DE60320362D1 - Verfahren zur Herstellung von Dipeptiden - Google Patents

Verfahren zur Herstellung von Dipeptiden

Info

Publication number
DE60320362D1
DE60320362D1 DE60320362T DE60320362T DE60320362D1 DE 60320362 D1 DE60320362 D1 DE 60320362D1 DE 60320362 T DE60320362 T DE 60320362T DE 60320362 T DE60320362 T DE 60320362T DE 60320362 D1 DE60320362 D1 DE 60320362D1
Authority
DE
Germany
Prior art keywords
dipeptides
preparation
ala
dipeptide
atp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60320362T
Other languages
English (en)
Other versions
DE60320362T2 (de
Inventor
Shin-Ichi Hashimoto
Kazuhiko Tabata
Aya Kubota
Hajime Ikeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Application granted granted Critical
Publication of DE60320362D1 publication Critical patent/DE60320362D1/de
Publication of DE60320362T2 publication Critical patent/DE60320362T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE60320362T 2002-12-26 2003-12-29 Verfahren zur Herstellung von Dipeptiden Expired - Lifetime DE60320362T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002376054 2002-12-26
JP2002376054 2002-12-26
JP2003420887 2003-12-18
JP2003420887 2003-12-18

Publications (2)

Publication Number Publication Date
DE60320362D1 true DE60320362D1 (de) 2008-05-29
DE60320362T2 DE60320362T2 (de) 2009-07-23

Family

ID=32473734

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60320362T Expired - Lifetime DE60320362T2 (de) 2002-12-26 2003-12-29 Verfahren zur Herstellung von Dipeptiden

Country Status (12)

Country Link
US (2) US7514242B2 (de)
EP (3) EP1908773B8 (de)
JP (1) JP4447467B2 (de)
KR (1) KR101043562B1 (de)
CN (1) CN100400660C (de)
AT (1) ATE392430T1 (de)
AU (1) AU2003296151A1 (de)
CA (1) CA2511553C (de)
DE (1) DE60320362T2 (de)
ES (2) ES2544480T3 (de)
HK (1) HK1086296A1 (de)
WO (1) WO2004058960A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050106703A1 (en) * 2003-11-05 2005-05-19 Kyowa Hakko Kogyo Co., Ltd. Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms
US20050148048A1 (en) * 2003-11-27 2005-07-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
US20080213827A1 (en) * 2004-06-25 2008-09-04 Hashimoto Shin-Ichi Process For Producing Dipeptides or Dipeptide Derivatives
JP5424531B2 (ja) * 2004-06-25 2014-02-26 協和発酵バイオ株式会社 ジペプチドまたはジペプチド誘導体の製造法
EP1627884B9 (de) * 2004-06-25 2010-10-20 Kyowa Hakko Bio Co., Ltd. Verfahren zur Herstellung von Dipeptiden
DE602006010990D1 (de) * 2005-03-18 2010-01-21 Kyowa Hakko Bio Co Ltd Verfahren zur dipeptidherstellung
CN101151369B (zh) * 2005-03-29 2017-02-15 协和发酵生化株式会社 二肽的结晶及其制备方法
WO2007034807A1 (ja) 2005-09-20 2007-03-29 Kyowa Hakko Kogyo Co., Ltd. ジペプチド含有経口用組成物
JPWO2007066430A1 (ja) * 2005-12-08 2009-05-14 協和発酵キリン株式会社 ペプチドの製造法
US20090197303A1 (en) * 2005-12-27 2009-08-06 Kyowa Hakko Kogyo Co., Ltd. Process for producing dipeptides
CN101479292A (zh) 2006-06-28 2009-07-08 协和发酵生化株式会社 寡肽的纯化方法
WO2008038613A1 (fr) 2006-09-25 2008-04-03 Kyowa Hakko Bio Co., Ltd. Procédé de production de dipeptide
JPWO2008056759A1 (ja) * 2006-11-09 2010-02-25 協和発酵バイオ株式会社 ジペプチドの製造法
WO2008123607A1 (ja) * 2007-04-04 2008-10-16 Kyowa Hakko Bio Co., Ltd. ジペプチドの製造法
JP5319521B2 (ja) 2007-04-06 2013-10-16 協和発酵バイオ株式会社 ジペプチドの製造法
US20100248307A1 (en) * 2007-08-31 2010-09-30 Kyowa Hakko Bio Co., Ltd. Peptide production method
EP2840138B1 (de) 2008-05-12 2016-11-16 Kyowa Hakko Bio Co., Ltd. Verfahren zur Herstellung von Cis-4-hydroxy-L-prolin
DE102009002044A1 (de) * 2009-03-31 2010-10-07 Evonik Degussa Gmbh Dipeptide als Futtermitteladditive
CN101643712B (zh) * 2009-09-15 2010-12-29 南京师范大学 高效转化谷氨酰胺合成l-茶氨酸的大肠杆菌菌株及其应用
CA2779889C (en) 2009-11-06 2018-01-02 Kyowa Hakko Bio Co., Ltd. A method to enhance endurance
JPWO2012017925A1 (ja) 2010-08-02 2013-10-03 協和発酵キリン株式会社 物質の製造方法
JP5951953B2 (ja) * 2011-10-07 2016-07-13 協和発酵バイオ株式会社 新規ジペプチド合成酵素およびそれを用いたジペプチドの製造法
US20130225684A1 (en) 2012-02-28 2013-08-29 Kyowa Hakko Bio Co., Ltd. Methods and compositions for enhancement of vision performance
KR101495597B1 (ko) * 2013-10-16 2015-02-26 한국식품연구원 젓갈 유래 바실러스속 미생물 및 이를 이용하여 s-아데노실-l-메티오닌을 대량 생산하는 방법
CN103897023A (zh) * 2014-02-28 2014-07-02 苏州维泰生物技术有限公司 一种合成甘氨酸半胱氨酸伪二肽模块的新方法
CN105510497A (zh) * 2015-11-30 2016-04-20 精晶药业股份有限公司 L-丙氨酰-l-丙氨酸的定量检测方法
CN106552600B (zh) * 2016-10-18 2019-06-25 武汉理工大学 一种磁性壳核结构纳米粒子及其制备方法与应用
CN108048372B (zh) * 2018-01-30 2021-07-02 西南大学 一种短小芽孢杆菌及其防治蚕核型多角体病毒感染的应用
JPWO2021261564A1 (de) 2020-06-25 2021-12-30

