MX394320B - Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos - Google Patents

Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos

Info

Publication number
MX394320B
MX394320B MX2021000432A MX2021000432A MX394320B MX 394320 B MX394320 B MX 394320B MX 2021000432 A MX2021000432 A MX 2021000432A MX 2021000432 A MX2021000432 A MX 2021000432A MX 394320 B MX394320 B MX 394320B
Authority
MX
Mexico
Prior art keywords
solid forms
phenylbenzo
isoquinolin
dihydro
substituted
Prior art date
Application number
MX2021000432A
Other languages
English (en)
Other versions
MX2021000432A (es
Inventor
Craig Bates
David P Reed
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2021000432A publication Critical patent/MX2021000432A/es
Publication of MX394320B publication Critical patent/MX394320B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a formas sólidas de diclorhidrato de (R)-6-(2-fluorofenil)-N-(3-(2-(2-metoxietilamino)etil)fenil)-5,6-dihidrobenzo[h]quinazolin-2-amina y a métodos para preparar y utilizar las mismas.
MX2021000432A 2015-12-17 2016-12-16 Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos MX394320B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Publications (2)

Publication Number Publication Date
MX2021000432A MX2021000432A (es) 2022-07-28
MX394320B true MX394320B (es) 2025-03-24

Family

ID=59057612

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2021000432A MX394320B (es) 2015-12-17 2016-12-16 Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos
MX2018007414A MX385671B (es) 2015-12-17 2016-12-16 Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018007414A MX385671B (es) 2015-12-17 2016-12-16 Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-amina sustituidos.

Country Status (19)

Country Link
US (3) US9981921B2 (es)
EP (2) EP4019499A1 (es)
JP (2) JP2018537499A (es)
KR (1) KR20180086508A (es)
CN (1) CN108368061A (es)
AU (2) AU2016369523B2 (es)
BR (1) BR112018012095A2 (es)
CA (1) CA3006081A1 (es)
EA (2) EA202091691A1 (es)
ES (1) ES2935818T3 (es)
HK (1) HK1256825A1 (es)
IL (1) IL259556B2 (es)
MX (2) MX394320B (es)
NZ (1) NZ742695A (es)
PH (2) PH12018501246A1 (es)
SA (1) SA518391805B1 (es)
SG (1) SG11201804670PA (es)
TW (2) TWI771280B (es)
WO (1) WO2017106642A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016369520B2 (en) 2015-12-17 2021-02-18 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
KR20180086508A (ko) * 2015-12-17 2018-07-31 아르퀼 인코포레이티드 치환된 5,6-디하이드로-6-페닐벤조[f]이소퀴놀린-2-아민 화합물의 고체 형태
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma
JP7641247B2 (ja) 2022-03-02 2025-03-06 日立建機株式会社 機械の性能診断装置

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
WO1998028281A1 (en) * 1996-12-23 1998-07-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
JP2007524619A (ja) * 2003-06-18 2007-08-30 テバ ファーマシューティカル インダストリーズ リミティド フルバスタチンナトリウム結晶型、その調製方法、これを含有する組成物、およびその使用法
JP2010514810A (ja) * 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
CA2748491C (en) 2008-12-30 2019-08-06 Arqule, Inc. Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
EA024026B1 (ru) * 2010-11-25 2016-08-31 Рациофарм Гмбх Новые соли и полиморфные формы афатиниба
WO2012177852A1 (en) 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
JP2014530805A (ja) * 2011-09-30 2014-11-20 スンシネ ルアケ プハルマ カンパニー リミテッド アジルサルタンの結晶形並びにその製造及び使用
AU2016369520B2 (en) * 2015-12-17 2021-02-18 Arqule, Inc. Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
KR20180086508A (ko) * 2015-12-17 2018-07-31 아르퀼 인코포레이티드 치환된 5,6-디하이드로-6-페닐벤조[f]이소퀴놀린-2-아민 화합물의 고체 형태
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Also Published As

