MX374298B - Método para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. - Google Patents
Método para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios.Info
- Publication number
- MX374298B MX374298B MX2018009502A MX2018009502A MX374298B MX 374298 B MX374298 B MX 374298B MX 2018009502 A MX2018009502 A MX 2018009502A MX 2018009502 A MX2018009502 A MX 2018009502A MX 374298 B MX374298 B MX 374298B
- Authority
- MX
- Mexico
- Prior art keywords
- pyrrolo
- preparing
- pyrimidine compound
- intermediaries
- formula
- Prior art date
Links
- -1 PYRROLO[3,2-D]PYRIMIDINE COMPOUND Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- VMDGIQUJSYPMLF-UHFFFAOYSA-N C(CCC)OC=1N=C(C2=C(N=1)C(=CN2)CC1=CC=C(C=C1)CN1CCCC1)N Chemical compound C(CCC)OC=1N=C(C2=C(N=1)C(=CN2)CC1=CC=C(C=C1)CN1CCCC1)N VMDGIQUJSYPMLF-UHFFFAOYSA-N 0.000 abstract 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610082028.3A CN107043378A (zh) | 2016-02-05 | 2016-02-05 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| PCT/CN2017/072893 WO2017133686A1 (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2018009502A MX2018009502A (es) | 2018-12-11 |
| MX374298B true MX374298B (es) | 2025-03-06 |
Family
ID=59500148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018009502A MX374298B (es) | 2016-02-05 | 2017-02-04 | Método para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US10654856B2 (https=) |
| EP (1) | EP3412673B1 (https=) |
| JP (1) | JP6877449B2 (https=) |
| KR (1) | KR102371500B1 (https=) |
| CN (2) | CN107043378A (https=) |
| AR (1) | AR107549A1 (https=) |
| AU (1) | AU2017214134B2 (https=) |
| BR (1) | BR112018015879B1 (https=) |
| CA (1) | CA3013520C (https=) |
| CL (1) | CL2018002094A1 (https=) |
| DK (1) | DK3412673T3 (https=) |
| EA (1) | EA034581B1 (https=) |
| ES (1) | ES2852323T3 (https=) |
| HR (1) | HRP20210103T1 (https=) |
| HU (1) | HUE053455T2 (https=) |
| IL (1) | IL260999B (https=) |
| LT (1) | LT3412673T (https=) |
| MX (1) | MX374298B (https=) |
| MY (1) | MY190551A (https=) |
| NZ (1) | NZ744885A (https=) |
| PH (1) | PH12018501642B1 (https=) |
| PL (1) | PL3412673T3 (https=) |
| PT (1) | PT3412673T (https=) |
| SG (1) | SG11201806685VA (https=) |
| SI (1) | SI3412673T1 (https=) |
| TW (1) | TW201728590A (https=) |
| UA (1) | UA124100C2 (https=) |
| WO (1) | WO2017133686A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| MA44007A (fr) | 2016-02-05 | 2018-12-19 | Denali Therapeutics Inc | Inhibiteurs du récepteur interagissant avec protéine kinase 1 |
| JP7287708B2 (ja) | 2019-02-08 | 2023-06-06 | プロジェニア インコーポレイテッド | Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途 |
| JP7811014B2 (ja) | 2020-03-02 | 2026-02-04 | プロジェニア インコーポレイテッド | 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法 |
| CN116322751A (zh) | 2020-08-04 | 2023-06-23 | 蛋白科技先锋 | 包含能够动力学控制的佐剂的mRNA疫苗 |
| JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| US20230355750A1 (en) | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009082247A1 (en) * | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| ES2467108T3 (es) | 2008-12-09 | 2014-06-11 | Gilead Sciences, Inc. | Moduladores de receptores tipo toll |
| LT2906563T (lt) * | 2012-10-10 | 2018-06-11 | Janssen Sciences Ireland Uc | Pirolo[3,2-d]pirimidino dariniai virusinių infekcijų ir kitų ligų gydymui |
| MX358025B (es) * | 2012-11-20 | 2018-08-02 | Glaxosmithkline Llc Star | Compuestos novedosos. |
| US9550785B2 (en) * | 2012-11-20 | 2017-01-24 | Glaxosmithkline Llc | Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
| JP6484253B2 (ja) * | 2014-05-01 | 2019-03-13 | ノバルティス アーゲー | Ｔｏｌｌ様受容体７アゴニストとしての化合物および組成物 |
| CN105367576A (zh) | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| HUE054672T2 (hu) | 2014-08-15 | 2021-09-28 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | TLR7 agonistaként alkalmazott pirrolopirimidin vegyületek |
| CA3004173C (en) | 2015-11-05 | 2020-07-14 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 7-(thiazol-5-yl)pyrrolopyrimidine compound as tlr7 agonist |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043380A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| CN107043377A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
-
2016
- 2016-02-05 CN CN201610082028.3A patent/CN107043378A/zh active Pending
-
2017
- 2017-02-03 TW TW106103696A patent/TW201728590A/zh unknown
- 2017-02-04 CA CA3013520A patent/CA3013520C/en active Active
- 2017-02-04 AU AU2017214134A patent/AU2017214134B2/en active Active
- 2017-02-04 UA UAA201809087A patent/UA124100C2/uk unknown
- 2017-02-04 JP JP2018540720A patent/JP6877449B2/ja active Active
- 2017-02-04 SG SG11201806685VA patent/SG11201806685VA/en unknown
- 2017-02-04 LT LTEP17747006.9T patent/LT3412673T/lt unknown
- 2017-02-04 PT PT177470069T patent/PT3412673T/pt unknown
- 2017-02-04 US US16/075,300 patent/US10654856B2/en active Active
- 2017-02-04 WO PCT/CN2017/072893 patent/WO2017133686A1/zh not_active Ceased
- 2017-02-04 SI SI201730605T patent/SI3412673T1/sl unknown
- 2017-02-04 MY MYPI2018702701A patent/MY190551A/en unknown
- 2017-02-04 BR BR112018015879-8A patent/BR112018015879B1/pt active IP Right Grant
- 2017-02-04 PL PL17747006T patent/PL3412673T3/pl unknown
- 2017-02-04 NZ NZ744885A patent/NZ744885A/en unknown
- 2017-02-04 EA EA201891769A patent/EA034581B1/ru not_active IP Right Cessation
- 2017-02-04 CN CN201780009748.XA patent/CN108602832B/zh active Active
- 2017-02-04 HU HUE17747006A patent/HUE053455T2/hu unknown
- 2017-02-04 KR KR1020187024628A patent/KR102371500B1/ko active Active
- 2017-02-04 MX MX2018009502A patent/MX374298B/es active IP Right Grant
- 2017-02-04 ES ES17747006T patent/ES2852323T3/es active Active
- 2017-02-04 DK DK17747006.9T patent/DK3412673T3/da active
- 2017-02-04 EP EP17747006.9A patent/EP3412673B1/en active Active
- 2017-02-04 HR HRP20210103TT patent/HRP20210103T1/hr unknown
- 2017-02-06 AR ARP170100298A patent/AR107549A1/es active IP Right Grant
-
2018
- 2018-08-02 PH PH12018501642A patent/PH12018501642B1/en unknown
- 2018-08-03 CL CL2018002094A patent/CL2018002094A1/es unknown
- 2018-08-05 IL IL260999A patent/IL260999B/en active IP Right Grant
-
2020
- 2020-04-13 US US16/847,394 patent/US20200239484A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX374298B (es) | Método para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. | |
| PH12018501643A1 (en) | Tlr7 agonist crystalline form a, preparation method and use thereof | |
| NZ726356A (en) | Processes for preparing antiviral compounds | |
| NZ727996A (en) | Thieno [3,2-d] pyrimidine, furo [3,2,d] pyrimidine, and pyrrolo [3,2-d] pyrimidines useful for treating respiratory syncytial virus infections | |
| UY34219A (es) | Compuestos de 2-(2,4,5-anilino sustituido)pirimidina | |
| EA201891772A1 (ru) | Трифторацетатная соль агониста tlr7 и ее кристаллическая форма b, способы получения и использование | |
| DOP2017000300A (es) | PROCESOS E INTERMEDIARIOS PARA LA PREPARACIÓN DE {1-(ETILSULFONIL)-3-[4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL]AZETIDIN-3-IL}ACETONITRILO | |
| MX2015013745A (es) | Preparacion de intermediarios de pirimidina utiles para la preparacion de maci tentano. | |
| AR102570A1 (es) | Síntesis de copanlisib, su sal diclorhidrato, intermediarios para su preparación e hidratos de los mismos | |
| MX2017011330A (es) | Proceso quimico para preparar derivados de pirimidina y sus intermediarios. | |
| CO2018008253A2 (es) | Proceso para preparar compuestos de 7h-pirrolo[2,3-d]pirimidina | |
| MX394320B (es) | Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos | |
| PH12018502246A1 (en) | Substituted fused pyrimidinone compounds | |
| CU24518B1 (es) | Derivados sustituidos de 6-(1h-pirazol-1-il)pirimidin-4-amina | |
| TN2017000065A1 (en) | A tetrahydropyrrolo[3,4-d][1,3]thiazine-derivative as bace inhibitor | |
| MX2014012822A (es) | Proceso para elaborar derivados de naftiridina. | |
| CO2017002070A2 (es) | Un proceso para la preparación de derivados de 3-fenil/heteroaril-6-fenoxi-8-alquilamino-imidazo[1,2-b] piridazina | |
| AR114477A1 (es) | Método para la preparación de una 1,2,4-triazolona 2,4,5-trisustituida |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |