MXPA05000819A - Composiciones de vacunas que contienen arreglos de antigeno amiloide beta 1-6. - Google Patents
Composiciones de vacunas que contienen arreglos de antigeno amiloide beta 1-6.Info
- Publication number
- MXPA05000819A MXPA05000819A MXPA05000819A MXPA05000819A MXPA05000819A MX PA05000819 A MXPA05000819 A MX PA05000819A MX PA05000819 A MXPA05000819 A MX PA05000819A MX PA05000819 A MXPA05000819 A MX PA05000819A MX PA05000819 A MXPA05000819 A MX PA05000819A
- Authority
- MX
- Mexico
- Prior art keywords
- virus
- peptide
- seq
- composition
- amino acid
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 207
- 239000000427 antigen Substances 0.000 title claims abstract description 187
- 102000036639 antigens Human genes 0.000 title claims abstract description 186
- 108091007433 antigens Proteins 0.000 title claims abstract description 186
- 229960005486 vaccine Drugs 0.000 title claims abstract description 98
- 238000003491 array Methods 0.000 title claims abstract description 16
- 239000002245 particle Substances 0.000 claims abstract description 177
- 230000000890 antigenic effect Effects 0.000 claims abstract description 98
- 238000000034 method Methods 0.000 claims abstract description 83
- 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 76
- 230000003252 repetitive effect Effects 0.000 claims abstract description 41
- 230000028993 immune response Effects 0.000 claims abstract description 40
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 238000011282 treatment Methods 0.000 claims abstract description 17
- 239000003814 drug Substances 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 10
- 230000005875 antibody response Effects 0.000 claims abstract description 9
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 292
- 108090000623 proteins and genes Proteins 0.000 claims description 238
- 102000004169 proteins and genes Human genes 0.000 claims description 199
- 230000027455 binding Effects 0.000 claims description 185
- 101710132601 Capsid protein Proteins 0.000 claims description 156
- 150000001413 amino acids Chemical class 0.000 claims description 90
- 101710125418 Major capsid protein Proteins 0.000 claims description 87
- 241000700605 Viruses Species 0.000 claims description 87
- 101710094648 Coat protein Proteins 0.000 claims description 86
- 101710141454 Nucleoprotein Proteins 0.000 claims description 86
- 101710083689 Probable capsid protein Proteins 0.000 claims description 86
- 239000012634 fragment Substances 0.000 claims description 84
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 claims description 81
- 210000000234 capsid Anatomy 0.000 claims description 69
- 238000000576 coating method Methods 0.000 claims description 64
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 60
- 230000003053 immunization Effects 0.000 claims description 59
- 238000002649 immunization Methods 0.000 claims description 57
- 241000282414 Homo sapiens Species 0.000 claims description 47
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 45
- 241001515965 unidentified phage Species 0.000 claims description 45
- 239000002671 adjuvant Substances 0.000 claims description 42
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 35
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 35
- 238000003780 insertion Methods 0.000 claims description 32
- 230000037431 insertion Effects 0.000 claims description 32
- 230000001580 bacterial effect Effects 0.000 claims description 29
- 241001465754 Metazoa Species 0.000 claims description 27
- 238000006467 substitution reaction Methods 0.000 claims description 17
- 241001529936 Murinae Species 0.000 claims description 15
- 238000012217 deletion Methods 0.000 claims description 15
- 230000037430 deletion Effects 0.000 claims description 15
- -1 linker amino acid Chemical class 0.000 claims description 15
- 201000010099 disease Diseases 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 230000003612 virological effect Effects 0.000 claims description 12
- 241000700721 Hepatitis B virus Species 0.000 claims description 10
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 10
- 241000709737 Enterobacteria phage GA Species 0.000 claims description 8
- 241000709738 Enterobacteria phage fr Species 0.000 claims description 8
- 241000712079 Measles morbillivirus Species 0.000 claims description 7
- 102000019040 Nuclear Antigens Human genes 0.000 claims description 7
- 108010051791 Nuclear Antigens Proteins 0.000 claims description 7
- 241001505332 Polyomavirus sp. Species 0.000 claims description 7
- 241000710960 Sindbis virus Species 0.000 claims description 7
- 241001672158 Acinetobacter phage AP205 Species 0.000 claims description 6
- 241000700199 Cavia porcellus Species 0.000 claims description 6
- 241000709747 Enterobacteria phage R17 Species 0.000 claims description 6
- 241000709744 Enterobacterio phage MS2 Species 0.000 claims description 6
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims description 6
- 241000288906 Primates Species 0.000 claims description 6
- 241001278054 Enterobacteria phage NL95 Species 0.000 claims description 5
- 241000709739 Enterobacteria phage f2 Species 0.000 claims description 5
- 241000709749 Pseudomonas phage PP7 Species 0.000 claims description 5
- 241001430294 unidentified retrovirus Species 0.000 claims description 5
- 241001278075 Enterobacteria phage MX1 Species 0.000 claims description 4
- 241000701806 Human papillomavirus Species 0.000 claims description 4
- 241000269368 Xenopus laevis Species 0.000 claims description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 4
- 108700010839 phage proteins Proteins 0.000 claims description 3
- 239000003937 drug carrier Substances 0.000 claims description 2
- 108700010850 rotavirus proteins Proteins 0.000 claims 1
- 108010088515 amyloid beta-protein (1-6) Proteins 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 description 193
- 235000001014 amino acid Nutrition 0.000 description 92
- 229940024606 amino acid Drugs 0.000 description 92
- 241000699670 Mus sp. Species 0.000 description 71
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 70
- 102000004196 processed proteins & peptides Human genes 0.000 description 70
- 239000011248 coating agent Substances 0.000 description 63
- 210000004027 cell Anatomy 0.000 description 62
- 230000014509 gene expression Effects 0.000 description 57
- 238000003752 polymerase chain reaction Methods 0.000 description 56
- 238000005859 coupling reaction Methods 0.000 description 51
- 229920001184 polypeptide Polymers 0.000 description 45
- 241000588724 Escherichia coli Species 0.000 description 44
- 108010000916 Fimbriae Proteins Proteins 0.000 description 41
- 230000008878 coupling Effects 0.000 description 38
- 238000010168 coupling process Methods 0.000 description 38
- 208000037259 Amyloid Plaque Diseases 0.000 description 37
- 239000013612 plasmid Substances 0.000 description 37
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 34
- 230000004927 fusion Effects 0.000 description 33
- 210000004556 brain Anatomy 0.000 description 32
- 241000699666 Mus <mouse, genus> Species 0.000 description 31
- 229910019142 PO4 Inorganic materials 0.000 description 31
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 31
- 239000010452 phosphate Substances 0.000 description 31
- 238000006243 chemical reaction Methods 0.000 description 30
- 239000000243 solution Substances 0.000 description 30
- 238000011830 transgenic mouse model Methods 0.000 description 30
- 239000013598 vector Substances 0.000 description 30
- 238000002965 ELISA Methods 0.000 description 27
- 210000002966 serum Anatomy 0.000 description 24
- 239000004971 Cross linker Substances 0.000 description 23
- 241000699660 Mus musculus Species 0.000 description 23
- 125000000539 amino acid group Chemical group 0.000 description 23
- 238000000746 purification Methods 0.000 description 23
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 23
- 239000000126 substance Substances 0.000 description 23
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 22
- 238000010276 construction Methods 0.000 description 22
- 239000000047 product Substances 0.000 description 22
- 210000004899 c-terminal region Anatomy 0.000 description 21
- 230000000875 corresponding effect Effects 0.000 description 21
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 20
- 102000037865 fusion proteins Human genes 0.000 description 20
- 108020001507 fusion proteins Proteins 0.000 description 20
- 229920002684 Sepharose Polymers 0.000 description 19
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 18
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 18
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 18
- 210000001744 T-lymphocyte Anatomy 0.000 description 18
- 239000008366 buffered solution Substances 0.000 description 18
- 230000001105 regulatory effect Effects 0.000 description 18
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 17
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 17
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 17
- 230000035772 mutation Effects 0.000 description 17
- 238000005119 centrifugation Methods 0.000 description 16
- 208000015181 infectious disease Diseases 0.000 description 16
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 14
- 235000011130 ammonium sulphate Nutrition 0.000 description 14
- 230000015572 biosynthetic process Effects 0.000 description 14
- 239000000562 conjugate Substances 0.000 description 14
- 238000004448 titration Methods 0.000 description 14
- 239000011230 binding agent Substances 0.000 description 13
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 description 12
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 12
- 239000002773 nucleotide Substances 0.000 description 12
- 125000003729 nucleotide group Chemical group 0.000 description 12
- 239000011780 sodium chloride Substances 0.000 description 12
- 239000006228 supernatant Substances 0.000 description 12
- 210000003719 b-lymphocyte Anatomy 0.000 description 11
- 238000010367 cloning Methods 0.000 description 11
- 239000013604 expression vector Substances 0.000 description 11
- 102000046783 human APP Human genes 0.000 description 11
- 230000002163 immunogen Effects 0.000 description 11
- 230000009467 reduction Effects 0.000 description 11
- 238000007792 addition Methods 0.000 description 10
- 238000004458 analytical method Methods 0.000 description 10
- 208000002672 hepatitis B Diseases 0.000 description 10
- 230000002458 infectious effect Effects 0.000 description 10
- 230000003993 interaction Effects 0.000 description 10
- 239000002609 medium Substances 0.000 description 10
- 239000011541 reaction mixture Substances 0.000 description 10
- 238000011144 upstream manufacturing Methods 0.000 description 10
- 241000282693 Cercopithecidae Species 0.000 description 9
- 230000008021 deposition Effects 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 238000002523 gelfiltration Methods 0.000 description 9
- 230000004048 modification Effects 0.000 description 9
- 238000012986 modification Methods 0.000 description 9
- 150000007523 nucleic acids Chemical group 0.000 description 9
- 239000002243 precursor Substances 0.000 description 9
- 238000010186 staining Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 241000894006 Bacteria Species 0.000 description 8
- 108090000565 Capsid Proteins Proteins 0.000 description 8
- 102100023321 Ceruloplasmin Human genes 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 8
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 8
- 241000282412 Homo Species 0.000 description 8
- 241000124008 Mammalia Species 0.000 description 8
- 108091008874 T cell receptors Proteins 0.000 description 8
- 238000000502 dialysis Methods 0.000 description 8
- 239000000499 gel Substances 0.000 description 8
- 210000000987 immune system Anatomy 0.000 description 8
- 230000006698 induction Effects 0.000 description 8
- 229930182817 methionine Natural products 0.000 description 8
- 108020004707 nucleic acids Proteins 0.000 description 8
- 102000039446 nucleic acids Human genes 0.000 description 8
- 238000011002 quantification Methods 0.000 description 8
- 238000012163 sequencing technique Methods 0.000 description 8
- 238000003786 synthesis reaction Methods 0.000 description 8
- 231100000331 toxic Toxicity 0.000 description 8
- 230000002588 toxic effect Effects 0.000 description 8
- 241000701447 unidentified baculovirus Species 0.000 description 8
- 238000002255 vaccination Methods 0.000 description 8
- WCMOHMXWOOBVMZ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)CCN1C(=O)C=CC1=O WCMOHMXWOOBVMZ-UHFFFAOYSA-N 0.000 description 7
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 7
- 241000710929 Alphavirus Species 0.000 description 7
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 7
- 241000282560 Macaca mulatta Species 0.000 description 7
- 241000702670 Rotavirus Species 0.000 description 7
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 7
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 7
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 7
- 229960000723 ampicillin Drugs 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 235000018417 cysteine Nutrition 0.000 description 7
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 7
- 239000003446 ligand Substances 0.000 description 7
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 7
- 229910052757 nitrogen Inorganic materials 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 230000002829 reductive effect Effects 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 238000001338 self-assembly Methods 0.000 description 7
- 239000005720 sucrose Substances 0.000 description 7
- 241000712461 unidentified influenza virus Species 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 241000388186 Deltapapillomavirus 4 Species 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 6
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 238000013459 approach Methods 0.000 description 6
- 235000009697 arginine Nutrition 0.000 description 6
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 6
- 239000003638 chemical reducing agent Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 230000009089 cytolysis Effects 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 102000018358 immunoglobulin Human genes 0.000 description 6
- 239000006166 lysate Substances 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 6
- 238000011321 prophylaxis Methods 0.000 description 6
- 230000002441 reversible effect Effects 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 125000003396 thiol group Chemical group [H]S* 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 5
- 241000271566 Aves Species 0.000 description 5
- 241000283707 Capra Species 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 241000714209 Norwalk virus Species 0.000 description 5
- 102000002067 Protein Subunits Human genes 0.000 description 5
- 241000282898 Sus scrofa Species 0.000 description 5
- 108010067390 Viral Proteins Proteins 0.000 description 5
- 238000013019 agitation Methods 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 238000004587 chromatography analysis Methods 0.000 description 5
- 238000001493 electron microscopy Methods 0.000 description 5
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 5
- 210000001320 hippocampus Anatomy 0.000 description 5
- 210000004201 immune sera Anatomy 0.000 description 5
- 229940042743 immune sera Drugs 0.000 description 5
- 238000011532 immunohistochemical staining Methods 0.000 description 5
- 238000010348 incorporation Methods 0.000 description 5
- 206010022000 influenza Diseases 0.000 description 5
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 210000000478 neocortex Anatomy 0.000 description 5
- 210000002569 neuron Anatomy 0.000 description 5
- 230000008520 organization Effects 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 230000010076 replication Effects 0.000 description 5
