MX339149B - Inhibidores de replicacion del virus de influenza. - Google Patents

Inhibidores de replicacion del virus de influenza.

Info

Publication number
MX339149B
MX339149B MX2014001067A MX2014001067A MX339149B MX 339149 B MX339149 B MX 339149B MX 2014001067 A MX2014001067 A MX 2014001067A MX 2014001067 A MX2014001067 A MX 2014001067A MX 339149 B MX339149 B MX 339149B
Authority
MX
Mexico
Prior art keywords
patient
influenza viruses
pharmaceutically acceptable
structural formula
biological sample
Prior art date
Application number
MX2014001067A
Other languages
English (en)
Spanish (es)
Other versions
MX2014001067A (es
Inventor
Hongbo Deng
Paul S Charifson
Michael P Clark
Upul K Bandarage
Randy S Bethiel
Michael J Boyd
Ioana Davies
John P Duffy
Luc J Farmer
Huai Gao
Wenxin Gu
Joseph M Kennedy
Brian Ledford
Mark W Ledeboer
Francois Maltais
Emanuele Perola
Tiansheng Wang
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX339149(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2014001067A publication Critical patent/MX2014001067A/es
Publication of MX339149B publication Critical patent/MX339149B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
MX2014001067A 2011-08-01 2012-08-01 Inhibidores de replicacion del virus de influenza. MX339149B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161513793P 2011-08-01 2011-08-01
PCT/US2012/049097 WO2013019828A1 (en) 2011-08-01 2012-08-01 Inhibitors of influenza viruses replication

Publications (2)

Publication Number Publication Date
MX2014001067A MX2014001067A (es) 2014-03-27
MX339149B true MX339149B (es) 2016-05-13

Family

ID=46650922

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014001067A MX339149B (es) 2011-08-01 2012-08-01 Inhibidores de replicacion del virus de influenza.

Country Status (37)

Country Link
US (5) US9051319B2 (enEXAMPLES)
EP (2) EP3147284B1 (enEXAMPLES)
JP (3) JP5917692B2 (enEXAMPLES)
KR (1) KR101967172B1 (enEXAMPLES)
CN (3) CN103764654B (enEXAMPLES)
AP (1) AP3867A (enEXAMPLES)
AR (1) AR087418A1 (enEXAMPLES)
AU (2) AU2012290127B2 (enEXAMPLES)
CA (1) CA2844054C (enEXAMPLES)
CL (1) CL2014000245A1 (enEXAMPLES)
CO (1) CO6940412A2 (enEXAMPLES)
CY (1) CY1118726T1 (enEXAMPLES)
DK (1) DK2739623T3 (enEXAMPLES)
EA (3) EA037372B1 (enEXAMPLES)
EC (1) ECSP14013189A (enEXAMPLES)
ES (2) ES2763535T3 (enEXAMPLES)
GE (2) GEP201706698B (enEXAMPLES)
HK (1) HK1223915A1 (enEXAMPLES)
HR (1) HRP20170421T1 (enEXAMPLES)
HU (1) HUE033752T2 (enEXAMPLES)
IL (2) IL230618A (enEXAMPLES)
IN (1) IN2014CN00562A (enEXAMPLES)
LT (1) LT2739623T (enEXAMPLES)
ME (1) ME02638B (enEXAMPLES)
MX (1) MX339149B (enEXAMPLES)
PE (1) PE20141209A1 (enEXAMPLES)
PH (1) PH12014500257A1 (enEXAMPLES)
PL (1) PL2739623T3 (enEXAMPLES)
PT (1) PT2739623T (enEXAMPLES)
RS (1) RS55858B1 (enEXAMPLES)
SG (2) SG10201503833SA (enEXAMPLES)
SI (1) SI2739623T1 (enEXAMPLES)
TW (3) TWI619715B (enEXAMPLES)
UA (2) UA118010C2 (enEXAMPLES)
UY (1) UY34234A (enEXAMPLES)
WO (1) WO2013019828A1 (enEXAMPLES)
ZA (2) ZA201400604B (enEXAMPLES)

