MX387646B - Derivados de tienopirrol para uso en seleccion como diana de proteínas, composiciones, métodos y usos de los mismos. - Google Patents
Derivados de tienopirrol para uso en seleccion como diana de proteínas, composiciones, métodos y usos de los mismos.Info
- Publication number
- MX387646B MX387646B MX2019007434A MX2019007434A MX387646B MX 387646 B MX387646 B MX 387646B MX 2019007434 A MX2019007434 A MX 2019007434A MX 2019007434 A MX2019007434 A MX 2019007434A MX 387646 B MX387646 B MX 387646B
- Authority
- MX
- Mexico
- Prior art keywords
- diseases
- protein
- methods
- conditions
- disease
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000018883 protein targeting Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 6
- 102000004127 Cytokines Human genes 0.000 abstract 4
- 108090000695 Cytokines Proteins 0.000 abstract 4
- 201000010099 disease Diseases 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- 102100034357 Casein kinase I isoform alpha Human genes 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 101000994700 Homo sapiens Casein kinase I isoform alpha Proteins 0.000 abstract 1
- 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 abstract 1
- 101000599042 Homo sapiens Zinc finger protein Aiolos Proteins 0.000 abstract 1
- 108010013958 Ikaros Transcription Factor Proteins 0.000 abstract 1
- 102000017182 Ikaros Transcription Factor Human genes 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 abstract 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 206010046851 Uveitis Diseases 0.000 abstract 1
- 102100037798 Zinc finger protein Aiolos Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000017455 cell-cell adhesion Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 230000004853 protein function Effects 0.000 abstract 1
- 230000007111 proteostasis Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención proporciona compuestos que modulan la función de proteína, para restaurar la homeostasis de proteína, que incluye actividad de citocina, CK1a, GSPT1, aiolos, y/o ikaros, y adhesión de célulacélula. La invención proporciona métodos para modular enfermedades mediadas por proteína, tal como enfermedades mediadas por citocina, trastornos, condiciones, o respuestas. Se proporcionan composiciones, que incluyen en combinación con otra citocina y mediadores inflamatorios. Se proporcionan métodos de tratamiento, aminoración, o prevención de enfermedades, tratarnos, o condiciones asociadas con una proteína, tal como enfermedades, trastornos, y condiciones asociadas con citocinas, que incluyen inflamación, fibromialgia, artritis reumatoide, osteoartritis, espondilitis anquilosante, psoriasis, artritis psoriática, enfermedades inflamatorias de intestino, enfermedad de Crohn, colitis ulcerativa, uveítis, enfermedades inflamatorias de pulmón, enfermedad pulmonar obstructiva crónica, enfermedad de Alzheimer, y cáncer.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662437400P | 2016-12-21 | 2016-12-21 | |
| US201762485563P | 2017-04-14 | 2017-04-14 | |
| US201762538203P | 2017-07-28 | 2017-07-28 | |
| PCT/US2017/067353 WO2018118947A1 (en) | 2016-12-21 | 2017-12-19 | Thienopyrrole derivatives for use in targeting proteins, compositions, methods, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2019007434A MX2019007434A (es) | 2019-08-16 |
| MX387646B true MX387646B (es) | 2025-03-18 |
Family
ID=60991575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019007434A MX387646B (es) | 2016-12-21 | 2017-12-19 | Derivados de tienopirrol para uso en seleccion como diana de proteínas, composiciones, métodos y usos de los mismos. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10040804B2 (es) |
| EP (1) | EP3559005A1 (es) |
| JP (1) | JP2020504711A (es) |
| KR (1) | KR20190093205A (es) |
| CN (1) | CN110099907A (es) |
| AU (1) | AU2017382176A1 (es) |
| CA (1) | CA3043938A1 (es) |
| IL (1) | IL267323A (es) |
| MX (1) | MX387646B (es) |
| RU (1) | RU2771166C2 (es) |
| TW (2) | TW201835089A (es) |
| WO (1) | WO2018118947A1 (es) |
| ZA (1) | ZA201903479B (es) |
