MX387259B - Agonistas receptores de glp-1 y usos de los mismos - Google Patents

Agonistas receptores de glp-1 y usos de los mismos

Info

Publication number
MX387259B
MX387259B MX2019007077A MX2019007077A MX387259B MX 387259 B MX387259 B MX 387259B MX 2019007077 A MX2019007077 A MX 2019007077A MX 2019007077 A MX2019007077 A MX 2019007077A MX 387259 B MX387259 B MX 387259B
Authority
MX
Mexico
Prior art keywords
glp
receptor agonists
aza
benzimidazoles
compounds
Prior art date
Application number
MX2019007077A
Other languages
English (en)
Other versions
MX2019007077A (es
Inventor
Alan M Mathiowetz
Chris Limberakis
David A Griffith
David James Edmonds
David W Piotrowski
Gajendra Ingle
Gary Erik Aspnes
John M Curto
Kentaro Futatsugi
Kim Huard
Mark E Flanagan
Matthew S Dowling
Roger B Ruggeri
Scott W Bagley
Wenhua Jiao
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60702906&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX387259(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of MX2019007077A publication Critical patent/MX2019007077A/es
Publication of MX387259B publication Critical patent/MX387259B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)

Abstract

Se proveen en la presente 6 acidos carboxilicos de benzimidazoles y 4-aza, 5-aza, 7- aza y 4,7-diaza-benzimidazoles como agonistas de GLP-1R, procesos para hacer dichos compuestos, y metodos que comprenden administrar dichos compuestos a un mamifero en necesidad de los mismos.
MX2019007077A 2016-12-16 2017-12-01 Agonistas receptores de glp-1 y usos de los mismos MX387259B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662435533P 2016-12-16 2016-12-16
PCT/IB2017/057577 WO2018109607A1 (en) 2016-12-16 2017-12-01 Glp-1 receptor agonists and uses thereof

Publications (2)

Publication Number Publication Date
MX2019007077A MX2019007077A (es) 2019-08-01
MX387259B true MX387259B (es) 2025-03-18

Family

ID=60702906

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007077A MX387259B (es) 2016-12-16 2017-12-01 Agonistas receptores de glp-1 y usos de los mismos

Country Status (41)

Country Link
US (7) US10208019B2 (es)
EP (1) EP3555064B9 (es)
JP (2) JP6637641B1 (es)
KR (2) KR102466418B1 (es)
CN (1) CN110325530B (es)
AR (1) AR110387A1 (es)
AU (1) AU2017374860B2 (es)
BR (1) BR112019012211A2 (es)
CA (1) CA2988721C (es)
CL (1) CL2019001651A1 (es)
CO (1) CO2019006046A2 (es)
CR (1) CR20190289A (es)
CU (1) CU24573B1 (es)
CY (1) CY1125716T1 (es)
DK (1) DK3555064T5 (es)
DO (1) DOP2019000166A (es)
EA (1) EA037318B1 (es)
EC (1) ECSP19041071A (es)
ES (1) ES2934789T3 (es)
FI (1) FI3555064T3 (es)
GE (1) GEP20217265B (es)
HR (1) HRP20221437T1 (es)
HU (1) HUE060533T2 (es)
IL (1) IL267288B (es)
LT (1) LT3555064T (es)
MA (1) MA56480B1 (es)
MD (1) MD3555064T2 (es)
MX (1) MX387259B (es)
MY (1) MY195385A (es)
PE (1) PE20191501A1 (es)
PH (1) PH12019501360B1 (es)
PL (1) PL3555064T3 (es)
PT (1) PT3555064T (es)
RS (1) RS63849B9 (es)
RU (1) RU2740135C1 (es)
SI (1) SI3555064T1 (es)
TW (1) TWI713809B (es)
UA (1) UA122035C2 (es)
UY (1) UY37514A (es)
WO (1) WO2018109607A1 (es)
ZA (1) ZA201904616B (es)

