IL91826A0 - Human growth hormone analogs - Google Patents

Human growth hormone analogs

Info

Publication number
IL91826A0
IL91826A0 IL91826A IL9182689A IL91826A0 IL 91826 A0 IL91826 A0 IL 91826A0 IL 91826 A IL91826 A IL 91826A IL 9182689 A IL9182689 A IL 9182689A IL 91826 A0 IL91826 A0 IL 91826A0
Authority
IL
Israel
Prior art keywords
host cell
growth hormone
human growth
hormone analogs
superoxide dismutase
Prior art date
Application number
IL91826A
Other languages
English (en)
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Priority to IL91826A priority Critical patent/IL91826A0/xx
Publication of IL91826A0 publication Critical patent/IL91826A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0089Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormones [GH] (Somatotropin)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • C12N15/73Expression systems using phage (lambda) regulatory sequences
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
    • Y10S530/825Bacteria
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
IL91826A 1983-07-15 1989-09-28 Human growth hormone analogs IL91826A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL91826A IL91826A0 (en) 1983-07-15 1989-09-28 Human growth hormone analogs

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51418883A 1983-07-15 1983-07-15
IL72396A IL72396A (en) 1983-07-15 1984-07-12 Expression vectors for enhanced production of polypeptides,plasmids containing the vectors,hosts containing the plasmids and products manufactured thereby
IL91826A IL91826A0 (en) 1983-07-15 1989-09-28 Human growth hormone analogs

Publications (1)

Publication Number Publication Date
IL91826A0 true IL91826A0 (en) 1990-06-10

Family

ID=24046152

Family Applications (8)

Application Number Title Priority Date Filing Date
IL72396A IL72396A (en) 1983-07-15 1984-07-12 Expression vectors for enhanced production of polypeptides,plasmids containing the vectors,hosts containing the plasmids and products manufactured thereby
IL91826A IL91826A (en) 1983-07-15 1984-07-12 Human growth hormone analog
IL91828A IL91828A (en) 1983-07-15 1984-07-12 Method of isolating and purifying animal growth hormones or analogs thereof produced by genetically engineered bacteria
IL91826A IL91826A0 (en) 1983-07-15 1989-09-28 Human growth hormone analogs
IL91828A IL91828A0 (en) 1983-07-15 1989-09-28 Method of isolating and purifying animal growth hormones or analogs thereof produced by genetically engineered bacteria
IL101629A IL101629A0 (en) 1983-07-15 1992-04-17 Expression vectors for enhanced production of polypeptides,plasmids containing the vectors,hosts containing the plasmids,products manufactured thereby and related methods
IL10810893A IL108108A0 (en) 1983-07-15 1993-12-21 Expression vectors and related methods
IL11217894A IL112178A0 (en) 1983-07-15 1994-12-29 Expression plasmid having unique insertion site

Family Applications Before (3)

Application Number Title Priority Date Filing Date
IL72396A IL72396A (en) 1983-07-15 1984-07-12 Expression vectors for enhanced production of polypeptides,plasmids containing the vectors,hosts containing the plasmids and products manufactured thereby
IL91826A IL91826A (en) 1983-07-15 1984-07-12 Human growth hormone analog
IL91828A IL91828A (en) 1983-07-15 1984-07-12 Method of isolating and purifying animal growth hormones or analogs thereof produced by genetically engineered bacteria

Family Applications After (4)

Application Number Title Priority Date Filing Date
IL91828A IL91828A0 (en) 1983-07-15 1989-09-28 Method of isolating and purifying animal growth hormones or analogs thereof produced by genetically engineered bacteria
IL101629A IL101629A0 (en) 1983-07-15 1992-04-17 Expression vectors for enhanced production of polypeptides,plasmids containing the vectors,hosts containing the plasmids,products manufactured thereby and related methods
IL10810893A IL108108A0 (en) 1983-07-15 1993-12-21 Expression vectors and related methods
IL11217894A IL112178A0 (en) 1983-07-15 1994-12-29 Expression plasmid having unique insertion site

Country Status (22)

