CN107043378A - 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 - Google Patents
一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 Download PDFInfo
- Publication number
- CN107043378A CN107043378A CN201610082028.3A CN201610082028A CN107043378A CN 107043378 A CN107043378 A CN 107043378A CN 201610082028 A CN201610082028 A CN 201610082028A CN 107043378 A CN107043378 A CN 107043378A
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- China
- Prior art keywords
- compound
- formula
- preparation
- independently selected
- heterocycloalkyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CCCCOc1nc(*)c2[n]cc(C(c3ccc(C=O)cc3)N)c2n1 Chemical compound CCCCOc1nc(*)c2[n]cc(C(c3ccc(C=O)cc3)N)c2n1 0.000 description 3
- LSMOGYZFHZFYRX-UHFFFAOYSA-N Cc1c2[n](C)ccc2nc(C)n1 Chemical compound Cc1c2[n](C)ccc2nc(C)n1 LSMOGYZFHZFYRX-UHFFFAOYSA-N 0.000 description 1
- BPKZZFKLMGDUQF-UHFFFAOYSA-N Cc1nc(Cl)c2[nH]ccc2n1 Chemical compound Cc1nc(Cl)c2[nH]ccc2n1 BPKZZFKLMGDUQF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (31)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610082028.3A CN107043378A (zh) | 2016-02-05 | 2016-02-05 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| TW106103696A TW201728590A (zh) | 2016-02-05 | 2017-02-03 | 吡咯并［３，２－ｄ］嘧啶類化合物的製備方法及其中間體 |
| EP17747006.9A EP3412673B1 (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| US16/075,300 US10654856B2 (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-D]pyrimidine compound, and intermediates thereof |
| ES17747006T ES2852323T3 (es) | 2016-02-05 | 2017-02-04 | Método de preparación del compuesto pirrolo[3,2-d]pirimidina e intermedios del mismo |
| CN201780009748.XA CN108602832B (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CA3013520A CA3013520C (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| MYPI2018702701A MY190551A (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| DK17747006.9T DK3412673T3 (da) | 2016-02-05 | 2017-02-04 | Fremgangsmåde til fremstilling af pyrrolo[3,2-D]pyrimidin-forbindelse og mellemprodukter deraf |
| BR112018015879-8A BR112018015879B1 (pt) | 2016-02-05 | 2017-02-04 | Processo para preparação de pirrol[3,2-d]pirimidina, e seus intermediários composto, composição farmacêutica e usos de compostos |
| AU2017214134A AU2017214134B2 (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| LTEP17747006.9T LT3412673T (lt) | 2016-02-05 | 2017-02-04 | Pirolo[3,2-d]pirimidino junginio gamybos būdas ir jo tarpiniai junginiai |
| SG11201806685VA SG11201806685VA (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| NZ744885A NZ744885A (en) | 2016-02-05 | 2017-02-04 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| PL17747006T PL3412673T3 (pl) | 2016-02-05 | 2017-02-04 | Sposób otrzymywania związku pirolo[3,2-d]pirymidynowego i jego produktów pośrednich |
| HRP20210103TT HRP20210103T1 (hr) | 2016-02-05 | 2017-02-04 | Postupak za proizvodnju spoja pirol0[3,2-d]pirimidina, kao i odgovarajućih intermedijera |
| SI201730605T SI3412673T1 (sl) | 2016-02-05 | 2017-02-04 | Postopek za pripravo pirolo(3,2-d)pirimidinske spojine in njenih intermediatov |
| PCT/CN2017/072893 WO2017133686A1 (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| KR1020187024628A KR102371500B1 (ko) | 2016-02-05 | 2017-02-04 | 피롤로[3,2-d]피리미딘 화합물의 제조 방법, 및 이의 중간체 |
| MX2018009502A MX374298B (es) | 2016-02-05 | 2017-02-04 | Método para preparar compuesto de pirrolo[3,2-d]pirimidina y sus intermediarios. |
| EA201891769A EA034581B1 (ru) | 2016-02-05 | 2017-02-04 | Способ получения соединения пирроло[3,2-d]пиримидина и промежуточных соединений |