Families Citing this family (161)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3433256T (pt) 2016-10-24 2019-10-31 Astrazeneca Derivados de 6,7,8,9-tetrahidro-3h-pirazolo[4,3-f]isoquinolina úteis no tratamento do cancro
ES2922379T3 (es) 2016-12-16 2022-09-14 Janssen Pharmaceutica Nv Compuestos de imidazo[4,5,D]pirrolo[2,3,B]piridina como inhibidores de Janus quinasas
JOP20190144A1 (ar) 2016-12-16 2019-06-16 Janssen Pharmaceutica Nv إيميدازو بيرولو بيريدين كمثبطات لعائلة jak الخاصة بإنزيمات الكيناز
AU2017374860B2 (en) 2016-12-16 2021-09-02 Pfizer Inc. GLP-1 receptor agonists and uses thereof
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
KR102246668B1 (ko) 2017-01-30 2021-04-29 아스트라제네카 아베 에스트로겐 수용체 조절인자
US12372530B2 (en) * 2017-11-15 2025-07-29 Beth Israel Deaconess Medical Center, Inc. Markers for the diagnosis and treatment of non-alcoholic steatohepatitis (NASH) and advanced liver fibrosis
MX2020012376A (es) 2018-05-18 2021-03-09 Incyte Corp Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b.
US10934279B2 (en) * 2018-06-13 2021-03-02 Pfizer Inc. GLP-1 receptor agonists and uses thereof
PT3806855T (pt) * 2018-06-15 2023-05-03 Pfizer Agonistas dos receptores de glp-1 e suas utilizações
TW202016110A (zh) 2018-06-15 2020-05-01 比利時商健生藥品公司 Ｊａｋ激酶家族之小分子抑制劑
BR112020025605A2 (pt) 2018-06-15 2021-03-23 Reata Pharmaceuticals, Inc. compostos de pirazol e imidazol para inibição de il-17 e rorgama
EP3810141A1 (en) 2018-06-20 2021-04-28 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
MA53097A (fr) 2018-07-05 2021-05-12 Incyte Corp Dérivés de pyrazine fusionnés en tant qu'inhibiteurs d'a2a/a2b
US11254660B2 (en) 2018-08-31 2022-02-22 Pfizer Inc. Combinations for treatment of NASH/NAFLD and related diseases
AU2019382642B2 (en) * 2018-11-22 2025-05-29 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
CN121081472A (zh) 2018-12-13 2025-12-09 拓臻股份有限公司 一种THRβ受体激动剂化合物及其制备方法和用途
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
US10954221B2 (en) 2019-04-12 2021-03-23 Qilu Regor Therapeutics Inc. GLP-1R agonists and uses thereof
CU20210083A7 (es) * 2019-04-12 2022-05-11 Qilu Regor Therapeutics Inc Agonistas de glp-1r
SG11202111980QA (en) 2019-04-29 2021-11-29 Confo Therapeutics N V Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
CA3140972C (en) * 2019-05-20 2024-06-18 Pfizer Inc. Combinations comprising benzodioxol as glp-1r agonists for use in the treatment of nash/nafld and related diseases
TW202115086A (zh) 2019-06-28 2021-04-16 美商輝瑞大藥廠 Bckdk抑制劑
TWI751585B (zh) * 2019-06-28 2022-01-01 美商美國禮來大藥廠 類升糖素肽1受體促效劑
US20220363673A1 (en) 2019-06-28 2022-11-17 Pfizer Inc. 5-(Thiophen-2-YL)-1 H-Tetrazole Derivative as BCKDK Inhibitors Useful for Treating Various Diseases
WO2021018023A1 (zh) * 2019-08-01 2021-02-04 济南泰达领创医药技术有限公司 小分子glp-1受体调节剂
US12215105B2 (en) 2019-09-13 2025-02-04 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
TWI771766B (zh) 2019-10-04 2022-07-21 美商輝瑞股份有限公司 二醯基甘油醯基轉移酶２ 抑制劑
BR112022007627A2 (pt) * 2019-10-25 2022-07-12 Gilead Sciences Inc Compostos moduladores do glp-1r
IL292943A (en) * 2019-11-15 2022-07-01 Ildong Pharmaceutical Co Ltd glp-1 receptor agonist and use thereof
KR20210059584A (ko) * 2019-11-15 2021-05-25 일동제약(주) Glp-1 수용체 작용제 및 이의 용도
WO2021112538A1 (en) 2019-12-02 2021-06-10 Hyundai Pharm Co., Ltd. Glp-1 receptor agonist
HUE067201T2 (hu) 2019-12-10 2024-10-28 Lilly Co Eli Eljárás és intermedier oxetan-2-il-metánamin elõállítására
