EA201891430A1 - Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений - Google Patents

Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений

Info

Publication number
EA201891430A1
EA201891430A1 EA201891430A EA201891430A EA201891430A1 EA 201891430 A1 EA201891430 A1 EA 201891430A1 EA 201891430 A EA201891430 A EA 201891430A EA 201891430 A EA201891430 A EA 201891430A EA 201891430 A1 EA201891430 A1 EA 201891430A1
Authority
EA
Eurasian Patent Office
Prior art keywords
solid forms
phenilbenzo
izohinolin
dihydro
substituted
Prior art date
Application number
EA201891430A
Other languages
English (en)
Other versions
EA036295B1 (ru
Inventor
Крейг Бэйтс
Дэвид П. Рид
Original Assignee
Аркьюл, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Аркьюл, Инк. filed Critical Аркьюл, Инк.
Publication of EA201891430A1 publication Critical patent/EA201891430A1/ru
Publication of EA036295B1 publication Critical patent/EA036295B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Настоящее изобретение относится к твердым формам дигидрохлорида (R)-6-(2-фторфенил)-N-(3-(2-метоксиэтиламино)этил)фенил)-5,6-дигидробензо[h]хиназолин-2-амина, способам их получения и применения.
EA201891430A 2015-12-17 2016-12-16 Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений EA036295B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268747P 2015-12-17 2015-12-17
PCT/US2016/067164 WO2017106642A1 (en) 2015-12-17 2016-12-16 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds

Publications (2)

Publication Number Publication Date
EA201891430A1 true EA201891430A1 (ru) 2018-11-30
EA036295B1 EA036295B1 (ru) 2020-10-22

Family

ID=59057612

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201891430A EA036295B1 (ru) 2015-12-17 2016-12-16 Твердые формы замещенных 5,6-дигидро-6-фенилбензо[f]изохинолин-2-аминовых соединений
EA202091691A EA202091691A1 (ru) 2015-12-17 2016-12-16 ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA202091691A EA202091691A1 (ru) 2015-12-17 2016-12-16 ТВЕРДЫЕ ФОРМЫ ЗАМЕЩЕННЫХ 5,6-ДИГИДРО-6-ФЕНИЛБЕНЗО[f]ИЗОХИНОЛИН-2-АМИНОВЫХ СОЕДИНЕНИЙ

Country Status (19)

Country Link
US (3) US9981921B2 (ru)
EP (2) EP3390369B1 (ru)
JP (2) JP2018537499A (ru)
KR (1) KR20180086508A (ru)
CN (1) CN108368061A (ru)
AU (2) AU2016369523B2 (ru)
BR (1) BR112018012095A2 (ru)
CA (1) CA3006081A1 (ru)
EA (2) EA036295B1 (ru)
ES (1) ES2935818T3 (ru)
HK (1) HK1256825A1 (ru)
IL (1) IL259556B2 (ru)
MX (2) MX2018007414A (ru)
NZ (1) NZ742695A (ru)
PH (2) PH12018501246A1 (ru)
SA (1) SA518391805B1 (ru)
SG (1) SG11201804670PA (ru)
TW (2) TWI796250B (ru)
WO (1) WO2017106642A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI748972B (zh) 2015-12-17 2021-12-11 美商亞闊股份有限公司 製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法
MX2018007414A (es) * 2015-12-17 2018-11-09 Arqule Inc Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f¬]isoqui nolin-2-amina sustituidos.
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US6057329A (en) 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
PL1638937T3 (pl) * 2003-06-18 2009-06-30 Teva Pharmaceutical Industries Ltd Krystaliczna postać XIV soli sodowej fluwastatyny, sposoby jej wytwarzania, kompozycje farmaceutyczne zawierające tę postać oraz sposoby ich stosowania
CN110551105B (zh) 2006-12-29 2022-10-18 里格尔制药公司 用作axl抑制剂的取代三唑
TWI461410B (zh) 2008-12-30 2014-11-21 Arqule Inc 經取代之５，６－二氫－６－苯基苯並〔f〕異喹啉－２－胺化合物類
EA024026B1 (ru) * 2010-11-25 2016-08-31 Рациофарм Гмбх Новые соли и полиморфные формы афатиниба
WO2012177852A1 (en) 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
US9802954B2 (en) * 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2760859A1 (en) * 2011-09-30 2014-08-06 Sunshine Lake Pharma Co., Ltd Crystalline forms of azilsartan and preparation and uses thereof
TWI748972B (zh) * 2015-12-17 2021-12-11 美商亞闊股份有限公司 製備經取代5,6-二氫-6-苯基苯并[f]異喹啉-2-胺之方法
MX2018007414A (es) * 2015-12-17 2018-11-09 Arqule Inc Formas solidas de compuestos de 5,6-dihidro-6-fenilbenzo[f¬]isoqui nolin-2-amina sustituidos.
US9847831B2 (en) 2016-04-08 2017-12-19 Ciena Corporation Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system

Also Published As

Publication number Publication date
PH12020551465A1 (en) 2021-07-26
TWI771280B (zh) 2022-07-21
MX2018007414A (es) 2018-11-09
JP2022031797A (ja) 2022-02-22
US10227311B2 (en) 2019-03-12
AU2022201947B2 (en) 2023-07-27
SA518391805B1 (ar) 2022-12-21
JP2018537499A (ja) 2018-12-20
IL259556B2 (en) 2023-09-01
EP3390369A4 (en) 2019-08-14
IL259556B1 (en) 2023-05-01
IL259556A (en) 2018-07-31
US20180258055A1 (en) 2018-09-13
EA036295B1 (ru) 2020-10-22
US10717710B2 (en) 2020-07-21
CA3006081A1 (en) 2017-06-22
BR112018012095A2 (pt) 2018-11-27
AU2016369523A1 (en) 2018-06-07
SG11201804670PA (en) 2018-07-30
CN108368061A (zh) 2018-08-03
EP3390369A1 (en) 2018-10-24
EP3390369B1 (en) 2022-11-02
NZ742695A (en) 2022-10-28
TWI796250B (zh) 2023-03-11
EP4019499A1 (en) 2022-06-29
TW202241854A (zh) 2022-11-01
KR20180086508A (ko) 2018-07-31
MX2021000432A (es) 2022-07-28
AU2016369523B2 (en) 2021-12-23
US9981921B2 (en) 2018-05-29
WO2017106642A1 (en) 2017-06-22
US20200002293A1 (en) 2020-01-02
EA202091691A1 (ru) 2021-01-29
TW201736352A (zh) 2017-10-16
HK1256825A1 (zh) 2019-10-04
PH12018501246A1 (en) 2019-02-04
AU2022201947A1 (en) 2022-04-14
ES2935818T3 (es) 2023-03-10
US20170174636A1 (en) 2017-06-22

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