- 108091008146 restriction endonucleases Proteins 0.000 description 5
- 210000003705 ribosome Anatomy 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 230000009261 transgenic effect Effects 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 4
- 101800001204 Capsid protein beta Proteins 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 241000709661 Enterovirus Species 0.000 description 4
- 241000724791 Filamentous phage Species 0.000 description 4
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 108091034117 Oligonucleotide Proteins 0.000 description 4
- 241001631646 Papillomaviridae Species 0.000 description 4
- 241000700159 Rattus Species 0.000 description 4
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 108020005038 Terminator Codon Proteins 0.000 description 4
- 108700019146 Transgenes Proteins 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 4
- 230000001054 cortical effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 238000009795 derivation Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 206010014599 encephalitis Diseases 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 4
- 230000028996 humoral immune response Effects 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 239000002054 inoculum Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000012188 paraffin wax Substances 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000007170 pathology Effects 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
- 108091033319 polynucleotide Proteins 0.000 description 4
- 102000040430 polynucleotide Human genes 0.000 description 4
- 239000002157 polynucleotide Substances 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 230000003362 replicative effect Effects 0.000 description 4
- 230000001629 suppression Effects 0.000 description 4
- 210000001103 thalamus Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000014616 translation Effects 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 3
- 238000009010 Bradford assay Methods 0.000 description 3
- 101150083464 CP gene Proteins 0.000 description 3
- 101100028482 Caenorhabditis elegans pal-1 gene Proteins 0.000 description 3
- 108091026890 Coding region Proteins 0.000 description 3
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 3
- 241000709743 Enterobacteria phage SP Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 241000283073 Equus caballus Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 3
- 206010029240 Neuritis Diseases 0.000 description 3
- 102000007999 Nuclear Proteins Human genes 0.000 description 3
- 108010089610 Nuclear Proteins Proteins 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000125945 Protoparvovirus Species 0.000 description 3
- 235000009001 Quillaja saponaria Nutrition 0.000 description 3
- 241000710799 Rubella virus Species 0.000 description 3
- 241000710961 Semliki Forest virus Species 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- PZBFGYYEXUXCOF-UHFFFAOYSA-N TCEP Chemical compound OC(=O)CCP(CCC(O)=O)CCC(O)=O PZBFGYYEXUXCOF-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000004279 alanine Nutrition 0.000 description 3
- 230000004075 alteration Effects 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 210000001159 caudate nucleus Anatomy 0.000 description 3
- 230000002490 cerebral effect Effects 0.000 description 3
- 238000010382 chemical cross-linking Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000002299 complementary DNA Substances 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- 210000000805 cytoplasm Anatomy 0.000 description 3
- 239000000539 dimer Substances 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 241001493065 dsRNA viruses Species 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 230000000763 evoking effect Effects 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- 239000013613 expression plasmid Substances 0.000 description 3
- 208000015756 familial Alzheimer disease Diseases 0.000 description 3
- 238000010353 genetic engineering Methods 0.000 description 3
- 210000002443 helper t lymphocyte Anatomy 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 3
- 229940072221 immunoglobulins Drugs 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 235000018977 lysine Nutrition 0.000 description 3
- 230000035800 maturation Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 230000007388 microgliosis Effects 0.000 description 3
- 238000010172 mouse model Methods 0.000 description 3
- 229920005615 natural polymer Polymers 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 230000035755 proliferation Effects 0.000 description 3
- 229930000044 secondary metabolite Natural products 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000002739 subcortical effect Effects 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- 238000001890 transfection Methods 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 238000005199 ultracentrifugation Methods 0.000 description 3
- 241000701161 unidentified adenovirus Species 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 2
- 241000711404 Avian avulavirus 1 Species 0.000 description 2
- 230000007082 Aβ accumulation Effects 0.000 description 2
- 101001106957 Bos taurus Ribonuclease pancreatic Proteins 0.000 description 2
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 2
- 241000282994 Cervidae Species 0.000 description 2
- 241001502567 Chikungunya virus Species 0.000 description 2
- 206010008631 Cholera Diseases 0.000 description 2
- 206010008761 Choriomeningitis lymphocytic Diseases 0.000 description 2
- 241000150230 Crimean-Congo hemorrhagic fever orthonairovirus Species 0.000 description 2
- 241000938605 Crocodylia Species 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 2
- 241000450599 DNA viruses Species 0.000 description 2
- 241000712471 Dhori virus Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 2
- 208000000655 Distemper Diseases 0.000 description 2
- 238000012286 ELISA Assay Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000991587 Enterovirus C Species 0.000 description 2
- 206010066919 Epidemic polyarthritis Diseases 0.000 description 2
- 208000000832 Equine Encephalomyelitis Diseases 0.000 description 2
- 241000723754 Flock house virus Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 206010018341 Gliosis Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 241000829111 Human polyomavirus 1 Species 0.000 description 2
- 241000726041 Human respirovirus 1 Species 0.000 description 2
- 241000430519 Human rhinovirus sp. Species 0.000 description 2
- 241000711450 Infectious bronchitis virus Species 0.000 description 2
- 241000701460 JC polyomavirus Species 0.000 description 2
- 241000710842 Japanese encephalitis virus Species 0.000 description 2
- 241000701646 Kappapapillomavirus 2 Species 0.000 description 2
- 241000710912 Kunjin virus Species 0.000 description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 108010052285 Membrane Proteins Proteins 0.000 description 2
- 241001092142 Molina Species 0.000 description 2
- 241000711386 Mumps virus Species 0.000 description 2
- 102000016943 Muramidase Human genes 0.000 description 2
- 108010014251 Muramidase Proteins 0.000 description 2
- 241000711408 Murine respirovirus Species 0.000 description 2
- 241000710908 Murray Valley encephalitis virus Species 0.000 description 2
- 241001467552 Mycobacterium bovis BCG Species 0.000 description 2
- 241001457453 Nairobi sheep disease virus Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 108700026244 Open Reading Frames Proteins 0.000 description 2
- 241000150218 Orthonairovirus Species 0.000 description 2
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 2
- 241000710778 Pestivirus Species 0.000 description 2
- 206010035664 Pneumonia Diseases 0.000 description 2
- 241000711902 Pneumovirus Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000710884 Powassan virus Species 0.000 description 2
- 102100022033 Presenilin-1 Human genes 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 108010001267 Protein Subunits Proteins 0.000 description 2
- 108010019653 Pwo polymerase Proteins 0.000 description 2
- 241001454523 Quillaja saponaria Species 0.000 description 2
- 108020004511 Recombinant DNA Proteins 0.000 description 2
- 241000725643 Respiratory syncytial virus Species 0.000 description 2
- 241000713124 Rift Valley fever virus Species 0.000 description 2
- 241000711897 Rinderpest morbillivirus Species 0.000 description 2
- 241000710942 Ross River virus Species 0.000 description 2
- 241000710801 Rubivirus Species 0.000 description 2
- 239000012506 Sephacryl® Substances 0.000 description 2
- 208000001203 Smallpox Diseases 0.000 description 2
- 241000710888 St. Louis encephalitis virus Species 0.000 description 2
- 108091081024 Start codon Proteins 0.000 description 2
- 108010090804 Streptavidin Proteins 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 241000723873 Tobacco mosaic virus Species 0.000 description 2
- 229920004890 Triton X-100 Polymers 0.000 description 2
- 241000713152 Uukuniemi virus Species 0.000 description 2
- 241000711970 Vesiculovirus Species 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 241000710772 Yellow fever virus Species 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 238000000137 annealing Methods 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 208000037875 astrocytosis Diseases 0.000 description 2
- 230000007341 astrogliosis Effects 0.000 description 2
- 229960000190 bacillus calmette–guérin vaccine Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000031018 biological processes and functions Effects 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 230000007969 cellular immunity Effects 0.000 description 2
- 235000013330 chicken meat Nutrition 0.000 description 2
- 238000012411 cloning technique Methods 0.000 description 2
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 2
- SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical compound C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 208000025688 early-onset autosomal dominant Alzheimer disease Diseases 0.000 description 2
- 239000012636 effector Substances 0.000 description 2
- 210000001353 entorhinal cortex Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 2
- 229960002143 fluorescein Drugs 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005194 fractionation Methods 0.000 description 2
- 238000001641 gel filtration chromatography Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 108010067216 glycyl-glycyl-glycine Proteins 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000001894 hemadsorption Effects 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 125000001072 heteroaryl group Chemical group 0.000 description 2
- 230000000951 immunodiffusion Effects 0.000 description 2
- 238000003364 immunohistochemistry Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 238000011005 laboratory method Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 208000001419 lymphocytic choriomeningitis Diseases 0.000 description 2
- 239000012139 lysis buffer Substances 0.000 description 2
- 229960000274 lysozyme Drugs 0.000 description 2
- 239000004325 lysozyme Substances 0.000 description 2
- 235000010335 lysozyme Nutrition 0.000 description 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 201000011475 meningoencephalitis Diseases 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000001823 molecular biology technique Methods 0.000 description 2
- 230000007171 neuropathology Effects 0.000 description 2
- 210000004940 nucleus Anatomy 0.000 description 2
- 238000006384 oligomerization reaction Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002018 overexpression Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000007505 plaque formation Effects 0.000 description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000012474 protein marker Substances 0.000 description 2
- 238000001742 protein purification Methods 0.000 description 2
- 230000012743 protein tagging Effects 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 229960003471 retinol Drugs 0.000 description 2
- 235000020944 retinol Nutrition 0.000 description 2
- 239000011607 retinol Substances 0.000 description 2
- 238000010839 reverse transcription Methods 0.000 description 2
- 238000004007 reversed phase HPLC Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 2
- 238000002741 site-directed mutagenesis Methods 0.000 description 2
- ULARYIUTHAWJMU-UHFFFAOYSA-M sodium;1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O ULARYIUTHAWJMU-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000012086 standard solution Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 241001529453 unidentified herpesvirus Species 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 229940051021 yellow-fever virus Drugs 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 1
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- DIYPCWKHSODVAP-UHFFFAOYSA-N 1-[3-(2,5-dioxopyrrol-1-yl)benzoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1=CC=CC(N2C(C=CC2=O)=O)=C1 DIYPCWKHSODVAP-UHFFFAOYSA-N 0.000 description 1
- CULQNACJHGHAER-UHFFFAOYSA-N 1-[4-[(2-iodoacetyl)amino]benzoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)C1=CC=C(NC(=O)CI)C=C1 CULQNACJHGHAER-UHFFFAOYSA-N 0.000 description 1
- AOPDRZXCEAKHHW-UHFFFAOYSA-N 1-pentoxypentane Chemical compound CCCCCOCCCCC AOPDRZXCEAKHHW-UHFFFAOYSA-N 0.000 description 1
- UFBJCMHMOXMLKC-UHFFFAOYSA-N 2,4-dinitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O UFBJCMHMOXMLKC-UHFFFAOYSA-N 0.000 description 1
- ASNTZYQMIUCEBV-UHFFFAOYSA-N 2,5-dioxo-1-[6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoyloxy]pyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)CCCCCNC(=O)CCSSC1=CC=CC=N1 ASNTZYQMIUCEBV-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- CNNSWSHYGANWBM-UHFFFAOYSA-N 6-chloro-2,3-dimethylquinoxaline Chemical compound C1=C(Cl)C=C2N=C(C)C(C)=NC2=C1 CNNSWSHYGANWBM-UHFFFAOYSA-N 0.000 description 1
- 101710159080 Aconitate hydratase A Proteins 0.000 description 1
- 101710159078 Aconitate hydratase B Proteins 0.000 description 1
- 241000701242 Adenoviridae Species 0.000 description 1
- 241000701386 African swine fever virus Species 0.000 description 1
- 241001036151 Aichi virus 1 Species 0.000 description 1
- IPWKGIFRRBGCJO-IMJSIDKUSA-N Ala-Ser Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](CO)C([O-])=O IPWKGIFRRBGCJO-IMJSIDKUSA-N 0.000 description 1
- 241001135972 Aleutian mink disease virus Species 0.000 description 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
- 102100034278 Annexin A6 Human genes 0.000 description 1
- 108090000656 Annexin A6 Proteins 0.000 description 1
- 241000269350 Anura Species 0.000 description 1
- 102000007592 Apolipoproteins Human genes 0.000 description 1
- 108010071619 Apolipoproteins Proteins 0.000 description 1
- 241000239223 Arachnida Species 0.000 description 1
- 241000712892 Arenaviridae Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 241000701802 Aviadenovirus Species 0.000 description 1
- 241001114034 Avian polyomavirus Species 0.000 description 1
- 108090001008 Avidin Proteins 0.000 description 1
- 241000700663 Avipoxvirus Species 0.000 description 1
- 102000019260 B-Cell Antigen Receptors Human genes 0.000 description 1
- 108010012919 B-Cell Antigen Receptors Proteins 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 241000518500 Batken virus Species 0.000 description 1
- 241001302800 Beak and feather disease virus Species 0.000 description 1
- 241000120506 Bluetongue virus Species 0.000 description 1
- 241001118702 Border disease virus Species 0.000 description 1
- 241000701083 Bovine alphaherpesvirus 1 Species 0.000 description 1
- 241001227615 Bovine foamy virus Species 0.000 description 1
- 241000711895 Bovine orthopneumovirus Species 0.000 description 1
- 241000701822 Bovine papillomavirus Species 0.000 description 1
- 241000621124 Bovine papular stomatitis virus Species 0.000 description 1
- 241000701922 Bovine parvovirus Species 0.000 description 1
