DE69939836D1 - Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung - Google Patents

Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung

Info

Publication number
DE69939836D1
DE69939836D1 DE69939836T DE69939836T DE69939836D1 DE 69939836 D1 DE69939836 D1 DE 69939836D1 DE 69939836 T DE69939836 T DE 69939836T DE 69939836 T DE69939836 T DE 69939836T DE 69939836 D1 DE69939836 D1 DE 69939836D1
Authority
DE
Germany
Prior art keywords
production
virus
antigen
particles
coated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69939836T
Other languages
English (en)
Inventor
Wolfgang A Renner
Frank Hennecke
Lars Nieba
Martin Bachmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cytos Biotechnology AG
Original Assignee
Cytos Biotechnology AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology AG filed Critical Cytos Biotechnology AG
Application granted granted Critical
Publication of DE69939836D1 publication Critical patent/DE69939836D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69939836T 1998-11-30 1999-11-30 Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung Expired - Lifetime DE69939836D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11041498P 1998-11-30 1998-11-30
US14278899P 1999-07-08 1999-07-08
PCT/IB1999/001925 WO2000032227A2 (en) 1998-11-30 1999-11-30 Ordered molecular presentation of antigens, method of preparation and use

Publications (1)

Publication Number Publication Date
DE69939836D1 true DE69939836D1 (de) 2008-12-11

Family

ID=26808005

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69939836T Expired - Lifetime DE69939836D1 (de) 1998-11-30 1999-11-30 Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung

Country Status (17)