TWI809334B (zh) * 2019-12-10 2023-07-21 美商輝瑞股份有限公司 ２－（（４－（（Ｓ）－２－（５－氯吡啶－２－基）－２－甲基苯并〔ｄ〕〔１，３〕二氧呃－４－基）哌啶－１－基）甲基）－１－（（（Ｓ）－氧呾－２－基）甲基）－１Ｈ－苯并〔ｄ〕咪唑－６－羧酸１，３－二羥基－２－（羥基甲基）丙烷－２－胺鹽之固體形式
CN115335374B (zh) 2020-01-29 2025-05-27 吉利德科学公司 Glp-1r调节化合物
FI4097099T3 (fi) 2020-02-07 2024-07-30 Gasherbrum Bio Inc Heterosyklisiä glp-1-agonisteja
WO2021160127A1 (en) * 2020-02-13 2021-08-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
JP2022058085A (ja) 2020-02-24 2022-04-11 ファイザー・インク ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ
JP2021134211A (ja) 2020-02-24 2021-09-13 ファイザー・インク Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ
MY207021A (en) * 2020-03-18 2025-01-24 Lg Chemical Ltd Glp-1 receptor agonist, pharmaceutical composition comprising same, and method for preparing same
CN115279750B (zh) * 2020-03-18 2024-06-21 株式会社Lg化学 Glp-1受体激动剂、包含该激动剂的药物组合物及其制备方法
CN115348863A (zh) * 2020-03-27 2022-11-15 辉瑞公司 以2-[(4-{6-[(4-氰基-2-氟苄基)氧基]吡啶-2-基}哌啶-1-基)甲基]-1-[(2s)-氧杂环丁烷-2-基甲基]-1h-苯并咪唑-6-甲酸或其药学上的盐治疗2型糖尿病或肥胖症或体重过重
CN113493447B (zh) * 2020-04-03 2024-06-11 轩竹(北京)医药科技有限公司 Glp-1受体激动剂
TW202144340A (zh) * 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
PE20221838A1 (es) 2020-04-24 2022-11-29 Astrazeneca Ab Formulaciones farmaceuticas
IL297216A (en) 2020-04-24 2022-12-01 Astrazeneca Ab Dosage regimen for the treatment of cancer
EP4143183B1 (en) * 2020-04-29 2025-10-22 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
DK4157832T3 (da) * 2020-05-27 2024-09-23 Qilu Regor Therapeutics Inc Salt af krystalformer af glp-1r-agonister og anvendelser deraf
MX2022015026A (es) * 2020-06-04 2023-01-04 Hangzhou Sciwind Biosciences Co Ltd Compuesto heteroaromatico de imidazol de cinco miembros y uso del mismo.
ES2994968T3 (en) 2020-06-09 2025-02-04 Pfizer Spiro compounds as melanocortin 4 receptor antagonists and uses thereof
WO2021249492A1 (zh) * 2020-06-10 2021-12-16 南京明德新药研发有限公司 甲基取代的苯并二噁唑类化合物及其应用
CN117645601A (zh) * 2020-06-10 2024-03-05 重庆康丁医药技术有限公司 一种具有心血管益处的glp-1小分子
CN113816948B (zh) * 2020-06-19 2023-08-11 江苏恒瑞医药股份有限公司 稠合咪唑类衍生物、其制备方法及其在医药上的应用
WO2021254470A1 (zh) * 2020-06-19 2021-12-23 江苏恒瑞医药股份有限公司 6-氧代-3,6-二氢吡啶类衍生物、其制备方法及其在医药上的应用
CN113831337B (zh) * 2020-06-24 2023-03-24 广州市恒诺康医药科技有限公司 Glp-1受体激动剂及其药物组合物和用途
TW202214622A (zh) 2020-08-06 2022-04-16 大陸商上海齊魯銳格醫藥研發有限公司 Ｇｌｐ－１ｒ促效劑及其用途
CR20230066A (es) * 2020-08-06 2023-05-29 Gasherbrum Bio Inc Agonistas del glp-1 heterocíclicos
CA3192601A1 (en) * 2020-08-21 2022-02-24 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
JP2023538949A (ja) * 2020-08-28 2023-09-12 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
JP2023539584A (ja) 2020-09-01 2023-09-15 江蘇恒瑞医薬股▲ふん▼有限公司 縮合イミダゾール誘導体、その調製方法及びその医薬的応用
WO2022053651A2 (en) 2020-09-10 2022-03-17 Precirix N.V. Antibody fragment against fap
WO2022068772A1 (zh) * 2020-09-29 2022-04-07 深圳信立泰药业股份有限公司 一种苯并咪唑类衍生物及其制备方法和医药用途
WO2022078152A1 (zh) * 2020-10-12 2022-04-21 杭州中美华东制药有限公司 苯并咪唑酮类glp-1受体激动剂及其用途
JP2023546055A (ja) * 2020-10-13 2023-11-01 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
CN116547278A (zh) * 2020-10-13 2023-08-04 加舒布鲁姆生物公司 杂环glp-1激动剂
US20230382899A1 (en) * 2020-10-14 2023-11-30 Qilu Regor Therapeutics Inc. Crystal forms of glp-1r agonists and uses thereof
CN114478497B (zh) * 2020-11-12 2023-10-20 杭州中美华东制药有限公司 芳基烷基酸类glp-1受体激动剂及其用途
US11851419B2 (en) 2020-11-20 2023-12-26 Gilead Sciences, Inc. GLP-1R modulating compounds
