KR102371500B1 - 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 - Google Patents

피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 Download PDF

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KR102371500B1
KR102371500B1 KR1020187024628A KR20187024628A KR102371500B1 KR 102371500 B1 KR102371500 B1 KR 102371500B1 KR 1020187024628 A KR1020187024628 A KR 1020187024628A KR 20187024628 A KR20187024628 A KR 20187024628A KR 102371500 B1 KR102371500 B1 KR 102371500B1
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compound
formula
acid
sodium
hydroxide
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KR20180104724A (ko
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자오종 딩
페이 순
잉후 후
이룽 주
루이 자오
링 양
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치아타이 티안큉 파마수티컬 그룹 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020187024628A 2016-02-05 2017-02-04 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 Active KR102371500B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN201610082028.3 2016-02-05
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

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KR20180104724A KR20180104724A (ko) 2018-09-21
KR102371500B1 true KR102371500B1 (ko) 2022-03-07

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KR1020187024628A Active KR102371500B1 (ko) 2016-02-05 2017-02-04 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체

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US (2) US10654856B2 (https=)
EP (1) EP3412673B1 (https=)
JP (1) JP6877449B2 (https=)
KR (1) KR102371500B1 (https=)
CN (2) CN107043378A (https=)
AR (1) AR107549A1 (https=)
AU (1) AU2017214134B2 (https=)
BR (1) BR112018015879B1 (https=)
CA (1) CA3013520C (https=)
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DK (1) DK3412673T3 (https=)
EA (1) EA034581B1 (https=)
ES (1) ES2852323T3 (https=)
HR (1) HRP20210103T1 (https=)
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CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
MA44007A (fr) 2016-02-05 2018-12-19 Denali Therapeutics Inc Inhibiteurs du récepteur interagissant avec protéine kinase 1
JP7287708B2 (ja) 2019-02-08 2023-06-06 プロジェニア インコーポレイテッド Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途
JP7811014B2 (ja) 2020-03-02 2026-02-04 プロジェニア インコーポレイテッド 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗
JP2023536954A (ja) 2020-08-04 2023-08-30 プロジェニア インコーポレイテッド 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途
US20230355750A1 (en) 2020-08-04 2023-11-09 Progeneer Inc. Kinetically acting adjuvant ensemble
IL314082A (en) 2022-01-12 2024-09-01 Denali Therapeutics Inc Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide

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WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
LT2906563T (lt) * 2012-10-10 2018-06-11 Janssen Sciences Ireland Uc Pirolo[3,2-d]pirimidino dariniai virusinių infekcijų ir kitų ligų gydymui
JP6484253B2 (ja) * 2014-05-01 2019-03-13 ノバルティス アーゲー Ｔｏｌｌ様受容体７アゴニストとしての化合物および組成物
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
HUE054672T2 (hu) 2014-08-15 2021-09-28 Chia Tai Tianqing Pharmaceutical Group Co Ltd TLR7 agonistaként alkalmazott pirrolopirimidin vegyületek
CA3004173C (en) 2015-11-05 2020-07-14 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. 7-(thiazol-5-yl)pyrrolopyrimidine compound as tlr7 agonist
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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BR112018015879A2 (pt) 2018-12-26
MX2018009502A (es) 2018-12-11
PH12018501642A1 (en) 2019-06-03
HRP20210103T1 (hr) 2021-03-05
TW201728590A (zh) 2017-08-16
EP3412673A1 (en) 2018-12-12
WO2017133686A1 (zh) 2017-08-10
NZ744885A (en) 2022-07-01
US20190040072A1 (en) 2019-02-07
EA201891769A1 (ru) 2019-04-30
ES2852323T3 (es) 2021-09-13
CL2018002094A1 (es) 2018-12-07
AR107549A1 (es) 2018-05-09
MX374298B (es) 2025-03-06
CA3013520A1 (en) 2017-08-10
LT3412673T (lt) 2021-03-10
AU2017214134A1 (en) 2018-08-23
JP6877449B2 (ja) 2021-05-26
CN108602832A (zh) 2018-09-28
HUE053455T2 (hu) 2021-06-28
PT3412673T (pt) 2021-02-15
SG11201806685VA (en) 2018-09-27
PH12018501642B1 (en) 2019-06-03
UA124100C2 (uk) 2021-07-21
CN107043378A (zh) 2017-08-15
KR20180104724A (ko) 2018-09-21
US20200239484A1 (en) 2020-07-30
US10654856B2 (en) 2020-05-19
CA3013520C (en) 2022-07-19
EA034581B1 (ru) 2020-02-21
PL3412673T3 (pl) 2021-07-26
HK1259183A1 (zh) 2019-11-29
IL260999B (en) 2021-02-28
SI3412673T1 (sl) 2021-04-30
JP2019505531A (ja) 2019-02-28
BR112018015879B1 (pt) 2024-02-15
DK3412673T3 (da) 2021-01-18
AU2017214134B2 (en) 2020-08-27
EP3412673B1 (en) 2020-11-25
CN108602832B (zh) 2020-10-09
EP3412673A4 (en) 2019-07-03
MY190551A (en) 2022-04-27

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