| UAA201809087A UA124100C2 (uk) | 2016-02-05 | 2017-02-04 | Спосіб одержання сполуки піроло[3,2-d]піримідину і проміжних сполук |
| HK19101234.3A HK1259183B (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3，2-d]嘧啶类化合物的制备方法及其中间体 |
| PT177470069T PT3412673T (pt) | 2016-02-05 | 2017-02-04 | Método para preparar composto de pirrolo[3,2-d]pirimidina, e intermediários dos mesmos |
| HUE17747006A HUE053455T2 (hu) | 2016-02-05 | 2017-02-04 | Eljárás pirrolo[3,2-D]pirimidin vegyület elõállítására és intermedierjei |
| JP2018540720A JP6877449B2 (ja) | 2016-02-05 | 2017-02-04 | ピロロ［３，２−ｄ］ピリミジン化合物を調製するための方法、及びそれらの中間体 |
| ARP170100298A AR107549A1 (es) | 2016-02-05 | 2017-02-06 | Un proceso para preparar compuesto de pirrolo[3,2-d]pirimidina y su intermediario |
| PH12018501642A PH12018501642A1 (en) | 2016-02-05 | 2018-08-02 | Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof |
| CL2018002094A CL2018002094A1 (es) | 2016-02-05 | 2018-08-03 | Un proceso para preparar compuesto de pirrolo[3,2–d]pirimidina y su intermediario |
| IL260999A IL260999B (en) | 2016-02-05 | 2018-08-05 | A method for the preparation of a pyrrolo[3,2-d] pyrimidine compound, and its intermediates |
| US16/847,394 US20200239484A1 (en) | 2016-02-05 | 2020-04-13 | Method for preparing pyrrolo[3,2,-d]pyrimidine compound, and intermediates thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610082028.3A CN107043378A (zh) | 2016-02-05 | 2016-02-05 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107043378A true CN107043378A (zh) | 2017-08-15 |
Family
ID=59500148
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610082028.3A Pending CN107043378A (zh) | 2016-02-05 | 2016-02-05 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CN201780009748.XA Active CN108602832B (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201780009748.XA Active CN108602832B (zh) | 2016-02-05 | 2017-02-04 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US10654856B2 (https=) |
| EP (1) | EP3412673B1 (https=) |
| JP (1) | JP6877449B2 (https=) |
| KR (1) | KR102371500B1 (https=) |
| CN (2) | CN107043378A (https=) |
| AR (1) | AR107549A1 (https=) |
| AU (1) | AU2017214134B2 (https=) |
| BR (1) | BR112018015879B1 (https=) |
| CA (1) | CA3013520C (https=) |
| CL (1) | CL2018002094A1 (https=) |
| DK (1) | DK3412673T3 (https=) |
| EA (1) | EA034581B1 (https=) |
| ES (1) | ES2852323T3 (https=) |
| HR (1) | HRP20210103T1 (https=) |
| HU (1) | HUE053455T2 (https=) |
| IL (1) | IL260999B (https=) |
| LT (1) | LT3412673T (https=) |
| MX (1) | MX374298B (https=) |
| MY (1) | MY190551A (https=) |
| NZ (1) | NZ744885A (https=) |
| PH (1) | PH12018501642A1 (https=) |
| PL (1) | PL3412673T3 (https=) |
| PT (1) | PT3412673T (https=) |
| SG (1) | SG11201806685VA (https=) |
| SI (1) | SI3412673T1 (https=) |
| TW (1) | TW201728590A (https=) |
| UA (1) | UA124100C2 (https=) |
| WO (1) | WO2017133686A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| IL287136B2 (en) | 2016-02-05 | 2023-09-01 | Denali Therapeutics Inc | Receptor inhibitors - interacting with protein kinase 1 |
| WO2020162705A1 (ko) | 2019-02-08 | 2020-08-13 | 성균관대학교산학협력단 | 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도 |
| CA3170551A1 (en) | 2020-03-02 | 2021-09-10 | Yong Taik Lim | Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof |
| US20230277525A1 (en) | 2020-08-04 | 2023-09-07 | Progeneer Inc | Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof |
| JP7690221B2 (ja) | 2020-08-04 | 2025-06-10 | プロジェニア インコーポレイテッド | 動力学的に作用するアジュバントアンサンブル |
| US20230346924A1 (en) | 2020-08-04 | 2023-11-02 | Progeneer Inc. | Mrna vaccine comprising adjuvant capable of kinetic control |