US20240246959A1 (en) 2020-11-27 2024-07-25 Shenzhen Salubris Pharmaceuticals Co., Ltd. Benzimidazole derivative and preparation method therefor and medical use thereof
CN114591308B (zh) * 2020-12-03 2024-03-08 苏州闻泰医药科技有限公司 一类glp-1r受体激动剂化合物及其用途
US20220193063A1 (en) * 2020-12-15 2022-06-23 Pfizer Inc. Metabolites of glp1r agonists
US12065434B2 (en) * 2020-12-15 2024-08-20 Pfizer Inc. Metabolites of GLP1R agonists
MX2023007569A (es) * 2020-12-25 2023-09-21 Xizang Haisco Pharmaceutical Co Ltd Derivado de anillo de cinco miembros y uso medico de este.
CN114805336A (zh) * 2021-01-20 2022-07-29 江苏恒瑞医药股份有限公司 稠合咪唑类化合物、其制备方法及其在医药上的应用
US20230089073A1 (en) * 2021-01-28 2023-03-23 Carmot Therapeutics, Inc. Gpcr receptor agonists, pharmaceutical compositions comprising the same, and methods for their use
CN117043154A (zh) * 2021-01-28 2023-11-10 卡莫特医疗有限公司 Gpcr受体激动剂、包含其的药物组合物以及它们的使用方法
US12252488B2 (en) 2021-02-12 2025-03-18 Nimbus Saturn, Inc. HPK1 antagonists and uses thereof
WO2022184849A1 (en) 2021-03-04 2022-09-09 Les Laboratoires Servier Glp-1r agonists, uses and pharmaceutical compositions thereof
WO2022187856A1 (en) 2021-03-05 2022-09-09 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
AU2022233254A1 (en) 2021-03-11 2023-10-26 Janssen Pharmaceutica Nv Lorpucitinib for use in the treatment of jak mediated disorders
US12091404B2 (en) 2021-03-11 2024-09-17 Gilead Sciences, Inc. GLP-1R modulating compounds
WO2022192430A1 (en) * 2021-03-11 2022-09-15 Gilead Sciences, Inc. Glp-1r modulating compounds
US20240208952A1 (en) 2021-03-22 2024-06-27 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Thiophene glp-1 receptor agonist and use thereof
WO2022202864A1 (ja) 2021-03-24 2022-09-29 塩野義製薬株式会社 縮合環を有するｇｌｐ－１受容体作動薬を含有する医薬組成物
US12071442B2 (en) 2021-03-29 2024-08-27 Nimbus Saturn, Inc. Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists
AU2022263410B2 (en) * 2021-04-21 2024-08-01 Gilead Sciences, Inc. Carboxy-benzimidazole glp-1r modulating compounds
JP2024516291A (ja) * 2021-05-03 2024-04-12 カーモット セラピューティクス インコーポレイテッド ベンゾイミダゾイルｇｌｐ－１受容体アゴニスト、それを含む医薬組成物、及びそれらの使用方法
TWI843104B (zh) * 2021-05-20 2024-05-21 美商美國禮來大藥廠 類升糖素肽1受體促效劑
CN117098758A (zh) * 2021-06-24 2023-11-21 杭州中美华东制药有限公司 Glp-1受体激动剂及其组合物和用途
CN117715906A (zh) * 2021-07-21 2024-03-15 和博医药有限公司 胰高血糖素样肽-1受体调节剂及其用途
CN113480534B (zh) * 2021-07-23 2022-05-13 广州必贝特医药股份有限公司 苯并咪唑或氮杂苯并咪唑-6-羧酸类化合物及其应用
WO2023011395A1 (zh) * 2021-08-02 2023-02-09 深圳信立泰药业股份有限公司 Glp-1r激动剂化合物的盐及其制备方法和医药用途
WO2023011539A1 (zh) * 2021-08-04 2023-02-09 上海翰森生物医药科技有限公司 环烯类衍生物调节剂、其制备方法和应用
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
KR20240054335A (ko) * 2021-08-31 2024-04-25 화이자 인코포레이티드 2-[(4-｛6-[(4-시아노-2-플루오로벤질)옥시]피리딘-2-일｝피페리딘-1-일)메틸]-1-[(2s)-옥세탄-2-일메틸]-1h-벤즈이미다졸-6-카르복실산,1,3-디히드록시-2-(히드록시메틸)프로판-2-아민 염의 고체 형태
CN113548982B (zh) * 2021-09-03 2022-05-06 上海三牧化工技术有限公司 一种4-氰基-2-氟苄醇的制备方法
CN118948849A (zh) 2021-09-08 2024-11-15 盐野义制药株式会社 用于预防和治疗与抗肥胖作用有关的疾病的药物
HRP20251161T1 (hr) 2021-09-27 2025-11-21 Terns Pharmaceuticals, Inc. Benzimidazol karboksilne kisele kao agonisti glp-1r
WO2023057414A1 (en) 2021-10-05 2023-04-13 Astrazeneca Ab Certain octahydrofuro[3,4- b]pyrazines as glp-1 receptor modulators
US20250115612A1 (en) 2021-10-05 2025-04-10 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes and octahydrofuro[3,4-b]pyrazines as glp-1 receptor modulators
