ES8604252A1 - Un metodo para recuperar una hormona de credimiento de un animal purificada - Google Patents
Un metodo para recuperar una hormona de credimiento de un animal purificadaInfo
- Publication number
- ES8604252A1 ES8604252A1 ES544976A ES544976A ES8604252A1 ES 8604252 A1 ES8604252 A1 ES 8604252A1 ES 544976 A ES544976 A ES 544976A ES 544976 A ES544976 A ES 544976A ES 8604252 A1 ES8604252 A1 ES 8604252A1
- Authority
- ES
- Spain
- Prior art keywords
- vector
- dna sequence
- host cell
- new
- plasmids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/73—Expression systems using phage (lambda) regulatory sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Abstract
METODO DE RECUPERACION DE HORMONAS DE CRECIMIENTO DE UN ANIMAL PURIFICADA, O UN ANALOGO DE ESTA, A PARTIR DE UNA CELULA BACTERIANA EN LA QUE SE HA PRODUCIDO LA HORMONA DE CRECIMIENTO DEL ANIMAL MEDIANTE LA EXPRESION DE UN PLASMIDO QUE CONTIENE UNA SECUENCIA DNA CODIFICANTE DE LA HORMONA O ANALOGO. COMPRENDE LA DESTRUCCION DE LA PARED CELULAR DE LAS CELULAS BACTERIANAS; AJUSTAR EL PH DEL LISADO PRODUCIDO A PH NEUTRO; SOLUBILIZAR EL PRECIPITADO ASI FORMADO MEDIANTE ALCALINIZACION; SEPARAR EL PRECIPITADO DE LA HORMONA O ANALOGO SOLUBILIZADO DEL RESTO DE LOS COMPONENTES MEDIANTE CROMATOGRAFIA DE FILTRACION EN GEL; Y SOMETER LA HORMONA O EL ANALOGO A CROMATOGRAFIA DE INTERCAMBIO IONICO PARA CONCENTRARLOS Y RECUPERARLOS. ESTAS HORMONAS TIENEN APLICACIONES PARA ESTIMULAR LA PRODUCCION DE LECHE O CARNE EN ANIMALES BOVINOS Y PARA TRATAR LA DEFICIENCIA DE LA HORMONA DEL CRECIMIENTO EN EL HOMBRE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51418883A | 1983-07-15 | 1983-07-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES544976A0 ES544976A0 (es) | 1986-01-16 |
ES8604252A1 true ES8604252A1 (es) | 1986-01-16 |
Family
ID=24046152
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES534321A Expired ES8602947A1 (es) | 1983-07-15 | 1984-07-13 | Un metodo para producir un polipeptido. |
ES544976A Expired ES8604252A1 (es) | 1983-07-15 | 1985-07-08 | Un metodo para recuperar una hormona de credimiento de un animal purificada |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES534321A Expired ES8602947A1 (es) | 1983-07-15 | 1984-07-13 | Un metodo para producir un polipeptido. |
Country Status (22)
Country | Link |
---|---|
US (3) | US4871835A (es) |
EP (3) | EP0319049B1 (es) |
JP (3) | JPH0687780B2 (es) |
AT (2) | ATE136934T1 (es) |
AU (2) | AU577298B2 (es) |
BG (2) | BG49718A3 (es) |
BR (1) | BR8403523A (es) |
CA (1) | CA1254527A (es) |
CZ (1) | CZ282867B6 (es) |
DD (2) | DD229427A5 (es) |
DE (2) | DE3485003D1 (es) |
DK (1) | DK347184A (es) |
ES (2) | ES8602947A1 (es) |
FI (1) | FI90564C (es) |
HK (1) | HK128095A (es) |
HU (1) | HU209878B (es) |
IE (2) | IE64174B1 (es) |
IL (8) | IL72396A (es) |
NZ (2) | NZ227962A (es) |
RO (1) | RO91332B (es) |
SK (1) | SK278576B6 (es) |
ZA (1) | ZA845345B (es) |
Families Citing this family (67)
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US5340926A (en) * | 1983-03-25 | 1994-08-23 | Celltech, Limited | Process for the recovery of recombinantly produced protein from insoluble aggregate |
US5236828A (en) * | 1983-07-06 | 1993-08-17 | Papas Takis S | Plasmid pJL6 |
US5670371A (en) * | 1983-07-15 | 1997-09-23 | Bio-Technology General Corp. | Bacterial expression of superoxide dismutase |
BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
US5332805A (en) * | 1984-02-03 | 1994-07-26 | Celltech Limited | Process for the recovery of recombinantly produced chymosin from insoluble aggregate |
DE3585170D1 (de) * | 1984-03-06 | 1992-02-27 | Lilly Co Eli | Expressionsvektoren fuer rinderwachstumshormonderivate. |
US5759816A (en) * | 1984-08-27 | 1998-06-02 | Bio-Technology General Corp. | Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods |
US6030611A (en) * | 1984-08-27 | 2000-02-29 | Bio-Technology General Corp. | Therapeutic SOD compositions and uses thereof |
CA1340597C (en) * | 1984-08-27 | 1999-06-22 | Haim Aviv | Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods |
CA1267615A (en) * | 1984-08-27 | 1990-04-10 | Dan Hadary | Method for recovering purified growth hormones from genetically engineered microorganisms |
US5162217A (en) * | 1984-08-27 | 1992-11-10 | Bio-Technology General Corp. | Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof |
US5112744A (en) * | 1984-08-27 | 1992-05-12 | Bio-Technology General Corp. | Plasmids for the production of human Cu-Zn superoxide dismutase, bacterial hosts containing the plasmids and methods for production and recovery of such superoxide dismutase |
US5143836A (en) * | 1984-08-27 | 1992-09-01 | Bio-Technology General Corp. | Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof |
US4743546A (en) * | 1985-02-13 | 1988-05-10 | Biotechnica International, Inc. | Controlled gene excision |
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FR2579223B1 (fr) * | 1985-03-25 | 1988-12-09 | Genetica | Procede de preparation microbiologique de la serum-albumine humaine |
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US5958879A (en) * | 1989-10-12 | 1999-09-28 | Ohio University/Edison Biotechnology Institute | Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal |
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US4767709A (en) * | 1984-06-28 | 1988-08-30 | The Johns Hopkins University | Growth-related hormones |
DE3426532A1 (de) * | 1984-07-18 | 1986-01-30 | Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig | Verwendung einer dna-sequenz zur expression sowie dna-struktur und expressionsvektor mit der dna-sequenz |
CA1340597C (en) * | 1984-08-27 | 1999-06-22 | Haim Aviv | Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods |
US4612367A (en) * | 1985-04-08 | 1986-09-16 | Eli Lilly And Company | Process for purifying growth hormone-like materials |
US4677196A (en) * | 1985-09-06 | 1987-06-30 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
US4656255A (en) * | 1985-09-09 | 1987-04-07 | International Minerals & Chemical Corp. | Protein recovery |
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1984
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1985
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1988
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1989
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1992
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1993
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1994
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1995
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Effective date: 20051017 |