ATE412434T1 - Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung - Google Patents
Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendungInfo
- Publication number
- ATE412434T1 ATE412434T1 AT99972928T AT99972928T ATE412434T1 AT E412434 T1 ATE412434 T1 AT E412434T1 AT 99972928 T AT99972928 T AT 99972928T AT 99972928 T AT99972928 T AT 99972928T AT E412434 T1 ATE412434 T1 AT E412434T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- virus
- antigen
- particles
- coated
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000013566 allergen Substances 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 239000002245 particle Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 2
- 230000003252 repetitive effect Effects 0.000 abstract 2
- 230000003612 virological effect Effects 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 201000005505 Measles Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 238000003491 array Methods 0.000 abstract 1
- 210000000234 capsid Anatomy 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11041498P | 1998-11-30 | 1998-11-30 | |
| US14278899P | 1999-07-08 | 1999-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412434T1 true ATE412434T1 (de) | 2008-11-15 |
Family
ID=26808005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99972928T ATE412434T1 (de) | 1998-11-30 | 1999-11-30 | Molekulare anordnung von allergenen, verfahren zur deren herstellung und deren verwendung |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7229624B2 (de) |
| EP (1) | EP1135162B1 (de) |
| JP (1) | JP2010510960A (de) |
| CN (2) | CN1193791C (de) |
| AT (1) | ATE412434T1 (de) |
| AU (1) | AU768807B2 (de) |
| BR (1) | BR9915771A (de) |
| CA (1) | CA2354183A1 (de) |
| DE (1) | DE69939836D1 (de) |
| DK (1) | DK1135162T3 (de) |
| ES (1) | ES2317711T3 (de) |
| IL (2) | IL143441A0 (de) |
| MX (1) | MXPA01005389A (de) |
| NZ (1) | NZ512456A (de) |
| PL (1) | PL192016B1 (de) |
| RU (1) | RU2245163C2 (de) |
| WO (1) | WO2000032227A2 (de) |
Families Citing this family (69)
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|---|---|---|---|---|
| AU770802B2 (en) | 1998-10-21 | 2004-03-04 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Virus-like particles for the induction of autoantibodies |
| US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
| US7476517B2 (en) | 1999-06-30 | 2009-01-13 | Evotec Ag | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| US20040014033A1 (en) | 1999-06-30 | 2004-01-22 | Evotec Biosystems Ag, A Corporation Of Germany | Virus like particles, their preparation and their use preferably in pharmaceutical screening and functional genomics |
| WO2001085208A2 (en) | 2000-05-05 | 2001-11-15 | Cytos Biotechnology Ag | Molecular antigen arrays and vaccines |
| DE60037263T2 (de) * | 2000-12-29 | 2008-10-09 | Evotec Ag | Virus-ähnliche Partikel, ihre Herstellung und ihre Verwendung beim pharmazeutischen Screening und funktionelle Genomanwendungen |
| EP1362109B1 (de) * | 2001-01-18 | 2009-06-10 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Oligomerische komplexe von chimären proteinen mit verbessertem immunogenen potential |
| AU2007202761B2 (en) * | 2001-01-19 | 2010-01-21 | Kuros Biosciences Ag | Molecular antigen array |
| US7320793B2 (en) * | 2001-01-19 | 2008-01-22 | Cytos Biotechnology Ag | Molecular antigen array |
| US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
| US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
| DE60234375D1 (de) | 2001-09-14 | 2009-12-24 | Cytos Biotechnology Ag | VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG |
| AU2002347404A1 (en) * | 2001-09-14 | 2003-04-01 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| RU2350622C2 (ru) * | 2001-10-05 | 2009-03-27 | Цитос Байотекнолоджи Аг | Конъюгат ангиотензиновой пептидной составляющей с носителем, композиция вакцины, способ иммунизации животного и способ лечения или профилактики физического нарушения, ассоциированного с активируемой ренином ангиотензиновой системой |
| US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| MXPA04002644A (es) | 2001-10-05 | 2004-07-08 | Cytos Biotechnology Ag | Conjugados que portan un peptido de angiotensina y usos de los mismos. |
| CA2462857C (en) * | 2001-10-05 | 2012-01-24 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
| KR20050044314A (ko) * | 2001-11-07 | 2005-05-12 | 사이토스 바이오테크놀로지 아게 | 뼈 질환 치료용 항원 어레이 |
| ES2320638T3 (es) * | 2001-11-07 | 2009-05-27 | Cytos Biotechnology Ag | Disposicion ordenada de antigenos il-5, il-13 o eotasina, para el tratamiento de enfermedades alergicas con un componente eosinofilico. |
| AU2003205623A1 (en) * | 2002-01-18 | 2003-07-30 | Cytos Biotechnology Ag | Prion protein carrier-conjugates |
| EP1545625B1 (de) | 2002-06-07 | 2011-08-24 | Kentucky Bioprocessing, LLC | Flexlibler aufbau- und darreichungs-plattform von impfstoffen |
| PL375306A1 (en) * | 2002-06-20 | 2005-11-28 | Cytos Biotechnology Ag | Packaged virus-like particles for use as adjuvants: method of preparation and use |
| AU2003246690B2 (en) | 2002-07-17 | 2010-03-11 | Cytos Biotechnology Ag | Molecular antigen arrays using a virus like particle derived from the AP205 coat protein |
| NZ537003A (en) * | 2002-07-18 | 2008-03-28 | Cytos Biotechnology Ag | Hapten-carrier conjugates comprising virus like particles and uses thereof |
| EP1524994B1 (de) * | 2002-07-19 | 2011-04-27 | Cytos Biotechnology AG | Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays |
| US20040076645A1 (en) * | 2002-07-19 | 2004-04-22 | Bachmann Martin F. | Ghrelin-carrier conjugates |
| WO2004016283A2 (en) * | 2002-08-14 | 2004-02-26 | Avidis Sa | Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| JP5022028B2 (ja) | 2003-03-26 | 2012-09-12 | サイトス・バイオテクノロジー・アクチェンゲゼルシャフト | メラン−aペプチドアナログ−ウイルス様粒子コンジュゲート |
| EP1623229A2 (de) * | 2003-05-15 | 2006-02-08 | Cytos Biotechnology AG | Selektion von b-zellen mit gewünschter spezifität: verfahren zur herstellung und deren verwendung |
| US7923109B2 (en) * | 2004-01-05 | 2011-04-12 | Board Of Regents, The University Of Texas System | Inorganic nanowires |
| KR20060128924A (ko) * | 2004-01-20 | 2006-12-14 | 사이토스 바이오테크놀로지 아게 | 그레린-담체 접합체 |
| AR044603A1 (es) | 2004-06-03 | 2005-09-21 | Consejo Nac Invest Cient Tec | Proteinas quimericas aisladas de lumazina sintetasa modificada para la presentacion multiple de moleculas y sus aplicaciones |
| US7862829B2 (en) * | 2004-07-09 | 2011-01-04 | University Of North Carolina At Chapel Hill | Viral adjuvants |
| WO2006037787A2 (en) | 2004-10-05 | 2006-04-13 | Cytos Biotechnology Ag | Vlp-antigen conjugates and their uses as vaccines |
| WO2006045796A2 (en) | 2004-10-25 | 2006-05-04 | Cytos Biotechnology Ag | Gastric inhibitory polypeptide (gip) antigen arrays and uses thereof |
| GB0424563D0 (en) | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| US7767212B2 (en) * | 2005-03-18 | 2010-08-03 | Cytos Biotechnology Ag | CAT allergen conjugates and uses thereof |
| FR2885901B1 (fr) * | 2005-05-17 | 2008-02-29 | Chelator Sa | Para-tertio-butylcalix(6)arenes portant des fonctions triacides en positions 2,4 et 6, membranes liquides supportees et materiaux supports les comportant et leurs utilisations |
