DE60333370D1 - Zur bildung von partikeln fähiges hbv-precore-protein - Google Patents

Zur bildung von partikeln fähiges hbv-precore-protein

Info

Publication number
DE60333370D1
DE60333370D1 DE60333370T DE60333370T DE60333370D1 DE 60333370 D1 DE60333370 D1 DE 60333370D1 DE 60333370 T DE60333370 T DE 60333370T DE 60333370 T DE60333370 T DE 60333370T DE 60333370 D1 DE60333370 D1 DE 60333370D1
Authority
DE
Germany
Prior art keywords
precore protein
hbv precore
particles
hbv
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60333370T
Other languages
English (en)
Inventor
Noboru Maki
Tatsuji Kimura
Shintaro Yagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Life Science Institute Inc
Original Assignee
Advanced Life Science Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Life Science Institute Inc filed Critical Advanced Life Science Institute Inc
Application granted granted Critical
Publication of DE60333370D1 publication Critical patent/DE60333370D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10123—Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
DE60333370T 2002-09-06 2003-09-05 Zur bildung von partikeln fähiges hbv-precore-protein Expired - Lifetime DE60333370D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002261666 2002-09-06
PCT/JP2003/011389 WO2004022585A1 (ja) 2002-09-06 2003-09-05 粒子形成能を有するhbvプレコア蛋白質

Publications (1)

Publication Number Publication Date
DE60333370D1 true DE60333370D1 (de) 2010-08-26

Family

ID=31973137

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60333370T Expired - Lifetime DE60333370D1 (de) 2002-09-06 2003-09-05 Zur bildung von partikeln fähiges hbv-precore-protein

Country Status (12)

Country Link
US (2) US7713532B2 (de)
EP (1) EP1535927B1 (de)
JP (1) JP4459054B2 (de)
KR (1) KR101093783B1 (de)
CN (1) CN100547001C (de)
AT (1) ATE473997T1 (de)
AU (1) AU2003261977A1 (de)
CA (1) CA2497972C (de)
DE (1) DE60333370D1 (de)
ES (1) ES2344737T3 (de)
HK (1) HK1081207A1 (de)
WO (1) WO2004022585A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4386660B2 (ja) * 2003-03-25 2009-12-16 株式会社先端生命科学研究所 Ｈｂｖ−ｒｎａを含むｈｂｖ粒子
ATE493659T1 (de) * 2004-05-19 2011-01-15 Advanced Life Science Inst Inc Verfahren zum nachweis von hepatitis-b-virus
JP2007538232A (ja) * 2004-05-19 2007-12-27 メルボルン ヘルス Ｂ型肝炎のための治療薬、予防薬、および診断薬
JP5332011B2 (ja) * 2006-10-30 2013-11-06 株式会社先端生命科学研究所 Ｂ型肝炎ウイルスの高感度免疫学的分析方法及び免疫学的分析用試薬
KR100836745B1 (ko) * 2007-01-31 2008-06-10 (주)두비엘 Ｈｂｖ 백신 및 그의 제조 방법
CN103217533B (zh) * 2012-01-21 2016-01-06 厦门大学 Anti-HBc定量检测方法及其在监控慢性乙肝患者病情发展和预测治疗疗效中的用途
EP2948469A4 (de) * 2013-01-23 2016-11-02 Univ Leland Stanford Junior Stabilisiertes hepatitis-b-kern-polypeptid
JPWO2015133613A1 (ja) * 2014-03-07 2017-04-06 雅史 溝上 Ｂ型肝炎ウイルスレポーターベクター、ｂ型肝炎ウイルス様粒子及びそれを用いたｂ型肝炎治療薬のスクリーニング方法
JP7072213B2 (ja) 2017-12-21 2022-05-20 国立研究開発法人理化学研究所 Ｂ型肝炎抗原タンパク質を標的としたイメージング用ｐｅｔプローブ
WO2020255425A1 (ja) * 2019-06-21 2020-12-24 国立研究開発法人理化学研究所 抗ｈｂｖ剤
CN113322302B (zh) * 2021-06-02 2023-08-11 重庆医科大学 一种hbv完整病毒颗粒的免疫捕获分子检测方法
CN113777329B (zh) * 2021-09-16 2023-07-18 何秋富 一种视黄醇结合蛋白测定试剂盒及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1234040A2 (de) 1999-12-03 2002-08-28 Innogenetics N.V. Hbv sequenzen
CA2419046C (en) 2000-08-11 2007-10-02 Advanced Life Science Institute, Inc. Method for detecting or measuring hbv

Also Published As

Publication number Publication date
JP4459054B2 (ja) 2010-04-28
CN1694898A (zh) 2005-11-09
ATE473997T1 (de) 2010-07-15
HK1081207A1 (en) 2006-05-12
US7713532B2 (en) 2010-05-11
EP1535927B1 (de) 2010-07-14
EP1535927A4 (de) 2006-06-21
EP1535927A1 (de) 2005-06-01
CA2497972C (en) 2016-04-26
WO2004022585A1 (ja) 2004-03-18
US8383333B2 (en) 2013-02-26
US20100285444A1 (en) 2010-11-11
KR20050053636A (ko) 2005-06-08
AU2003261977A1 (en) 2004-03-29
ES2344737T3 (es) 2010-09-06
CA2497972A1 (en) 2004-03-18
KR101093783B1 (ko) 2011-12-19
US20060166187A1 (en) 2006-07-27
CN100547001C (zh) 2009-10-07
JPWO2004022585A1 (ja) 2005-12-22

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