NO173742C - Fremgangsmaate for fremstilling av et IFN- alpha-ekspresjonsplasmid og poly-peptid med IFN-aktivitet - Google Patents

Fremgangsmaate for fremstilling av et IFN- alpha-ekspresjonsplasmid og poly-peptid med IFN-aktivitet

Info

Publication number
NO173742C
NO173742C NO834792A NO834792A NO173742C NO 173742 C NO173742 C NO 173742C NO 834792 A NO834792 A NO 834792A NO 834792 A NO834792 A NO 834792A NO 173742 C NO173742 C NO 173742C
Authority
NO
Norway
Prior art keywords
ifn
preparation
expression plasmid
polypeptide
procedure
Prior art date
Application number
NO834792A
Other languages
English (en)
Norwegian (no)
Other versions
NO173742B (no
NO834792L (no
Inventor
Marc-Bruce Dworkin
Eva Dworkin-Rastl
Guenther Adolf
Peter Meindl
Peter Swetly
Rudolf Hauptmann
Norbert Hauel
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of NO834792L publication Critical patent/NO834792L/no
Publication of NO173742B publication Critical patent/NO173742B/no
Publication of NO173742C publication Critical patent/NO173742C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/68—Stabilisation of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
NO834792A 1982-12-24 1983-12-23 Fremgangsmaate for fremstilling av et IFN- alpha-ekspresjonsplasmid og poly-peptid med IFN-aktivitet NO173742C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823247922 DE3247922A1 (de) 1982-12-24 1982-12-24 Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten

Publications (3)

Publication Number Publication Date
NO834792L NO834792L (no) 1984-06-25
NO173742B NO173742B (no) 1993-10-18
NO173742C true NO173742C (no) 1994-01-26

Family

ID=6181687

Family Applications (1)

Application Number Title Priority Date Filing Date
NO834792A NO173742C (no) 1982-12-24 1983-12-23 Fremgangsmaate for fremstilling av et IFN- alpha-ekspresjonsplasmid og poly-peptid med IFN-aktivitet

Country Status (19)

Country Link
EP (1) EP0115613B1 (el)
JP (2) JPH088868B2 (el)
KR (1) KR930005455B1 (el)
AT (1) ATE62018T1 (el)
AU (1) AU579991B2 (el)
DD (1) DD216043A5 (el)
DE (2) DE3247922A1 (el)
DK (1) DK576983A (el)
ES (4) ES528350A0 (el)
FI (1) FI86991C (el)
GR (1) GR78766B (el)
HU (1) HU202277B (el)
IL (1) IL70523A (el)
MX (1) MX9202878A (el)
NO (1) NO173742C (el)
NZ (1) NZ206700A (el)
SU (2) SU1366064A3 (el)
UA (1) UA8035A1 (el)
ZA (1) ZA839519B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3584198D1 (de) * 1984-08-01 1991-10-31 Boehringer Ingelheim Int Neue genetische sequenzen, die durch sie codierten interferon-peptide vom typ i und diese sie produzierende organismen.
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
IL95223A (en) * 1984-12-06 1992-08-18 Synergen Biolog Inc Dna sequence for production of serine protease inhibitors
FI90990C (fi) * 1984-12-18 1994-04-25 Boehringer Ingelheim Int Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi
DK156072C (da) * 1985-04-03 1989-11-06 Nordisk Gentofte Syntetisk dna-sekvens indeholdende et ribosombindingssted
DK151585D0 (da) * 1985-04-03 1985-04-03 Nordisk Gentofte Dna-sekvens
DE3514113A1 (de) * 1985-04-19 1986-10-23 Hoechst Ag, 6230 Frankfurt Veraenderung der dna-sequenz zwischen shine-dalgarno-sequenz und startcodon des trp-operons zur steigerung der proteinexpression
US4874703A (en) * 1985-08-26 1989-10-17 Eli Lilly And Company Expression vectors for use in E. coli
DE3607835A1 (de) * 1986-03-10 1987-09-24 Boehringer Ingelheim Int Hybridinterferone, deren verwendung als arzneimittel und als zwischenprodukte zur herstellung von antikoerpern und deren verwendung sowie verfahren zu ihrer herstellung
DE3642096A1 (de) * 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1990005186A1 (en) * 1988-11-04 1990-05-17 The Upjohn Company Somatotropin expression using a serratia promoter
EP0626448A3 (de) * 1993-05-26 1998-01-14 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Herstellung und Reinigung von alpha-Interferon
US5531880A (en) * 1994-09-13 1996-07-02 Microelectronics And Computer Technology Corporation Method for producing thin, uniform powder phosphor for display screens
FR2724665B1 (fr) * 1994-09-16 1996-12-20 Rhone Poulenc Rorer Sa Procede de production de proteines recombinantes, plasmides et cellules modifiees

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
ATE25985T1 (de) * 1980-06-12 1987-04-15 Japan Found Cancer Plasmid.
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
IE52755B1 (en) * 1980-08-26 1988-02-17 Univ California Bovine pre-growth and growth hormone
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms
DE3220116A1 (de) * 1982-05-28 1983-12-01 Dr. Karl Thomae Gmbh, 7950 Biberach Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
DE3247923A1 (de) * 1982-12-24 1984-06-28 Dr. Karl Thomae Gmbh, 7950 Biberach Neue oligonucleotide und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI86991C (fi) 1992-11-10
ES8503372A1 (es) 1985-02-16
IL70523A (en) 1991-08-16
NZ206700A (en) 1987-11-27
AU2283283A (en) 1984-06-28
NO173742B (no) 1993-10-18
ES8501798A1 (es) 1984-12-01
DK576983D0 (da) 1983-12-14
EP0115613A2 (de) 1984-08-15
DK576983A (da) 1984-06-25
SU1417800A3 (ru) 1988-08-15
FI86991B (fi) 1992-07-31
FI834700A (fi) 1984-06-25
DE3382233D1 (de) 1991-05-02
JPS59162888A (ja) 1984-09-13
ES8506090A1 (es) 1985-06-16
KR840007105A (ko) 1984-12-05
MX9202878A (es) 1992-06-30
ES533213A0 (es) 1985-06-16
JPH088868B2 (ja) 1996-01-31
ZA839519B (en) 1985-08-28
NO834792L (no) 1984-06-25
DD216043A5 (de) 1984-11-28
GR78766B (el) 1984-10-02
FI834700A0 (fi) 1983-12-21
IL70523A0 (en) 1984-03-30
UA8035A1 (uk) 1995-12-26
ES8504930A1 (es) 1985-04-16
ES528350A0 (es) 1984-12-01
AU579991B2 (en) 1988-12-22
ATE62018T1 (de) 1991-04-15
DE3247922A1 (de) 1984-06-28
SU1366064A3 (ru) 1988-01-07
ES533197A0 (es) 1985-02-16
HU202277B (en) 1991-02-28
EP0115613B1 (de) 1991-03-27
EP0115613A3 (en) 1986-07-23
ES533214A0 (es) 1985-04-16
JP2637328B2 (ja) 1997-08-06
JPH05214000A (ja) 1993-08-24
KR930005455B1 (ko) 1993-06-22

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