Country Link
US (1) US7229624B2 (de)
EP (1) EP1135162B1 (de)
JP (1) JP2010510960A (de)
CN (2) CN1193791C (de)
AT (1) ATE412434T1 (de)
AU (1) AU768807B2 (de)
BR (1) BR9915771A (de)
CA (1) CA2354183A1 (de)
DE (1) DE69939836D1 (de)
DK (1) DK1135162T3 (de)
ES (1) ES2317711T3 (de)
IL (2) IL143441A0 (de)
MX (1) MXPA01005389A (de)
NZ (1) NZ512456A (de)
PL (1) PL192016B1 (de)
RU (1) RU2245163C2 (de)
WO (1) WO2000032227A2 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770802B2 (en) 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
US7476517B2 (en) 1999-06-30 2009-01-13 Evotec Ag Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
US20040014033A1 (en) 1999-06-30 2004-01-22 Evotec Biosystems Ag, A Corporation Of Germany Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
EP1219705B1 (de) * 2000-12-29 2007-11-28 Evotec AG Virus-ähnliche Partikel, ihre Herstellung und ihre Verwendung beim pharmazeutischen Screening und funktionelle Genomanwendungen
ATE433491T1 (de) * 2001-01-18 2009-06-15 Vlaams Interuniv Inst Biotech Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
AU2007202761B2 (en) * 2001-01-19 2010-01-21 Kuros Biosciences Ag Molecular antigen array
US7094409B2 (en) * 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
EP2196217A1 (de) * 2001-09-14 2010-06-16 Cytos Biotechnology AG Verpackung von immunstimulierenden Mitteln in virusähnischen Partikeln: Herstellungsverfahren und Verwendung
US20030091593A1 (en) * 2001-09-14 2003-05-15 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
JP4671389B2 (ja) * 2001-10-05 2011-04-13 サイトス バイオテクノロジー アーゲー アンジオテンシンペプチド−担体複合体およびその使用
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
BR0213117A (pt) 2001-10-05 2004-09-21 Cytos Biotechnology Ag Conjugados peptìdeo angiotensina-veìculo e seus usos
EP1441764B1 (de) * 2001-11-07 2008-10-29 Cytos Biotechnology AG Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen
CA2466492A1 (en) * 2001-11-07 2003-05-15 Cytos Biotechnology Ag Antigen arrays presenting il-5, il-13 or eotaxin for treatment of allergic eosinophilic diseases
WO2003059386A2 (en) * 2002-01-18 2003-07-24 Cytos Biotechnology Ag Prion protein carrier-conjugates
CA2486118A1 (en) 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
WO2004000351A1 (en) * 2002-06-20 2003-12-31 Cytos Biotechnology Ag Packaged virus-like particles for use as adjuvants: method of preparation and use
EP1532167B1 (de) 2002-07-17 2012-01-25 Cytos Biotechnology AG Molekulare antigen-anordnung durch verwendung eines virus-ähnlichen partikels vom virus ap205
WO2004009116A2 (en) 2002-07-18 2004-01-29 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
AU2003250110C1 (en) * 2002-07-19 2008-05-29 Novartis Ag Vaccine compositions containing amyloid beta1-6 antigen arrays
RU2325202C2 (ru) * 2002-07-19 2008-05-27 Цитос Байотекнолоджи Аг Конъюгаты грелин-носитель
CA2494971A1 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
CA2517675A1 (en) 2003-03-26 2004-10-07 Cytos Biotechnology Ag Packaging of immunostimulatory oligonucleotides into virus-like particles: method of preparation and use
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
WO2004102198A2 (en) * 2003-05-15 2004-11-25 Cytos Biotechnology Ag Selection of b cells with specificity of interest: method of preparation and use
US7923109B2 (en) 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
RU2006130006A (ru) * 2004-01-20 2008-02-27 Цитос Биотехнологи Аг (Ch) Конъюгаты грелин-носитель
AR044603A1 (es) 2004-06-03 2005-09-21 Consejo Nac Invest Cient Tec Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones
CA2572921C (en) 2004-07-09 2017-01-03 The University Of North Carolina At Chapel Hill Replication-competent and propagation-defective venezuelan equine encephalitis (vee) viral adjuvants
EP1812051A2 (de) 2004-10-05 2007-08-01 Cytos Biotechnology AG Vlp-antigen-konjugate und ihre verwendung als vakzine
KR20070073896A (ko) 2004-10-25 2007-07-10 사이토스 바이오테크놀로지 아게 위 억제 폴리펩티드(ｇｉｐ) 항원 어레이 및 그의 용도
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
KR20070112225A (ko) * 2005-03-18 2007-11-22 사이토스 바이오테크놀로지 아게 고양이 알레르겐 컨쥬게이트 및 그의 용도
WO2007039552A1 (en) 2005-09-28 2007-04-12 Cytos Biotechnology Ag Interleukin-1 conjugates and uses thereof
US20070184068A1 (en) 2005-12-14 2007-08-09 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007092315A2 (en) * 2006-02-03 2007-08-16 The Regents Of The University Of California Immunostimulation by cpg oligonucleotide-virus complexes
CA2932591C (en) 2006-02-07 2023-07-25 Ticketmaster Methods and systems for reducing burst usage of a networked computer system
RU2476595C2 (ru) 2006-06-12 2013-02-27 Цитос Биотехнологи Аг Способы упаковки олигонуклеотидов в вирусоподобные частицы рнк-содержащих бактериофагов
CA2671873C (en) 2006-12-12 2018-10-09 Brian Stephen Sproat Oligonucleotides containing high concentrations of guanine monomers
WO2009109428A2 (en) * 2008-02-01 2009-09-11 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
EP2865389A1 (de) 2008-12-09 2015-04-29 Pfizer Vaccines LLC IgE CH3 Peptid-Impfstoff
PL222497B1 (pl) 2009-06-26 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej
JP2013500326A (ja) 2009-07-30 2013-01-07 ファイザー バクシーンズ エルエルシー 抗原性タウペプチドおよびその使用
EP2473605B1 (de) 2009-09-03 2018-04-11 Pfizer Vaccines LLC Pcsk9-impfstoff
EP2942061A3 (de) 2010-06-07 2016-01-13 Pfizer Vaccines LLC Ige-ch3-peptidimpfstoff
CN103282378B (zh) 2010-10-06 2015-03-11 华盛顿大学商业中心 多肽及其在治疗和限制呼吸道合胞病毒感染中的用途
CN102146411B (zh) * 2011-01-06 2013-01-02 中国人民解放军第三军医大学第三附属医院 新型双功能抗瘢痕和组织纤维化寡聚核苷酸药物
WO2012131504A1 (en) 2011-03-02 2012-10-04 Pfizer Inc. Pcsk9 vaccine
WO2013003752A2 (en) 2011-06-30 2013-01-03 University Of Washington Through Its Center For Commercialization Methods for design of epitope scaffolds
EP2736537A4 (de) 2011-07-29 2015-04-15 Selecta Biosciences Inc Synthetische nanotransporter zur erzeugung humoraler und cytotoxischer t-lymphocy (ctl)-immunreaktionen
EP2834263B9 (de) 2012-04-05 2019-02-27 University Of Washington Through Its Center For Commercialization Epitope-scaffold immunogenische peptide gegen rsv
CN109394752A (zh) * 2013-10-21 2019-03-01 德雷克塞尔大学 治疗慢性乙型肝炎病毒感染的sting激动剂的用途
WO2015123291A1 (en) 2014-02-11 2015-08-20 The Usa, As Represented By The Secretary, Dept. Of Health And Human Services Pcsk9 vaccine and methods of using the same
JP6409528B2 (ja) * 2014-11-27 2018-10-24 Jnc株式会社 アミノ基を含むイオン交換基とブチル基を含む疎水性基とを有する多孔性セルロース粒子及びそれを含むクロマトグラフィー担体ならびにｂ型肝炎ウィルスのウィルス様粒子の精製方法
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
GB201616365D0 (en) * 2016-09-27 2016-11-09 Helsingin Yliopisto Non-genetic modification of enveloped viruses
WO2019173438A1 (en) 2018-03-06 2019-09-12 Stc. Unm Compositions and methods for reducing serum triglycerides
US10907161B2 (en) 2018-04-19 2021-02-02 Checkmate Pharmaceuticals, Inc. Synthetic RIG-I-like receptor agonists
WO2021016509A1 (en) 2019-07-24 2021-01-28 Unm Rainforest Innovations Malaria immunogen and methods for using same
MX2022004825A (es) 2019-10-23 2022-10-10 Regeneron Pharma Agonistas sintéticos del receptor similar a rig i.
US12121574B2 (en) 2021-09-28 2024-10-22 Unm Rainforest Innovations Malaria immunogen and methods for using same
WO2024049946A1 (en) 2022-08-31 2024-03-07 Unm Rainforest Innovations Compositions targeting apoptosis-associated speck-like protein with caspase activation and recruitment domain (asc) and methods of use

