ATE412434T1 - Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung - Google Patents

Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung

Info

Publication number
ATE412434T1
ATE412434T1 AT99972928T AT99972928T ATE412434T1 AT E412434 T1 ATE412434 T1 AT E412434T1 AT 99972928 T AT99972928 T AT 99972928T AT 99972928 T AT99972928 T AT 99972928T AT E412434 T1 ATE412434 T1 AT E412434T1
Authority
AT
Austria
Prior art keywords
production
virus
antigen
particles
coated
Prior art date
Application number
AT99972928T
Other languages
English (en)
Inventor
Wolfgang Renner
Frank Hennecke
Lars Nieba
Martin Bachmann
Original Assignee
Cytos Biotechnology Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytos Biotechnology Ag filed Critical Cytos Biotechnology Ag
Application granted granted Critical
Publication of ATE412434T1 publication Critical patent/ATE412434T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99972928T 1998-11-30 1999-11-30 Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung ATE412434T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11041498P 1998-11-30 1998-11-30
US14278899P 1999-07-08 1999-07-08

Publications (1)

Publication Number Publication Date
ATE412434T1 true ATE412434T1 (de) 2008-11-15

Family

ID=26808005

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99972928T ATE412434T1 (de) 1998-11-30 1999-11-30 Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung

Country Status (17)

