ES2019874B3 - Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva. - Google Patents

Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva.

Info

Publication number
ES2019874B3
ES2019874B3 ES86307767T ES86307767T ES2019874B3 ES 2019874 B3 ES2019874 B3 ES 2019874B3 ES 86307767 T ES86307767 T ES 86307767T ES 86307767 T ES86307767 T ES 86307767T ES 2019874 B3 ES2019874 B3 ES 2019874B3
Authority
ES
Spain
Prior art keywords
somatotropin
mammals
improved bioactivity
selective deamidation
deamidation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86307767T
Other languages
English (en)
Inventor
Gary C Harbour
John G Hoogerheide
Robert L Garlick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ES2019874B3 publication Critical patent/ES2019874B3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ES86307767T 1986-10-08 1986-10-08 Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva. Expired - Lifetime ES2019874B3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19860307767 EP0263206B1 (en) 1986-10-08 1986-10-08 Enhanced bioactivity of mammalian somatotropin through selective deamidation

Publications (1)

Publication Number Publication Date
ES2019874B3 true ES2019874B3 (es) 1991-07-16

Family

ID=8196174

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86307767T Expired - Lifetime ES2019874B3 (es) 1986-10-08 1986-10-08 Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva.

Country Status (3)

Country Link
EP (1) EP0263206B1 (es)
ES (1) ES2019874B3 (es)
GR (1) GR3001464T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089473A (en) * 1988-08-29 1992-02-18 Monsanto Company Somatotropin variants and their use
US5663305A (en) * 1989-07-10 1997-09-02 The Upjohn Company Somatotropin analogs
EP0482124B1 (en) * 1989-07-10 1993-12-22 The Upjohn Company Somatotropin analogs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52755B1 (en) * 1980-08-26 1988-02-17 Univ California Bovine pre-growth and growth hormone
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty

Also Published As

Publication number Publication date
EP0263206A1 (en) 1988-04-13
GR3001464T3 (en) 1992-10-08
EP0263206B1 (en) 1990-12-12

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