US20240417393A1 (en) 2021-10-05 2024-12-19 Astrazeneca Ab Certain 2,5-diazabicyclo[4.2.0]octanes as glp-1 receptor modulators
TWI843243B (zh) * 2021-10-22 2024-05-21 大陸商盛世泰科生物醫藥技術（蘇州）股份有限公司 作為glp-1受體激動劑的化合物、包含其的藥物組成物及其用途
TW202334129A (zh) 2021-10-25 2023-09-01 美商拓臻製藥公司 作為ｇｌｐ—１ｒ促效劑的化合物
MX2024006739A (es) 2021-12-01 2024-06-19 Pfizer Derivados de acido 3-fenil-1-benzotiofeno-2-carboxilico como inhibidores de alfa cetoacido deshidrogenasa quinasa de cadena ramificada para el tratamiento de diabetes, enfermedad renal, esteatohepatitis no alcoholica (nash) e insuficiencia cardiaca.
CA3239813A1 (en) * 2021-12-03 2023-06-08 Lu Gan Crystal forms of thienoimidazole compound and preparation method thereof
US20250129048A1 (en) 2021-12-06 2025-04-24 Pfizer Inc. Melanocortin 4 receptor antagonists and uses thereof
JPWO2023106310A1 (es) * 2021-12-07 2023-06-15
US20250066338A1 (en) 2021-12-16 2025-02-27 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
US20250042882A1 (en) 2021-12-16 2025-02-06 Astrazeneca Ab Certain 3-azabicyclo[3.1.0]hexanes as glp-1 receptor modulators
WO2023124824A1 (zh) * 2021-12-29 2023-07-06 海思科医药集团股份有限公司 一种glp-1激动剂的盐及其晶型和在医药上的应用
CN118613476A (zh) * 2022-01-10 2024-09-06 西藏海思科制药有限公司 一种glp-1激动剂盐及其晶型及在医药上的应用
JP2025506474A (ja) * 2022-02-09 2025-03-11 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
JP2025506473A (ja) * 2022-02-09 2025-03-11 ガシャーブラム・バイオ・インコーポレイテッド ヘテロ環ｇｌｐ－１アゴニスト
WO2023164050A1 (en) 2022-02-23 2023-08-31 Terns Pharmaceuticals, Inc. Compounds as glp-1r agonists
EP4491625A1 (en) * 2022-03-08 2025-01-15 Guangzhou Unirise Pharmaceutical Co., Ltd. Benzo bicyclic compound, and preparation method and application thereof
EP4490155A1 (en) * 2022-03-09 2025-01-15 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
EP4496797A1 (en) 2022-03-21 2025-01-29 Gasherbrum Bio, Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
EP4508047A1 (en) 2022-04-14 2025-02-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
IL318992A (en) 2022-05-02 2025-04-01 Precirix N V Cancer treatment through advance directives
CN117003744B (zh) * 2022-07-18 2025-08-15 厦门市博瑞来医药科技有限公司 五元并六元化合物、其中间体、制备方法、组合物和应用
CN119585249A (zh) * 2022-07-22 2025-03-07 辉瑞公司 用于制备2-[(4-{6-[(4-氰基-2-氟芐基)氧基]吡啶-2-基}哌啶-1-基)甲基]-1-[(2s)-氧杂环丁烷-2-基甲基]-1h-苯并咪唑-6-羧酸，1,3-二羟基-2-(羟基甲基)丙-2-胺盐的方法及中间体
CN115536638B (zh) * 2022-08-15 2023-10-13 上海交通大学 一种三氮唑类化合物及其应用
WO2024051700A1 (zh) * 2022-09-05 2024-03-14 德睿智药(苏州)新药研发有限公司 作为glp1r激动剂的新型芳基氘代苄醚取代杂环类化合物
KR20250047817A (ko) * 2022-09-06 2025-04-04 민드랭크 테라퓨틱스 (수저우) 뉴 드러그 리서치 앤 디벨롭먼트 컴퍼니, 리미티드 Glp-1r 작용제 화합물의 결정다형체 및 이의 제조 방법과 용도
JPWO2024063143A1 (es) 2022-09-22 2024-03-28
AU2023358062A1 (en) 2022-10-07 2025-03-20 Pfizer Inc. Hsd17b13 inhibitors and/or degraders
EP4605076A1 (en) 2022-10-18 2025-08-27 Pfizer Inc. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers
KR20250105662A (ko) 2022-11-11 2025-07-08 일라이 릴리 앤드 캄파니 글루카곤-유사 펩티드 1 수용체 효능제
EP4619098A1 (en) 2022-11-16 2025-09-24 Eli Lilly and Company Glucagon-like peptide 1 receptor agonists
AU2023394509A1 (en) * 2022-12-13 2025-07-10 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. Salt-type glp-1 receptor agonist, crystal form thereof, preparation method therefor, pharmaceutical composition thereof, and use thereof
EP4634169A1 (en) 2022-12-16 2025-10-22 Pfizer Inc. 3-fluoro-4-hydroxybenzmide-containing inhibitors and/or degraders and uses thereof