| TW202334164A (zh) | 2022-01-12 | 2023-09-01 | 美商戴納立製藥公司 | （Ｓ）－５－苄基－Ｎ－（５－甲基－４－側氧基－２，３，４，５－四氫吡啶並［３，２－ｂ］［１，４］氧氮呯－３－基）－４Ｈ－１，２，４－三唑－３－甲醯胺的晶型 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009082247A1 (en) * | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| RS53347B (sr) | 2008-12-09 | 2014-10-31 | Gilead Sciences, Inc. | Modulatori toll-sličnih receptora |
| DK2906563T3 (en) * | 2012-10-10 | 2018-06-06 | Janssen Sciences Ireland Uc | PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES |
| EA028480B1 (ru) * | 2012-11-20 | 2017-11-30 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Новые соединения |
| AU2013348217B2 (en) | 2012-11-20 | 2016-10-06 | Glaxosmithkline Llc | Novel compounds |
| PL3137470T3 (pl) * | 2014-05-01 | 2021-10-11 | Novartis Ag | Związki i kompozycje jako agonisty receptora toll-like 7 |
| HRP20210927T1 (hr) * | 2014-08-15 | 2021-09-03 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Spojevi pirolopirimidina koje se koriste kao agonist tlr7 |
| CN105367576A (zh) | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| UA121345C2 (uk) | 2015-11-05 | 2020-05-12 | Чіа Тай Тяньцин Фармасьютікал Груп Ко., Лтд. | 7-(тіазол-5-іл)піролопіримідин як агоніст рецептора tlr7 |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043380A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| CN107043377A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
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2016
- 2016-02-05 CN CN201610082028.3A patent/CN107043378A/zh active Pending
-
2017
- 2017-02-03 TW TW106103696A patent/TW201728590A/zh unknown
- 2017-02-04 CN CN201780009748.XA patent/CN108602832B/zh active Active
- 2017-02-04 PT PT177470069T patent/PT3412673T/pt unknown
- 2017-02-04 SG SG11201806685VA patent/SG11201806685VA/en unknown
- 2017-02-04 EP EP17747006.9A patent/EP3412673B1/en active Active
- 2017-02-04 WO PCT/CN2017/072893 patent/WO2017133686A1/zh not_active Ceased
- 2017-02-04 AU AU2017214134A patent/AU2017214134B2/en active Active
- 2017-02-04 PL PL17747006T patent/PL3412673T3/pl unknown
- 2017-02-04 UA UAA201809087A patent/UA124100C2/uk unknown
- 2017-02-04 KR KR1020187024628A patent/KR102371500B1/ko active Active
- 2017-02-04 LT LTEP17747006.9T patent/LT3412673T/lt unknown
- 2017-02-04 HU HUE17747006A patent/HUE053455T2/hu unknown
- 2017-02-04 MY MYPI2018702701A patent/MY190551A/en unknown
- 2017-02-04 HR HRP20210103TT patent/HRP20210103T1/hr unknown
- 2017-02-04 ES ES17747006T patent/ES2852323T3/es active Active
- 2017-02-04 NZ NZ744885A patent/NZ744885A/en unknown
- 2017-02-04 US US16/075,300 patent/US10654856B2/en active Active
- 2017-02-04 JP JP2018540720A patent/JP6877449B2/ja active Active
- 2017-02-04 SI SI201730605T patent/SI3412673T1/sl unknown
- 2017-02-04 CA CA3013520A patent/CA3013520C/en active Active
- 2017-02-04 EA EA201891769A patent/EA034581B1/ru not_active IP Right Cessation
- 2017-02-04 DK DK17747006.9T patent/DK3412673T3/da active
- 2017-02-04 BR BR112018015879-8A patent/BR112018015879B1/pt active IP Right Grant
- 2017-02-04 MX MX2018009502A patent/MX374298B/es active IP Right Grant
- 2017-02-06 AR ARP170100298A patent/AR107549A1/es active IP Right Grant
-
2018
- 2018-08-02 PH PH12018501642A patent/PH12018501642A1/en unknown
- 2018-08-03 CL CL2018002094A patent/CL2018002094A1/es unknown
- 2018-08-05 IL IL260999A patent/IL260999B/en active IP Right Grant
-
2020
- 2020-04-13 US US16/847,394 patent/US20200239484A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170815 |
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| WD01 | Invention patent application deemed withdrawn after publication |