- 241001506128 Bovine rotavirus strain NCDV/G6 Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000701931 Canine parvovirus Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 241000700664 Capripoxvirus Species 0.000 description 1
- 241000710190 Cardiovirus Species 0.000 description 1
- 241000010804 Caulobacter vibrioides Species 0.000 description 1
- 208000005145 Cerebral amyloid angiopathy Diseases 0.000 description 1
- 241000711969 Chandipura virus Species 0.000 description 1
- 102100030972 Coatomer subunit beta Human genes 0.000 description 1
- 101710186199 Coatomer subunit beta Proteins 0.000 description 1
- 241000204955 Colorado tick fever virus Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108020004635 Complementary DNA Proteins 0.000 description 1
- 241001275954 Cortinarius caperatus Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 241000723655 Cowpea mosaic virus Species 0.000 description 1
- 241000701022 Cytomegalovirus Species 0.000 description 1
- 206010011968 Decreased immune responsiveness Diseases 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 208000001490 Dengue Diseases 0.000 description 1
- 206010012310 Dengue fever Diseases 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- 241000702421 Dependoparvovirus Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 208000006586 Ectromelia Diseases 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- 241000710188 Encephalomyocarditis virus Species 0.000 description 1
- 101000742439 Enterobacteria phage T4 Head formation protein Proteins 0.000 description 1
- 241000709691 Enterovirus E Species 0.000 description 1
- 241000701081 Equid alphaherpesvirus 1 Species 0.000 description 1
- 241001598169 Equid alphaherpesvirus 3 Species 0.000 description 1
- 241000725578 Equid gammaherpesvirus 2 Species 0.000 description 1
- 241000283086 Equidae Species 0.000 description 1
- 108091029865 Exogenous DNA Proteins 0.000 description 1
- 241000725579 Feline coronavirus Species 0.000 description 1
- 241000701915 Feline panleukopenia virus Species 0.000 description 1
- 241001280522 Feline picornavirus Species 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 241000711950 Filoviridae Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 208000007212 Foot-and-Mouth Disease Diseases 0.000 description 1
- 101710177291 Gag polyprotein Proteins 0.000 description 1
- 241000701063 Gallid alphaherpesvirus 1 Species 0.000 description 1
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 206010061192 Haemorrhagic fever Diseases 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 208000009889 Herpes Simplex Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 241000700586 Herpesviridae Species 0.000 description 1
- 241000701020 Herpesvirus sylvilagus Species 0.000 description 1
- 101001033280 Homo sapiens Cytokine receptor common subunit beta Proteins 0.000 description 1
- 208000012860 Horse disease Diseases 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 244000309469 Human enteric coronavirus Species 0.000 description 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000713340 Human immunodeficiency virus 2 Species 0.000 description 1
- 241000701828 Human papillomavirus type 11 Species 0.000 description 1
- 241000341655 Human papillomavirus type 16 Species 0.000 description 1
- 241000709701 Human poliovirus 1 Species 0.000 description 1
- 241000617996 Human rotavirus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 208000004467 Infectious Canine Hepatitis Diseases 0.000 description 1
- 241000701377 Iridoviridae Species 0.000 description 1
- 241000120527 Kemerovo virus Species 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 241000712902 Lassa mammarenavirus Species 0.000 description 1
- 241000700563 Leporipoxvirus Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 206010024503 Limb reduction defect Diseases 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 241001115401 Marburgvirus Species 0.000 description 1
- 241000701244 Mastadenovirus Species 0.000 description 1
- 101710091157 Maturation protein A2 Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 241000710185 Mengo virus Species 0.000 description 1
- 241000712045 Morbillivirus Species 0.000 description 1
- 241000711466 Murine hepatitis virus Species 0.000 description 1
- 241001135960 Murine rotavirus Species 0.000 description 1
- 101100010166 Mus musculus Dok3 gene Proteins 0.000 description 1
- 241000282339 Mustela Species 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 1
- 241000588650 Neisseria meningitidis Species 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 241000710944 O'nyong-nyong virus Species 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 241000725177 Omsk hemorrhagic fever virus Species 0.000 description 1
- 241000702259 Orbivirus Species 0.000 description 1
- 241000700629 Orthopoxvirus Species 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 241000700639 Parapoxvirus Species 0.000 description 1
- 241000701945 Parvoviridae Species 0.000 description 1
- 241000237988 Patellidae Species 0.000 description 1
- 241000150350 Peribunyaviridae Species 0.000 description 1
- 241000312117 Phago Species 0.000 description 1
- FSXRLASFHBWESK-HOTGVXAUSA-N Phe-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 FSXRLASFHBWESK-HOTGVXAUSA-N 0.000 description 1
- 241000709664 Picornaviridae Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 229940124939 Pox vaccine Drugs 0.000 description 1
- 241000700625 Poxviridae Species 0.000 description 1
- 108010036933 Presenilin-1 Proteins 0.000 description 1
- 108010036908 Presenilin-2 Proteins 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000589614 Pseudomonas stutzeri Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241001092473 Quillaja Species 0.000 description 1
- 102000044126 RNA-Binding Proteins Human genes 0.000 description 1
- 101710105008 RNA-binding protein Proteins 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000702247 Reoviridae Species 0.000 description 1
- 206010051497 Rhinotracheitis Diseases 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 241000714213 San Miguel sea lion virus Species 0.000 description 1
- 241001135555 Sandfly fever Sicilian virus Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 241000555745 Sciuridae Species 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 108010034546 Serratia marcescens nuclease Proteins 0.000 description 1
- 241000702677 Simian rotavirus Species 0.000 description 1
- 241000701093 Suid alphaherpesvirus 1 Species 0.000 description 1
- 241000700568 Suipoxvirus Species 0.000 description 1
- 101150052863 THY1 gene Proteins 0.000 description 1
- 241000712908 Tacaribe mammarenavirus Species 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 241000710924 Togaviridae Species 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 241000870995 Variola Species 0.000 description 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 description 1
- 241001494970 Vesicular exanthema of swine virus Species 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 101000936049 Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) Outer membrane lipoprotein Blc Proteins 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 241000710951 Western equine encephalitis virus Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 108700010877 adenoviridae proteins Proteins 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 238000000246 agarose gel electrophoresis Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 230000009435 amidation Effects 0.000 description 1
- 238000007112 amidation reaction Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 239000001166 ammonium sulphate Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000003941 amyloidogenesis Effects 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 101150031224 app gene Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 241000701792 avian adenovirus Species 0.000 description 1