EP4650353A1 (en) 2023-01-13 2025-11-19 Shanghai Institute of Materia Medica, Chinese Academy of Sciences 4-alkoxy benzimidazole-6-carboxylic acid derivative serving as glp-1 receptor agonist
WO2024160271A1 (zh) * 2023-02-02 2024-08-08 江苏豪森药业集团有限公司 一种环烯类化合物的盐、晶型及其制备方法和应用
CN118496200A (zh) * 2023-02-14 2024-08-16 成都康弘药业集团股份有限公司 吲唑啉酮类化合物及其制备方法和用途
IL322686A (en) 2023-02-16 2025-10-01 Gasherbrum Bio Inc Heterocyclic glp-1 agonists
TW202504595A (zh) * 2023-03-29 2025-02-01 美商拓臻製藥公司 Ｇｌｐ—１ｒ促效劑之多晶型及鹽
TW202506131A (zh) 2023-04-07 2025-02-16 美商拓臻製藥公司 ＧＬＰ－１Ｒ及ＴＨＲβ激動劑之組合以及其使用方法
WO2024212742A1 (zh) * 2023-04-10 2024-10-17 上海研健新药研发有限公司 一种glp-1r激动剂，其制备方法和应用
WO2024214038A1 (en) 2023-04-14 2024-10-17 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
CN118812522A (zh) * 2023-04-21 2024-10-22 苏州闻泰医药科技有限公司 一种glp-1r受体激动剂化合物盐、其晶型、其制备方法和应用
AR133241A1 (es) 2023-07-13 2025-09-10 Aconcagua Bio Inc Compuestos, composiciones y métodos
TW202521528A (zh) 2023-07-13 2025-06-01 美商雅空嘉閣生物公司 化合物、組合物及方法
CN116675680B (zh) * 2023-08-02 2023-10-20 药康众拓(北京)医药科技有限公司 一种氘代化合物及其制备方法、药物和应用
WO2025057134A2 (en) 2023-09-14 2025-03-20 Ascletis Pharma (China) Co., Limited Glp-1r agonist and therapeutic method thereof
TW202515865A (zh) * 2023-09-21 2025-04-16 南韓商尹諾衛醫藥有限公司 製備取代的稠合咪唑衍生物的方法
WO2025069009A1 (en) 2023-09-29 2025-04-03 Graviton Bioscience Bv Rock2 inhibitors in the treatment of obesity
WO2025083727A1 (en) * 2023-10-20 2025-04-24 Dr. Reddy's Laboratories Limited Amorpous solid dispersons of danuglipron free acid and process thereof
WO2025099561A1 (en) 2023-11-07 2025-05-15 Pfizer Inc. Oral controlled-release matrix formulations of 2-[(4-{6-[(4-cyano-2-fluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(2s)-oxetan-2-ylmethyl]-1h-benzimidazole-6-carboxylic acid or a pharmaceutically salt thereof
US20250163168A1 (en) 2023-11-17 2025-05-22 Pfizer Inc. Novel antibodies and antibody conjugates for the treatment of metabolic disorders
US12291530B1 (en) 2023-11-24 2025-05-06 Ascletis Pharma (China) Co., Limited GLP-1R agonist and therapeutic method thereof
WO2025140533A1 (en) * 2023-12-27 2025-07-03 Insilico Medicine Ip Limited Novel compounds as glp-1r agonists and uses thereof
WO2025140532A1 (en) * 2023-12-27 2025-07-03 Insilico Medicine Ip Limited Novel compounds as glp-1r agonists and uses thereof
WO2025158275A1 (en) * 2024-01-24 2025-07-31 Pfizer Inc. Combination therapy using glucose-dependent insulinotropic polypeptide receptor antagonist compounds and glp-1 receptor agonist compounds
WO2025163561A1 (en) 2024-02-01 2025-08-07 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof
WO2025171341A2 (en) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. Compounds and compositions for treating conditions associated with calcitonin receptor and/or amylin receptor activity
WO2025171340A1 (en) 2024-02-08 2025-08-14 Aconcagua Bio, Inc. The treatment of calcitonin- and/or amylin-receptor associated conditions
KR20250125490A (ko) 2024-02-14 2025-08-22 주식회사 종근당 Glp-1 수용체 작용제 및 이의 용도
WO2025171806A1 (en) * 2024-02-18 2025-08-21 Rezubio Pharmaceuticals Co., Ltd Methods for weight management and mitigation of vesceral malaise
WO2025189141A1 (en) 2024-03-08 2025-09-12 Annapurna Bio, Inc. Methods for treating obesity and increasing weight loss
US20250326741A1 (en) 2024-04-22 2025-10-23 Pfizer Inc. Glucose-dependent insulinotropic polypeptide receptor antagonists and uses thereof