| AU2006298767B2 (en) | 2005-09-28 | 2013-01-10 | Cytos Biotechnology Ag | Interleukin-1 conjugates and uses thereof |
| US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
| WO2007092315A2 (en) * | 2006-02-03 | 2007-08-16 | The Regents Of The University Of California | Immunostimulation by cpg oligonucleotide-virus complexes |
| CA2637184C (en) | 2006-02-07 | 2016-08-16 | Ticketmaster | Methods and systems for reducing burst usage of a networked computer system |
| CN101466720B (zh) | 2006-06-12 | 2013-01-02 | 赛托斯生物技术公司 | 向rna噬菌体的病毒样颗粒内包装寡核苷酸的方法 |
| JP5389662B2 (ja) | 2006-12-12 | 2014-01-15 | サイトス バイオテクノロジー アーゲー | 高濃度のグアニン・モノマーを含有するオリゴヌクレオチド |
| CA2713879C (en) * | 2008-02-01 | 2020-01-07 | Alpha-O Peptides Ag | Self-assembling peptide nanoparticles useful as vaccines |
| PE20110891A1 (es) | 2008-12-09 | 2011-12-23 | Pfizer Vaccines Llc | Vacuna de peptido ch3 de ige |
| PL222497B1 (pl) | 2009-06-26 | 2016-08-31 | Inst Biochemii I Biofizyki Pan | Wektorowa cząsteczka wirusopodobna, sposób jej wytwarzania, kompozycja farmaceutyczna oraz zastosowanie wektorowej cząsteczki wirusopodobnej |
| IN2012DN00446A (de) | 2009-07-30 | 2015-05-15 | Pfizer Vaccines Llc | |
| PE20121544A1 (es) | 2009-09-03 | 2012-12-02 | Pfizer Vaccines Llc | Vacuna de pcsk9 |
| EP2575868A1 (de) | 2010-06-07 | 2013-04-10 | Pfizer Vaccines LLC | Ige-ch3-peptidimpfstoff |
| WO2012048115A2 (en) | 2010-10-06 | 2012-04-12 | University Of Washington Through Its Center For Commercialization | Polypeptides and their use in treating and limiting respiratory syncytial virus infection |
| CN102146411B (zh) * | 2011-01-06 | 2013-01-02 | 中国人民解放军第三军医大学第三附属医院 | 新型双功能抗瘢痕和组织纤维化寡聚核苷酸药物 |
| US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
| WO2013003752A2 (en) | 2011-06-30 | 2013-01-03 | University Of Washington Through Its Center For Commercialization | Methods for design of epitope scaffolds |
| US20130028857A1 (en) | 2011-07-29 | 2013-01-31 | Selecta Biosciences, Inc. | Synthetic nanocarriers comprising polymers comprising multiple immunomodulatory agents |
| WO2013152274A1 (en) | 2012-04-05 | 2013-10-10 | University Of Washington Through Its Center For Commercialization | Epitope- scaffold immunogens against respiratory syncytial virusm (rsv) |
| KR20160065858A (ko) * | 2013-10-21 | 2016-06-09 | 드렉셀유니버시티 | 만성 b형 간염 바이러스 감염을 치료하기 위한 스팅 효능제의 사용 |
| US10279019B2 (en) | 2014-02-11 | 2019-05-07 | Stc.Unm | PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same |
| JP6409528B2 (ja) * | 2014-11-27 | 2018-10-24 | Jnc株式会社 | アミノ基を含むイオン交換基とブチル基を含む疎水性基とを有する多孔性セルロース粒子及びそれを含むクロマトグラフィー担体ならびにb型肝炎ウィルスのウィルス様粒子の精製方法 |
| WO2017179025A1 (en) | 2016-04-15 | 2017-10-19 | Alk-Abelló A/S | Epitope polypeptides of ragweed pollen allergens |
| GB201616365D0 (en) * | 2016-09-27 | 2016-11-09 | Helsingin Yliopisto | Non-genetic modification of enveloped viruses |
| WO2019173438A1 (en) | 2018-03-06 | 2019-09-12 | Stc. Unm | Compositions and methods for reducing serum triglycerides |
| CN112105733B (zh) | 2018-04-19 | 2024-10-29 | 查美特制药公司 | 合成rig-i样受体激动剂 |
| US12161710B2 (en) | 2019-07-24 | 2024-12-10 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| CN115279905B (zh) | 2019-10-23 | 2026-03-17 | 里珍纳龙药品有限公司 | 合成rig-i样受体激动剂 |
| US12121574B2 (en) | 2021-09-28 | 2024-10-22 | Unm Rainforest Innovations | Malaria immunogen and methods for using same |
| EP4581044A1 (de) | 2022-08-31 | 2025-07-09 | Unm Rainforest Innovations | Zusammensetzungen zum targeting von apoptose-assoziiertem spek-ähnlichem protein mit caspaseaktivierungs- und rekrutierungsdomäne (asc) und verfahren zur verwendung |
