CU20190056A7 - Ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas receptores de glp-1, útiles para tratar o prevenir enfermedades cardiometabólicas - Google Patents
Ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas receptores de glp-1, útiles para tratar o prevenir enfermedades cardiometabólicasInfo
- Publication number
- CU20190056A7 CU20190056A7 CU2019000056A CU20190056A CU20190056A7 CU 20190056 A7 CU20190056 A7 CU 20190056A7 CU 2019000056 A CU2019000056 A CU 2019000056A CU 20190056 A CU20190056 A CU 20190056A CU 20190056 A7 CU20190056 A7 CU 20190056A7
- Authority
- CU
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- Prior art keywords
- aza
- benzimidazoles
- diaza
- glp
- useful
- Prior art date
Links
- 208000001145 Metabolic Syndrome Diseases 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 title abstract 2
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 title 1
- ZKAMEFMDQNTDFK-UHFFFAOYSA-N 1h-imidazo[4,5-b]pyrazine Chemical class C1=CN=C2NC=NC2=N1 ZKAMEFMDQNTDFK-UHFFFAOYSA-N 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 108010086246 Glucagon-Like Peptide-1 Receptor Proteins 0.000 abstract 1
- 102100032882 Glucagon-like peptide 1 receptor Human genes 0.000 abstract 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 abstract 1
- 208000001280 Prediabetic State Diseases 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 1
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 abstract 1
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
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- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract
<p>La presente invención se refiere a 6 ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas de GLP-1R, de fórmula general I:</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>útiles en el tratamiento o prevención de enfermedades cardiometabólicas como diabetes, pre-diabetes, esteatohepatitis no alcohólica y enfermedad cardiovascular.</p>
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662435533P | 2016-12-16 | 2016-12-16 | |
| PCT/IB2017/057577 WO2018109607A1 (en) | 2016-12-16 | 2017-12-01 | Glp-1 receptor agonists and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20190056A7 true CU20190056A7 (es) | 2020-01-03 |
| CU24573B1 CU24573B1 (es) | 2022-01-13 |
Family
ID=60702906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2019000056A CU24573B1 (es) | 2016-12-16 | 2017-12-01 | Ácidos carboxílicos de benzimidazoles y 4-aza, 5-aza, 7-aza y 4,7-diaza-benzimidazoles como agonistas receptores de glp-1, útiles para tratar o prevenir enfermedades cardiometabólicas |
Country Status (42)
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