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| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| RU2771166C2 (ru) | 2016-12-21 | 2022-04-27 | Биотерикс, Инк. | Производные тиенопиррола для применения для нацеливания на белки, композиции с указанными производными, способы и применения |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| EP3679026A1 (en) | 2017-09-04 | 2020-07-15 | C4 Therapeutics, Inc. | Glutarimide |
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| CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
| EP3710002A4 (en) | 2017-11-16 | 2021-07-07 | C4 Therapeutics, Inc. | DEGRADATION AND DEGRADATION AGENTS FOR TARGETED PROTEIN DEGRADATION |
| WO2019191112A1 (en) | 2018-03-26 | 2019-10-03 | C4 Therapeutics, Inc. | Cereblon binders for the degradation of ikaros |
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| EP3578561A1 (en) | 2018-06-04 | 2019-12-11 | F. Hoffmann-La Roche AG | Spiro compounds |
| AU2019284605A1 (en) * | 2018-06-13 | 2020-12-10 | Biotheryx, Inc. | Fused thiophene compounds |
| IL280984B2 (en) | 2018-08-22 | 2025-02-01 | Cullgen Shanghai Inc | Tropomyosin receptor kinase (TRK) inhibitor compounds and methods of use |
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| CN120698985A (zh) | 2018-12-20 | 2025-09-26 | C4医药公司 | 靶向蛋白降解 |
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| FR3092581A1 (fr) * | 2019-02-12 | 2020-08-14 | Impact Biomedicines, Inc | Formes cristallines d'un inhibiteur de jak2 |
| EA202192738A1 (ru) | 2019-04-12 | 2022-03-17 | С4 Терапьютикс, Инк. | Трициклические соединения, обеспечивающие разрушение белка ikaros и белка aiolos |
| AU2020283744A1 (en) * | 2019-05-24 | 2021-12-09 | Biotheryx, Inc. | Compounds targeting proteins and pharmaceutical compositions thereof, and their therapeutic applications |
| BR112022009514A2 (pt) | 2019-11-19 | 2022-08-16 | Bristol Myers Squibb Co | Compostos úteis como inibidores de proteína helios |
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-
2017
- 2017-12-19 RU RU2019115392A patent/RU2771166C2/ru active
- 2017-12-19 CN CN201780079826.3A patent/CN110099907A/zh active Pending
- 2017-12-19 KR KR1020197018882A patent/KR20190093205A/ko not_active Ceased
- 2017-12-19 JP JP2019526486A patent/JP2020504711A/ja active Pending
- 2017-12-19 WO PCT/US2017/067353 patent/WO2018118947A1/en not_active Ceased
- 2017-12-19 CA CA3043938A patent/CA3043938A1/en not_active Abandoned
- 2017-12-19 EP EP17829823.8A patent/EP3559005A1/en not_active Withdrawn
- 2017-12-19 MX MX2019007434A patent/MX387646B/es unknown
- 2017-12-19 US US15/847,628 patent/US10040804B2/en active Active
- 2017-12-19 AU AU2017382176A patent/AU2017382176A1/en not_active Abandoned
- 2017-12-21 TW TW106145115A patent/TW201835089A/zh unknown
- 2017-12-21 TW TW109142439A patent/TWI756957B/zh not_active IP Right Cessation
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2018
- 2018-06-18 US US16/011,090 patent/US10336771B2/en active Active
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2019
- 2019-05-30 ZA ZA2019/03479A patent/ZA201903479B/en unknown
- 2019-06-13 IL IL267323A patent/IL267323A/en unknown
- 2019-06-28 US US16/457,409 patent/US10889593B2/en active Active
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2021
- 2021-01-11 US US17/146,479 patent/US11345714B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2019115392A (ru) | 2021-01-22 |
| MX2019007434A (es) | 2019-08-16 |
| TW202120514A (zh) | 2021-06-01 |
| WO2018118947A1 (en) | 2018-06-28 |
| TWI756957B (zh) | 2022-03-01 |
| RU2771166C2 (ru) | 2022-04-27 |
| US20180170948A1 (en) | 2018-06-21 |
| JP2020504711A (ja) | 2020-02-13 |
| ZA201903479B (en) | 2021-09-29 |
| CN110099907A (zh) | 2019-08-06 |
| AU2017382176A1 (en) | 2019-05-30 |
| RU2019115392A3 (es) | 2021-05-14 |
| KR20190093205A (ko) | 2019-08-08 |
| US11345714B2 (en) | 2022-05-31 |
| US10040804B2 (en) | 2018-08-07 |
| US10336771B2 (en) | 2019-07-02 |
| US20210139500A1 (en) | 2021-05-13 |
| US10889593B2 (en) | 2021-01-12 |
| EP3559005A1 (en) | 2019-10-30 |
| US20180298027A1 (en) | 2018-10-18 |
| CA3043938A1 (en) | 2018-06-28 |
| IL267323A (en) | 2019-08-29 |
| TW201835089A (zh) | 2018-10-01 |
| US20190322683A1 (en) | 2019-10-24 |
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