- 210000003578 bacterial chromosome Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 239000013592 cell lysate Substances 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012412 chemical coupling Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 230000006999 cognitive decline Effects 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 230000003920 cognitive function Effects 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000005332 contagious pustular dermatitis Diseases 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000007771 core particle Substances 0.000 description 1
- 239000007799 cork Substances 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 230000003436 cytoskeletal effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 208000025729 dengue disease Diseases 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000000368 destabilizing effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- FSXRLASFHBWESK-UHFFFAOYSA-N dipeptide phenylalanyl-tyrosine Natural products C=1C=C(O)C=CC=1CC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FSXRLASFHBWESK-UHFFFAOYSA-N 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- 208000005098 feline infectious peritonitis Diseases 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 206010016629 fibroma Diseases 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 210000003495 flagella Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000030414 genetic transfer Effects 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 description 1
- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical class [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 102000055647 human CSF2RB Human genes 0.000 description 1
- 102000001476 human anionic polypeptide fraction Human genes 0.000 description 1
- 108010093673 human anionic polypeptide fraction Proteins 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 150000003949 imides Chemical class 0.000 description 1
- 230000006303 immediate early viral mRNA transcription Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 230000002584 immunomodulator Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 230000007787 long-term memory Effects 0.000 description 1
- 230000027928 long-term synaptic potentiation Effects 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000015654 memory Effects 0.000 description 1
- 229960003151 mercaptamine Drugs 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 208000005871 monkeypox Diseases 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical class OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 208000009091 myxoma Diseases 0.000 description 1
- 230000001423 neocortical effect Effects 0.000 description 1
- 210000002682 neurofibrillary tangle Anatomy 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 125000006501 nitrophenyl group Chemical group 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000002895 organic esters Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003534 oscillatory effect Effects 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001322 periplasm Anatomy 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 210000000063 presynaptic terminal Anatomy 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 210000004129 prosencephalon Anatomy 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- VUFNRPJNRFOTGK-UHFFFAOYSA-M sodium;1-[4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexanecarbonyl]oxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)C1CCC(CN2C(C=CC2=O)=O)CC1 VUFNRPJNRFOTGK-UHFFFAOYSA-M 0.000 description 1
- MIDXXTLMKGZDPV-UHFFFAOYSA-M sodium;1-[6-(2,5-dioxopyrrol-1-yl)hexanoyloxy]-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].O=C1C(S(=O)(=O)[O-])CC(=O)N1OC(=O)CCCCCN1C(=O)C=CC1=O MIDXXTLMKGZDPV-UHFFFAOYSA-M 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 229940043517 specific immunoglobulins Drugs 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000007470 synaptic degeneration Effects 0.000 description 1
- 230000003956 synaptic plasticity Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 102000013498 tau Proteins Human genes 0.000 description 1
- 108010026424 tau Proteins Proteins 0.000 description 1
- 150000003568 thioethers Chemical class 0.000 description 1
- 230000009258 tissue cross reactivity Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000013638 trimer Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 241000990167 unclassified Simian adenoviruses Species 0.000 description 1
- 201000006266 variola major Diseases 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39663902P | 2002-07-19 | 2002-07-19 | |
| US47043203P | 2003-05-15 | 2003-05-15 | |
| PCT/EP2003/007864 WO2004016282A1 (en) | 2002-07-19 | 2003-07-18 | Vaccine compositions containing amyloid beta1-6 antigen arrays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05000819A true MXPA05000819A (es) | 2005-08-29 |
Family
ID=31891336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05000819A MXPA05000819A (es) | 2002-07-19 | 2003-07-18 | Composiciones de vacunas que contienen arreglos de antigeno amiloide beta 1-6. |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US7279165B2 (enExample) |
| EP (2) | EP1524994B1 (enExample) |
| JP (1) | JP4644488B2 (enExample) |
| KR (2) | KR101070078B1 (enExample) |
| CN (2) | CN1674934B (enExample) |
| AT (1) | ATE506964T1 (enExample) |
| AU (1) | AU2003250110C1 (enExample) |
| BR (1) | BR0312792A (enExample) |
| CA (1) | CA2492930C (enExample) |
| CY (1) | CY1111751T1 (enExample) |
| DE (1) | DE60336902D1 (enExample) |
| DK (1) | DK1524994T3 (enExample) |
| EC (1) | ECSP055551A (enExample) |
| IL (1) | IL166227A (enExample) |
| MX (1) | MXPA05000819A (enExample) |
| NO (1) | NO337574B1 (enExample) |
| NZ (1) | NZ537688A (enExample) |
| PL (1) | PL217409B1 (enExample) |
| PT (1) | PT1524994E (enExample) |
| RU (1) | RU2450827C2 (enExample) |
| SI (1) | SI1524994T1 (enExample) |
| WO (1) | WO2004016282A1 (enExample) |
| ZA (1) | ZA200500151B (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7094409B2 (en) * | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| CA2492826C (en) | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| EP1532167B1 (en) * | 2002-07-17 | 2012-01-25 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
| KR101228376B1 (ko) * | 2002-07-18 | 2013-01-31 | 사이토스 바이오테크놀로지 아게 | 합텐-캐리어 컨쥬게이트 및 그의 용도 |
| AU2003250110C1 (en) * | 2002-07-19 | 2008-05-29 | Novartis Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| ZA200507562B (en) | 2003-03-26 | 2006-11-29 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| AT413946B (de) * | 2004-07-13 | 2006-07-15 | Mattner Frank Dr | Impfstoff gegen die alzheimer-krankheit |
| WO2006037787A2 (en) * | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
| GB0424563D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| AU2011253800B2 (en) * | 2004-11-05 | 2013-08-22 | Novartis Ag | Composition comprising VLP and amyloid-beta peptide |
| WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
| JP5442251B2 (ja) * | 2005-05-26 | 2014-03-12 | サイトス バイオテクノロジー アーゲー | 拡張可能な発酵方法 |
| JPWO2006126682A1 (ja) * | 2005-05-27 | 2008-12-25 | 財団法人化学及血清療法研究所 | アルツハイマー病の予防・治療用ワクチン |
| CN101506236B (zh) | 2005-11-30 | 2012-12-12 | 雅培制药有限公司 | 抗淀粉样β蛋白的单克隆抗体及其用途 |
| RU2442793C2 (ru) | 2005-11-30 | 2012-02-20 | Эбботт Лэборетриз | АНТИТЕЛА ПРОТИВ ГЛОБУЛОМЕРА Аβ, ИХ АНТИГЕНСВЯЗЫВАЮЩИЕ ЧАСТИ, СООТВЕТСТВУЮЩИЕ ГИБРИДОМЫ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОРЫ, КЛЕТКИ-ХОЗЯЕВА, СПОСОБЫ ПОЛУЧЕНИЯ УКАЗАННЫХ АНТИТЕЛ, КОМПОЗИЦИИ, СОДЕРЖАЩИЕ УКАЗАННЫЕ АНТИТЕЛА, ПРИМЕНЕНИЯ УКАЗАННЫХ АНТИТЕЛ И СПОСОБЫ ИСПОЛЬЗОВАНИЯ УКАЗАННЫХ АНТИТЕЛ |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| EP2035448A4 (en) | 2006-06-01 | 2010-11-03 | Elan Pharm Inc | NEUROACTIVE FRAGMENTS OF APP |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| ES2498040T3 (es) | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009143465A1 (en) * | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Method of imaging abnormal deposits or plaques |