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58110600A (ja) 1981-12-25 1983-07-01 Kyowa Hakko Kogyo Co Ltd ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
JPS59106298A (ja) 1982-12-09 1984-06-19 Kazutomo Imahori ペプチド又はペプチド誘導体の合成法
JPS58209992A (ja) 1982-05-27 1983-12-07 Kazutomo Imahori ペプチド又はペプチド誘導体の合成法
JPS58209991A (ja) 1982-05-27 1983-12-07 Kazutomo Imahori ペプチド又はペプチド誘導体の合成法
JPS58146539A (ja) 1982-01-26 1983-09-01 Kazutomo Imahori ペプチド又はペプチド誘導体の合成法
ATE255162T1 (de) 1983-01-13 2003-12-15 Max Planck Gesellschaft Transgene dicotyledone pflanzenzellen und pflanzen
NL8300698A (nl) 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
DE3588230D1 (de) 1984-05-11 2001-09-13 Syngenta Participations Ag Transformation von Pflanzenerbgut
ZA872705B (en) 1986-04-22 1987-10-05 Immunex Corporation Human g-csf protein expression
JPS63233798A (ja) 1986-10-09 1988-09-29 Kyowa Hakko Kogyo Co Ltd ５′−グアニル酸の製造法
IL84459A (en) 1986-12-05 1993-07-08 Agracetus Apparatus and method for the injection of carrier particles carrying genetic material into living cells
EP0832981A1 (de) 1987-02-17 1998-04-01 Pharming B.V. DNA-Sequenzen die Proteine zwecks effizienter Abscheidung zur Milchdrüse leiten
JP2545078B2 (ja) 1987-04-06 1996-10-16 協和醗酵工業株式会社 核酸関連物質の製造法
JP2928287B2 (ja) 1988-09-29 1999-08-03 協和醗酵工業株式会社 新規ポリペプチド
JPH0322979A (ja) 1989-06-19 1991-01-31 Kyowa Hakko Kogyo Co Ltd 新規プラスミノーゲン活性化因子
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
JP3131322B2 (ja) 1991-12-17 2001-01-31 協和醗酵工業株式会社 新規α２→３シアリルトランスフェラーゼ
US5591616A (en) 1992-07-07 1997-01-07 Japan Tobacco, Inc. Method for transforming monocotyledons
JP3756946B2 (ja) 1993-03-29 2006-03-22 協和醗酵工業株式会社 α１，３−フコシルトランスフェラーゼ
IT1264712B1 (it) 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
AU4220397A (en) 1996-09-17 1998-04-14 Kyowa Hakko Kogyo Co. Ltd. Processes for producing sugar nucleotides and complex carbohydrates
EP1097214A2 (de) 1998-07-10 2001-05-09 Institut für Pflanzengenetik und Kulturpflanzenforschung Gene zur biosynthese von anticapsin und bacilysin, ihre isolierung und verwendung
US20020064834A1 (en) * 1999-03-29 2002-05-30 Sascha Doekel Microbiological production method for alpha-L-aspartyl-L-phenylalanine