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WO2006127587A1 (en) * 2005-05-20 2006-11-30 Vertex Pharmaceuticals Incorporated Pyrrolopyridines useful as inhibitors of protein kinase
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
PT2442809T (pt) 2009-06-17 2016-12-06 Vertex Pharma Inibidores da replicação de vírus da gripe
ES2804528T3 (es) 2011-07-05 2021-02-08 Vertex Pharma Procesos y productos intermedios para la producción de azaindoles
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US9296727B2 (en) 2013-10-07 2016-03-29 Vertex Pharmaceuticals Incorporated Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
LT3068782T (lt) * 2013-11-13 2018-09-10 Vertex Pharmaceuticals Incorporated Gripo virusų replikacijos inhibitorių paruošimo būdai
UA121376C2 (uk) 2013-11-13 2020-05-25 Вертекс Фармасьютикалз Інкорпорейтед Інгібітори реплікації вірусів грипу
CN103922966B (zh) * 2014-04-14 2015-10-21 武汉大学 作为甲型流感病毒抑制剂的甲酰胺和异腈类化合物及其制备与应用
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MA40773A (fr) * 2014-10-02 2017-08-08 Vertex Pharma Variants du virus influenza a
MA40772A (fr) * 2014-10-02 2017-08-08 Vertex Pharma Variants du virus de la grippe a
JP6704416B2 (ja) * 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
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KR20180087290A (ko) 2015-11-27 2018-08-01 얀센 사이언시즈 아일랜드 유씨 인플루엔자 바이러스 감염에서 사용하기 위한 복소환식 인돌
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HUE056457T2 (hu) * 2016-01-07 2022-02-28 Janssen Sciences Ireland Unlimited Co Pirrolo-[2-3,b]pirimidin-piridinekkel szubsztituált pentánsavak influenza vírusfertõzések kezelésére
SI3405466T1 (sl) 2016-01-20 2021-02-26 Janssen Sciences Ireland Unlimited Company Aril substituirani pirimidini za uporabo pri okužbi z virusom gripe
EP3492469B1 (en) 2016-07-26 2021-12-01 Suzhou Longbiotech Pharmaceuticals Co., Ltd. Compound as selective jak inhibitor, and salt and therapeutic use thereof
WO2018033082A1 (en) 2016-08-16 2018-02-22 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
US10647693B2 (en) 2016-08-30 2020-05-12 North & South Brother Pharmacy Investment Company Limited Inhibitors of influenza virus replication, application methods and uses thereof
CN106478460B (zh) * 2016-09-28 2018-06-12 衢州学院 一种手性N-Boc-3-氨基-4-芳基-丁酸的合成方法
KR102554019B1 (ko) 2016-12-15 2023-07-11 선샤인 레이크 파르마 컴퍼니 리미티드 인플루엔자 바이러스 복제의 억제제 및 이의 용도
US11098042B2 (en) 2017-01-05 2021-08-24 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication and uses thereof
CN110446711B (zh) 2017-03-02 2022-02-15 广东东阳光药业有限公司 流感病毒复制抑制剂及其用途
US11944679B2 (en) 2017-03-14 2024-04-02 The Regents Of The University Of California Genome-wide identification of immune evasion functions in a virus
CN109384783A (zh) * 2017-08-09 2019-02-26 银杏树药业(苏州)有限公司 新型杂环化合物及其作为抗流感病毒抑制剂的医药用途
TWI821343B (zh) * 2018-07-27 2023-11-11 美商共結晶製藥公司 流感病毒複製之抑制劑
CN112979647B (zh) * 2021-03-12 2022-05-20 浙江大学 含氮杂氨基酸的氮杂吲哚衍生物及制备和应用

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CY1118726T1 (el) 2017-07-12
JP6259855B2 (ja) 2018-01-10
TWI594997B (zh) 2017-08-11
EA201692506A2 (ru) 2017-06-30
TW201738241A (zh) 2017-11-01
EA037372B1 (ru) 2021-03-22
US9394302B2 (en) 2016-07-19
LT2739623T (lt) 2017-04-10
EP3147284A1 (en) 2017-03-29
MX2014001067A (es) 2014-03-27
HK1223915A1 (zh) 2017-08-11
AU2016228190B2 (en) 2018-11-08
DK2739623T3 (en) 2017-04-24
EA023423B1 (ru) 2016-06-30
US20140094473A1 (en) 2014-04-03
US9051319B2 (en) 2015-06-09
CN105503862B (zh) 2018-02-02

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