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038154B1 (de) * 1980-04-15 1983-09-21 Beecham Group Plc Mit Polysarkosinen modifizierte Allergene
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
CA1319101C (en) 1986-09-03 1993-06-15 Marta Iris Sabara Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules
US5374426A (en) * 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
US5143726A (en) * 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
GB8903313D0 (en) * 1989-02-14 1989-04-05 Wellcome Found Conjugates
EP0425082B1 (de) 1989-09-04 1995-04-26 Evans Medical Limited Vakzine gegen Bordetella
US5178882A (en) 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
US5334394A (en) * 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
SE9003978D0 (sv) * 1990-12-13 1990-12-13 Henrik Garoff Dna expressionssystem baserade paa ett virus replikon
EP0563091A1 (de) 1990-12-20 1993-10-06 SMITHKLINE BEECHAM BIOLOGICALS s.a. Impfstoffe auf basis hepatitis-b-oberflächenantigen
JPH06508371A (ja) * 1991-06-21 1994-09-22 ユニバーシティー オブ シンシナティ 経口投与できる治療用タンパク質及びその製法
GB9114003D0 (en) * 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
US6004763A (en) * 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
WO1994017813A1 (en) * 1993-02-08 1994-08-18 Paravax, Inc. Defective sindbis virus vectors that express toxoplasma gondii p30 antigens
US6015686A (en) * 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US6180771B1 (en) * 1993-12-08 2001-01-30 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor
AT402898B (de) 1994-08-08 1997-09-25 Int Centre Genetic Eng & Bio Molekulares präsentiersystem
WO1996030523A2 (en) 1995-03-31 1996-10-03 Hans Wolf Antigen presentation system based on retrovirus-like particles
US5792462A (en) * 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
JPH09202735A (ja) * 1996-01-25 1997-08-05 Nof Corp リポソーム型アレルギー治療薬
IL125590A (en) 1996-03-01 2001-08-26 Novartis Ag Peptide immunogens, process for their preparation and use thereof as vaccines against allergies
US5786161A (en) * 1996-06-06 1998-07-28 Miltenyi Biotec. Gmbh Isolation and characterization of allergen-binding cells for diagnosis of hypersensitivity
US5770380A (en) * 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
SE9604815D0 (sv) * 1996-12-20 1996-12-20 Pharmacia & Upjohn Ab A metod of diagnosis
WO1999007839A2 (en) 1997-08-05 1999-02-18 Vlaams Interuniversitair Instituut Voor Biotechnologie Immunoprotective influenza antigen and its use in vaccination
DK1054689T3 (da) * 1998-02-12 2004-01-26 Apovia Inc Strategisk modificerede hepatitis B-kerneproteiner og derivater deraf
TWI227241B (en) 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
AU770802B2 (en) * 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
PL348766A1 (en) * 1998-12-04 2002-06-03 Biogen Hbv core antigen particles with multiple immunogenic components attached via peptide ligands
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines

Also Published As

Publication number Publication date
CN100534529C (zh) 2009-09-02
CN1679932A (zh) 2005-10-12
WO2000032227A3 (en) 2000-10-12
IL143441A0 (en) 2002-04-21
DK1135162T3 (da) 2009-01-19
ATE412434T1 (de) 2008-11-15
PL192016B1 (pl) 2006-08-31
CA2354183A1 (en) 2000-06-08
EP1135162A2 (de) 2001-09-26
NZ512456A (en) 2003-10-31
JP2010510960A (ja) 2010-04-08
EP1135162B1 (de) 2008-10-29
RU2245163C2 (ru) 2005-01-27
CN1333693A (zh) 2002-01-30
US20040136962A1 (en) 2004-07-15
MXPA01005389A (es) 2003-03-27
IL143441A (en) 2006-10-31
WO2000032227A2 (en) 2000-06-08
CN1193791C (zh) 2005-03-23
AU768807B2 (en) 2004-01-08
BR9915771A (pt) 2001-12-26
ES2317711T3 (es) 2009-04-16
PL348452A1 (en) 2002-05-20
US7229624B2 (en) 2007-06-12
AU1402000A (en) 2000-06-19

Similar Documents

Publication Publication Date Title
DE69939836D1 (de) Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung
DK0862633T3 (da) VP-antigen af JC-virus
WO2001085208A3 (en) Molecular antigen arrays and vaccines
EP1262555A4 (de) Hohle protein-nanopartikel, darauf basierende transporter und verfahren zum einbringen von substanzen in zellen
FR20C1016I2 (fr) Vaccins recombinants issu du virus de la stomatite vesiculaire dirige contre les fievres hemorragiques virales
DE60234375D1 (de) VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
DE69732407D1 (de) Verfahren fuer die replikation von influenza in zellkultur und die bei diesem verfahren hergestellten influenza-viren
BR0206565A (pt) Arranjo de antìgeno molecular
DE69934885D1 (de) Neue methoden und interferon defiziente substrate zur vermehrung von viren
ATE386105T1 (de) Chimäre humane papillomavirus (hpv) l1 moleküle und deren verwendungen
BR0312935A (pt) Partìcula semelhante a vìrus, muteìna, vetores para produzir a referida partìcula e proteìna recombinante, composição, processo para produção de fileira ordena e repetitva de antìgeno, molécula de ácido nucléico, célula hospedeira, método para produção da referida partìcula e uso da composição de vacina
DE69227400D1 (de) Impfstoffe und Verfahren zu ihrer Herstellung
DE3486160D1 (de) Modifizierte lebende pseudo-rabies-viren, diese enthaltende impfstoffe gegen pseudo-rabies, verfahren zur herstellung und verfahren zur verwendung derselben.
ATE489969T1 (de) Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
DE60207194D1 (de) Verfahren zur identifizierung, isolierung und herstellung von antigenen eines spezifischen pathogens
DE3684255D1 (de) Thymidinkinase-deletionsmutanten von bovinem herpesvirus-1, diese enthaltende impfstoffe gegen bovine rhinotracheitis und verfahren zu deren herstellung und verwendung.
DE60203975D1 (de) Verfahren zur Herstellung von magnetischen Teilchen, magnetische Teilchen und magnetischer Werkstoff
ATE412428T1 (de) Antigen-raster enthaltend rankl zur behandlung von knochenerkrankungen
ATE287726T1 (de) Kombinationsimpfstoff gegen hav und masernvirus und verfahren zu seiner produktion
EP0825403A3 (de) Labortrockner
ATE205256T1 (de) Verfahren zur herstellung von alpha-interferon
EP1057889A4 (de) Verbessertes immunogen für inaktivierten impfstoff gegen infektion mit japanischen encephalitis viren und verfahren zu dessen herstellung
DE60333370D1 (de) Zur bildung von partikeln fähiges hbv-precore-protein
ID29405A (id) Protein antigen tumor sart-3 yang baru dan peptida-peptida antigen tumornya
ATE494909T1 (de) Zusammensetzungen mit antigen-komplexen,verfahren zu ihrer herstellung und verfahren zur verwendung derantigen-komplexe zur vakzinierung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition