KR102371500B1 - 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 - Google Patents

피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 Download PDF

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KR102371500B1
KR102371500B1 KR1020187024628A KR20187024628A KR102371500B1 KR 102371500 B1 KR102371500 B1 KR 102371500B1 KR 1020187024628 A KR1020187024628 A KR 1020187024628A KR 20187024628 A KR20187024628 A KR 20187024628A KR 102371500 B1 KR102371500 B1 KR 102371500B1
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compound
formula
acid
sodium
hydroxide
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KR20180104724A (ko
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자오종 딩
페이 순
잉후 후
이룽 주
루이 자오
링 양
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치아타이 티안큉 파마수티컬 그룹 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
KR1020187024628A 2016-02-05 2017-02-04 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 Active KR102371500B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN201610082028.3 2016-02-05
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

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KR20180104724A KR20180104724A (ko) 2018-09-21
KR102371500B1 true KR102371500B1 (ko) 2022-03-07

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KR1020187024628A Active KR102371500B1 (ko) 2016-02-05 2017-02-04 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체

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US (2) US10654856B2 (https=)
EP (1) EP3412673B1 (https=)
JP (1) JP6877449B2 (https=)
KR (1) KR102371500B1 (https=)
CN (2) CN107043378A (https=)
AR (1) AR107549A1 (https=)
AU (1) AU2017214134B2 (https=)
BR (1) BR112018015879B1 (https=)
CA (1) CA3013520C (https=)
CL (1) CL2018002094A1 (https=)
DK (1) DK3412673T3 (https=)
EA (1) EA034581B1 (https=)
ES (1) ES2852323T3 (https=)
HR (1) HRP20210103T1 (https=)
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IL (1) IL260999B (https=)
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MY (1) MY190551A (https=)
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PT (1) PT3412673T (https=)
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TW (1) TW201728590A (https=)
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CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
IL287136B2 (en) 2016-02-05 2023-09-01 Denali Therapeutics Inc Receptor inhibitors - interacting with protein kinase 1
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
CA3170551A1 (en) 2020-03-02 2021-09-10 Yong Taik Lim Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof
JP7690221B2 (ja) 2020-08-04 2025-06-10 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
US20230346924A1 (en) 2020-08-04 2023-11-02 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control
TW202334164A (zh) 2022-01-12 2023-09-01 美商戴納立製藥公司 （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型

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WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
RS53347B (sr) 2008-12-09 2014-10-31 Gilead Sciences, Inc. Modulatori toll-sličnih receptora
DK2906563T3 (en) * 2012-10-10 2018-06-06 Janssen Sciences Ireland Uc PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES
PL3137470T3 (pl) * 2014-05-01 2021-10-11 Novartis Ag Związki i kompozycje jako agonisty receptora toll-like 7
HRP20210927T1 (hr) * 2014-08-15 2021-09-03 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Spojevi pirolopirimidina koje se koriste kao agonist tlr7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
UA121345C2 (uk) 2015-11-05 2020-05-12 Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. 7-(тіазол-5-іл)піролопіримідин як агоніст рецептора tlr7
CN107043379A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途

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WO2014081644A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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MY190551A (en) 2022-04-27
CL2018002094A1 (es) 2018-12-07
TW201728590A (zh) 2017-08-16
HK1259183A1 (zh) 2019-11-29
DK3412673T3 (da) 2021-01-18
PT3412673T (pt) 2021-02-15
EP3412673B1 (en) 2020-11-25
US20190040072A1 (en) 2019-02-07
AU2017214134B2 (en) 2020-08-27
KR20180104724A (ko) 2018-09-21
SG11201806685VA (en) 2018-09-27
PL3412673T3 (pl) 2021-07-26
CN108602832B (zh) 2020-10-09
IL260999B (en) 2021-02-28
WO2017133686A1 (zh) 2017-08-10
BR112018015879A2 (pt) 2018-12-26
CA3013520C (en) 2022-07-19
LT3412673T (lt) 2021-03-10
PH12018501642B1 (en) 2019-06-03
CA3013520A1 (en) 2017-08-10
AR107549A1 (es) 2018-05-09
JP2019505531A (ja) 2019-02-28
HRP20210103T1 (hr) 2021-03-05
MX374298B (es) 2025-03-06
NZ744885A (en) 2022-07-01
PH12018501642A1 (en) 2019-06-03
JP6877449B2 (ja) 2021-05-26
EP3412673A1 (en) 2018-12-12
AU2017214134A1 (en) 2018-08-23
ES2852323T3 (es) 2021-09-13
US20200239484A1 (en) 2020-07-30
EA034581B1 (ru) 2020-02-21
EA201891769A1 (ru) 2019-04-30
CN108602832A (zh) 2018-09-28
US10654856B2 (en) 2020-05-19
BR112018015879B1 (pt) 2024-02-15
CN107043378A (zh) 2017-08-15
EP3412673A4 (en) 2019-07-03
UA124100C2 (uk) 2021-07-21
HUE053455T2 (hu) 2021-06-28
MX2018009502A (es) 2018-12-11
SI3412673T1 (sl) 2021-04-30

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