SG11201804670PA - Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds - Google Patents
Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compoundsInfo
- Publication number
- SG11201804670PA SG11201804670PA SG11201804670PA SG11201804670PA SG11201804670PA SG 11201804670P A SG11201804670P A SG 11201804670PA SG 11201804670P A SG11201804670P A SG 11201804670PA SG 11201804670P A SG11201804670P A SG 11201804670PA SG 11201804670P A SG11201804670P A SG 11201804670PA
- Authority
- SG
- Singapore
- Prior art keywords
- sfl
- lioz
- alp
- tof
- uopdaiatd
- Prior art date
Links
- IKLWZGVCUZDMEL-UHFFFAOYSA-N 6-phenyl-5,6-dihydrobenzo[f]isoquinolin-2-amine Chemical class C1=NC(N)=CC(C2=CC=CC=C22)=C1CC2C1=CC=CC=C1 IKLWZGVCUZDMEL-UHFFFAOYSA-N 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
- 241000728904 Iais Species 0.000 abstract 2
- 241000816088 Papia Species 0.000 abstract 1
- 241000364051 Pima Species 0.000 abstract 1
- 238000007735 ion beam assisted deposition Methods 0.000 abstract 1
- 230000036651 mood Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Oours IN gulsn pug guurdaKT Jo spotifam pug `appoTtpalpitilp auTure-z-ugozeumb[q]ozuagoipitilp-o'c-(pivatTd(pitlla(oulurepitllaiixotpam o -z)-z)-€)-N-;ivalTdoionll-z)-9-(N) Jo suuoj epos gam/will uoproildde wasaid ata :lanisqv (is) ---11 Gleos-?Taii-z 0 OE 63 EZ LZ 9Z EZ b& EZ - 33 43 OZ 6 Ill LL g 91. 74 E3 n 44 U 6 9 L 9 g b A :, a INJ A ' l V 4 j '''') S \ 4 12E HD II SONII0d1A103 3NINV - - Z NIIONMOOSIMOZN3HIAN3Hd - - 9 011CIAHICI - 9'S CHIGIIISELGS JO SIA1110A CHIOS :NUT (17S) 'ID 'NO 'HO 'ED 'IA `33 'ZIG 10 00 53 01 31 00 `NO `NO `fa '30 `ZD '113 '113 '03 'ND '13 'HD 'VD 'ZEE ((q)j•gfr an swawpuawn 'AEI 'MEI 'NH 'NH 'HEE 'OH 'Ha 'VE1 'ZV '11 1 $ '0V fo id!adat fo wand ay) w paysyqndad aq 01 pun sw!tip IN `NV 'iv 'Dv `gy alp fumuawn ,tof i!wy awp alp fo uoptmcbca alp adopq — :(amtiptiati uopdaiatd piuoptiu fo pub (Lona dof papia!pup asyvuaipo ssaiun) salmis paluOisaia (Ts) (4 -- )/z 1.4v) idocat pivas piuopvudam qpivi — *(sa) t000z rIquinT 0 3 :pagswind `uoigumgem 'oh `anuany Jo Topism aims murnvisuuad ((p)z rfr ainy) wapid 66Z T ' c m AoTooD !le 10 .10M tinna :slualir (17L) ii pawatf aq pun ,tof itiddv 01 ivawappua sduvoyddv 01 sal — 'mew ( ' *(Sfl) 9L0£0 awisdumil moN tro - a :LIT alnll JaPun suollgigRail urtpuof Lt !•, : i pima 'anti *(Sfl) 9L0£0 awls dumil moN ' 11121 1Tod troll A 011110 1. £S !IBAD `satva :sioluaAuI (ZL) *(01. 'CLI `NS '11\1 '111AI '11/\1 `YIN 'AO `OD 'NO 'VD 'ND 'ID '03 'AD 'fa ',1H) IdVO '(Ni 'IAIS . (sfi) €08 T 0 suasmpessuN `uoigulling `)IS 'IS `35 `sx 'lax 'id 'Id 'ON 'IN 'IN `NIAI '31AI 'Al 'was gem ouo Isrusal *DM '119611V lug311ddlir (IL) `fil `ii `II `SI 'AI 'fIH '2IH 'NO 'ED '21,1 'IA '53 'Ad 'NCI `30 `ZD 'AD 'HD 'OH '1/1 'IN IV) urodamd `(Ni 'll Sfl (S T CCZ T 'L T) S TN nclumon L T LtL'89Z/Z9 1111 `Z)I 'ON 'AEI 'ZV '1AIV) urIgamd `G\AZ '1A1Z '011 'Z1 :ma iCipolld WO `ZS 'IS IS 'CIS `A01 `VI\I 'ZIAI 'NUN `Si 'Ni 'AN 'NO Ingug :aanauuri uopumqnd (9z) `HO 'MED OdIIIV :(amtiptiati uopdaiatd piuo!fat fo puq (Loan ,tof papidyiu! asymaipo ssaiun) salmis painOisall (,g) tIsTigul :aagaugrI 11 111,1 (SZ) *i\AZ '1A.7 'IVZ (9T0CZT '90 9TO - 10 €1 111000 0 9T `NA `DA 'Zfl 'Sfl 'On 'Vfl 'LI 'II 'Ni `NI 'Ni 'LL 'Hi :alga 11 111,1 IguoliguialuI (ZZ) `AS 'AS 'IS 'IAIS IS `NS 'OS 'as 'as `DS 'VS `A01 'fill 179 T L90/9 T OZSIVIDd 'S11 'ON 'VO 'Id 'id 'fid 'Od 'Ad `Vd 'NO `ZN 'ON 'IN :iaqtunN uopuNddv puoputualiq (IZ) `ON `VI\I 'ZIAI 'AIAI `MAT 'NUN 'MAI 'NW 'ON 'AIN 'ON VIAI 'Al `ill `Si 'Ni `Ni '31 'VI `ZN 'MN `IIN 'cIN (i 0 . 900Z) Z BYTE XI9V (10 . 9002)178/6EZ GrZ03 `NM 'FIN 'ON '1N 'cif `SI '2II 'NI '1I 'cu 'f1H 'NH `NH :uonnagissun maim puoputualui (Ts) Jaqvunic IV uopuowind INIAMMERIIIME113114041110MERIEMEME ZI79901/LIOZ mumjuunjui OA% 40 10d 1 OdIAA (LIOZ*907Z)LIOZ aunt ZZ s-: ma uopuomind puopuunjui (Er) i: IlEaltta IMMITELUOTUT ,,- uopuziuuno .-_. Apadom junpallajui ppom (60 (iDa) AJNIIII NOUN/MOOD INILINd Ma IllaNfl GIFISIrllifld NOUNDIrlddV INNOUNNIIIINI (ZI)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562268747P | 2015-12-17 | 2015-12-17 | |
PCT/US2016/067164 WO2017106642A1 (en) | 2015-12-17 | 2016-12-16 | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201804670PA true SG11201804670PA (en) | 2018-07-30 |
Family
ID=59057612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201804670PA SG11201804670PA (en) | 2015-12-17 | 2016-12-16 | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
Country Status (19)
Country | Link |
---|---|
US (3) | US9981921B2 (en) |
EP (2) | EP4019499A1 (en) |
JP (2) | JP2018537499A (en) |
KR (1) | KR20180086508A (en) |
CN (1) | CN108368061A (en) |
AU (2) | AU2016369523B2 (en) |
BR (1) | BR112018012095A2 (en) |
CA (1) | CA3006081A1 (en) |
EA (2) | EA202091691A1 (en) |
ES (1) | ES2935818T3 (en) |
HK (1) | HK1256825A1 (en) |
IL (1) | IL259556B2 (en) |
MX (2) | MX2021000432A (en) |
NZ (1) | NZ742695A (en) |
PH (2) | PH12018501246A1 (en) |
SA (1) | SA518391805B1 (en) |
SG (1) | SG11201804670PA (en) |
TW (2) | TWI771280B (en) |
WO (1) | WO2017106642A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017106639A1 (en) | 2015-12-17 | 2017-06-22 | Arqule, Inc. | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
MX2021000432A (en) * | 2015-12-17 | 2022-07-28 | Arqule Inc | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinoli n-2-amine compounds. |
WO2022053708A1 (en) | 2020-09-14 | 2022-03-17 | Basilea Pharmaceutica International AG | Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
EP0946523A1 (en) | 1996-12-23 | 1999-10-06 | Celltech Therapeutics Limited | Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors |
GB9713087D0 (en) * | 1997-06-20 | 1997-08-27 | Celltech Therapeutics Ltd | Chemical compounds |
DE602004018494D1 (en) * | 2003-06-18 | 2009-01-29 | Teva Pharma | FLUVASTATIN SODIUM IN CRYSTAL FORM XIV, METHOD FOR THE PRODUCTION THEREOF, COMPOSITIONS COMPRISING THIS AND CORRESPONDING METHOD OF USE |
AU2007342007A1 (en) * | 2006-12-29 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | Substituted triazoles useful as Axl inhibitors |
WO2010078421A1 (en) * | 2008-12-30 | 2010-07-08 | Arqule, Inc. | Substituted 5,6-dihydro-6-phenylbenzo[f] isoquinolin-2-amine compounds |
EA024026B1 (en) * | 2010-11-25 | 2016-08-31 | Рациофарм Гмбх | Novel salts and polymorphic forms of afatinib |
US8815854B2 (en) * | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
US9802954B2 (en) * | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
WO2013044816A1 (en) * | 2011-09-30 | 2013-04-04 | Sunshine Lake Pharma Co., Ltd. | Crystalline forms of azilsartan and preparation and uses thereof |
WO2017106639A1 (en) * | 2015-12-17 | 2017-06-22 | Arqule, Inc. | Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine |
MX2021000432A (en) * | 2015-12-17 | 2022-07-28 | Arqule Inc | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinoli n-2-amine compounds. |
US9847831B2 (en) | 2016-04-08 | 2017-12-19 | Ciena Corporation | Dual wavelenth optical time domain reflectometer systems and methods embedded in a WDM system |
-
2016
- 2016-12-16 MX MX2021000432A patent/MX2021000432A/en unknown
- 2016-12-16 WO PCT/US2016/067164 patent/WO2017106642A1/en active Application Filing
- 2016-12-16 EP EP21216052.7A patent/EP4019499A1/en active Pending
- 2016-12-16 NZ NZ742695A patent/NZ742695A/en unknown
- 2016-12-16 ES ES16876769T patent/ES2935818T3/en active Active
- 2016-12-16 BR BR112018012095A patent/BR112018012095A2/en not_active Application Discontinuation
- 2016-12-16 KR KR1020187020340A patent/KR20180086508A/en not_active Application Discontinuation
- 2016-12-16 SG SG11201804670PA patent/SG11201804670PA/en unknown
- 2016-12-16 IL IL259556A patent/IL259556B2/en unknown
- 2016-12-16 AU AU2016369523A patent/AU2016369523B2/en active Active
- 2016-12-16 MX MX2018007414A patent/MX2018007414A/en unknown
- 2016-12-16 EA EA202091691A patent/EA202091691A1/en unknown
- 2016-12-16 EP EP16876769.7A patent/EP3390369B1/en active Active
- 2016-12-16 TW TW105141873A patent/TWI771280B/en active
- 2016-12-16 JP JP2018531388A patent/JP2018537499A/en active Pending
- 2016-12-16 CA CA3006081A patent/CA3006081A1/en active Pending
- 2016-12-16 TW TW111124239A patent/TWI796250B/en active
- 2016-12-16 CN CN201680073181.8A patent/CN108368061A/en active Pending
- 2016-12-16 US US15/381,414 patent/US9981921B2/en active Active
- 2016-12-16 EA EA201891430A patent/EA036295B1/en unknown
-
2018
- 2018-04-30 US US15/966,091 patent/US10227311B2/en active Active
- 2018-06-13 PH PH12018501246A patent/PH12018501246A1/en unknown
- 2018-06-13 SA SA518391805A patent/SA518391805B1/en unknown
- 2018-12-12 HK HK18115910.5A patent/HK1256825A1/en unknown
-
2019
- 2019-01-30 US US16/261,744 patent/US10717710B2/en active Active
-
2020
- 2020-09-14 PH PH12020551465A patent/PH12020551465A1/en unknown
-
2021
- 2021-11-26 JP JP2021191696A patent/JP2022031797A/en active Pending
-
2022
- 2022-03-21 AU AU2022201947A patent/AU2022201947B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201804670PA (en) | Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds | |
FR2964577B1 (en) | CONTROL SYSTEM FOR AGRICULTURAL SPRAY EQUIPMENT | |
JP2016504275A5 (en) | ||
EP1790665A4 (en) | Process for producing water-soluble hyaluronic acid modification | |
WO2008118820A3 (en) | Somatic cell reprogramming | |
WO2011065800A3 (en) | Pyrimidine derivative, method for preparing same and pharmaceutical composition containing same | |
CN106358347A (en) | Remote stage lighting control system | |
GEP20115332B (en) | Herbal composition for inflammatory disorders | |
CN104824141A (en) | Cereal airing and turning device | |
CN109922248A (en) | A kind of realtime graphic identification device based on artificial intelligence | |
EP2837268A1 (en) | Lighting system and control unit for same | |
EP3106002B1 (en) | Lighting system and method for operating a lighting system having an integrated safety concept | |
WO2008117707A1 (en) | Ground crystal of olmesartan medoxomil | |
CN105379609A (en) | Intelligent watering method for intra-area green belt | |
CN204317004U (en) | A kind of novel tobacco transplanter | |
CN104469444A (en) | Device for feeding virtual pets through intelligent television terminal | |
EP3976883A4 (en) | Block with artificial grass to grass pavement stones | |
EP3147264A3 (en) | Systems and methods for mechanically combining loose scrap | |
MX2009003740A (en) | Pegylated pth as pth receptor modulators and uses thereof. | |
EP2270947A3 (en) | Method and device for energy distribution | |
CN113940156A (en) | Vegetation planting device for ecological restoration of limestone mine refuse dump | |
EP1188726A3 (en) | Aggregate, in particular for concrete, and process of production | |
CN109663683A (en) | A kind of paint finishing that wireless control pneumatically separates | |
DE102015120686A1 (en) | Truck with a portable radio control unit and method for operating a truck from a distance with a portable radio control unit | |
EP2572907A3 (en) | Control system for a hydraulically operated tool connected to an agricultural tractor, and a method for using the same |