Country Link
US (1) US7229624B2 (de)
EP (1) EP1135162B1 (de)
JP (1) JP2010510960A (de)
CN (2) CN1193791C (de)
AT (1) ATE412434T1 (de)
AU (1) AU768807B2 (de)
BR (1) BR9915771A (de)
CA (1) CA2354183A1 (de)
DE (1) DE69939836D1 (de)
DK (1) DK1135162T3 (de)
ES (1) ES2317711T3 (de)
IL (2) IL143441A0 (de)
MX (1) MXPA01005389A (de)
NZ (1) NZ512456A (de)
PL (1) PL192016B1 (de)
RU (1) RU2245163C2 (de)
WO (1) WO2000032227A2 (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770802B2 (en) 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
US7476517B2 (en) 1999-06-30 2009-01-13 Evotec Ag Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
US20040014033A1 (en) 1999-06-30 2004-01-22 Evotec Biosystems Ag, A Corporation Of Germany Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics
WO2001085208A2 (en) 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines
DE60037263T2 (de) * 2000-12-29 2008-10-09 Evotec Ag Virus-ähnliche Partikel, ihre Herstellung und ihre Verwendung beim pharmazeutischen Screening und funktionelle Genomanwendungen
EP1362109B1 (de) * 2001-01-18 2009-06-10 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential
AU2007202761B2 (en) * 2001-01-19 2010-01-21 Kuros Biosciences Ag Molecular antigen array
US7320793B2 (en) * 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
US7094409B2 (en) 2001-01-19 2006-08-22 Cytos Biotechnology Ag Antigen arrays for treatment of allergic eosinophilic diseases
US7128911B2 (en) 2001-01-19 2006-10-31 Cytos Biotechnology Ag Antigen arrays for treatment of bone disease
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
AU2002347404A1 (en) * 2001-09-14 2003-04-01 Cytos Biotechnology Ag In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles
RU2350622C2 (ru) * 2001-10-05 2009-03-27 Цитос Байотекнолоджи Аг Конъюгат ангиотензиновой пептидной составляющей с носителем, композиция вакцины, способ иммунизации животного и способ лечения или профилактики физического нарушения, ассоциированного с активируемой ренином ангиотензиновой системой
US7115266B2 (en) 2001-10-05 2006-10-03 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
MXPA04002644A (es) 2001-10-05 2004-07-08 Cytos Biotechnology Ag Conjugados que portan un peptido de angiotensina y usos de los mismos.
CA2462857C (en) * 2001-10-05 2012-01-24 Cytos Biotechnology Ag Angiotensin peptide-carrier conjugates and uses thereof
KR20050044314A (ko) * 2001-11-07 2005-05-12 사이토스 바이오테크놀로지 아게 뼈 질환 치료용 항원 어레이
ES2320638T3 (es) * 2001-11-07 2009-05-27 Cytos Biotechnology Ag Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico.
AU2003205623A1 (en) * 2002-01-18 2003-07-30 Cytos Biotechnology Ag Prion protein carrier-conjugates
EP1545625B1 (de) 2002-06-07 2011-08-24 Kentucky Bioprocessing, LLC Flexlibler aufbau- und darreichungs-plattform von impfstoffen
PL375306A1 (en) * 2002-06-20 2005-11-28 Cytos Biotechnology Ag Packaged virus-like particles for use as adjuvants: method of preparation and use
AU2003246690B2 (en) 2002-07-17 2010-03-11 Cytos Biotechnology Ag Molecular antigen arrays using a virus like particle derived from the AP205 coat protein
NZ537003A (en) * 2002-07-18 2008-03-28 Cytos Biotechnology Ag Hapten-carrier conjugates comprising virus like particles and uses thereof
EP1524994B1 (de) * 2002-07-19 2011-04-27 Cytos Biotechnology AG Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays
US20040076645A1 (en) * 2002-07-19 2004-04-22 Bachmann Martin F. Ghrelin-carrier conjugates
WO2004016283A2 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
US7537767B2 (en) 2003-03-26 2009-05-26 Cytis Biotechnology Ag Melan-A- carrier conjugates
JP5022028B2 (ja) 2003-03-26 2012-09-12 サイトス・バイオテクノロジー・アクチェンゲゼルシャフト メラン−aペプチドアナログ−ウイルス様粒子コンジュゲート
EP1623229A2 (de) * 2003-05-15 2006-02-08 Cytos Biotechnology AG Selektion von b-zellen mit gewünschter spezifität: verfahren zur herstellung und deren verwendung
US7923109B2 (en) * 2004-01-05 2011-04-12 Board Of Regents, The University Of Texas System Inorganic nanowires
KR20060128924A (ko) * 2004-01-20 2006-12-14 사이토스 바이오테크놀로지 아게 그레린-담체 접합체
AR044603A1 (es) 2004-06-03 2005-09-21 Consejo Nac Invest Cient Tec Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones
US7862829B2 (en) * 2004-07-09 2011-01-04 University Of North Carolina At Chapel Hill Viral adjuvants
WO2006037787A2 (en) 2004-10-05 2006-04-13 Cytos Biotechnology Ag Vlp-antigen conjugates and their uses as vaccines
WO2006045796A2 (en) 2004-10-25 2006-05-04 Cytos Biotechnology Ag Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
US7767212B2 (en) * 2005-03-18 2010-08-03 Cytos Biotechnology Ag CAT allergen conjugates and uses thereof
FR2885901B1 (fr) * 2005-05-17 2008-02-29 Chelator Sa Para-tertio-butylcalix(6)arenes portant des fonctions triacides en positions 2,4 et 6, membranes liquides supportees et materiaux supports les comportant et leurs utilisations
AU2006298767B2 (en) 2005-09-28 2013-01-10 Cytos Biotechnology Ag Interleukin-1 conjugates and uses thereof
US20070184068A1 (en) 2005-12-14 2007-08-09 Cytos Biotechnology Ag Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity
WO2007092315A2 (en) * 2006-02-03 2007-08-16 The Regents Of The University Of California Immunostimulation by cpg oligonucleotide-virus complexes
CA2637184C (en) 2006-02-07 2016-08-16 Ticketmaster Methods and systems for reducing burst usage of a networked computer system
CN101466720B (zh) 2006-06-12 2013-01-02 赛托斯生物技术公司 向rna噬菌体的病毒样颗粒内包装寡核苷酸的方法
JP5389662B2 (ja) 2006-12-12 2014-01-15 サイトス バイオテクノロジー アーゲー 高濃度のグアニン・モノマーを含有するオリゴヌクレオチド
CA2713879C (en) * 2008-02-01 2020-01-07 Alpha-O Peptides Ag Self-assembling peptide nanoparticles useful as vaccines
PE20110891A1 (es) 2008-12-09 2011-12-23 Pfizer Vaccines Llc Vacuna de peptido ch3 de ige
PL222497B1 (pl) 2009-06-26 2016-08-31 Inst Biochemii I Biofizyki Pan Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej
IN2012DN00446A (de) 2009-07-30 2015-05-15 Pfizer Vaccines Llc
PE20121544A1 (es) 2009-09-03 2012-12-02 Pfizer Vaccines Llc Vacuna de pcsk9
EP2575868A1 (de) 2010-06-07 2013-04-10 Pfizer Vaccines LLC Ige-ch3-peptidimpfstoff
WO2012048115A2 (en) 2010-10-06 2012-04-12 University Of Washington Through Its Center For Commercialization Polypeptides and their use in treating and limiting respiratory syncytial virus infection
CN102146411B (zh) * 2011-01-06 2013-01-02 中国人民解放军第三军医大学第三附属医院 新型双功能抗瘢痕和组织纤维化寡聚核苷酸药物
US20140004142A1 (en) 2011-03-02 2014-01-02 Pfizer Inc. Pcsk9 vaccine
WO2013003752A2 (en) 2011-06-30 2013-01-03 University Of Washington Through Its Center For Commercialization Methods for design of epitope scaffolds
US20130028857A1 (en) 2011-07-29 2013-01-31 Selecta Biosciences, Inc. Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents
WO2013152274A1 (en) 2012-04-05 2013-10-10 University Of Washington Through Its Center For Commercialization Epitope- scaffold immunogens against respiratory syncytial virusm (rsv)
KR20160065858A (ko) * 2013-10-21 2016-06-09 드렉셀유니버시티 만성 b형 간염 바이러스 감염을 치료하기 위한 스팅 효능제의 사용
US10279019B2 (en) 2014-02-11 2019-05-07 Stc.Unm PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
JP6409528B2 (ja) * 2014-11-27 2018-10-24 Jnc株式会社 アミノ基を含むイオン交換基とブチル基を含む疎水性基とを有する多孔性セルロース粒子及びそれを含むクロマトグラフィー担体ならびにb型肝炎ウィルスのウィルス様粒子の精製方法
WO2017179025A1 (en) 2016-04-15 2017-10-19 Alk-Abelló A/S Epitope polypeptides of ragweed pollen allergens
GB201616365D0 (en) * 2016-09-27 2016-11-09 Helsingin Yliopisto Non-genetic modification of enveloped viruses
WO2019173438A1 (en) 2018-03-06 2019-09-12 Stc. Unm Compositions and methods for reducing serum triglycerides
CN112105733B (zh) 2018-04-19 2024-10-29 查美特制药公司 合成rig-i样受体激动剂
US12161710B2 (en) 2019-07-24 2024-12-10 Unm Rainforest Innovations Malaria immunogen and methods for using same
CN115279905B (zh) 2019-10-23 2026-03-17 里珍纳龙药品有限公司 合成rig-i样受体激动剂
US12121574B2 (en) 2021-09-28 2024-10-22 Unm Rainforest Innovations Malaria immunogen and methods for using same
EP4581044A1 (de) 2022-08-31 2025-07-09 Unm Rainforest Innovations Zusammensetzungen zum targeting von apoptose-assoziiertem spek-ähnlichem protein mit caspaseaktivierungs- und rekrutierungsdomäne (asc) und verfahren zur verwendung
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0038154B1 (de) * 1980-04-15 1983-09-21 Beecham Group Plc Mit Polysarkosinen modifizierte Allergene
US4722840A (en) 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
US5374426A (en) 1986-09-03 1994-12-20 University Of Saskatchewan Rotavirus nucleocapsid protein VP6 in vaccine compositions
