MX2022007801A - Formas polimorficas de rad1901-2hcl. - Google Patents

Formas polimorficas de rad1901-2hcl.

Info

Publication number
MX2022007801A
MX2022007801A MX2022007801A MX2022007801A MX2022007801A MX 2022007801 A MX2022007801 A MX 2022007801A MX 2022007801 A MX2022007801 A MX 2022007801A MX 2022007801 A MX2022007801 A MX 2022007801A MX 2022007801 A MX2022007801 A MX 2022007801A
Authority
MX
Mexico
Prior art keywords
rad1901
2hcl
polymorphic forms
forms
various polymorphic
Prior art date
Application number
MX2022007801A
Other languages
English (en)
Inventor
Alex Eberlin
Michael Paul Cruskie
Joshua Kyle Bolger
Jonathan Blake Mckenzie
Pratik Sheth
Richard Edwards
Michael Markey
Original Assignee
Radius Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radius Pharmaceuticals Inc filed Critical Radius Pharmaceuticals Inc
Publication of MX2022007801A publication Critical patent/MX2022007801A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Conductive Materials (AREA)
  • Cosmetics (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a varias formas polimórficas de RAD1901-2HC1, que incluyen tres formas cristalinas y amorfas, preparadas y caracterizadas. También se describen usos de las varias formas polimórficas de RAD1901-2HC1 para el tratamiento de cáncer.
MX2022007801A 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl. MX2022007801A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762442921P 2017-01-05 2017-01-05

Publications (1)

Publication Number Publication Date
MX2022007801A true MX2022007801A (es) 2022-08-11

Family

ID=62709319

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2019007748A MX2019007748A (es) 2017-01-05 2018-01-05 Formas polimorficas de rad1901-2hcl.
MX2020010555A MX2020010555A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.
MX2022007801A MX2022007801A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
MX2019007748A MX2019007748A (es) 2017-01-05 2018-01-05 Formas polimorficas de rad1901-2hcl.
MX2020010555A MX2020010555A (es) 2017-01-05 2019-06-26 Formas polimorficas de rad1901-2hcl.

Country Status (19)

Country Link
US (5) US10385008B2 (es)
EP (2) EP3565542B1 (es)
JP (2) JP7481115B2 (es)
KR (4) KR102557321B1 (es)
CN (2) CN110191707A (es)
AU (2) AU2018205285C9 (es)
CA (1) CA3047411A1 (es)
DK (1) DK3565542T3 (es)
ES (1) ES2981967T3 (es)
FI (1) FI3565542T3 (es)
HR (1) HRP20240923T1 (es)
IL (2) IL267772B (es)
LT (1) LT3565542T (es)
MX (3) MX2019007748A (es)
PL (1) PL3565542T3 (es)
PT (1) PT3565542T (es)
RS (1) RS65694B1 (es)
SI (1) SI3565542T1 (es)
WO (1) WO2018129419A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3565542T (lt) * 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
CN112423844B (zh) * 2018-07-04 2024-08-13 雷迪厄斯制药公司 Rad1901-2hcl的多晶型形式
JP7504097B2 (ja) * 2018-12-06 2024-06-21 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｃｄｋ４／６阻害剤に耐性の癌を治療するための方法
WO2023064519A1 (en) 2021-10-14 2023-04-20 Teva Pharmaceuticals International Gmbh Solid state forms of elacestrant and processes for preparation thereof
WO2023224961A1 (en) 2022-05-16 2023-11-23 Exelixis, Inc. Cancer therapy using a combination of a cdk7 inhibitor with an oral serd
WO2023227029A1 (zh) * 2022-05-25 2023-11-30 苏州科睿思制药有限公司 艾拉司群二盐酸盐的晶型及其制备方法和用途
WO2024104268A1 (zh) * 2022-11-15 2024-05-23 苏州科睿思制药有限公司 艾拉司群二盐酸盐的共晶及其制备方法和用途

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