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO1994021615A1 (en) 1993-03-18 1994-09-29 Merck Sharp & Dohme Limited Benzimidazole derivatives
GB9305623D0 (en) 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
US20020169166A1 (en) * 2001-03-09 2002-11-14 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
US6960589B2 (en) * 2001-03-09 2005-11-01 Abbott Laboratories Benzimidazoles that are useful in treating sexual dysfunction
SE0100903D0 (sv) 2001-03-15 2001-03-15 Astrazeneca Ab Compounds
US20040127504A1 (en) * 2002-09-06 2004-07-01 Cowart Marlon D. Benzimidazoles that are useful in treating sexual dysfunction
EP1939194A4 (en) 2005-09-07 2010-12-08 Banyu Pharma Co Ltd BICYCLIC AROMATIC SUBSTITUTED PYRIDONE DERIVATIVE
WO2008012623A1 (en) 2006-07-25 2008-01-31 Pfizer Products Inc. Benzimidazolyl compounds as potentiators of mglur2 subtype of glutamate receptor
WO2010022055A2 (en) 2008-08-20 2010-02-25 Amgen Inc. Inhibitors of voltage-gated sodium channels
NZ595819A (en) 2009-04-02 2013-02-22 Merck Serono Sa DIHYDROOROTATE DEHYDROGENASE INHIBITORS; benzimidazole-4-carboxylic acid
SG185515A1 (en) * 2010-05-13 2012-12-28 Amgen Inc Nitrogen heterocyclic compounds useful as pde10 inhibitors
MY159058A (en) 2011-02-25 2016-12-15 Merck Sharp & Dohme Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agent
AU2017374860B2 (en) * 2016-12-16 2021-09-02 Pfizer Inc. GLP-1 receptor agonists and uses thereof