Country Link
US (3) US4871835A (xx)
EP (3) EP0319049B1 (xx)
JP (3) JPH0687780B2 (xx)
AT (2) ATE66959T1 (xx)
AU (2) AU577298B2 (xx)
BG (2) BG49718A3 (xx)
BR (1) BR8403523A (xx)
CA (1) CA1254527A (xx)
CZ (1) CZ282867B6 (xx)
DD (2) DD240217A5 (xx)
DE (2) DE3486425T2 (xx)
DK (1) DK347184A (xx)
ES (2) ES8602947A1 (xx)
FI (1) FI90564C (xx)
HK (1) HK128095A (xx)
HU (1) HU209878B (xx)
IE (2) IE64174B1 (xx)
IL (8) IL72396A (xx)
NZ (2) NZ227962A (xx)
RO (1) RO91332B (xx)
SK (1) SK278576B6 (xx)
ZA (1) ZA845345B (xx)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340926A (en) * 1983-03-25 1994-08-23 Celltech, Limited Process for the recovery of recombinantly produced protein from insoluble aggregate
US5236828A (en) * 1983-07-06 1993-08-17 Papas Takis S Plasmid pJL6
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
US5332805A (en) * 1984-02-03 1994-07-26 Celltech Limited Process for the recovery of recombinantly produced chymosin from insoluble aggregate
EP0159123B1 (en) * 1984-03-06 1992-01-15 Eli Lilly And Company Vectors for expressing bovine growth hormone derivatives
US6030611A (en) * 1984-08-27 2000-02-29 Bio-Technology General Corp. Therapeutic SOD compositions and uses thereof
US5162217A (en) * 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US5143836A (en) * 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US5112744A (en) * 1984-08-27 1992-05-12 Bio-Technology General Corp. Plasmids for the production of human Cu-Zn superoxide dismutase, bacterial hosts containing the plasmids and methods for production and recovery of such superoxide dismutase
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
US4743546A (en) * 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
FR2579223B1 (fr) * 1985-03-25 1988-12-09 Genetica Procede de preparation microbiologique de la serum-albumine humaine
EP0229110B1 (en) 1985-06-26 1992-05-20 The Upjohn Company Solubilization and oxidation of somatotropin from transformed microorganisms
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
US4874703A (en) * 1985-08-26 1989-10-17 Eli Lilly And Company Expression vectors for use in E. coli
US5631227A (en) * 1985-09-18 1997-05-20 The Upjohn Company Somatotropin analogs
JPS63500941A (ja) * 1985-09-18 1988-04-07 ジ・アップジョン・カンパニ− 選択的脱アミノ化による哺乳動物ソマトトロピンの生物学的活性の増強
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
ES2019874B3 (es) * 1986-10-08 1991-07-16 Upjohn Co Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva.
US5089406A (en) * 1987-01-07 1992-02-18 Allied-Signal Inc. Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
GB8701848D0 (en) * 1987-01-28 1987-03-04 Celltech Ltd Polypeptides
US5240837A (en) * 1987-02-19 1993-08-31 The Upjohn Company CDNAS encoding somatotropin, expression vectors and hosts
JP2580303B2 (ja) * 1987-02-19 1997-02-12 ジ・アップジョン・カンパニー 異種蛋白をコ−ド付けするcDNA類、発現ベクタ−類および宿主類
US5104796A (en) * 1987-04-06 1992-04-14 International Minerals & Chemical Corp. High titer production of human somatomedin c
US5047504A (en) * 1987-04-28 1991-09-10 Amgen, Inc. Method for purifying granulocyte-macrophage colony stimulating factor
US4966841A (en) * 1987-05-22 1990-10-30 The Board Of Regents Of The University Of Washington Enhanced vector production and expression of recombinant DNA products
US5030563A (en) * 1987-07-07 1991-07-09 Genetics Institute, Inc. Bacterial hypersecretion using mutant repressor sequence
US5079345A (en) * 1988-08-19 1992-01-07 Eli Lilly And Company Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
EP0365858B1 (en) * 1988-10-26 1994-11-30 American Cyanamid Company Process for reducing the aggregate content of growth hormone-like materials
US6780613B1 (en) * 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
WO1990004788A1 (en) 1988-10-28 1990-05-03 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants
JPH04503154A (ja) * 1988-11-07 1992-06-11 ルニベルシー・ド・ルタ・ア・リージュ 変型ヒト成長ホルモン
US4975529A (en) * 1989-08-18 1990-12-04 Monsanto Company Method of folding somatotropins
US5958879A (en) * 1989-10-12 1999-09-28 Ohio University/Edison Biotechnology Institute Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal
US6583115B1 (en) 1989-10-12 2003-06-24 Ohio University/Edison Biotechnology Institute Methods for treating acromegaly and giantism with growth hormone antagonists
IE912345A1 (en) * 1990-08-03 1992-02-12 Pharmacia Ab Treatment of human lactation failure
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