Also Published As

Publication number Publication date
CN1720325A (zh) 2006-01-11
CA2511553C (en) 2013-07-30
HK1086296A1 (en) 2006-09-15
JP4447467B2 (ja) 2010-04-07
EP1433791B1 (de) 2008-04-16
WO2004058960A1 (ja) 2004-07-15
DE60320362T2 (de) 2009-07-23
ATE392430T1 (de) 2008-05-15
US20040171106A1 (en) 2004-09-02
EP1433791A2 (de) 2004-06-30
EP1983059A2 (de) 2008-10-22
EP1908773B1 (de) 2015-07-22
JPWO2004058960A1 (ja) 2006-04-27
CA2511553A1 (en) 2004-07-15
EP1908773A3 (de) 2008-04-16
US8039236B2 (en) 2011-10-18
EP1983059A3 (de) 2009-04-22
ES2306835T3 (es) 2008-11-16
KR20050084466A (ko) 2005-08-26
CN100400660C (zh) 2008-07-09
EP1908773A2 (de) 2008-04-09
KR101043562B1 (ko) 2011-06-22
EP1433791A3 (de) 2005-03-30
US7514242B2 (en) 2009-04-07
EP1908773B8 (de) 2015-09-09
US20090191589A1 (en) 2009-07-30
ES2544480T3 (es) 2015-08-31
AU2003296151A1 (en) 2004-07-22

Similar Documents

Publication Publication Date Title
DE60320362D1 (de) Verfahren zur Herstellung von Dipeptiden
ATE478944T1 (de) Zytokin ligand zur behandlung von asthma und atemwegsüberreaktivität
DE60332024D1 (de) Verfahren zur herstellung von soja protein
ATE454396T1 (de) Verfahren zur herstellung von polypeptidmischungen unter anwendung von aufgereinigter bromwasserstoffsäure
DE60230274D1 (de) Verfahren zur herstellung von l-aminosäuren durch enterobacteriaceae-stämmen mit verstärkter expression des pts-g
ATE354668T1 (de) Verfahren zur herstellung von tripeptiden
ATE474847T1 (de) Verfahren zur herstellung von dipeptiden
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
IL172729A0 (en) Reagents and methods for the formation of disulfide bonds and the glycosylation of proteins
DE60323994D1 (de) Verfahren zur herstellung von 2-chlor-1,1,1,2,3,3,3-heptafluorpropan, hexafluorpropen und 1,1,1,2,3,3,3-heptafluorpropan
BRPI0406037A (pt) Produto de carne ou análogo de carne contendo soja, e, método para preparar o mesmo
DE50208306D1 (de) Verfahren zur Herstellung von nicht-proteinogenen L-Aminosäuren
DE60205955D1 (de) Verfahren zur Herstellung von L-Aminosäuren
ATE204851T1 (de) Verfahren zur herstellung von retrovial protease hemmenden zwischenprodukten
DE60219800D1 (de) Verfahren zur herstellung von cilastatin
DE50005649D1 (de) Verfahren zur Herstellung von Alkylphosphonsäuren
ATE304000T1 (de) Verfahren zur herstellung von n-carboxyanhydriden von aminosäuren
ATE271561T1 (de) Verfahren zur herstellung von einer amid verbindung
ATE239695T1 (de) Stereoselektive verfahren zur herstellung von gabapentinanalogen
DE69939751D1 (de) Verfahren zur Herstellung von S-Aryl-Cystein
ATE444304T1 (de) Verfahren zur herstellung von tripeptid- zwischenprodukten zur herstellung von lhrh- antagonisten
DE50109809D1 (de) Verfahren zur Herstellung von D- oder L-Menthol
AU2003202489A1 (en) Screening method
DE60230097D1 (de) Verfahren zur herstellung von 1,5-diaminonaphthalinen
ATE265421T1 (de) Verfahren zur herstellung von midodrin

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: HASHIMOTO, SHIN-ICHI, HOFU-SHI YAMAGUCHI 747-8, JP

Inventor name: TABATA, KAZUHIKO, MACHIDA-SHI TOKYO 194-8533, JP

Inventor name: KUBOTA, AYA, HOFU-SHI YAMAGUCHI 747-8522, JP

Inventor name: IKEDA, HAJIME, MACHIDA-SHI TOKYO 194-8533, JP

8364 No opposition during term of opposition