Also Published As

Publication number Publication date
BR112019012211A2 (pt) 2019-11-12
CY1125716T1 (el) 2024-02-16
US20180170908A1 (en) 2018-06-21
PE20191501A1 (es) 2019-10-22
CA2988721C (en) 2023-09-05
CU20190056A7 (es) 2020-01-03
UY37514A (es) 2018-07-31
US10851081B2 (en) 2020-12-01
EP3555064B9 (en) 2023-03-01
CN110325530A (zh) 2019-10-11
ECSP19041071A (es) 2019-06-30
NZ754428A (en) 2024-05-31
PH12019501360A1 (en) 2020-02-10
TWI713809B (zh) 2020-12-21
GEP20217265B (en) 2021-06-25
US20190119255A1 (en) 2019-04-25
DK3555064T5 (da) 2023-05-01
PT3555064T (pt) 2023-01-20
CN110325530B (zh) 2022-01-11
LT3555064T (lt) 2023-01-10
EP3555064B1 (en) 2022-11-23
RS63849B1 (sr) 2023-01-31
US10208019B2 (en) 2019-02-19
ES2934789T9 (es) 2023-04-26
US20200255406A1 (en) 2020-08-13
PH12019501360B1 (en) 2024-02-21
AU2017374860A1 (en) 2019-06-20
AU2017374860B2 (en) 2021-09-02
DK3555064T3 (da) 2022-12-12
JP2020063287A (ja) 2020-04-23
EA037318B1 (ru) 2021-03-11
IL267288A (en) 2019-08-29
MA56480B1 (fr) 2022-12-30
EA201991193A1 (ru) 2020-01-15
KR20190094433A (ko) 2019-08-13
US20210047298A1 (en) 2021-02-18
CL2019001651A1 (es) 2019-10-04
WO2018109607A1 (en) 2018-06-21
US20230124938A1 (en) 2023-04-20
US11512070B2 (en) 2022-11-29
FI3555064T3 (fi) 2023-01-31
MD3555064T2 (ro) 2023-08-31
ES2934789T3 (es) 2023-02-27
PL3555064T3 (pl) 2023-03-06
HUE060533T2 (hu) 2023-03-28
US20250257052A1 (en) 2025-08-14
US12319669B2 (en) 2025-06-03
DOP2019000166A (es) 2019-07-31
CU24573B1 (es) 2022-01-13
MA56480A (fr) 2022-04-27
TW201835066A (zh) 2018-10-01
ZA201904616B (en) 2021-05-26
JP6982054B2 (ja) 2021-12-17
UA122035C2 (uk) 2020-08-25
US20240034725A1 (en) 2024-02-01
US11802121B2 (en) 2023-10-31
CA2988721A1 (en) 2018-06-16
RS63849B9 (sr) 2023-06-30
JP6637641B1 (ja) 2020-01-29
SI3555064T1 (sl) 2023-02-28
KR102466418B1 (ko) 2022-11-14
KR102314286B1 (ko) 2021-10-21
MY195385A (en) 2023-01-18
KR20210127782A (ko) 2021-10-22
HRP20221437T1 (hr) 2023-02-03
RU2740135C1 (ru) 2021-01-11
AR110387A1 (es) 2019-03-27
US10669259B2 (en) 2020-06-02
EP3555064A1 (en) 2019-10-23
CO2019006046A2 (es) 2019-06-19
IL267288B (en) 2021-06-30
MX2019007077A (es) 2019-08-01
JP2020511411A (ja) 2020-04-16
CR20190289A (es) 2019-08-21

Similar Documents

Publication Publication Date Title
MX387259B (es) Agonistas receptores de glp-1 y usos de los mismos
MX2020013624A (es) Agonistas del receptor glp-1 y usos de los mismos.
MX389121B (es) Agonistas del receptor de glp-1 y usos de los mismos
GT201700146A (es) Compuestos de triazolopirimidina y usos de los mismos
CR20190063A (es) 3-metil pirazinas 2,5-disustituídas y 3-metil pirazinas 2,5,6-trisustituídas como inhibidores alostéricos de shp2
CO2017004525A2 (es) Dihidropirrolopiridinas inhibidoras de ror-gamma
MX2018009257A (es) Derivados de benzimidazol como moduladores de ror-gamma.
MX377384B (es) Derivados de bencimidazol como inhibidores de tirosina cinasa erbb para el tratamiento del cáncer.
CL2017000640A1 (es) Nuevos activadores de la guanilato ciclasa soluble y su uso
ECSP14002542A (es) Nuevos 2h–indazoles como antagonistas del receptor ep2
MX376599B (es) Derivados de purina como agonistas del receptor de cannabinoides 2 (cb2).
UY35947A (es) Compuestos antagonistas selectivos de n-metil-d-aspartato (nmda) subtipo nr2b y composiciones que los contienen
CL2016002469A1 (es) Sulfamidasa modificada y su producción
UY34761A (es) Composiciones parasiticidas que comprenden derivados de benzimidazol, métodos y usos de los mismos.
MX394179B (es) Liraglutida en afecciones cardiovasculares.
EA202092674A1 (ru) Агонисты рецептора glp-1 и их применение
CO2017002963A2 (es) Espiro-tiazolonas
UY35443A (es) Derivados oxindol con un sustituyente oxetano y uso de los mismos para tratar enfermedades relacionadas con la vasopresina