Publication number Publication date
HK1256825A1 (zh) 2019-10-04
PH12020551465A1 (en) 2021-07-26
US10717710B2 (en) 2020-07-21
ES2935818T3 (es) 2023-03-10
TW201736352A (zh) 2017-10-16
AU2016369523A1 (en) 2018-06-07
EA202091691A1 (ru) 2021-01-29
EA201891430A1 (ru) 2018-11-30
MX2021000432A (es) 2022-07-28
NZ742695A (en) 2022-10-28
EP3390369A4 (en) 2019-08-14
MX2018007414A (es) 2018-11-09
US9981921B2 (en) 2018-05-29
IL259556A (en) 2018-07-31
EP4019499A1 (en) 2022-06-29
JP2018537499A (ja) 2018-12-20
US20170174636A1 (en) 2017-06-22
CA3006081A1 (en) 2017-06-22
CN108368061A (zh) 2018-08-03
EA036295B1 (ru) 2020-10-22
JP2022031797A (ja) 2022-02-22
EP3390369A1 (en) 2018-10-24
US10227311B2 (en) 2019-03-12
US20200002293A1 (en) 2020-01-02
US20180258055A1 (en) 2018-09-13
IL259556B2 (en) 2023-09-01
SG11201804670PA (en) 2018-07-30
IL259556B1 (en) 2023-05-01
BR112018012095A2 (pt) 2018-11-27
SA518391805B1 (ar) 2022-12-21
TWI796250B (zh) 2023-03-11
MX385671B (es) 2025-03-18
AU2022201947A1 (en) 2022-04-14
TW202241854A (zh) 2022-11-01
AU2022201947B2 (en) 2023-07-27
TWI771280B (zh) 2022-07-21
EP3390369B1 (en) 2022-11-02
WO2017106642A1 (en) 2017-06-22
KR20180086508A (ko) 2018-07-31
AU2016369523B2 (en) 2021-12-23
PH12018501246A1 (en) 2019-02-04

Similar Documents

Publication Publication Date Title
PH12017502090A1 (en) Heterocyclic amides as kinase inhibitors
EP3503709A4 (en) OPTIMIZING A SHARED FERTILIZER APPLICATION
IL286912A (en) Process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid
EA201891024A1 (ru) Соединения-ингибиторы tank-связывающей киназы
UY34219A (es) Compuestos de 2-(2,4,5-anilino sustituido)pirimidina
MX2018003058A (es) Formas solidas de derivados de isoquinolinona, proceso de fabricacion, composiciones que las contienen y metodos de uso de las mismas.
MX393838B (es) Uso de compuestos heterociclicos para controlar nematodos.
LT3160958T (lt) (s)-6-((1-acetilpiperidin-4-il)amino)-n-(3-(3,4-dihidroizochinolin-2(1h)-yl)-2-hidroksipropil)pirimidin-4-karboksamido kristalinės druskos
MX2019013645A (es) Inhibidores de quinasa y usos de los mismos.
ECSP17030878A (es) Formas cristalinas de 5-cloro-n4-[2-(dimetilfosforil)fenil]-n2-{2-metoxi-4-[4-(4-metilpiperazin-1-il)piperidin-1-il]pirimidina-2,4-diamina
UY36737A (es) 3-amino-1,5,6,7-tetrahidro-4h-indol-4-onas
UY37517A (es) Métodos de síntesis de compuestos tiazoles sustituidos
PH12020551465A1 (en) Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
DK3412673T3 (da) Fremgangsmåde til fremstilling af pyrrolo[3,2-D]pyrimidin-forbindelse og mellemprodukter deraf
DK3658547T3 (da) Fremgangsmåde til fremstilling af n-(5-(4-(4-formyl-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamid
BR112017024613A2 (pt) Processos e intermediários para a preparação de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d] pirimidin-4-il)- 1h-pirazol-1-il]azetidin-3-il}acetonitrila
MX388612B (es) Intermediarios para preparar herbicidas de piridazinona y proceso para prepararlos.
DK3390407T3 (da) Fremgangsmåder til fremstilling af heterocykliske 1,3-benzodioxolforbindelser
EP3448852A4 (en) NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF TYROSINE KINASE BCR-ABL
BR112016029510A2 (pt) métodos para a preparação de um composto, e, composto intermediário.
MX2017013248A (es) Compuesto del inhibidor fgfr4 cristalino y usos del mismo.
CL2020001346A1 (es) Polimorfos y formas sólidas de un compuesto de pirimidinilamino-pirazol y métodos de producción.
DK3624795T3 (da) Kondenserede, heteroaromatiske anilinforbindelser til behandling af hudforstyrrelser
IL283902A (en) Co-crystal of ketoprofen, compositions comprising the same, process of producing the same, and uses thereof
MX2015013414A (es) N-(2-ciano heterociclil)pirazolo piridonas como inhibidores de janus quinasa.