DK0559795T3 (da) * 1990-11-30 1996-01-29 Monoclonetics Int Fremgangsmåder til diagnosticering af kroniske smerter i lænderegionen og halshvrivelsøjlen
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
JP3417558B2 (ja) * 1991-05-10 2003-06-16 ジェネンテク,インコーポレイテッド 配位子作用薬および拮抗薬の選択
US5395761A (en) * 1991-11-27 1995-03-07 Eli Lilly And Company Plasmid pHKY334, an expression vector for EK-BGH and host cells transformed therewith
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
US20020142965A1 (en) * 1994-11-15 2002-10-03 Metabolic Pharmaceuticals, Ltd. Treatment of obesity
US6335319B1 (en) 1994-11-15 2002-01-01 Metabolic Pharmaceuticals, Inc. Treatment of obesity
WO1996040203A1 (en) * 1995-06-07 1996-12-19 Ohio University/Edison Biotechnology Institute Methods of treatment using growth hormone antagonists
KR970006498A (ko) * 1995-07-31 1997-02-21 유충식 활성형 인성장호르몬의 정제 방법
PT1568772E (pt) * 1995-09-21 2010-04-14 Genentech Inc Variantes da hormona do crescimento humana
US5849293A (en) * 1996-01-11 1998-12-15 Cornell Research Foundation, Inc. Use of human transferrin in controlling insulin levels
AU723494B2 (en) * 1996-02-13 2000-08-31 Jcr Pharmaceuticals Co., Ltd. Mutant human growth hormones and their uses
EP1012189B1 (en) 1997-09-08 2007-10-31 Metabolic Pharmaceuticals Ltd. Treatment of obesity
DE19951765A1 (de) * 1999-10-27 2001-05-03 Thomas Schweder Wirts-Vektor-Systeme zur Überproduktion von thermolabilen Enzymen psychrophiler Organismen
KR100400638B1 (ko) * 2000-12-06 2003-10-08 주식회사 엘지생명과학 재조합 인간 성장호르몬 유사체의 분리방법
IL157378A0 (en) 2001-03-09 2004-02-19 Genentech Inc Process for production of polypeptides
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
EP2386571B1 (en) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR68404B (xx) * 1979-06-01 1981-12-29 Univ California
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4426323A (en) * 1980-01-10 1984-01-17 Ionics, Incorporated Selected recovery of proteins from fermentation broths
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
BR8101972A (pt) * 1980-06-06 1982-08-17 Biogen Nv Vetor, processo para sua producao, processo para produzir uma molecula recombinante de dna, e processo para produzir um polipeptideo
US4352443A (en) * 1980-06-24 1982-10-05 U.S. Cap & Closure, Inc. Dispenser having a trigger-bulb pump
JPS6045848B2 (ja) * 1980-07-31 1985-10-12 株式会社林原生物化学研究所 ヒト成長ホルモンの製造方法
IE52755B1 (en) * 1980-08-26 1988-02-17 Univ California Bovine pre-growth and growth hormone
DE3231658A1 (xx) 1981-01-21 1983-11-17
EP0061250A3 (en) * 1981-03-23 1983-09-28 Biogen N.V. Improved process for recovering products produced by host organisms
NZ201918A (en) * 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US4436815A (en) * 1981-11-27 1984-03-13 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cells
US4665160A (en) * 1982-03-22 1987-05-12 Genentech, Inc. Novel human growth hormone like protein HGH-V encoded in the human genome
GB2129810B (en) * 1982-06-07 1985-09-18 Celltech Ltd A process for the preparation of chymosin
EP0103395A3 (en) * 1982-08-17 1985-05-22 Biogen N.V. Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
EP0111814A3 (en) * 1982-12-16 1985-08-14 Mgi Pharma, Inc. The cloning and expression of nucleotide sequences encoding bovine growth hormone
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
CA1224168A (en) * 1982-12-23 1987-07-14 Dean H. Hamer Human growth hormone produced by recombinant dna in mouse cells
US4728609A (en) * 1983-01-10 1988-03-01 Hoffmann-La-Roche Inc. Recombinant growth hormone releasing factor
JPS59145876A (ja) * 1983-02-09 1984-08-21 株式会社リコー 開閉体用のヒンジ
ATE53220T1 (de) * 1983-03-07 1990-06-15 Hoffmann La Roche Polypeptide.
JPH06102034B2 (ja) * 1983-03-25 1994-12-14 セルテク リミテツド タンパク質の生産方法
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
AU587176B2 (en) * 1984-02-14 1989-08-10 Mycogen Plant Science, Inc. Transfer vector
US4767709A (en) * 1984-06-28 1988-08-30 The Johns Hopkins University Growth-related hormones
DE3426532A1 (de) * 1984-07-18 1986-01-30 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verwendung einer dna-sequenz zur expression sowie dna-struktur und expressionsvektor mit der dna-sequenz
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US4612367A (en) * 1985-04-08 1986-09-16 Eli Lilly And Company Process for purifying growth hormone-like materials
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery

Also Published As

Publication number Publication date
SK524684A3 (en) 1997-10-08
DE3486425D1 (de) 1996-05-23
IL112178A0 (en) 1995-03-15
ATE66959T1 (de) 1991-09-15
JP3146161B2 (ja) 2001-03-12
IL101629A0 (en) 1992-12-30
IE64174B1 (en) 1995-07-12
EP0319049A2 (en) 1989-06-07
ES534321A0 (es) 1985-12-01
DE3485003D1 (de) 1991-10-10
RO91332B (ro) 1987-05-01
JPS6091986A (ja) 1985-05-23
DD240217A5 (de) 1986-10-22
HU209878B (en) 1994-11-28
IL72396A (en) 1992-05-25
US4831120A (en) 1989-05-16
EP0691406A1 (en) 1996-01-10
EP0319049A3 (en) 1990-01-03
ES8604252A1 (es) 1986-01-16
IL91828A (en) 1992-05-25
EP0319049B1 (en) 1996-04-17
NZ208897A (en) 1990-06-26
AU615663B2 (en) 1991-10-10
AU1977788A (en) 1988-12-22
JP2568376B2 (ja) 1997-01-08
AU3034584A (en) 1985-01-17
JPH09131190A (ja) 1997-05-20
IL72396A0 (en) 1984-11-30
IE922469A1 (en) 1985-01-15
HUT34543A (en) 1985-03-28
SK278576B6 (en) 1997-10-08
IE841818L (en) 1985-01-15
FI90564B (fi) 1993-11-15
CZ524684A3 (en) 1997-07-16
ES8602947A1 (es) 1985-12-01
FI842842A (fi) 1985-01-16
US4997916A (en) 1991-03-05
ATE136934T1 (de) 1996-05-15
FI842842A0 (fi) 1984-07-13
IL108108A0 (en) 1994-04-12
BR8403523A (pt) 1985-06-25
ES544976A0 (es) 1986-01-16
AU577298B2 (en) 1988-09-22
DK347184D0 (da) 1984-07-13
US4871835A (en) 1989-10-03
HK128095A (en) 1995-08-18
ZA845345B (en) 1985-03-27
FI90564C (fi) 1994-02-25
DD229427A5 (de) 1985-11-06
DK347184A (da) 1985-01-16
CA1254527A (en) 1989-05-23
JPH0799990A (ja) 1995-04-18
EP0131843B1 (en) 1991-09-04
EP0131843A1 (en) 1985-01-23
BG49721A3 (en) 1992-01-15
BG49718A3 (en) 1992-01-15
NZ227962A (en) 1990-06-26
CZ282867B6 (cs) 1997-11-12
IL91826A (en) 1992-05-25
RO91332A (ro) 1987-04-30
IL91828A0 (en) 1990-06-10
JPH0687780B2 (ja) 1994-11-09
DE3486425T2 (de) 1996-10-17

Similar Documents

Publication Publication Date Title
IL91826A0 (en) Human growth hormone analogs
DE3479321D1 (en) Biosynthetically produced human nerve growth factor, process for producing it, compositions containing it, dna sequence encoding it, vectors containing the sequence and host cells transformed thereby
ZA869487B (en) Process for the improvement of the expression of eukaryont proteins
DE3666838D1 (en) Plasmid vectors for expression in escherichia coli and/or bacillus subtilis
CA1262533C (en) HIGH YIELD PRODUCTION OF SWINE GROWTH HORMONE
AU3078684A (en) Improved e. coli plasmid containing modified 5' cipoprotein sequence
ES2003085A6 (es) Procedimiento para inducir de una forma controlada la expresion de genes eucarioticos de interes en celulas hospedantes eucarioticas apropiadas
ES550865A0 (es) Un procedimiento para preparar el plasmido pksr101
GB2210373A (en) Recombinant plasmid dna ppr-il2-19,coding for synthsis of human interleukin-2 and strain of bacteria escherichia coli vniigenetika vl 903 (ppr-il2-19)
SU1500675A1 (ru) ыгБФФ єБТгЕЧЛМ ЕвГИЕЩЙГИЙБ ГЦУЙk ЛГЬЦОоълЕФпМ јОЭ ЬЦОлюЕИЛЭ у}` БФЛИЦ`т}k у}` јЛјЕъЦТГЛїлБИЦъЛИБ