석시네이트 염 |
UA80543C2 (en) * | 2001-12-04 | 2007-10-10 | Wyeth Corp | Method for the preparation of o-desmethylvenlafaxine |
RU2004139075A (ru) | 2002-06-10 | 2005-06-27 | Уайт (Us) | Новые формиат 0-десметилвенлафаксина |
TWI306092B (en) | 2003-03-11 | 2009-02-11 | Wyeth Corp | Process for preparation of phenethylamine derivatives |
EP1711167A1 (en) | 2004-02-06 | 2006-10-18 | Wyeth | Multiparticulate o-desmethylvenlafaxine salts and uses thereof |
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