CA1319101C (en) 1986-09-03 1993-06-15 Marta Iris Sabara Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules
US5143726A (en) * 1986-12-09 1992-09-01 The Scripps Research Institute T cell epitopes of the hepatitis B virus nucleocapsid protein
RU2092180C1 (ru) * 1988-06-22 1997-10-10 Эпплаид Микробиолоджи Инк. Антимикробная композиция
GB8903313D0 (en) * 1989-02-14 1989-04-05 Wellcome Found Conjugates
DE69018926T2 (de) 1989-09-04 1995-08-24 Wellcome Found Vakzine gegen Bordetella.
US5178882A (en) 1990-06-22 1993-01-12 The Regents Of The University Of California Viral decoy vaccine
US5334394A (en) * 1990-06-22 1994-08-02 The Regents Of The University Of California Human immunodeficiency virus decoy
SE9003978D0 (sv) 1990-12-13 1990-12-13 Henrik Garoff Dna expressionssystem baserade paa ett virus replikon
EP0563091A1 (de) 1990-12-20 1993-10-06 SMITHKLINE BEECHAM BIOLOGICALS s.a. Impfstoffe auf basis hepatitis-b-oberflächenantigen
JPH06508371A (ja) * 1991-06-21 1994-09-22 ユニバーシティー オブ シンシナティ 経口投与できる治療用タンパク質及びその製法
GB9114003D0 (en) * 1991-06-28 1991-08-14 Mastico Robert A Chimaeric protein
FR2695563B1 (fr) 1992-09-11 1994-12-02 Pasteur Institut Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires.
US6004763A (en) 1992-09-11 1999-12-21 Institut Pasteur Antigen-carrying microparticles and their use in the induction of humoral or cellular responses
WO1994017813A1 (en) * 1993-02-08 1994-08-18 Paravax, Inc. Defective sindbis virus vectors that express toxoplasma gondii p30 antigens
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US6180771B1 (en) * 1993-12-08 2001-01-30 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p III, and uses therefor
AT402898B (de) 1994-08-08 1997-09-25 Int Centre Genetic Eng & Bio Molekulares präsentiersystem
EP0817854A2 (de) 1995-03-31 1998-01-14 Wolf, Hans, Prof. Dr. Verfahren zur antigenpräsentation, aufbauend auf retrovirusähnlichen partikeln
US5792462A (en) * 1995-05-23 1998-08-11 University Of North Carolina At Chapel Hill Alphavirus RNA replicon systems
JPH09202735A (ja) * 1996-01-25 1997-08-05 Nof Corp リポソーム型アレルギー治療薬
CN1174998C (zh) 1996-03-01 2004-11-10 诺瓦提斯公司 用于预防和治疗过敏的肽免疫原
US5786161A (en) * 1996-06-06 1998-07-28 Miltenyi Biotec. Gmbh Isolation and characterization of allergen-binding cells for diagnosis of hypersensitivity
US5770380A (en) 1996-09-13 1998-06-23 University Of Pittsburgh Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold
GB9621091D0 (en) 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
SE9604815D0 (sv) * 1996-12-20 1996-12-20 Pharmacia & Upjohn Ab A metod of diagnosis
DE69832706T2 (de) 1997-08-05 2006-08-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Immunschützendes influenzaantigen und dessen verwendung zur impfung
NZ506245A (en) * 1998-02-12 2003-08-29 Immune Complex Corp Strategically modified hepatitis b core proteins and their derivatives
TWI227241B (en) 1998-06-20 2005-02-01 United Biomedical Inc IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate
AU770802B2 (en) * 1998-10-21 2004-03-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Virus-like particles for the induction of autoantibodies
AU770225B2 (en) * 1998-12-04 2004-02-19 Biogen Idec Ma Inc. HBV core antigen particles with multiple immunogenic components attached via peptide ligands
WO2001085208A2 (en) * 2000-05-05 2001-11-15 Cytos Biotechnology Ag Molecular antigen arrays and vaccines

Also Published As

Publication number Publication date
IL143441A0 (en) 2002-04-21
CN1679932A (zh) 2005-10-12
CN1193791C (zh) 2005-03-23
WO2000032227A3 (en) 2000-10-12
CA2354183A1 (en) 2000-06-08
NZ512456A (en) 2003-10-31
DK1135162T3 (da) 2009-01-19
MXPA01005389A (es) 2003-03-27
EP1135162B1 (de) 2008-10-29
RU2245163C2 (ru) 2005-01-27
JP2010510960A (ja) 2010-04-08
CN1333693A (zh) 2002-01-30
US7229624B2 (en) 2007-06-12
CN100534529C (zh) 2009-09-02
WO2000032227A2 (en) 2000-06-08
EP1135162A2 (de) 2001-09-26
PL192016B1 (pl) 2006-08-31
DE69939836D1 (de) 2008-12-11
IL143441A (en) 2006-10-31
US20040136962A1 (en) 2004-07-15
PL348452A1 (en) 2002-05-20
ES2317711T3 (es) 2009-04-16
AU1402000A (en) 2000-06-19
BR9915771A (pt) 2001-12-26
AU768807B2 (en) 2004-01-08

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