| WO2025242657A1 (en) | 2024-05-21 | 2025-11-27 | Shape Biopharmaceuticals Ag | Lipopeptide building blocks and aggregates |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0038154B1 (de) * | 1980-04-15 | 1983-09-21 | Beecham Group Plc | Mit Polysarkosinen modifizierte Allergene |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US5374426A (en) | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| CA1319101C (en) | 1986-09-03 | 1993-06-15 | Marta Iris Sabara | Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules |
| US5143726A (en) * | 1986-12-09 | 1992-09-01 | The Scripps Research Institute | T cell epitopes of the hepatitis B virus nucleocapsid protein |
| RU2092180C1 (ru) * | 1988-06-22 | 1997-10-10 | Эпплаид Микробиолоджи Инк. | Антимикробная композиция |
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| US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
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| EP0817854A2 (de) | 1995-03-31 | 1998-01-14 | Wolf, Hans, Prof. Dr. | Verfahren zur antigenpräsentation, aufbauend auf retrovirusähnlichen partikeln |
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-
1999
- 1999-11-30 CN CNB998155063A patent/CN1193791C/zh not_active Expired - Fee Related
- 1999-11-30 EP EP99972928A patent/EP1135162B1/de not_active Expired - Lifetime
- 1999-11-30 MX MXPA01005389A patent/MXPA01005389A/es not_active IP Right Cessation
- 1999-11-30 DE DE69939836T patent/DE69939836D1/de not_active Expired - Lifetime
- 1999-11-30 ES ES99972928T patent/ES2317711T3/es not_active Expired - Lifetime
- 1999-11-30 NZ NZ512456A patent/NZ512456A/en not_active IP Right Cessation
- 1999-11-30 CA CA002354183A patent/CA2354183A1/en not_active Abandoned
- 1999-11-30 AU AU14020/00A patent/AU768807B2/en not_active Ceased
- 1999-11-30 BR BR9915771-3A patent/BR9915771A/pt not_active Application Discontinuation
- 1999-11-30 RU RU2001118274/15A patent/RU2245163C2/ru not_active IP Right Cessation
- 1999-11-30 JP JP2000584918A patent/JP2010510960A/ja active Pending
- 1999-11-30 CN CNB2005100541588A patent/CN100534529C/zh not_active Expired - Fee Related
- 1999-11-30 IL IL14344199A patent/IL143441A0/xx active IP Right Grant
- 1999-11-30 PL PL348452A patent/PL192016B1/pl unknown
- 1999-11-30 WO PCT/IB1999/001925 patent/WO2000032227A2/en not_active Ceased
- 1999-11-30 DK DK99972928T patent/DK1135162T3/da active
- 1999-11-30 AT AT99972928T patent/ATE412434T1/de not_active IP Right Cessation
-
2001
- 2001-05-29 IL IL143441A patent/IL143441A/en not_active IP Right Cessation
-
2003
- 2003-12-12 US US10/733,582 patent/US7229624B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL143441A0 (en) | 2002-04-21 |
| CN1679932A (zh) | 2005-10-12 |
| CN1193791C (zh) | 2005-03-23 |
| WO2000032227A3 (en) | 2000-10-12 |
| CA2354183A1 (en) | 2000-06-08 |
| NZ512456A (en) | 2003-10-31 |
| DK1135162T3 (da) | 2009-01-19 |
| MXPA01005389A (es) | 2003-03-27 |
| EP1135162B1 (de) | 2008-10-29 |
| RU2245163C2 (ru) | 2005-01-27 |
| JP2010510960A (ja) | 2010-04-08 |
| CN1333693A (zh) | 2002-01-30 |
| US7229624B2 (en) | 2007-06-12 |
| CN100534529C (zh) | 2009-09-02 |
| WO2000032227A2 (en) | 2000-06-08 |
| EP1135162A2 (de) | 2001-09-26 |
| PL192016B1 (pl) | 2006-08-31 |
| DE69939836D1 (de) | 2008-12-11 |
| IL143441A (en) | 2006-10-31 |
| US20040136962A1 (en) | 2004-07-15 |
| PL348452A1 (en) | 2002-05-20 |
| ES2317711T3 (es) | 2009-04-16 |
| AU1402000A (en) | 2000-06-19 |
| BR9915771A (pt) | 2001-12-26 |
| AU768807B2 (en) | 2004-01-08 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |