MX357314B - Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. - Google Patents

Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.

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Publication number
MX357314B
MX357314B MX2013007827A MX2013007827A MX357314B MX 357314 B MX357314 B MX 357314B MX 2013007827 A MX2013007827 A MX 2013007827A MX 2013007827 A MX2013007827 A MX 2013007827A MX 357314 B MX357314 B MX 357314B
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Mexico
Prior art keywords
vaccines
amino acid
natural amino
acid replication
dependent microorganisms
Prior art date
Application number
MX2013007827A
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English (en)
Inventor
Tian Feng
Hehli Brad
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX357314B publication Critical patent/MX357314B/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/22—Processes using, or culture media containing, cellulose or hydrolysates thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/185—Escherichia
    • C12R2001/19—Escherichia coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/32—Mycobacterium

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a composiciones y métodos de producción de vacunas, incluyendo métodos en los que se dotan unas vacunas de organismos completos de capacidades limitadas de replicación, aumentando de ese modo la seguridad y la eficacia de la vacuna, a través del uso de aminoácidos no naturales o no codificados de manera natural. Una célula bacteriana que contiene un aminoácido no-natural, en donde la célula bacteriana es una célula del bacilo Johne (MAP), y el aminoácido no-natural ha sido incorporado específicamente en sitio en la secuencia de aminoácidos de un producto génico requerido para replicación donde dicha célula es capaz de replicación únicamente en la presencia de dicho aminoácido no-natural, y tiene una capacidad limitada o ninguna capacidad de replicación en ausencia de dicho aminoácido no-natural.
MX2013007827A 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. MX357314B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10068808P 2008-09-26 2008-09-26
PCT/US2009/058668 WO2010037062A1 (en) 2008-09-26 2009-09-28 Non-natural amino acid replication-dependent microorganisms and vaccines

Publications (1)

Publication Number Publication Date
MX357314B true MX357314B (es) 2018-07-04

Family

ID=42060136

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2013007822A MX348657B (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
MX2011003196A MX2011003196A (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
MX2013007823A MX343802B (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
MX2013007827A MX357314B (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
MX2013007822A MX348657B (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
MX2011003196A MX2011003196A (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.
MX2013007823A MX343802B (es) 2008-09-26 2009-09-28 Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales.

Country Status (23)

Country Link
US (3) US9121024B2 (es)
EP (1) EP2337846B1 (es)
JP (1) JP5709754B2 (es)
KR (1) KR101732054B1 (es)
CN (1) CN102224238B (es)
AU (1) AU2009296267B2 (es)
BR (1) BRPI0919031A2 (es)
CA (1) CA2738033C (es)
CO (1) CO6362045A2 (es)
DK (1) DK2337846T3 (es)
EA (1) EA201170493A1 (es)
ES (1) ES2660000T3 (es)
HU (1) HUE036343T2 (es)
IL (2) IL211712A (es)
MX (4) MX348657B (es)
NO (1) NO2337846T3 (es)
NZ (2) NZ607477A (es)
PE (1) PE20110480A1 (es)
PL (1) PL2337846T3 (es)
PT (1) PT2337846T (es)
TR (1) TR201802361T4 (es)
WO (1) WO2010037062A1 (es)
ZA (1) ZA201102717B (es)

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CN107418913B (zh) * 2017-06-14 2020-12-22 湖南省农业生物技术研究中心 一种转化污染土壤中重金属镉的微生物菌剂的应用
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