| ES2397641T3 (es) * | 2008-07-01 | 2013-03-08 | De Staat Der Nederlanden, Vert. Door De Minister Van Vws | Vacuna contra el intermediario de plegado amiloide |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| NZ598356A (en) * | 2009-07-30 | 2014-06-27 | Pfizer Vaccines Llc | Antigenic tau peptides and uses thereof |
| JP2013521233A (ja) | 2010-02-25 | 2013-06-10 | ヤンセン アルツハイマー イミュノセラピー | Ａβを標的とする免疫療法のＰＥＴモニタリング |
| AU2011234656B2 (en) * | 2010-03-29 | 2013-08-01 | Novartis Ag | Composition comprising the amyloid beta 1-6 peptide coupled to a virus-like particle and an adjuvant |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| JP5996527B2 (ja) | 2010-05-28 | 2016-09-21 | テラヴィア ホールディングス， インコーポレイテッド | 用途に応じた油を含む食品成分 |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| AU2012212079B2 (en) | 2011-02-02 | 2016-07-28 | Corbion Biotech, Inc. | Tailored oils produced from recombinant oleaginous microorganisms |
| KR20140050698A (ko) | 2011-07-29 | 2014-04-29 | 셀렉타 바이오사이언시즈, 인크. | 체액성 및 세포독성 t 림프구(ctl) 면역 반응을 발생시키는 합성 나노운반체 |
| HK1200849A1 (en) | 2011-12-22 | 2015-08-14 | F. Hoffmann-La Roche Ag | Full length antibody display system for eukaryotic cells and its use |
| SG11201406711TA (en) | 2012-04-18 | 2014-11-27 | Solazyme Inc | Tailored oils |
| US10195257B2 (en) | 2013-07-28 | 2019-02-05 | Qantu Therapeutics, Inc. | Vaccine formulations comprising quillaja desacylsaponins and beta amyloid peptides or tau protein to induce a Th2 immune response |
| MX369685B (es) | 2013-10-04 | 2019-11-19 | Terravia Holdings Inc | Aceites adaptables. |
| CN106574255A (zh) | 2014-07-10 | 2017-04-19 | 泰拉瑞亚控股公司 | 酮脂酰acp合酶基因及其用途 |
| DE16703049T1 (de) | 2015-01-15 | 2018-07-12 | University Of Copenhagen | Virusähnliche partikel mit effizienter epitopanzeige |
| CN107034198B (zh) * | 2015-07-15 | 2021-03-09 | 长春百克生物科技股份公司 | 一种嵌合诺如病毒p颗粒及其制备和应用 |
| ES2854726T3 (es) | 2015-10-30 | 2021-09-22 | The Univ Of Copenhagen | Partícula similar a virus con presentación eficiente de epítopos |
| CN113181106A (zh) | 2016-01-11 | 2021-07-30 | 沃达瑞公司 | 微针组合物及其使用方法 |
| WO2018237313A1 (en) * | 2017-06-23 | 2018-12-27 | American Type Culture Collection (Atcc) | Virus-like particles comprising zika antigen |
| US12227567B2 (en) | 2017-07-25 | 2025-02-18 | Truebinding, Inc. | Treating cancer by blocking the interaction of TIM-3 and its ligand |
| JP7255895B2 (ja) * | 2017-08-28 | 2023-04-11 | ボード オブ トラスティーズ オブ ミシガン ステイト ユニバーシティ | バクテリオファージおよびその変異体を使用したがんおよび感染を処置する組成物および方法 |
| CA3093715A1 (en) | 2018-04-19 | 2019-10-24 | Checkmate Pharmaceuticals, Inc. | Synthetic rig-i-like receptor agonists |
| CN116063520A (zh) | 2019-01-30 | 2023-05-05 | 真和制药有限公司 | 抗gal3抗体及其用途 |
| JP7707161B2 (ja) | 2019-10-23 | 2025-07-14 | チェックメイト ファーマシューティカルズ， インコーポレイテッド | 合成ｒｉｇ－ｉ様受容体アゴニスト |
| CN116157151A (zh) | 2020-05-26 | 2023-05-23 | 真和制药有限公司 | 通过阻断半乳凝素-3治疗炎性疾病的方法 |
| CN115819623A (zh) * | 2022-12-12 | 2023-03-21 | 长春百克生物科技股份公司 | 一种重组病毒样颗粒疫苗组合物的制备及应用 |
| WO2025018831A1 (ko) * | 2023-07-20 | 2025-01-23 | 주식회사 포스백스 | 파필로마바이러스 바이러스 유사입자 기반 항-아밀로이드 베타 알츠하이머병 백신 |
| KR20250017150A (ko) | 2023-07-20 | 2025-02-04 | 주식회사 포스백스 | 파필로마바이러스 바이러스 유사입자 기반 항-아밀로이드 베타 알츠하이머병 백신 |
Family Cites Families (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980000727A1 (en) | 1978-09-29 | 1980-04-17 | Secretary Energy Brit | Improvements in and relating to electrical power transmission in fluid wells |
| EP0038154B1 (en) | 1980-04-15 | 1983-09-21 | Beecham Group Plc | Allergens modified with polysarcosines |
| US5204096A (en) | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| DE3750176T2 (de) | 1986-09-22 | 1994-10-13 | Emory University, Atlanta, Ga. | Impfstoff und verfahren zur herstellung. |
| US5143726A (en) | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| US4918166A (en) | 1987-04-10 | 1990-04-17 | Oxford Gene Systems Limited | Particulate hybrid HIV antigens |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| JPH0656106B2 (ja) | 1988-10-29 | 1994-07-27 | マツダ株式会社 | 過給機付エンジンの吸気装置 |
| GB8903313D0 (en) | 1989-02-14 | 1989-04-05 | Wellcome Found | Conjugates |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB8913737D0 (en) | 1989-06-15 | 1989-08-02 | Univ Birmingham | A novel anti-allergy treatment |
| DK0425082T3 (da) | 1989-09-04 | 1995-07-03 | Evans Medical Ltd | Vacciner |
| NZ235315A (en) | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| CA2081482C (en) | 1990-04-27 | 2000-11-21 | Ellis L. Kline | Method and composition for treatment of central nervous system disease states associated with abnormal amyloid beta protein molecular organization |
| US5178882A (en) | 1990-06-22 | 1993-01-12 | The Regents Of The University Of California | Viral decoy vaccine |
| US5334394A (en) | 1990-06-22 | 1994-08-02 | The Regents Of The University Of California | Human immunodeficiency virus decoy |
| SE9003978D0 (sv) | 1990-12-13 | 1990-12-13 | Henrik Garoff | Dna expressionssystem baserade paa ett virus replikon |
| JPH06503821A (ja) | 1990-12-20 | 1994-04-28 | スミスクライン・ビーチャム・バイオロジカルス（ソシエテ・アノニム） | Ｂ型肝炎表面抗原に基づくワクチン |
| GB9101550D0 (en) | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
| GB9114003D0 (en) | 1991-06-28 | 1991-08-14 | Mastico Robert A | Chimaeric protein |
| ZA934199B (en) | 1992-06-18 | 1994-01-10 | Akzo Nv | Carrier system against gnrh |
| US6004763A (en) | 1992-09-11 | 1999-12-21 | Institut Pasteur | Antigen-carrying microparticles and their use in the induction of humoral or cellular responses |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| GB9227068D0 (en) | 1992-12-29 | 1993-02-24 | British Bio Technology | Novel proteinaceous particles |
| DE69418699T2 (de) | 1993-01-11 | 1999-09-30 | Dana-Farber Cancer Institute, Boston | Induktion der antworten zytotoxischer t-lymphozyten |
| WO1994017813A1 (en) | 1993-02-08 | 1994-08-18 | Paravax, Inc. | Defective sindbis virus vectors that express toxoplasma gondii p30 antigens |
| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
| US6180771B1 (en) | 1993-12-08 | 2001-01-30 | Immulogic Pharmaceutical Corp. | Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor |
| AT402898B (de) | 1994-08-08 | 1997-09-25 | Int Centre Genetic Eng & Bio | Molekulares präsentiersystem |
| US5935821A (en) | 1995-01-17 | 1999-08-10 | Board Of Trustees Of The University Of Kentucky | Polynucleotides related to monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma |
| WO1996028624A1 (en) | 1995-03-16 | 1996-09-19 | Owens Corning | Vacuum insulation panel having blended wool filler and method for manufacturing |
| CN1185811A (zh) | 1995-03-31 | 1998-06-24 | H·沃尔夫 | 依赖于逆转录病毒样颗粒的抗原呈递系统 |
| US5792462A (en) | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US5916616A (en) * | 1995-08-11 | 1999-06-29 | Nakano Vinegar Co., Ltd. | Process for producing starch noodles by extrusion |
| JPH09202735A (ja) | 1996-01-25 | 1997-08-05 | Nof Corp | リポソーム型アレルギー治療薬 |
| AU719609B2 (en) | 1996-03-01 | 2000-05-11 | Novartis Ag | Peptide immunogens for vaccination against and treatment of allergy |
| US5786161A (en) | 1996-06-06 | 1998-07-28 | Miltenyi Biotec. Gmbh | Isolation and characterization of allergen-binding cells for diagnosis of hypersensitivity |
| ES2307300T3 (es) | 1996-07-24 | 2008-11-16 | Novartis Ag | Modelo animal transgenico para la enfermedad de alzheimer. |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| ATE441432T1 (de) | 1997-03-10 | 2009-09-15 | Ottawa Hospital Res Inst | Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien |
| US8173127B2 (en) * | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| ES2255181T3 (es) | 1997-08-05 | 2006-06-16 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Antigeno inmunoprotector contra la gripe y su uso en vacunacion. |
| US6169175B1 (en) | 1997-08-06 | 2001-01-02 | Centers For Disease Control And Prevention | Preparation and use of recombinant influenza A virus M2 construct vaccines |
| US6054312A (en) | 1997-08-29 | 2000-04-25 | Selective Genetics, Inc. | Receptor-mediated gene delivery using bacteriophage vectors |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| CA2312475C (en) | 1997-12-03 | 2010-08-03 | Brigham And Women's Hospital | Method of suppressing .beta.-amyloid-related changes in alzheimer's disease |
| CA2320488C (en) | 1998-02-12 | 2007-03-06 | Immune Complex, Corporation | Strategically modified hepatitis b core proteins and their derivatives |
| US5990085A (en) | 1998-05-04 | 1999-11-23 | Michigan State University | Inhibin-HBc fusion protein |
| TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
| US6927278B1 (en) * | 1998-09-01 | 2005-08-09 | Trustees Of The University Of Pennsylvania | Peptide scaffolds for transfer of molecules into eukaryotic cells |
| AU770802B2 (en) | 1998-10-21 | 2004-03-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Virus-like particles for the induction of autoantibodies |
| US6380364B1 (en) | 1998-11-23 | 2002-04-30 | Loyola University Of Chicago | Chimeric biotin-binding papillomavirus protein |
| DE69939836D1 (de) * | 1998-11-30 | 2008-12-11 | Cytos Biotechnology Ag | Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung |
| EP1135408B1 (en) | 1998-12-04 | 2011-09-21 | Biogen Idec MA Inc. | Hbv core antigen particles with multiple immunogenic components attached via peptide ligands |
| JP2002537403A (ja) | 1999-02-25 | 2002-11-05 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | ＩｇＥのＣ−イプシロン−３またはＣ−イプシロン−４ドメイン由来のエピトープまたはミモトープ、その拮抗薬、及びそれらの治療的使用 |
| CA2365970A1 (en) | 1999-04-07 | 2000-10-12 | Thomas Jefferson University | Chemokine-derived synthetic peptides |
| CA2349434A1 (en) * | 1999-09-03 | 2001-03-15 | Ramot University Authority For Applied Research & Industrial Development Ltd. | Agents and compositions and methods utilizing same useful in diagnosing and/or treating or preventing plaque forming diseases |
| US20020052311A1 (en) | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
| AU2001229592A1 (en) * | 2000-01-21 | 2001-07-31 | University Of Connecticut Health Center | Vaccines against neurodegenerative disorders |
| ME00183B (me) | 2000-02-21 | 2011-02-10 | Pharmexa As | Novi postupak za deregulaciju amiloida |
| DE60122300T2 (de) | 2000-04-07 | 2007-08-30 | The University Of Leeds | Hepatitis b kernprotein fusionsproteine |
| CA2407897A1 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| AU6616301A (en) | 2000-06-22 | 2002-01-02 | Celltech Pharmaceuticals Ltd | Modification of hepatitis b core antigen |
| US20030138769A1 (en) | 2000-08-16 | 2003-07-24 | Birkett Ashley J. | Immunogenic HBc chimer particles having enhanced stability |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) * | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| US7264810B2 (en) | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| CA2492826C (en) * | 2001-09-14 | 2016-12-13 | Cytos Biotechnology Ag | Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use |
| JP4360906B2 (ja) | 2001-09-14 | 2009-11-11 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| US20030219459A1 (en) | 2002-01-18 | 2003-11-27 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| EP1532167B1 (en) | 2002-07-17 | 2012-01-25 | Cytos Biotechnology AG | Molecular antigen arrays using a virus like particle derived from the ap205 coat protein |
| KR101228376B1 (ko) * | 2002-07-18 | 2013-01-31 | 사이토스 바이오테크놀로지 아게 | 합텐-캐리어 컨쥬게이트 및 그의 용도 |
| NZ537001A (en) | 2002-07-19 | 2007-04-27 | Cytos Biotechnology Ag | A composition comprising a virus-like particle and at least ghrelin or a ghrelin-derived peptide bound thereto |
| AU2003250110C1 (en) * | 2002-07-19 | 2008-05-29 | Novartis Ag | Vaccine compositions containing amyloid beta1-6 antigen arrays |
| US7537767B2 (en) * | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| ZA200507562B (en) * | 2003-03-26 | 2006-11-29 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
| JP2008513035A (ja) * | 2004-09-21 | 2008-05-01 | サイトス バイオテクノロジー アーゲー | Ａｐ２０５のコートタンパク質と抗原性ポリペプチドとの融合タンパク質を含んでなるウイルス粒子 |
| WO2006037787A2 (en) * | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
| US7572451B2 (en) * | 2004-10-25 | 2009-08-11 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (GIP) antigen arrays and uses thereof |
| MX2007006832A (es) * | 2004-12-13 | 2007-08-07 | Cytos Biotechnology Ag | Arreglos de antigeno interleucina 15 y usos de los mismos. |
| ES2424229T3 (es) * | 2005-03-18 | 2013-09-30 | Cytos Biotechnology Ag | Proteínas de fusión de alérgenos de gato y utilización de las mismas |
| EP1982729A1 (en) * | 2007-04-20 | 2008-10-22 | Cytos Biotechnology AG | Vaccination Regimen for B-Cell Vaccines |
-
2003
- 2003-07-18 AU AU2003250110A patent/AU2003250110C1/en not_active Ceased
- 2003-07-18 PL PL374935A patent/PL217409B1/pl unknown
- 2003-07-18 AT AT03787750T patent/ATE506964T1/de active
- 2003-07-18 US US10/622,087 patent/US7279165B2/en not_active Expired - Fee Related
- 2003-07-18 CN CN038197340A patent/CN1674934B/zh not_active Expired - Fee Related
- 2003-07-18 PT PT03787750T patent/PT1524994E/pt unknown
- 2003-07-18 BR BR0312792-3A patent/BR0312792A/pt not_active Application Discontinuation
- 2003-07-18 EP EP03787750A patent/EP1524994B1/en not_active Expired - Lifetime
- 2003-07-18 DE DE60336902T patent/DE60336902D1/de not_active Expired - Lifetime
- 2003-07-18 JP JP2004528447A patent/JP4644488B2/ja not_active Expired - Fee Related
- 2003-07-18 NZ NZ537688A patent/NZ537688A/en not_active IP Right Cessation
- 2003-07-18 DK DK03787750.3T patent/DK1524994T3/da active
- 2003-07-18 CA CA2492930A patent/CA2492930C/en not_active Expired - Fee Related
- 2003-07-18 EP EP10179563A patent/EP2338510A1/en not_active Withdrawn
- 2003-07-18 CN CN200910179761A patent/CN101711865A/zh active Pending
- 2003-07-18 KR KR1020057000932A patent/KR101070078B1/ko not_active Expired - Fee Related
- 2003-07-18 WO PCT/EP2003/007864 patent/WO2004016282A1/en not_active Ceased
- 2003-07-18 RU RU2005104824/10A patent/RU2450827C2/ru not_active IP Right Cessation
- 2003-07-18 MX MXPA05000819A patent/MXPA05000819A/es active IP Right Grant
- 2003-07-18 SI SI200332018T patent/SI1524994T1/sl unknown
- 2003-07-18 KR KR1020107025742A patent/KR20100125480A/ko not_active Ceased
-
2005
- 2005-01-07 ZA ZA200500151A patent/ZA200500151B/en unknown
- 2005-01-10 IL IL166227A patent/IL166227A/en active IP Right Grant
- 2005-01-19 EC EC2005005551A patent/ECSP055551A/es unknown
- 2005-02-18 NO NO20050894A patent/NO337574B1/no not_active IP Right Cessation
-
2007
- 2007-10-05 US US11/905,986 patent/US20090246215A1/en not_active Abandoned
-
2011
- 2011-07-22 CY CY20111100723T patent/CY1111751T1/el unknown
-
2013
- 2013-12-13 US US14/105,701 patent/US20140294876A1/en not_active Abandoned
-
2015
- 2015-07-01 US US14/788,896 patent/US20150374807A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7279165B2 (en) | Amyloid β1-6 antigen arrays | |
| EP1523372B1 (en) | Ghrelin-carrier conjugates | |
| US20090155302A1 (en) | Antigen Arrays for Treatment of Allergic Eosinophilic Diseases | |
| AU2002363382B2 (en) | Antigen arrays presenting IL-5, IL-3 or eotaxin for treatment of allergic eosinophilic diseases | |
| AU2002342891B2 (en) | Antigen arrays comprising RANKL for treatment of bone disease | |
| US7785873B2 (en) | Antigen arrays for treatment of bone disease | |
| AU2002363382A1 (en) | Antigen arrays presenting IL-5, IL-3 or eotaxin for treatment of allergic eosinophilic diseases | |
| AU2002342891A1 (en) | Antigen arrays comprising RANKL for treatment of bone disease | |
| WO2003059386A2 (en) | Prion protein carrier-conjugates | |
| AU2003257479B2 (en) | Ghrelin-carrier conjugates | |
| ES2365706T3 (es) | Composiciones de vacuna que contienen disposiciones de antígeno beta 1-6 amiloide. | |
| HK1156519A (en) | Vaccine compositions contanining amyloid beta1-6 antigen arrays | |
| ZA200402015B (en) | Antigen arrays comprising rankl for treatment of bone disease. | |
| HK1077009B (en) | Vaccine compositions containing amyloid beta1-6 antigen arrays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |